Aurora A kinase RNAi and small molecule inhibition of Aurora kinases with VE-465 induce apoptotic death in multiple myeloma cells

Leukemia and Lymphoma

Volumn 49, Issue 3, 2008, Pages 559-569

  Evans, Robert ^a   Naber, Claudia ^a   Steffler, Tara ^a   Checkland, Tamara ^a   Keats, Jonathan ^a   Maxwell, Christopher ^a   Perry, Troy ^a   Chau, Heidi ^a   Belch, Andrew ^a   Pilarski, Linda ^a   Reiman, Tony ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Aurora kinases; Multiple myeloma; Novel therapeutics; Pre clinical studies; RNA interference

Indexed keywords

AURORA A KINASE; AURORA KINASE INHIBITOR; DEXAMETHASONE; MELPHALAN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; VE 465;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BONE MARROW CELL; CANCER CELL CULTURE; CELL KILLING; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DRUG POTENTIATION; ENZYME INHIBITION; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; HUMAN TISSUE; MONOTHERAPY; MULTIPLE MYELOMA; PHENOTYPIC VARIATION; PRIORITY JOURNAL; RNA INTERFERENCE;

APOPTOSIS; BONE MARROW; CELL LINE, TUMOR; DRUG EVALUATION, PRECLINICAL; HUMANS; MULTIPLE MYELOMA; PIPERAZINES; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; RNA INTERFERENCE; RNA, SMALL INTERFERING; TUMOR CELLS, CULTURED;

EID: 39749106551     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.1080/10428190701824544     Document Type: Article

References (29)