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Volumn 22, Issue 1, 2011, Pages 128-140

TRAF2 phosphorylation promotes NF-κB-dependent gene expression and inhibits oxidative stress-induced cell death

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B KINASE; I KAPPA B KINASE INHIBITOR; INHIBITOR OF APOPTOSIS PROTEIN 1; PROTEIN BCL 2; SERINE; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2;

EID: 78651084030     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E10-06-0556     Document Type: Article
Times cited : (33)

References (52)
  • 1
    • 4544342570 scopus 로고    scopus 로고
    • Nuclear factor-kappaB: The enemy within
    • Aggarwal BB (2004). Nuclear factor-kappaB: the enemy within. Cancer Cell 6, 203-208.
    • (2004) Cancer Cell , vol.6 , pp. 203-208
    • Aggarwal, B.B.1
  • 2
    • 34547562418 scopus 로고    scopus 로고
    • Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma
    • Annunziata CM et al. (2007). Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma. Cancer Cell 12, 115-130.
    • (2007) Cancer Cell , vol.12 , pp. 115-130
    • Annunziata, C.M.1
  • 3
    • 58249115041 scopus 로고    scopus 로고
    • TRAF2 phosphorylation modulates tumor necrosis factor alpha-induced gene expression and cell resistance to apoptosis
    • Blackwell K, Zhang L, Thomas GS, Sun S, Nakano H, Habelhah H (2009). TRAF2 phosphorylation modulates tumor necrosis factor alpha-induced gene expression and cell resistance to apoptosis. Mol Cell Biol 29, 303-314.
    • (2009) Mol Cell Biol , vol.29 , pp. 303-314
    • Blackwell, K.1    Zhang, L.2    Thomas, G.S.3    Sun, S.4    Nakano, H.5    Habelhah, H.6
  • 4
    • 2342464085 scopus 로고    scopus 로고
    • The two NF-kappaB activation pathways and their role in innate and adaptive immunity
    • DOI 10.1016/j.it.2004.03.008, PII S1471490604001000
    • Bonizzi G, Karin M (2004). The two NF-kappaB activation pathways and their role in innate and adaptive immunity. Trends Immunol 25, 280-288. (Pubitemid 38610351)
    • (2004) Trends in Immunology , vol.25 , Issue.6 , pp. 280-288
    • Bonizzi, G.1    Karin, M.2
  • 5
    • 0034665047 scopus 로고    scopus 로고
    • Defi ciency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription
    • Bonnard M et al. (2000). Defi ciency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription. EMBO J 19, 4976-4985.
    • (2000) EMBO J , vol.19 , pp. 4976-4985
    • Bonnard, M.1
  • 6
    • 0035475338 scopus 로고    scopus 로고
    • Tumor necrosis factor receptor-associated factors (TRAFs)
    • Bradley JR, Pober JS (2001). Tumor necrosis factor receptor-associated factors (TRAFs). Oncogene 20, 6482-6491.
    • (2001) Oncogene , vol.20 , pp. 6482-6491
    • Bradley, J.R.1    Pober, J.S.2
  • 7
    • 23144449789 scopus 로고    scopus 로고
    • Ubiquitin signalling in the NF-kappaB pathway
    • Chen ZJ (2005). Ubiquitin signalling in the NF-kappaB pathway. Nat Cell Biol 7, 758-765.
    • (2005) Nat Cell Biol , vol.7 , pp. 758-765
    • Chen, Z.J.1
  • 8
    • 59649086030 scopus 로고    scopus 로고
    • Nonproteolytic functions of ubiquitin in cell signaling
    • Chen ZJ, Sun LJ (2009). Nonproteolytic functions of ubiquitin in cell signaling. Mol Cell 33, 275-286.
    • (2009) Mol Cell , vol.33 , pp. 275-286
    • Chen, Z.J.1    Sun, L.J.2
  • 9
    • 68949086679 scopus 로고    scopus 로고
    • Enhanced cytoprotective effects of the inhibitor of apoptosis protein cellular IAP1 through stabilization with TRAF2
    • Csomos RA, Brady GF, Duckett CS (2009). Enhanced cytoprotective effects of the inhibitor of apoptosis protein cellular IAP1 through stabilization with TRAF2. J Biol Chem 284, 20531-20539.
    • (2009) J Biol Chem , vol.284 , pp. 20531-20539
    • Csomos, R.A.1    Brady, G.F.2    Duckett, C.S.3
  • 10
    • 58249093873 scopus 로고    scopus 로고
    • Induction of hepatitis by JNK-mediated expression of TNF-alpha
    • Das M, Sabio G, Jiang F, Rincon M, Flavell RA, Davis RJ (2009). Induction of hepatitis by JNK-mediated expression of TNF-alpha. Cell 136, 249-260.
    • (2009) Cell , vol.136 , pp. 249-260
    • Das, M.1    Sabio, G.2    Jiang, F.3    Rincon, M.4    Flavell, R.A.5    Davis, R.J.6
  • 11
    • 0034644522 scopus 로고    scopus 로고
    • Signal transduction by the JNK group of MAP kinases
    • Davis RJ (2000). Signal transduction by the JNK group of MAP kinases. Cell 103, 239-252.
    • (2000) Cell , vol.103 , pp. 239-252
    • Davis, R.J.1
  • 13
    • 0033725155 scopus 로고    scopus 로고
    • The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation
    • Devin A, Cook A, Lin Y, Rodriguez Y, Kelliher M, Liu Z (2000). The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation. Immunity 12, 419-429.
    • (2000) Immunity , vol.12 , pp. 419-429
    • Devin, A.1    Cook, A.2    Lin, Y.3    Rodriguez, Y.4    Kelliher, M.5    Liu, Z.6
  • 14
    • 33646034316 scopus 로고    scopus 로고
    • Activation of IKK by TNFalpha requires site-specifi c ubiquitination of RIP1 and polyubiquitin binding by NEMO
    • Ea CK, Deng L, Xia ZP, Pineda G, Chen ZJ (2006). Activation of IKK by TNFalpha requires site-specifi c ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol Cell 22, 245-257.
    • (2006) Mol Cell , vol.22 , pp. 245-257
    • Ea, C.K.1    Deng, L.2    Xia, Z.P.3    Pineda, G.4    Chen, Z.J.5
  • 15
    • 0034730511 scopus 로고    scopus 로고
    • Vinblastine-induced phosphorylation of Bcl-2 and Bcl-XL is mediated by JNK and occurs in parallel with inactivation of the Raf-1/MEK/ ERK cascade
    • Fan M, Goodwin M, Vu T, Brantley-Finley C, Gaarde WA, Chambers TC (2000). Vinblastine-induced phosphorylation of Bcl-2 and Bcl-XL is mediated by JNK and occurs in parallel with inactivation of the Raf-1/MEK/ ERK cascade. J Biol Chem 275, 29980-29985.
    • (2000) J Biol Chem , vol.275 , pp. 29980-29985
    • Fan, M.1    Goodwin, M.2    Vu, T.3    Brantley-Finley, C.4    Gaarde, W.A.5    Chambers, T.C.6
  • 16
    • 40249115896 scopus 로고    scopus 로고
    • TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor
    • Gardam S, Sierro F, Basten A, Mackay F, Brink R (2008). TRAF2 and TRAF3 signal adapters act cooperatively to control the maturation and survival signals delivered to B cells by the BAFF receptor. Immunity 28, 391-401.
    • (2008) Immunity , vol.28 , pp. 391-401
    • Gardam, S.1    Sierro, F.2    Basten, A.3    Mackay, F.4    Brink, R.5
  • 17
    • 8444220390 scopus 로고    scopus 로고
    • TRAF2 differentially regulates the canonical and noncanonical pathways of NFkappaB activation in mature B cells
    • Grech AP, Amesbury M, Chan T, Gardam S, Basten A, Brink R (2004). TRAF2 differentially regulates the canonical and noncanonical pathways of NFkappaB activation in mature B cells. Immunity 21, 629-642.
    • (2004) Immunity , vol.21 , pp. 629-642
    • Grech, A.P.1    Amesbury, M.2    Chan, T.3    Gardam, S.4    Basten, A.5    Brink, R.6
  • 20
    • 1542380581 scopus 로고    scopus 로고
    • Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-kappaB
    • Habelhah H, Takahashi S, Cho SG, Kadoya T, Watanabe T, Ronai Z (2004). Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-kappaB. EMBO J 23, 322-332.
    • (2004) EMBO J , vol.23 , pp. 322-332
    • Habelhah, H.1    Takahashi, S.2    Cho, S.G.3    Kadoya, T.4    Watanabe, T.5    Ronai, Z.6
  • 21
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA (2000). The hallmarks of cancer. Cell 100, 57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 22
    • 38849199203 scopus 로고    scopus 로고
    • Shared principles in NF-kappaB signaling
    • Hayden MS, Ghosh S (2008). Shared principles in NF-kappaB signaling. Cell 132, 344-362.
    • (2008) Cell , vol.132 , pp. 344-362
    • Hayden, M.S.1    Ghosh, S.2
  • 23
    • 0037044575 scopus 로고    scopus 로고
    • The IkappaB-NF-kappaB signaling module: Temporal control and selective gene activation
    • DOI 10.1126/science.1071914
    • Hoffmann A, Levchenko A, Scott ML, Baltimore D (2002). The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science 298, 1241-1245. (Pubitemid 35285493)
    • (2002) Science , vol.298 , Issue.5596 , pp. 1241-1245
    • Hoffmann, A.1    Levchenko, A.2    Scott, M.L.3    Baltimore, D.4
  • 24
    • 14844327760 scopus 로고    scopus 로고
    • Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases
    • Kamata H, Honda S, Maeda S, Chang L, Hirata H, Karin M (2005). Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases. Cell 120, 649-661.
    • (2005) Cell , vol.120 , pp. 649-661
    • Kamata, H.1    Honda, S.2    Maeda, S.3    Chang, L.4    Hirata, H.5    Karin, M.6
  • 25
    • 0036546501 scopus 로고    scopus 로고
    • NF-kappaB in cancer: From innocent bystander to major culprit
    • Karin M, Cao Y, Greten FR, Li ZW (2002). NF-kappaB in cancer: from innocent bystander to major culprit. Nat Rev Cancer 2, 301-310.
    • (2002) Nat Rev Cancer , vol.2 , pp. 301-310
    • Karin, M.1    Cao, Y.2    Greten, F.R.3    Li, Z.W.4
  • 26
    • 34547660308 scopus 로고    scopus 로고
    • Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma
    • Keats JJ et al. (2007). Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma. Cancer Cell 12, 131-144.
    • (2007) Cancer Cell , vol.12 , pp. 131-144
    • Keats, J.J.1
  • 27
    • 0037462802 scopus 로고    scopus 로고
    • Tumor necrosis factor-regulated biphasic activation of NF-kappa B is required for cytokine-induced loss of skeletal muscle gene products
    • Ladner KJ, Caligiuri MA, Guttridge DC (2003). Tumor necrosis factor-regulated biphasic activation of NF-kappa B is required for cytokine-induced loss of skeletal muscle gene products. J Biol Chem 278, 2294-2303.
    • (2003) J Biol Chem , vol.278 , pp. 2294-2303
    • Ladner, K.J.1    Caligiuri, M.A.2    Guttridge, D.C.3
  • 29
    • 0036419909 scopus 로고    scopus 로고
    • Cytochrome P450 2B1 mediates oxidant injury in puromycin-induced nephrotic syndrome
    • Liu H, Bigler SA, Henegar JR, Baliga R (2002). Cytochrome P450 2B1 mediates oxidant injury in puromycin-induced nephrotic syndrome. Kidney Int 62, 868-876.
    • (2002) Kidney Int , vol.62 , pp. 868-876
    • Liu, H.1    Bigler, S.A.2    Henegar, J.R.3    Baliga, R.4
  • 30
    • 70349338906 scopus 로고    scopus 로고
    • Regulation of Bcl-2 phosphorylation in response to oxidative stress in cardiac myocytes
    • Markou T, Dowling AA, Kelly T, Lazou A (2009). Regulation of Bcl-2 phosphorylation in response to oxidative stress in cardiac myocytes. Free Radic Res 43, 809-816.
    • (2009) Free Radic Res , vol.43 , pp. 809-816
    • Markou, T.1    Dowling, A.A.2    Kelly, T.3    Lazou, A.4
  • 31
    • 0041853690 scopus 로고    scopus 로고
    • Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes
    • Micheau O, Tschopp J (2003). Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell 114, 181-190.
    • (2003) Cell , vol.114 , pp. 181-190
    • Micheau, O.1    Tschopp, J.2
  • 32
    • 0037223086 scopus 로고    scopus 로고
    • NF-kappaB activation by protein kinase C isoforms and B-cell function
    • Moscat J, Diaz-Meco MT, Rennert P (2003). NF-kappaB activation by protein kinase C isoforms and B-cell function. EMBO Rep 4, 31-36.
    • (2003) EMBO Rep , vol.4 , pp. 31-36
    • Moscat, J.1    Diaz-Meco, M.T.2    Rennert, P.3
  • 34
    • 27744559915 scopus 로고    scopus 로고
    • Recruitment of tumor necrosis factor receptor-associated factor family proteins to apoptosis signal-regulating kinase 1 signalosome is essential for oxidative stress-induced cell death
    • Noguchi T, Takeda K, Matsuzawa A, Saegusa K, Nakano H, Gohda J, Inoue J, Ichijo H (2005). Recruitment of tumor necrosis factor receptor-associated factor family proteins to apoptosis signal-regulating kinase 1 signalosome is essential for oxidative stress-induced cell death. J Biol Chem 280, 37033-37040.
    • (2005) J Biol Chem , vol.280 , pp. 37033-37040
    • Noguchi, T.1    Takeda, K.2    Matsuzawa, A.3    Saegusa, K.4    Nakano, H.5    Gohda, J.6    Inoue, J.7    Ichijo, H.8
  • 35
    • 0036020941 scopus 로고    scopus 로고
    • NF-kappaB as a therapeutic target in cancer
    • Orlowski RZ, Baldwin Jr AS (2002). NF-kappaB as a therapeutic target in cancer. Trends Mol Med 8, 385-389.
    • (2002) Trends Mol Med , vol.8 , pp. 385-389
    • Orlowski, R.Z.1    Baldwin Jr., A.S.2
  • 36
    • 0042525938 scopus 로고    scopus 로고
    • NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death
    • Sakon S et al. (2003). NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death. EMBO J 22, 3898-3909.
    • (2003) EMBO J , vol.22 , pp. 3898-3909
    • Sakon, S.1
  • 38
  • 40
    • 65949114424 scopus 로고    scopus 로고
    • Phosphorylation of TRAF2 within its RING domain inhibits stress-induced cell death by promoting IKK and suppressing JNK activation
    • Thomas GS, Zhang L, Blackwell K, Habelhah H (2009). Phosphorylation of TRAF2 within its RING domain inhibits stress-induced cell death by promoting IKK and suppressing JNK activation. Cancer Res 69, 3665-3672.
    • (2009) Cancer Res , vol.69 , pp. 3665-3672
    • Thomas, G.S.1    Zhang, L.2    Blackwell, K.3    Habelhah, H.4
  • 42
    • 56349164232 scopus 로고    scopus 로고
    • Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling
    • Vallabhapurapu S, Matsuzawa A, Zhang W, Tseng PH, Keats JJ, Wang H, Vignali DA, Bergsagel PL, Karin M (2008). Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling. Nat Immunol 9, 1364-1370.
    • (2008) Nat Immunol , vol.9 , pp. 1364-1370
    • Vallabhapurapu, S.1    Matsuzawa, A.2    Zhang, W.3    Tseng, P.H.4    Keats, J.J.5    Wang, H.6    Vignali, D.A.7    Bergsagel, P.L.8    Karin, M.9
  • 44
    • 0034982801 scopus 로고    scopus 로고
    • The TNF-receptor-associated factor family: Scaffold molecules for cytokine receptors, kinases and their regulators
    • Wajant H, Henkler F, Scheurich P (2001). The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators. Cell Signal 13, 389-400.
    • (2001) Cell Signal , vol.13 , pp. 389-400
    • Wajant, H.1    Henkler, F.2    Scheurich, P.3
  • 45
    • 24944489952 scopus 로고    scopus 로고
    • Stimulus specifi city of gene expression programs determined by temporal control of IKK activity
    • Werner SL, Barken D, Hoffmann A (2005). Stimulus specifi city of gene expression programs determined by temporal control of IKK activity. Science 309, 1857-1861.
    • (2005) Science , vol.309 , pp. 1857-1861
    • Werner, S.L.1    Barken, D.2    Hoffmann, A.3
  • 47
    • 33645703930 scopus 로고    scopus 로고
    • Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation
    • corrected
    • Wu CJ, Conze DB, Li T, Srinivasula SM, Ashwell JD (2006). Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]. Nat Cell Biol 8, 398-406.
    • (2006) Nat Cell Biol , vol.8 , pp. 398-406
    • Wu, C.J.1    Conze, D.B.2    Li, T.3    Srinivasula, S.M.4    Ashwell, J.D.5
  • 48
    • 0033499801 scopus 로고    scopus 로고
    • BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M
    • Yamamoto K, Ichijo H, Korsmeyer SJ (1999). BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M. Mol Cell Biol 19, 8469-8478.
    • (1999) Mol Cell Biol , vol.19 , pp. 8469-8478
    • Yamamoto, K.1    Ichijo, H.2    Korsmeyer, S.J.3
  • 49
    • 0031463025 scopus 로고    scopus 로고
    • Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-defi cient mice
    • Yeh WC et al. (1997). Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-defi cient mice. Immunity 7, 715-725.
    • (1997) Immunity , vol.7 , pp. 715-725
    • Yeh, W.C.1
  • 50
    • 77949332322 scopus 로고    scopus 로고
    • The RING domain of TRAF2 plays an essential role in the inhibition of TNFalpha-induced cell death but not in the activation of NF-kappaB
    • Zhang L, Blackwell K, Shi Z, Habelhah H (2010). The RING domain of TRAF2 plays an essential role in the inhibition of TNFalpha-induced cell death but not in the activation of NF-kappaB. J Mol Biol 396, 528-539.
    • (2010) J Mol Biol , vol.396 , pp. 528-539
    • Zhang, L.1    Blackwell, K.2    Shi, Z.3    Habelhah, H.4
  • 51
    • 65649150701 scopus 로고    scopus 로고
    • TRAF2 suppresses basal IKK activity in resting cells and TNFalpha can activate IKK in TRAF2 and TRAF5 double knockout cells
    • Zhang L, Blackwell K, Thomas GS, Sun S, Yeh WC, Habelhah H (2009). TRAF2 suppresses basal IKK activity in resting cells and TNFalpha can activate IKK in TRAF2 and TRAF5 double knockout cells. J Mol Biol 389, 495-510.
    • (2009) J Mol Biol , vol.389 , pp. 495-510
    • Zhang, L.1    Blackwell, K.2    Thomas, G.S.3    Sun, S.4    Yeh, W.C.5    Habelhah, H.6
  • 52
    • 0033712615 scopus 로고    scopus 로고
    • Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation
    • Zhang SQ, Kovalenko A, Cantarella G, Wallach D (2000). Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation. Immunity 12, 301-311.
    • (2000) Immunity , vol.12 , pp. 301-311
    • Zhang, S.Q.1    Kovalenko, A.2    Cantarella, G.3    Wallach, D.4


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