-
1
-
-
0032818964
-
Plasma levels of vascular endothelial growth factor are increased in patients with metastatic prostate cancer
-
Duque JL, Loughlin KR, Adam RM, et al. Plasma levels of vascular endothelial growth factor are increased in patients with metastatic prostate cancer. Urology 1999; 54:523-7.
-
(1999)
Urology
, vol.54
, pp. 523-527
-
-
Duque, J.L.1
Loughlin, K.R.2
Adam, R.M.3
-
2
-
-
0034772250
-
Prognostic significance of plasma vascular endothelial growth factor levels in patients with hormone-refractory prostate cancer treated on Cancer and Leukemia Group B 9480
-
George DJ, Halabi S, Shepard TF, et al. Prognostic significance of plasma vascular endothelial growth factor levels in patients with hormone-refractory prostate cancer treated on Cancer and Leukemia Group B 9480. Clin Cancer Res 2001; 7:1932-6.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1932-1936
-
-
George, D.J.1
Halabi, S.2
Shepard, T.F.3
-
3
-
-
0036795180
-
Antibody to vascular endothelial growth factor slows growth of an androgen-independent xenograft model of prostate cancer
-
Fox WD, Higgins B, Maiese KM, et al. Antibody to vascular endothelial growth factor slows growth of an androgen-independent xenograft model of prostate cancer. Clin Cancer Res 2002; 8:3226-31.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 3226-3231
-
-
Fox, W.D.1
Higgins, B.2
Maiese, K.M.3
-
4
-
-
0036023438
-
Anti-vascular endothelial growth factor receptor 2 antibody reduces tumorigenicity and metastasis in orthotopic prostate cancer xenografts via induction of endothelial cell apoptosis and reduction of endothelial cell matrix metalloproteinase type 9 production
-
Sweeney P, Karashima T, Kim SJ, et al. Anti-vascular endothelial growth factor receptor 2 antibody reduces tumorigenicity and metastasis in orthotopic prostate cancer xenografts via induction of endothelial cell apoptosis and reduction of endothelial cell matrix metalloproteinase type 9 production. Clin Cancer Res 2002; 8:2714-24.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 2714-2724
-
-
Sweeney, P.1
Karashima, T.2
Kim, S.J.3
-
5
-
-
0346880557
-
The use of bevacizumab with docetaxel and estramustine in hormone refractory prostate cancer (HRPC): Initial results of CALGB 90006
-
abstract 1578
-
Picus J, Halabi S, Rini B, et al. The use of bevacizumab with docetaxel and estramustine in hormone refractory prostate cancer (HRPC): Initial results of CALGB 90006. Proc Am Soc Clin Oncol 2003; 22(suppl):22s (abstract 1578).
-
(2003)
Proc Am Soc Clin Oncol
, vol.22
, Issue.SUPPL.
-
-
Picus, J.1
Halabi, S.2
Rini, B.3
-
6
-
-
53249135560
-
Combination of bevacizumab and docetaxel in docetaxel-pretreated hormone-refractory prostate cancer: A phase 2 study
-
Di Lorenzo G, Figg WD, Fossa SD, et al. Combination of bevacizumab and docetaxel in docetaxel-pretreated hormone-refractory prostate cancer: A phase 2 study. Eur Urol 2008; 54:1089-96
-
(2008)
Eur Urol
, vol.54
, pp. 1089-1096
-
-
Di Lorenzo, G.1
Figg, W.D.2
Fossa, S.D.3
-
7
-
-
77955714649
-
A randomized, double-blind, placebo-controlled phase III trial comparing docetaxel, prednisone, and placebo with docetaxel, prednisone, and bevacizumab in men with metastatic castration-resistant prostate cancer (mCRPC): Survival results of CALGB 90401
-
abstract LBA4511)
-
Kelly WK, Halabi S, Carducci MA, et al. A randomized, double-blind, placebo-controlled phase III trial comparing docetaxel, prednisone, and placebo with docetaxel, prednisone, and bevacizumab in men with metastatic castration-resistant prostate cancer (mCRPC): Survival results of CALGB 90401. J Clin Oncol 2010; 28(15 suppl):344s (abstract LBA4511).
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 SUPPL.
-
-
Kelly, W.K.1
Halabi, S.2
Carducci, M.A.3
-
8
-
-
40749122148
-
A phase II clinical trial of sorafenib in androgen-independent prostate cancer
-
Dahut WL, Scripture C, Posadas E, et al. A phase II clinical trial of sorafenib in androgen-independent prostate cancer. Clin Cancer Res 2008; 14:209-14.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 209-214
-
-
Dahut, W.L.1
Scripture, C.2
Posadas, E.3
-
9
-
-
67149130074
-
Final analysis of a phase II trial using sorafenib for metastatic castration-resistant prostate cancer
-
Aragon-Ching JB, Jain L, Gulley JL, et al. Final analysis of a phase II trial using sorafenib for metastatic castration-resistant prostate cancer. BJU Int 2009; 103:1636-40
-
(2009)
BJU Int
, vol.103
, pp. 1636-1640
-
-
Aragon-Ching, J.B.1
Jain, L.2
Gulley, J.L.3
-
10
-
-
65549099731
-
Phase II study of sunitinib in men with advanced prostate cancer
-
Dror Michaelson M, Regan MM, Oh WK, et al. Phase II study of sunitinib in men with advanced prostate cancer. Ann Oncol 2009; 20:913-20.
-
(2009)
Ann Oncol
, vol.20
, pp. 913-920
-
-
Dror Michaelson, M.1
Regan, M.M.2
Oh, W.K.3
-
11
-
-
77951887506
-
Sunitinib malate for metastatic castration-resistant prostate cancer following docetaxel-based chemotherapy
-
Sonpavde G, Periman PO, Bernold D, et al. Sunitinib malate for metastatic castration-resistant prostate cancer following docetaxel-based chemotherapy. Ann Oncol 2010; 21:319-24
-
(2010)
Ann Oncol
, vol.21
, pp. 319-324
-
-
Sonpavde, G.1
Periman, P.O.2
Bernold, D.3
-
12
-
-
65349186800
-
Aflibercept: An alternative strategy for inhibiting tumour angiogenesis by vascular endothelial growth factors
-
Chu QS. Aflibercept: An alternative strategy for inhibiting tumour angiogenesis by vascular endothelial growth factors. Expert Opin Biol Ther 2009; 9:263-71.
-
(2009)
Expert Opin Biol Ther
, vol.9
, pp. 263-271
-
-
Chu, Q.S.1
-
13
-
-
69249228874
-
A phase I dose escalation and pharmacokinetic (PK) study of intravenous aflibercept (VEGF trap) plus docetaxel in patients with advanced solid tumors: Preliminary results
-
abstract 3599
-
Isambert N, Freyer G, Zanetta S, et al. A phase I dose escalation and pharmacokinetic (PK) study of intravenous aflibercept (VEGF trap) plus docetaxel in patients with advanced solid tumors: Preliminary results. J Clin Oncol 2008; 26(15 suppl):177s (abstract 3599).
-
(2008)
J Clin Oncol
, vol.26
, Issue.15 SUPPL.
-
-
Isambert, N.1
Freyer, G.2
Zanetta, S.3
-
14
-
-
1942534043
-
The evolution of thalidomide and its IMiD derivatives as anticancer agents
-
Bartlett JB, Dredge K, Dalgleish AG. The evolution of thalidomide and its IMiD derivatives as anticancer agents. Nat Rev Cancer 2004; 4:314-22.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 314-322
-
-
Bartlett, J.B.1
Dredge, K.2
Dalgleish, A.G.3
-
15
-
-
0034783270
-
A randomized phase II trial of thalidomide, an angiogenesis inhibitor, in androgen-independent prostate cancer
-
Figg WD, Dahut W, Duray P, et al. A randomized phase II trial of thalidomide, an angiogenesis inhibitor, in androgen-independent prostate cancer. Clin Cancer Res 2001; 7:1888-93.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1888-1893
-
-
Figg, W.D.1
Dahut, W.2
Duray, P.3
-
16
-
-
4344682179
-
Randomized phase II trial of docetaxel plus thalidomide in androgen-independent prostate cancer
-
Dahut WL, Gulley JL, Arlen PM, et al. Randomized phase II trial of docetaxel plus thalidomide in androgen-independent prostate cancer. J Clin Oncol 2004; 22:2532-9.
-
(2004)
J Clin Oncol
, vol.22
, pp. 2532-2539
-
-
Dahut, W.L.1
Gulley, J.L.2
Arlen, P.M.3
-
17
-
-
77951644363
-
Phase II trial of bevacizumab, thalidomide, docetaxel, and prednisone in patients with metastatic castration-resistant prostate cancer
-
Ning YM, Gulley JL, Arlen PM, et al. Phase II trial of bevacizumab, thalidomide, docetaxel, and prednisone in patients with metastatic castration-resistant prostate cancer. J Clin Oncol 2010; 28:2070-6.
-
(2010)
J Clin Oncol
, Issue.28
, pp. 2070-2076
-
-
Ning, Y.M.1
Gulley, J.L.2
Arlen, P.M.3
-
18
-
-
35748959418
-
Phase I/II trial of GM-CSF and lenalidomide in patients with hormone refractory prostate cancer
-
abstract 15515
-
Dreicer R, Garcia J, Smith S, et al. Phase I/II trial of GM-CSF and lenalidomide in patients with hormone refractory prostate cancer. J Clin Oncol 2007; 25(18 suppl):651s (abstract 15515).
-
(2007)
J Clin Oncol
, vol.25
, Issue.18 SUPPL.
-
-
Dreicer, R.1
Garcia, J.2
Smith, S.3
-
19
-
-
67649405805
-
Clinical activity of ketoconazole and lenalidomide in castrate progressive prostate carcinoma: Preliminary results of a phase II trial
-
abstract 5143
-
Garcia JA, Triozzi P, Elson P, et al. Clinical activity of ketoconazole and lenalidomide in castrate progressive prostate carcinoma: Preliminary results of a phase II trial. J Clin Oncol 2008; 26(15 suppl):285s (abstract 5143).
-
(2008)
J Clin Oncol
, vol.26
, Issue.15 SUPPL.
-
-
Garcia, J.A.1
Triozzi, P.2
Elson, P.3
-
20
-
-
77749280814
-
A phase I open-label study using lenalidomide and docetaxel in castration-resistant prostate cancer
-
abstract 5156
-
Petrylak DP, Resto-Garces K, Tibyan M, et al. A phase I open-label study using lenalidomide and docetaxel in castration-resistant prostate cancer. J Clin Oncol 2009; 27(suppl): (abstract 5156
-
(2009)
J Clin Oncol
, vol.27
, Issue.SUPPL.
-
-
Petrylak, D.P.1
Resto-Garces, K.2
Tibyan, M.3
-
21
-
-
79955845812
-
Safety and activity of lenalidomide in elderly patients with chemotherapy-naive, castration-resistant prostate cancer (CRPC)
-
abstract e15125
-
Lestingi TM, Tolzien K, Kelby SK, et al. Safety and activity of lenalidomide in elderly patients with chemotherapy-naive, castration-resistant prostate cancer (CRPC). J Clin Oncol 2010; 28(15 suppl): (abstract e15125).
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 SUPPL.
-
-
Lestingi, T.M.1
Tolzien, K.2
Kelby, S.K.3
-
22
-
-
33845394305
-
Identification of ABR-215050 as lead second generation quinoline-3-carboxamide anti-angiogenic agent for the treatment of prostate cancer
-
Isaacs JT, Pili R, Qian DZ, et al. Identification of ABR-215050 as lead second generation quinoline-3-carboxamide anti-angiogenic agent for the treatment of prostate cancer. Prostate 2006; 66:1768-78.
-
(2006)
Prostate
, vol.66
, pp. 1768-1778
-
-
Isaacs, J.T.1
Pili, R.2
Qian, D.Z.3
-
23
-
-
77955710046
-
A randomized, multicenter, international phase II study of tasquinimod in chemotherapy-naïve patients with metastatic castrate-resistant prostate cancer
-
abstract 4510
-
Pili R, Haggman M, Stadler WM, et al. A randomized, multicenter, international phase II study of tasquinimod in chemotherapy-naïve patients with metastatic castrate-resistant prostate cancer. J Clin Oncol 2010; 28(15 suppl):344s (abstract 4510).
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 SUPPL.
-
-
Pili, R.1
Haggman, M.2
Stadler, W.M.3
-
24
-
-
38949208873
-
The potential of DMXAA (ASA404) in combination with docetaxel in advanced prostate cancer
-
McKeage MJ. The potential of DMXAA (ASA404) in combination with docetaxel in advanced prostate cancer. Expert Opin Investig Drugs 2008; 17:23-9.
-
(2008)
Expert Opin Investig Drugs
, vol.17
, pp. 23-29
-
-
McKeage, M.J.1
-
25
-
-
33846878300
-
5,6-dimethylxanthenoine-4-acetic acid (DMXAA) clinical potential in combination with taxane-based chemotherapy
-
McKeage MJ, Kelland LR. 5,6-dimethylxanthenoine-4-acetic acid (DMXAA) clinical potential in combination with taxane-based chemotherapy. Am J Cancer 2006; 5:155-62.
-
(2006)
Am J Cancer
, vol.5
, pp. 155-162
-
-
McKeage, M.J.1
Kelland, L.R.2
-
26
-
-
77952399799
-
Phase II study on the addition of ASA404 (vadimezan; 5,6- dimethylxanthenone-4-acetic acid) to docetaxel in CRMPC
-
Pili R, Rosenthal MA, Mainwaring PN, et al. Phase II study on the addition of ASA404 (vadimezan; 5,6-dimethylxanthenone-4-acetic acid) to docetaxel in CRMPC. Clin Cancer Res 2010; 16:2906-14.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 2906-2914
-
-
Pili, R.1
Rosenthal, M.A.2
Mainwaring, P.N.3
-
27
-
-
54749149761
-
NCCN Task Force Report: MTOR inhibition in solid tumors
-
Figlin RA, Brown E, Armstrong AJ, et al. NCCN Task Force Report: MTOR inhibition in solid tumors. J Natl Compr Canc Netw 2008; 6(suppl 5):S1-20.
-
(2008)
J Natl Compr Canc Netw
, vol.6
, Issue.SUPPL. 5
-
-
Figlin, R.A.1
Brown, E.2
Armstrong, A.J.3
-
28
-
-
45349109057
-
RAD001 (everolimus) inhibits growth of prostate cancer in the bone and the inhibitory effects are increased by combination with docetaxel and zoledronic acid
-
Morgan TM, Pitts TE, Gross TS, et al. RAD001 (everolimus) inhibits growth of prostate cancer in the bone and the inhibitory effects are increased by combination with docetaxel and zoledronic acid. Prostate 2008; 68:861-71.
-
(2008)
Prostate
, vol.68
, pp. 861-871
-
-
Morgan, T.M.1
Pitts, T.E.2
Gross, T.S.3
-
29
-
-
33751194771
-
Demonstration that temsirolimus preferentially inhibits the mTOR pathway in the tumors of prostate cancer patients with PTEN deficiencies
-
Thomas G, Speicher L, Reiter R, et al. Demonstration that temsirolimus preferentially inhibits the mTOR pathway in the tumors of prostate cancer patients with PTEN deficiencies. Clin Cancer Res 2005 24:9132s..
-
(2005)
Clin Cancer Res
, vol.24
-
-
Thomas, G.1
Speicher, L.2
Reiter, R.3
-
30
-
-
67349247607
-
Phase I trial of RAD001 and docetaxel in castration resistant prostate cancer with FDG-PET assessment of RAD001 activity
-
abstract 5069
-
Ross RW, Manola J, Oh WK, et al. Phase I trial of RAD001 and docetaxel in castration resistant prostate cancer with FDG-PET assessment of RAD001 activity. J Clin Oncol 2008; 26(15 suppl):266s (abstract 5069).
-
(2008)
J Clin Oncol
, vol.26
, Issue.15 SUPPL.
-
-
Ross, R.W.1
Manola, J.2
Oh, W.K.3
-
31
-
-
78651109710
-
Phase I trial of RAD001, bevacizumab, and docetaxel for castration-resistant prostate cancer (CRPC)
-
abstract 5154
-
Gross ME, Soscia J, Sakowsky S, et al. Phase I trial of RAD001, bevacizumab, and docetaxel for castration-resistant prostate cancer (CRPC). J Clin Oncol 2009; 27( 15 suppl):272s (abstract 5154).
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 SUPPL.
-
-
Gross, M.E.1
Soscia, J.2
Sakowsky, S.3
-
32
-
-
80054746971
-
Impact of temsirolimus and anti-androgen therapy on circulating tumor cell (CTC) biology in men with castration-resistant metastatic prostate cancer (CRPC): A phase II study
-
abstract TPS249
-
Armstrong AJ, Kemeny G, Turnbull JD, et al. Impact of temsirolimus and anti-androgen therapy on circulating tumor cell (CTC) biology in men with castration-resistant metastatic prostate cancer (CRPC): A phase II study. J Clin Oncol 2010; 28(15 suppl):43s (abstract TPS249).
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 SUPPL.
-
-
Armstrong, A.J.1
Kemeny, G.2
Turnbull, J.D.3
-
33
-
-
80455142320
-
A phase II study of maintenance therapy with temsirolimus after response to first-line docetaxel chemotherapy in castration-resistant prostate cancer (CRPC)
-
abstract TPS246
-
Emmenegger U, Sridhar SS, Booth CM, et al. A phase II study of maintenance therapy with temsirolimus after response to first-line docetaxel chemotherapy in castration-resistant prostate cancer (CRPC). J Clin Oncol 2010; 28(suppl):15s (abstract TPS246).
-
(2010)
J Clin Oncol
, vol.28
, Issue.SUPPL.
-
-
Emmenegger, U.1
Sridhar, S.S.2
Booth, C.M.3
-
34
-
-
0036479998
-
Emerging targets in the Akt pathway for treatment of androgen-independent prostatic adenocarcinoma
-
Graff JR. Emerging targets in the Akt pathway for treatment of androgen-independent prostatic adenocarcinoma. Expert Opin Ther Targets 2002; 6:103-13.
-
(2002)
Expert Opin Ther Targets
, vol.6
, pp. 103-113
-
-
Graff, J.R.1
-
35
-
-
1642535431
-
Akt activity determines sensitivity to mammalian target of rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expression
-
Gera JF, Mellinghoff IK, Shi Y, et al. Akt activity determines sensitivity to mammalian target of rapamycin (mTOR) inhibitors by regulating cyclin D1 and c-myc expression. J Biol Chem 2004; 279:2737-46.
-
(2004)
J Biol Chem
, vol.279
, pp. 2737-2746
-
-
Gera, J.F.1
Mellinghoff, I.K.2
Shi, Y.3
-
36
-
-
27744450731
-
A phase II study of perifosine in androgen independent prostate cancer
-
Posadas EM, Gulley J, Arlen PM, et al. A phase II study of perifosine in androgen independent prostate cancer. Cancer Biol Ther 2005; 4:1133-7.
-
(2005)
Cancer Biol Ther
, vol.4
, pp. 1133-1137
-
-
Posadas, E.M.1
Gulley, J.2
Arlen, P.M.3
-
37
-
-
77956587792
-
First-in-class phase I trial of a selective Akt inhibitor, MK2206, evaluating alternate day (QOD) and once weekly (QW) doses in advanced cancer patients with evidence of target modulation and antitumor activity
-
abstract 3009
-
Yap TA, Patnaik, Fearen AI, et al. First-in-class phase I trial of a selective Akt inhibitor, MK2206, evaluating alternate day (QOD) and once weekly (QW) doses in advanced cancer patients with evidence of target modulation and antitumor activity. J Clin Oncol 2010; 28(15 suppl):235s (abstract 3009).
-
(2010)
J Clin Oncol
, vol.28
, Issue.15 SUPPL.
-
-
Yap, T.A.1
Patnaik Fearen, A.I.2
-
38
-
-
0029077281
-
Overexpression of bcl-2 protects prostate cancer cells from apoptosis in vitro and confers resistance to androgen depletion in vivo
-
Raffo AJ, Perlman H, Chen MW, et al. Overexpression of bcl-2 protects prostate cancer cells from apoptosis in vitro and confers resistance to androgen depletion in vivo. Cancer Res 1995; 55:4438-45.
-
(1995)
Cancer Res
, vol.55
, pp. 4438-4445
-
-
Raffo, A.J.1
Perlman, H.2
Chen, M.W.3
-
39
-
-
0029851180
-
Bcl-2 overexpression combined with p53 protein accumulation correlates with hormone-refractory prostate cancer
-
Apakama I, Robinson MC, Walter NM, et al. Bcl-2 overexpression combined with p53 protein accumulation correlates with hormone-refractory prostate cancer. Br J Cancer 1996; 74:1258-62.
-
(1996)
Br J Cancer
, vol.74
, pp. 1258-1262
-
-
Apakama, I.1
Robinson, M.C.2
Walter, N.M.3
-
40
-
-
37149035009
-
In vivo evaluation of AT-101 (R-gossypol acetic acid) in androgen-independent growth of VCaP prostate cancer cells in combination with surgical castration
-
Loberg RD, McGregor N, Ying C, et al. In vivo evaluation of AT-101 (R-gossypol acetic acid) in androgen-independent growth of VCaP prostate cancer cells in combination with surgical castration. Neoplasia 2007; 9:1030-7.
-
(2007)
Neoplasia
, vol.9
, pp. 1030-1037
-
-
Loberg, R.D.1
McGregor, N.2
Ying, C.3
-
41
-
-
1442301661
-
The inhibitory effects of gossypol on human prostate cancer cells PC3 are associated with transforming growth factor β1 (TGFβ1) signal transduction pathway
-
Jiang J, Sugimoto Y, Liu S, et al. The inhibitory effects of gossypol on human prostate cancer cells PC3 are associated with transforming growth factor β1 (TGFβ1) signal transduction pathway. Anticancer Res 2004; 24:91-100.
-
(2004)
Anticancer Res
, vol.24
, pp. 91-100
-
-
Jiang, J.1
Sugimoto, Y.2
Liu, S.3
-
42
-
-
65649130832
-
An open-label, multicenter, phase I/II study of single-agent AT-101 in men with castrate-resistant prostate cancer
-
Liu G, Kelly WK, Wilding G, et al. An open-label, multicenter, phase I/II study of single-agent AT-101 in men with castrate-resistant prostate cancer. Clin Cancer Res 2009; 15:3172-6
-
(2009)
Clin Cancer Res
, vol.15
, pp. 3172-3176
-
-
Liu, G.1
Kelly, W.K.2
Wilding, G.3
-
43
-
-
78651095954
-
An open-label multicenter phase I/II study of AT-101 in combination with docetaxel and prednisone in men with hormone refractory prostate cancer
-
Gastrointestinal Cancers Symposium; February 14-16, 2008; San Francisco, CA. Abstract 152
-
MacVicar GR, Curti B, Somer B, et al. An open-label, multicenter, phase I/II study of AT-101 in combination with docetaxel and prednisone in men with hormone refractory prostate cancer. Presented at: The American Society of Clinical Oncology: 2008 Gastrointestinal Cancers Symposium; February 14-16, 2008; San Francisco, CA. Abstract 152.
-
(2008)
Presented at: The American Society of Clinical Oncology
-
-
MacVicar, G.R.1
Curti, B.2
Somer, B.3
-
44
-
-
76749144766
-
Targeting the cytoprotective chaperone, clusterin, for treatment of advanced cancer
-
Zoubeidi A, Chi K, Gleave M. Targeting the cytoprotective chaperone, clusterin, for treatment of advanced cancer. Clin Cancer Res 2010; 16:1088-93.
-
(2010)
Clin Cancer Res
, Issue.16
, pp. 1088-1093
-
-
Zoubeidi, A.1
Chi, K.2
Gleave, M.3
-
45
-
-
0033548566
-
Clusterin has chaperone-like activity similar to that of small heat shock proteins
-
Humphreys DT, Carver JA, Easterbrook-Smith SB, et al. Clusterin has chaperone-like activity similar to that of small heat shock proteins. J Biol Chem 1999; 274:6875-81.
-
(1999)
J Biol Chem
, vol.274
, pp. 6875-6881
-
-
Humphreys, D.T.1
Carver, J.A.2
Easterbrook-Smith, S.B.3
-
46
-
-
26944445883
-
Clusterin inhibits apoptosis by interacting with activated Bax
-
Zhang H, Kim JK, Edwards CA, et al. Clusterin inhibits apoptosis by interacting with activated Bax. Nat Cell Biol 2005; 7:909-15.
-
(2005)
Nat Cell Biol
, vol.7
, pp. 909-915
-
-
Zhang, H.1
Kim, J.K.2
Edwards, C.A.3
-
47
-
-
75149124457
-
Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF-kappaB activity in prostate cancer cells
-
Zoubeidi A, Ettinger S, Beraldi E, et al. Clusterin facilitates COMMD1 and I-kappaB degradation to enhance NF-kappaB activity in prostate cancer cells. Mol Cancer Res 2010; 8:119-30.
-
(2010)
Mol Cancer Res
, Issue.8
, pp. 119-130
-
-
Zoubeidi, A.1
Ettinger, S.2
Beraldi, E.3
-
48
-
-
0037083472
-
Clusterin expression is significantly enhanced in prostate cancer cells following androgen withdrawal therapy
-
July LV, Akbari M, Zellweger T, et al. Clusterin expression is significantly enhanced in prostate cancer cells following androgen withdrawal therapy. Prostate 2002; 50:179-88.
-
(2002)
Prostate
, vol.50
, pp. 179-188
-
-
July, L.V.1
Akbari, M.2
Zellweger, T.3
-
49
-
-
0034192382
-
Acquisition of chemoresistant phenotype by overexpression of the antiapoptotic gene testosterone-repressed prostate message-2 in prostate cancer xenograft models
-
Miyake H, Nelson C, Rennie PS, et al. Acquisition of chemoresistant phenotype by overexpression of the antiapoptotic gene testosterone-repressed prostate message-2 in prostate cancer xenograft models. Cancer Res 2000; 60:2547-54.
-
(2000)
Cancer Res
, vol.60
, pp. 2547-2554
-
-
Miyake, H.1
Nelson, C.2
Rennie, P.S.3
-
50
-
-
15944390264
-
Use of antisense oligonucleotides targeting the cytoprotective gene, clusterin, to enhance androgen- and chemo-sensitivity in prostate cancer
-
Gleave M, Miyake H. Use of antisense oligonucleotides targeting the cytoprotective gene, clusterin, to enhance androgen- and chemo-sensitivity in prostate cancer. World J Urol 2005; 23:38-46.
-
(2005)
World J Urol
, vol.23
, pp. 38-46
-
-
Gleave, M.1
Miyake, H.2
-
51
-
-
47649133156
-
Clusterin knockdown using the antisense oligonucleotide OGX-011 re-sensitizes docetaxel-refractory prostate cancer PC-3 cells to chemotherapy
-
Sowery RD, Hadaschik BA, So AI, et al. Clusterin knockdown using the antisense oligonucleotide OGX-011 re-sensitizes docetaxel-refractory prostate cancer PC-3 cells to chemotherapy. BJU Int 2008; 102:389-97.
-
(2008)
BJU Int
, vol.102
, pp. 389-397
-
-
Sowery, R.D.1
Hadaschik, B.A.2
So, A.I.3
-
52
-
-
38949153810
-
A phase I study of OGX-011, a 2-methoxyethyl phosphorothioate antisense to clusterin, in combination with docetaxel in patients with advanced cancer
-
Chi KN, Siu LL, Hirte H, et al. A phase I study of OGX-011, a 2-methoxyethyl phosphorothioate antisense to clusterin, in combination with docetaxel in patients with advanced cancer. Clin Cancer Res 2008; 14:833-9.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 833-839
-
-
Chi, K.N.1
Siu, L.L.2
Hirte, H.3
-
53
-
-
77957957234
-
Randomized phase II study of docetaxel and prednisone with or without OGX-011 in patients with metastatic castration-resistant prostate cancer
-
Chi KN, Hotte SJ, Yu EY, et al. Randomized phase II study of docetaxel and prednisone with or without OGX-011 in patients with metastatic castration-resistant prostate cancer. J Clin Oncol 2010; 28:4247-54.
-
(2010)
J Clin Oncol
, Issue.28
, pp. 4247-4254
-
-
Chi, K.N.1
Hotte, S.J.2
Yu, E.Y.3
-
55
-
-
55949136227
-
First human dose study evaluating safety and pharmacokinetics of LY2181308, an antisense oligonucleotide designed to inhibit survivin
-
abstract 3518
-
Talbot DC, Davies J, Callies S, et al. First human dose study evaluating safety and pharmacokinetics of LY2181308, an antisense oligonucleotide designed to inhibit survivin. J Clin Oncol 2008; 26(15 suppl):157s (abstract 3518).
-
(2008)
J Clin Oncol
, vol.26
, Issue.15 SUPPL.
-
-
Talbot, D.C.1
Davies, J.2
Callies, S.3
-
56
-
-
66649126940
-
Phase I study of YM155, a novel survivin suppressant, in patients with advanced solid tumors
-
Satoh T, Okamoto I, Miyazaki M, et al. Phase I study of YM155, a novel survivin suppressant, in patients with advanced solid tumors. Clin Cancer Res 2009; 15:3872-80.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 3872-3880
-
-
Satoh, T.1
Okamoto, I.2
Miyazaki, M.3
-
57
-
-
0037125383
-
Insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 as predictors of advanced stage prostate cancer
-
Chan JM, Stampfer MJ, Ma J, et al. Insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 as predictors of advanced stage prostate cancer. J Natl Cancer Inst 2002; 94:1099-106.
-
(2002)
J Natl Cancer Inst
, vol.94
, pp. 1099-1106
-
-
Chan, J.M.1
Stampfer, M.J.2
Ma, J.3
-
58
-
-
9244242088
-
Increased insulin-like growth factor 1 receptor expression and signaling are components of androgen-independent progression in a lineage-derived prostate cancer progression model
-
Krueckl SL, Sikes RA, Edlund NM, et al. Increased insulin-like growth factor 1 receptor expression and signaling are components of androgen-independent progression in a lineage-derived prostate cancer progression model. Cancer Res 2004; 64:8620-9.
-
(2004)
Cancer Res
, vol.64
, pp. 8620-8629
-
-
Krueckl, S.L.1
Sikes, R.A.2
Edlund, N.M.3
-
59
-
-
60349109398
-
Implications of insulin-like growth factor-1 for prostate cancer therapies
-
Kojima S, Inahara M, Suzuki H, et al. Implications of insulin-like growth factor-1 for prostate cancer therapies. Int J Urol 2009; 16:161-7.
-
(2009)
Int J Urol
, vol.16
, pp. 161-167
-
-
Kojima, S.1
Inahara, M.2
Suzuki, H.3
-
60
-
-
17144416483
-
In vivo effects of the human type 1 insulin-like growth factor receptor antibody A12 on androgen-dependent and androgen-independent xenograft human prostate tumors
-
Wu JD, Odman A, Higgins LM, et al. In vivo effects of the human type 1 insulin-like growth factor receptor antibody A12 on androgen-dependent and androgen-independent xenograft human prostate tumors. Clin Cancer Res 2005; 11:3065-74.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 3065-3074
-
-
Wu, J.D.1
Odman, A.2
Higgins, L.M.3
-
61
-
-
35948940097
-
An antibody targeting the type 1 insulin-like growth factor receptor enhances the castration-induced response in androgen-dependent prostate cancer
-
Plymate SR, Haugk K, Coleman I, et al. An antibody targeting the type 1 insulin-like growth factor receptor enhances the castration-induced response in androgen-dependent prostate cancer. Clin Cancer Res 2007; 13:6429-39.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 6429-6439
-
-
Plymate, S.R.1
Haugk, K.2
Coleman, I.3
-
62
-
-
34848903049
-
IMC-A12, a human IgG1 monoclonal antibody to the insulin-like growth factor I receptor
-
Rowinsky EK, Youssoufian H, Tonra JR, et al. IMC-A12, a human IgG1 monoclonal antibody to the insulin-like growth factor I receptor. Clin Cancer Res 2007; 13:5549s-55.
-
(2007)
Clin Cancer Res
, vol.13
-
-
Rowinsky, E.K.1
Youssoufian, H.2
Tonra, J.R.3
-
63
-
-
76749125262
-
A phase II study evaluating the efficacy and safety of single-agent IMC-A12, a monoclonal antibody against the insulin-like growth factor-1 receptor (IGF-IR), as monotherapy in patients with metastatic, asymptomatic castration-resistant prostate cancer
-
abstract 5142
-
Higano C, Alumkal J, Ryan CJ, et al. A phase II study evaluating the efficacy and safety of single-agent IMC-A12, a monoclonal antibody against the insulin-like growth factor-1 receptor (IGF-IR), as monotherapy in patients with metastatic, asymptomatic castration-resistant prostate cancer. J Clin Oncol 2009; 27(15 suppl):269s (abstract 5142).
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 SUPPL.
-
-
Higano, C.1
Alumkal, J.2
Ryan, C.J.3
-
64
-
-
77949448133
-
Figitumumab (CP-751,871) for cancer therapy
-
Gualberto A. Figitumumab (CP-751,871) for cancer therapy. Expert Opin Biol Ther 2010; 10:575-85.
-
(2010)
Expert Opin Biol Ther
, vol.10
, pp. 575-585
-
-
Gualberto A1
-
65
-
-
77955049754
-
The insulin-like growth factor-I receptor inhibitor figitumumab (CP-751,871) in combination with docetaxel in patients with advanced solid tumours: Results of a phase Ib dose-escalation, open-label study
-
Molife LR, Fong PC, Paccagnella L, et al. The insulin-like growth factor-I receptor inhibitor figitumumab (CP-751,871) in combination with docetaxel in patients with advanced solid tumours: Results of a phase Ib dose-escalation, open-label study. Br J Cancer 2010; 103:332-9.
-
(2010)
Br J Cancer
, vol.103
, pp. 332-339
-
-
Molife, L.R.1
Fong, P.C.2
Paccagnella, L.3
-
67
-
-
58149390625
-
Targeting Src signaling in metastatic bone disease
-
Araujo J, Logothetis C. Targeting Src signaling in metastatic bone disease. Int J Cancer 2009; 124:1-6.
-
(2009)
Int J Cancer
, vol.124
, pp. 1-6
-
-
Araujo, J.1
Logothetis, C.2
-
68
-
-
19944428353
-
Discovery of N-(2-chloro-6-methyl-phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide, a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays
-
Lombardo LJ, Lee FY, Chen P, et al. Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)-piperazin-1-yl)-2-methylpyrimidin-4-ylamino) thiazole-5-carboxamide, a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J Med Chem 2004; 47:6658-61.
-
(2004)
J Med Chem
, vol.47
, pp. 6658-6661
-
-
Lombardo, L.J.1
Lee, F.Y.2
Chen, P.3
-
69
-
-
27144547509
-
Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells
-
Nam S, Kim D, Cheng JQ, et al. Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells. Cancer Res 2005; 65:9185-9.
-
(2005)
Cancer Res
, vol.65
, pp. 9185-9189
-
-
Nam, S.1
Kim, D.2
Cheng, J.Q.3
-
70
-
-
44849134528
-
Targeting SRC family kinases inhibits growth and lymph node metastases of prostate cancer in an orthotopic nude mouse model
-
Park SI, Zhang J, Phillips KA, et al. Targeting SRC family kinases inhibits growth and lymph node metastases of prostate cancer in an orthotopic nude mouse model. Cancer Res 2008; 68:3323-33
-
(2008)
Cancer Res
, vol.68
, pp. 3323-3333
-
-
Park, S.I.1
Zhang, J.2
Phillips, K.A.3
-
71
-
-
73149115110
-
Phase II study of dasatinib in patients with metastatic castration-resistant prostate cancer
-
Yu EY, Wilding G, Posadas E, et al. Phase II study of dasatinib in patients with metastatic castration-resistant prostate cancer. Clin Cancer Res 2009; 15:7421-8.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 7421-7428
-
-
Yu, E.Y.1
Wilding, G.2
Posadas, E.3
-
72
-
-
70249151654
-
Dasatinib and docetaxel combination treatment for patients with castration-resistant progressive prostate cancer: A phase I/II study
-
abstract 5061
-
Araujo J, Armstrong AJ, Braud EL, et al. Dasatinib and docetaxel combination treatment for patients with castration-resistant progressive prostate cancer: A phase I/II study. J Clin Oncol 2009; 27(15 suppl):249s (abstract 5061).
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 SUPPL.
-
-
Araujo, J.1
Armstrong, A.J.2
Braud, E.L.3
-
73
-
-
54549086723
-
Src family kinase oncogenic potential and pathways in prostate cancer as revealed by AZD0530
-
Chang YM, Bai L, Liu S, et al. Src family kinase oncogenic potential and pathways in prostate cancer as revealed by AZD0530. Oncogene 2008; 27:6365-75.
-
(2008)
Oncogene
, vol.27
, pp. 6365-6375
-
-
Chang, Y.M.1
Bai, L.2
Liu, S.3
-
74
-
-
61749096864
-
A phase II trial of the Src-kinase inhibitor AZD0530 in patients with advanced castration-resistant prostate cancer: A California cancer consortium study
-
Lara PN, Jr, Longmate J, Evans CP, et al. A phase II trial of the Src-kinase inhibitor AZD0530 in patients with advanced castration-resistant prostate cancer: A California Cancer Consortium study. Anticancer Drugs 2009; 20:179-84.
-
(2009)
Anticancer Drugs
, vol.20
, pp. 179-184
-
-
Lara, P.N.1
Longmate Jr., J.2
Evans, C.P.3
-
75
-
-
51449112648
-
Potent and selective in vitro and in vivo inhibition of tumor proliferation by KX01, a novel non-ATP competitive Src inhibitor
-
abstract 3245
-
Hangauer D, Gelman I, Dyster L, et al. Potent and selective in vitro and in vivo inhibition of tumor proliferation by KX01, a novel non-ATP competitive Src inhibitor. Proc Am Assoc Cancer Res 2007; (abstract 3245).
-
(2007)
Proc Am Assoc Cancer Res
-
-
Hangauer, D.1
Gelman, I.2
Dyster, L.3
-
76
-
-
68449088438
-
KX01 (KX2-391), a Src-family kinase inhibitor targeting the peptide-binding domain, suppresses oncogenic proliferation in vitro and in vivo
-
(abstract 4983)
-
Bu Y, Gao L, Smolinsk M, et al. KX01 (KX2-391), a Src-family kinase inhibitor targeting the peptide-binding domain, suppresses oncogenic proliferation in vitro and in vivo. Proc Am Assoc Cancer Res 2008; (abstract 4983).
-
(2008)
Proc Am Assoc Cancer Res
-
-
Bu, Y.1
Gao, L.2
Smolinsk, M.3
-
77
-
-
76749135138
-
Results of a phase I trial of KX2-391, a novel non-ATP competitive substrate-pocket directed Src inhibitor, in patients with advanced malignancies
-
(abstract 3511)
-
Adjei AA, Cohen RB, Kurzrock R, et al. Results of a phase I trial of KX2-391, a novel non-ATP competitive substrate-pocket directed Src inhibitor, in patients with advanced malignancies. J Clin Oncol 2009; 27(15 suppl):148s (abstract 3511).
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 SUPPL.
-
-
Adjei, A.A.1
Cohen, R.B.2
Kurzrock, R.3
-
78
-
-
0035577854
-
Hedgehog signaling in animal development: Paradigms and principles
-
Ingham PW, McMahon AP. Hedgehog signaling in animal development: Paradigms and principles. Genes Dev 2001; 15:3059-87.
-
(2001)
Genes Dev
, vol.15
, pp. 3059-3087
-
-
Ingham, P.W.1
McMahon, A.P.2
-
79
-
-
6044243650
-
Hedgehog signaling in prostate regeneration, neoplasia and metastasis
-
Karhadkar SS, Bova GS, Abdallah N, et al. Hedgehog signaling in prostate regeneration, neoplasia and metastasis. Nature 2004; 431:707-12.
-
(2004)
Nature
, vol.431
, pp. 707-712
-
-
Karhadkar, S.S.1
Bova, G.S.2
Abdallah, N.3
-
80
-
-
1542357306
-
Roles for Hedgehog signaling in androgen production and prostate ductal morphogenesis
-
Berman DM, Desai N, Wang X, et al. Roles for Hedgehog signaling in androgen production and prostate ductal morphogenesis. Dev Biol 2004; 267:387-98.
-
(2004)
Dev Biol
, vol.267
, pp. 387-398
-
-
Berman, D.M.1
Desai, N.2
Wang, X.3
-
81
-
-
13644261744
-
Activation of the hedgehog pathway in advanced prostate cancer
-
Sheng T, Li C, Zhang X, et al. Activation of the hedgehog pathway in advanced prostate cancer. Mol Cancer 2004; 3:29.
-
(2004)
Mol Cancer
, vol.3
, pp. 29
-
-
Sheng, T.1
Li, C.2
Zhang, X.3
-
82
-
-
45849143363
-
Hedgehog signaling in androgen independent prostate cancer
-
Shaw G, Price AM, Ktori E, et al. Hedgehog signaling in androgen independent prostate cancer. Eur Urol 2008; 54:1333-43.
-
(2008)
Eur Urol
, vol.54
, pp. 1333-1343
-
-
Shaw, G.1
Price, A.M.2
Ktori, E.3
-
83
-
-
4344659678
-
Inhibition of prostate cancer proliferation by interference with sonic hedgehog-GLI1 signaling
-
Sanchez P, Hernandez AM, Stecca B, et al. Inhibition of prostate cancer proliferation by interference with sonic hedgehog-GLI1 signaling. Proc Natl Acad Sci USA 2004; 101:12561-6.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 12561-12566
-
-
Sanchez, P.1
Hernandez, A.M.2
Stecca, B.3
-
84
-
-
34249867843
-
Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists
-
Lauth M, Bergstrom A, Shimokawa T, et al. Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc Natl Acad Sci USA 2007; 104:8455-60.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 8455-8460
-
-
Lauth, M.1
Bergstrom, A.2
Shimokawa, T.3
-
85
-
-
77952903058
-
Vismodegib, a small-molecule inhibitor of the hedgehog pathway for the treatment of advanced cancers
-
De Smaele E, Ferretti E, Gulino A. Vismodegib, a small-molecule inhibitor of the hedgehog pathway for the treatment of advanced cancers. Curr Opin Investig Drugs 2010; 11:707-18.
-
(2010)
Curr Opin Investig Drugs
, vol.11
, pp. 707-718
-
-
De Smaele, E.1
Ferretti, E.2
Gulino, A.3
-
86
-
-
70349244812
-
Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449
-
Rudin CM, Hann CL, Laterra J, et al. Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. N Engl J Med 2009; 361:1173-8.
-
(2009)
N Engl J Med
, vol.361
, pp. 1173-1178
-
-
Rudin, C.M.1
Hann, C.L.2
Laterra, J.3
-
87
-
-
70349238733
-
Inhibition of the hedgehog pathway in advanced basal-cell carcinoma
-
Von Hoff DD, LoRusso PM, Rudin CM, et al. Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. N Engl J Med 2009; 361:1164-72.
-
(2009)
N Engl J Med
, vol.361
, pp. 1164-1172
-
-
Von Hoff, D.D.1
LoRusso, P.M.2
Rudin, C.M.3
-
88
-
-
77950492233
-
Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth
-
Kim J, Tang JY, Gong R, et al. Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell 2010; 17:388-99.
-
(2010)
Cancer Cell
, Issue.17
, pp. 388-399
-
-
Kim, J.1
Tang, J.Y.2
Gong, R.3
-
89
-
-
34248598317
-
Inhibition of angiogenesis by the antifungal drug itraconazole
-
Chong CR, Xu J, Lu J, et al. Inhibition of angiogenesis by the antifungal drug itraconazole. ACS Chem Biol 2007; 2:263-70.
-
(2007)
ACS Chem Biol
, vol.2
, pp. 263-270
-
-
Chong, C.R.1
Xu, J.2
Lu, J.3
-
90
-
-
77949539205
-
Cholesterol trafficking is required for mTOR activation in endothelial cells
-
Xu J, Dang Y, Ren YR, et al. Cholesterol trafficking is required for mTOR activation in endothelial cells. Proc Natl Acad Sci USA 2010; 107:4764-9.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 4764-4769
-
-
Xu, J.1
Dang, Y.2
Ren, Y.R.3
-
91
-
-
0034528599
-
Epigenetic regulation of androgen receptor gene expression in human prostate cancers
-
Nakayama T, Watanabe M, Suzuki H, et al. Epigenetic regulation of androgen receptor gene expression in human prostate cancers. Lab Invest 2000; 80:1789-96.
-
(2000)
Lab Invest
, vol.80
, pp. 1789-1796
-
-
Nakayama, T.1
Watanabe, M.2
Suzuki, H.3
-
92
-
-
59149089556
-
Histone deacetylases are required for androgen receptor function in hormone-sensitive and castrate-resistant prostate cancer
-
Welsbie DS, Xu J, Chen Y, et al. Histone deacetylases are required for androgen receptor function in hormone-sensitive and castrate-resistant prostate cancer. Cancer Res 2009; 69:958-66
-
(2009)
Cancer Res
, vol.69
, pp. 958-966
-
-
Welsbie, D.S.1
Xu, J.2
Chen, Y.3
-
93
-
-
72249110437
-
Vorinostat in advanced prostate cancer patients progressing on prior chemotherapy (NCI Trial 6862): Trial results and interleukin-6 analysis: A study by the Department of Defense Prostate Cancer Clinical Trial Consortium and
-
University of Chicago Phase 2 Consortium
-
Bradley D, Rathkopf D, Dunn R, et al. Vorinostat in advanced prostate cancer patients progressing on prior chemotherapy (NCI Trial 6862): Trial results and interleukin-6 analysis: A study by the Department of Defense Prostate Cancer Clinical Trial Consortium and University of Chicago Phase 2 Consortium. Cancer 2009; 115:5541-9.
-
(2009)
Cancer
, vol.115
, pp. 5541-5549
-
-
Bradley, D.1
Rathkopf, D.2
Dunn, R.3
-
94
-
-
77955588901
-
Phase Ib dose finding trial of intravenous panobinostat with docetaxel in patients with castration-resistant prostate cancer (CRPC)
-
abstract 5064
-
Rathkopf DE, Chi KN, Vaishampayan U, et al. Phase Ib dose finding trial of intravenous panobinostat with docetaxel in patients with castration-resistant prostate cancer (CRPC). J Clin Oncol 2009; 27(15 suppl):250s (abstract 5064).
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 SUPPL.
-
-
Rathkopf, D.E.1
Chi, K.N.2
Vaishampayan, U.3
-
95
-
-
77951884767
-
A phase I study of oral panobinostat alone and in combination with docetaxel in patients with castration-resistant prostate cancer
-
Rathkopf D, Wong BY, Ross RW, et al. A phase I study of oral panobinostat alone and in combination with docetaxel in patients with castration-resistant prostate cancer. Cancer Chemother Pharmacol 2010; 66:181-9.
-
(2010)
Cancer Chemother Pharmacol
, vol.66
, pp. 181-189
-
-
Rathkopf, D.1
Wong, B.Y.2
Ross, R.W.3
-
96
-
-
66749182280
-
DNA methylation changes in prostate cancer: Current developments and future clinical implementation
-
Hoque MO. DNA methylation changes in prostate cancer: Current developments and future clinical implementation. Expert Rev Mol Diagn 2009; 9:243-57.
-
(2009)
Expert Rev Mol Diagn
, vol.9
, pp. 243-257
-
-
Hoque, M.O.1
-
97
-
-
43949136445
-
Modes of action of the DNA methyltransferase inhibitors azacitidine and decitabine
-
Stresemann C, Lyko F. Modes of action of the DNA methyltransferase inhibitors azacitidine and decitabine. Int J Cancer 2008; 123:8-13.
-
(2008)
Int J Cancer
, vol.123
, pp. 8-13
-
-
Stresemann, C.1
Lyko, F.2
-
98
-
-
67650482968
-
Azacitidine improves antitumor effects of docetaxel and cisplatin in aggressive prostate cancer models
-
Festuccia C, Gravina G, D'Alessandro A, et al. Azacitidine improves antitumor effects of docetaxel and cisplatin in aggressive prostate cancer models. Endocr Relat Cancer 2009; 16:401-13.
-
(2009)
Endocr Relat Cancer
, vol.16
, pp. 401-413
-
-
Festuccia, C.1
Gravina, G.2
D'Alessandro, A.3
-
99
-
-
52949136114
-
Azacitidine for castration-resistant prostate cancer progressing on combined androgen blockade
-
(abstract 5172)
-
Sonpavde G, Aparicio AM, Delaune R, et al. Azacitidine for castration-resistant prostate cancer progressing on combined androgen blockade. J Clin Oncol 2008; 26(15 suppl):292s (abstract 5172).
-
(2008)
J Clin Oncol
, vol.26
, Issue.15 SUPPL.
-
-
Sonpavde, G.1
Aparicio, A.M.2
Delaune, R.3
-
102
-
-
77149157867
-
Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors
-
Mendes-Pereira AM, Martin SA, Brough R, et al. Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors. EMBO Mol Med 2009; 1:315-22.
-
(2009)
EMBO Mol Med
, vol.1
, pp. 315-322
-
-
Mendes-Pereira, A.M.1
Martin, S.A.2
Brough, R.3
-
103
-
-
67650471685
-
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
-
Fong PC, Boss DS, Yap TA, et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. N Engl J Med 2009; 361:123-34.
-
(2009)
N Engl J Med
, vol.361
, pp. 123-134
-
-
Fong, P.C.1
Boss, D.S.2
Yap, T.A.3
-
104
-
-
34249006299
-
ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models
-
Donawho CK, Luo Y, Luo Y, et al. ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models. Clin Cancer Res 2007; 13:2728-37
-
(2007)
Clin Cancer Res
, vol.13
, pp. 2728-2737
-
-
Donawho, C.K.1
Luo, Y.2
Luo, Y.3
-
105
-
-
73149110553
-
ABT-888 confers broad in vivo activity in combination with temozolomide in diverse tumors
-
Palma JP, Wang YC, Rodriguez LE, et al. ABT-888 confers broad in vivo activity in combination with temozolomide in diverse tumors. Clin Cancer Res 2009; 15:7277-90
-
(2009)
Clin Cancer Res
, vol.15
, pp. 7277-7290
-
-
Palma, J.P.1
Wang, Y.C.2
Rodriguez, L.E.3
-
106
-
-
65549138953
-
A Trojan horse in drug development: Targeting of thapsigargins towards prostate cancer cells
-
Christensen SB, Skytte DM, Denmeade SR, et al. A Trojan horse in drug development: Targeting of thapsigargins towards prostate cancer cells. Anticancer Agents Med Chem 2009; 9:276-94.
-
(2009)
Anticancer Agents Med Chem
, vol.9
, pp. 276-294
-
-
Christensen, S.B.1
Skytte, D.M.2
Denmeade, S.R.3
-
107
-
-
0042308774
-
Prostate-specific antigen-activated thapsigargin prodrug as targeted therapy for prostate cancer
-
Denmeade SR, Jakobsen CM, Janssen S, et al. Prostate-specific antigen-activated thapsigargin prodrug as targeted therapy for prostate cancer. J Natl Cancer Inst 2003; 95:990-1000.
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 990-1000
-
-
Denmeade, S.R.1
Jakobsen, C.M.2
Janssen, S.3
-
108
-
-
33644773458
-
Natural products as starting materials for development of second-generation SERCA inhibitors targeted towards prostate cancer cells
-
Søhoel H, Jensen AM, Møller JV, et al. Natural products as starting materials for development of second-generation SERCA inhibitors targeted towards prostate cancer cells. Bioorg Med Chem 2006; 14:2810-5.
-
(2006)
Bioorg Med Chem
, vol.14
, pp. 2810-2815
-
-
Søhoel, H.1
Jensen, A.M.2
Møller, J.V.3
-
109
-
-
66849140921
-
Amino acid containing thapsigargin analogues deplete androgen receptor protein via synthesis inhibition and induce the death of prostate cancer cells
-
Epub ahead of print
-
Vander Griend DJ, Antony L, Dalrymple SL, et al. Amino acid containing thapsigargin analogues deplete androgen receptor protein via synthesis inhibition and induce the death of prostate cancer cells. Mol Cancer Ther 2009; Epub ahead of print.
-
(2009)
Mol Cancer Ther
-
-
Vander Griend, D.J.1
Antony, L.2
Dalrymple, S.L.3
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