Histological disease in asian-americans with chronic hepatitis B, high hepatitis b virus DNA, and normal alanine aminotransferase levels

American Journal of Gastroenterology

Volumn 104, Issue 9, 2009, Pages 2206-2213

  Nguyen, Mindie H ^a,f   Garcia, Ruel T ^b,c   Trinh, Huy N ^b,c   Lam, Khoa D ^d   Weiss, Gerald ^e   Nguyen, Huy A ^b   Nguyen, Khanh K ^b   Keeffe, Emmet B ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b San Jose Gastroenterology   (United States)

^c Pacific Health Foundation   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e Regional Medical Center   (United States)

^f STANFORD UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; HEPATITIS B(E) ANTIGEN; VIRUS DNA;

ADULT; AGE DISTRIBUTION; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; ASIAN AMERICAN; CONTROLLED STUDY; FEMALE; GROUPS BY AGE; HEPATITIS B; HEPATITIS B VIRUS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LIVER BIOPSY; LIVER FIBROSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SCORING SYSTEM;

ADULT; ALANINE TRANSAMINASE; ASIAN AMERICANS; BIOPSY; DNA, VIRAL; FEMALE; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; LIVER; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; VIRAL LOAD;

EID: 69949154162     PISSN: 00029270     EISSN: 15720241     Source Type: Journal    
DOI: 10.1038/ajg.2009.248     Document Type: Article

References (23)

1. Lavanchy D. Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J Viral Hepat 2004; 11: 97-107.
2. McMahon BJ. Epidemiology and natural history of hepatitis B. Semin Liver Dis 2005; 25 (Suppl 1): 3-8.
3. Yim HJ, Lok AS. Natural history of chronic hepatitis B virus infection: what we knew in 1981 and what we know in 2005. Hepatology 2006; 43: S173-81.
4. Keeff e EB, Marcellin P. New and emerging treatment of chronic hepatitis B. Clin Gastroenterol Hepatol 2007; 5: 285-94.
5. Lok AS. Navigating the maze of hepatitis B treatments. Gastroenterology 2007; 132: 1586-94.
6. Chen CJ, Yang HI, Su J et al. Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level. JAMA 2006; 295: 65-73.
7. Iloeje UH, Yang HI, Su J et al. Predicting cirrhosis risk based on the level of circulating hepatitis B viral load. Gastroenterology 2006; 130: 678-86.
8. Lok AS, McMahon BJ. Chronic hepatitis B. Hepatology 2007; 45: 507-39.
9. Zacharakis GH, Koskinas J, Kotsiou S et al. Natural history of chronic HBV infection: a cohort study with up to 12 years follow-up in North Greece (part of the Interreg I-II/EC-project). J Med Virol 2005; 77: 173-9.
10. Th eise ND. Liver biopsy assessment in chronic viral hepatitis: a personal, practical approach. Mod Pathol 2007; 20 (Suppl 1): S3-S14.
11. Dienstag JL. Th e role of liver biopsy in chronic hepatitis C. Hepatology 2002; 36: S152-60.
12. Prati D, Taioli E, Zanella A et al. Updated defi nitions of healthy ranges for serum alanine aminotransferase levels. Ann Intern Med 2002; 137: 1-10.
13. Kariv R, Leshno M, Beth-Or A et al. Re-evaluation of serum alanine aminotransferase upper normal limit and its modulating factors in a large-scale population study. Liver Int 2006; 26: 445-50.
14. Kim HC, Nam CM, Jee SH et al. Normal serum aminotransferase concentration and risk of mortality from liver diseases: prospective cohort study. BMJ 2004; 328: 983-9.
15. Keeff e EB, Dieterich DT, Han SH et al. A treatment algorithm for the management of chronic hepatitis B virus infection in the United States: an update. Clin Gastroenterol Hepatol 2006; 4: 936-62.
16. Gui H XQ, Wang H, Lin Z et al. Predictors of signifi cant histological fi ndings in chronic hepatitis B patients with persistently normal ALT levels. Hepatology 2007; 46: 653A.
17. Jun Yong Park YNP, Kim DY, Paik YH et al. A high prevalence of signifi cant liver disease in asymptomatic hepatitis B patients with high viral load; candidates for antiviral therapy. Hepatology 2007; 46: 656A.
18. Wang CC, Deubner H, Shuhart M et al. High prevalence of signifi cant fi brosis in patients with immunotolerance to chronic hepatitis B infection (abstract). Hepatology 2005; 42: 573A.
19. Lai M, Hyatt BJ, Nasser I et al. Th e clinical signifi cance of persistently normal ALT in chronic hepatitis B infection. J Hepatol 2007; 47: 760-7.
20. Wang CC, Lim LY, Deubner H et al. Factors predictive of signifi cant hepatic fi brosis in adults with chronic hepatitis B and normal serum ALT. J Clin Gastroenterol 2008; 42: 820-6.
21. Park JY, Park YN, Kim DY et al. High prevalence of signifi cant histology in asymptomatic chronic hepatitis B patients with genotype C and high serum HBV DNA levels. J Viral Hepat 2008; 15: 615-21.
22. Kumar M, Sarin SK, Hissar S et al. Virologic and histologic features of chronic hepatitis B virus-infected asymptomatic patients with persistently normal ALT. Gastroenterology 2008; 134: 1376-84.
23. Wai CT, Greenson JK, Fontana RJ et al. A simple noninvasive index can predict both signifi cant fi brosis and cirrhosis in patients with chronic hepatitis C. Hepatology 2003; 38: 518-26.