Risk for hepatocellular carcinoma with respect to hepatitis B virus genotypes B/C, specific mutations of enhancer II/core promoter/precore regions and HBV DNA levels

Gut

Volumn 57, Issue 1, 2008, Pages 98-102

  Yuen, M F ^a   Tanaka, Y ^b   Shinkai, N ^b   Poon, R T ^a   But, D Yiu Kuen ^a   Fong, D Y T ^a   Fung, J ^a   Wong, D Ka Ho ^a   Yuen, J Chi Hang ^a   Mizokami, M ^b   Lai, C L ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CANCER DIAGNOSIS; CANCER PATIENT; COMPARATIVE STUDY; CONTROL GROUP; CONTROLLED STUDY; DNA SEQUENCE; FEMALE; GENE MUTATION; GENOTYPE; HEPATITIS B VIRUS; HUMAN; LABORATORY TEST; LIVER CELL CARCINOMA; LIVER CIRRHOSIS; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; WILD TYPE;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA, HEPATOCELLULAR; CASE-CONTROL STUDIES; DNA, VIRAL; ENHANCER ELEMENTS (GENETICS); FEMALE; GENOTYPE; HEPATITIS B VIRUS; HUMANS; LIVER NEOPLASMS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; MUTATION; PROMOTER REGIONS (GENETICS); ROC CURVE;

EID: 38349138512     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2007.119859     Document Type: Article

References (34)

1. Chen CH, Lee CM, Lu SN, et al. Clinical significance of hepatitis B virus (HBV) genotypes and precore and core promoter mutations affecting HBV e antigen expression in Taiwan. J Clin Microbiol 2005;43:6000-6
2. Lin CL, Liao LY, Wang CS, et al. Basal core-promoter mutant of hepatitis B virus and progression of liver disease in hepatitis B e antigen-negative chronic hepatitis B. Liver Int 2005;25:564-70.
3. Fang ZL, Yang J, Ge X, et al. Core promoter mutations (A(1762)T and G(1764)A) and viral genotype in chronic hepatitis B and hepatocellular caicinoma in Guangxi, China. J Med Virol 2002;68:33-40.
4. Tsubota A, Arase Y, Ren F, et al. Genotype may correlate with liver carcinogenesis and tumor characteristics in cirrhotic patients infected with hepatitis B virus subtype adw. J Med Virol 2001;65:257-65.
5. Chan HL, Hui AY, Wong ML, et al. Genotype C hepatitis B virus infection is associated with an increased risk of hepatocellular carcinoma. Gut 2004;53:1494-8.
6. Yuen MF, Tanaka Y, Mizokami M, et al. Role of hepatitis B virus genotypes Ba and C, core promoter and precore mutations an hepatocellular carcinoma: a case control study. Carcinogenesis 2004;25:1593-8.
7. Liu CJ, Chen BF, Chen PJ, et al. Role of hepatitis B virus precore/core promoter mutations and serum viral load on noncirrhotic hepatocellular carcinoma: a case-control study. J Infect Dis 2006;194:594-9.
8. Kao JH. Hepatitis B virus genotypes and hepatocellular carcinoma in Taiwan. Intervirology 2003;46:400-7.
9. Kao JH, Chen PJ, Lai MY, et al. Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B. Gastroenterology 2000;118:554-9.
10. Ozasa A, Tanaka Y, Onto E, et al. Influence of genotypes and precore mutations on fulminant or chronic outcome of acute hepatitis B virus infection. Hepatology 2006;44:326-34.
11. Omata M, Ehata T, Yokosuka O, et al. Mutations in the precore region of hepatitis B virus DNA in patients with fulminant and severe hepatitis. N Engl J Med 1991;324:1699-704.
12. Laskus T, Persing DH, Nowicki MJ, et al. Nucleotide sequence analysis of the precore region in patients with fulminant hepatitis B in the United States Gastroenterology 1993;105:1173-8
13. Karayiannis P, Alexopoulou A, Hadziyannis S, et al. Fulminant hepatitis associated with hepatitis B virus e antigen-negative infection: importance of host factors. Hepatology 1995;22:1628-34
14. Baptista M, Kramvis A, Kew MC. High prevalence of 1762(T) 1764(A) mutations in the basic core promoter of hepatitis B virus isolated from black Africans with hepatocellular carcinoma compared with asymptomatic carriers. Hepatology 1999;29:946-53.
15. Kao JH, Chen PJ, Lai MY, et al. Basal core promoter mutations of hepatitis B virus increase the risk of hepatocellular carcinoma in hepatitis B carriers. Gastroenterology 2003;124:327-34.
16. Sakamoto T, Tanaka Y, Orito E, et al. Novel subtypes (subgenotypes) of hepatitis B virus genotypes B and C among chronic liver disease patients in the Philippines. J Gen Virol 2006;87:1873-82.
17. Blackberg J, Kidd-Ljunggren K. Mutations within the hepatitis B virus genome among chronic hepatitis B patients with hepatocellular carcinoma. J Med Virol 2003;71:18-23
18. Takahashi K, Akahane Y, Hino K, et al. Hepatitis B virus genomic sequence in the circulation of hepatocellular carcinoma patients: comparative analysis of 40 full-length isolates. Arch Virol 1998;143:2313-26
19. Takahashi K, Ohta Y, Kanai K, et al. Clinical implications of mutations C-to-T1653 and T-to-C/A/G1753 of hepatitis B virus genotype C genome in chronic liver disease. Arch Virol 1999;144:1299-308.
20. Tanaka Y, Mukaide M, Orito E, et al. Specific mutations in enhancer II/core promoter of hepatitis B virus subgenotypes C1/C2 increase the risk of hepatocellular carcinoma. J Hepatol 2006;45:646-53.
21. Yuen MF, Sablon E, Yuan HJ, et al. Significance of hepatitis B genotype in acute exacerbation, HBeAg seroconversion, cirrhosis-related complications, and hepatocellular carcinoma. Hepatology 2003;37:562-7.
22. Wai CT, Greenson JK, Fontana RJ, et al. A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C. Hepatology 2003;38:518-26.
23. Sugauchi F, Orito E, Ichida T, et al. Epidemiologic and virologic characteristics of hepatitis B virus genotype B having the recombination with genotype C. Gastroenterology 2003;124:925-32.
24. Chen BF, Liu CJ, Jow GM, et al. High prevalence and mapping of pre-S deletion in hepatitis B virus carriers with progressive liver diseases. Gastroenterology 2006;130:1153-68.
25. Yuen MF, Sablon E, Tanaka Y, et al. Epidemiological study of hepatitis B virus genotypes, core promoter and precore mutations of chronic hepatitis B infection in Hong Kong. J Hepatol 2004;41:119-25.
26. Chu CJ, Hussain M, Lok AS. Hepatitis B virus genotype B is associated with earlier HBeAg seroconversion compared with hepatitis B virus genotype C. Gastroenterology 2002;122:1756-62.
27. Sumi H, Yokosuka O, Seki N, et al. Influence of hepatitis B virus genotypes on the progression of chronic type B liver disease. Hepatology 2003;37:19-26.
28. Yuen MF, Wong DKH, 2heng BJ, et al. Difference in T helper responses during hepatitis flares in HBeAg-positive patients with genotypes B and C: Implication for early HBeAg seroconversion. J Viral Hep 2006 (in press).
29. Kidd AH, Kidd-Ljunggren,K. A revised secondary structure model for the 3′-end of hepatitis B virus pregenomic RNA. Nucleic Acid Res 1996;24:3295-3301.
30. Li J, Buckwold VE, Hon MW, Ou JH. Mechanism of suppression of hepatitis B virus precore RNA transcription by a freguent double mutation. J Virol 1999;73:1239-1244.
31. Buckwold VE, Xu Z, Chen M, et al. Effects of a naturally occurred mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication. J Virol 1996;70:5845-51.
32. Fang ZL, Ling B, Wang SS, et al. HBV core promoter mutations prevail in patients with hepatocellular carcinoma from Guangxi, China. J Med Virol 1998;56:18-24.
33. Chauhan R, Kazim SN, Bhattacharjee J, et al. Basal core promoter, precore region mutations of HBV and their association with e antigen, genotype, and severity of liver disease in patients with chronic hepatitis B in India. J Med Virol 2006;78:1047-54.
34. Ito K, Tanaka Y, Orito E, et al. T1653 mutation in the box alpha increases the risk of hepatocellular carcinoma in patients with chronic hepatitis B virus genotype C infection. Clin Infect Dis 2006;42:1-7.