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Volumn 12, Issue 5, 2010, Pages

P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 4; EPIDERMAL GROWTH FACTOR RECEPTOR 2; LAMININ; PROTEIN CDC42; PROTEIN P190B RHOGAP; RAC1 PROTEIN; REACTIVE OXYGEN METABOLITE; REGULATOR PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; TETRACYCLINE; UNCLASSIFIED DRUG; ARHGAP5 PROTEIN, MOUSE; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; RHO GTPASE ACTIVATING PROTEIN; RHO GTPASE-ACTIVATING PROTEIN;

EID: 78650949091     PISSN: 14655411     EISSN: 1465542X     Source Type: Journal    
DOI: 10.1186/bcr2643     Document Type: Article
Times cited : (28)

References (54)
  • 1
    • 38449123547 scopus 로고    scopus 로고
    • Role of Rho GTPases in breast cancer
    • 10.2741/2718, 17981586
    • Tang Y, Olufemi L, Wang MT, Nie D. Role of Rho GTPases in breast cancer. Front Biosci 2008, 13:759-776. 10.2741/2718, 17981586.
    • (2008) Front Biosci , vol.13 , pp. 759-776
    • Tang, Y.1    Olufemi, L.2    Wang, M.T.3    Nie, D.4
  • 2
    • 0036488510 scopus 로고    scopus 로고
    • RHO-GTPases and Cancer
    • 10.1038/nrc725, 12635176
    • Sahai E, CJ. RHO-GTPases and Cancer. Nature Reviews Cancer 2002, 2:133-142. 10.1038/nrc725, 12635176.
    • (2002) Nature Reviews Cancer , vol.2 , pp. 133-142
    • Sahai, E.1
  • 4
    • 0032939619 scopus 로고    scopus 로고
    • Rho GTPases are over-expressed in human tumors
    • 10.1002/(SICI)1097-0215(19990531)81:5<682::AID-IJC2>3.0.CO;2-B, 10328216
    • Fritz G, Just I, Kaina B. Rho GTPases are over-expressed in human tumors. Int J Cancer 1999, 81:682-687. 10.1002/(SICI)1097-0215(19990531)81:5<682::AID-IJC2>3.0.CO;2-B, 10328216.
    • (1999) Int J Cancer , vol.81 , pp. 682-687
    • Fritz, G.1    Just, I.2    Kaina, B.3
  • 5
    • 0037048326 scopus 로고    scopus 로고
    • Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters
    • 10.1038/sj.bjc.6600510, 2364248, 12237774
    • Fritz G, Brachetti C, Bahlmann F, Schmidt M, Kaina B. Rho GTPases in human breast tumours: expression and mutation analyses and correlation with clinical parameters. Br J Cancer 2002, 87:635-644. 10.1038/sj.bjc.6600510, 2364248, 12237774.
    • (2002) Br J Cancer , vol.87 , pp. 635-644
    • Fritz, G.1    Brachetti, C.2    Bahlmann, F.3    Schmidt, M.4    Kaina, B.5
  • 6
    • 78650927755 scopus 로고    scopus 로고
    • Pleiotropic Functions of Rho GTPase Signaling: A Trojan Horse or Achilles' Heel for Breast Cancer Treatment?
    • 10.2174/138945010792006852, 20545614
    • McHenry PR, Vargo-Gogola T. Pleiotropic Functions of Rho GTPase Signaling: A Trojan Horse or Achilles' Heel for Breast Cancer Treatment?. Curr Drug Targets 11:1043-1058. 10.2174/138945010792006852, 20545614.
    • Curr Drug Targets , vol.11 , pp. 1043-1058
    • McHenry, P.R.1    Vargo-Gogola, T.2
  • 7
    • 33745233810 scopus 로고    scopus 로고
    • D4-GDI, a Rho GTPase regulator, promotes breast cancer cell invasiveness
    • 10.1158/0008-5472.CAN-05-4004, 16740694
    • Zhang Y, Zhang B. D4-GDI, a Rho GTPase regulator, promotes breast cancer cell invasiveness. Cancer Res 2006, 66:5592-5598. 10.1158/0008-5472.CAN-05-4004, 16740694.
    • (2006) Cancer Res , vol.66 , pp. 5592-5598
    • Zhang, Y.1    Zhang, B.2
  • 9
    • 0032831382 scopus 로고    scopus 로고
    • Inhibition of RhoGAP activity is sufficient for the induction of Rho-mediated actin reorganization
    • Vincent S, Settleman J. Inhibition of RhoGAP activity is sufficient for the induction of Rho-mediated actin reorganization. Eur J Cell Biol 1999, 78:539-548.
    • (1999) Eur J Cell Biol , vol.78 , pp. 539-548
    • Vincent, S.1    Settleman, J.2
  • 10
    • 0029594555 scopus 로고
    • P190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking
    • 10.1074/jbc.270.52.30919, 8537347
    • Burbelo PD, Miyamoto S, Utani A, Brill S, Yamada KM, Hall A, Yamada Y. p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking. J Biol Chem 1995, 270:30919-30926. 10.1074/jbc.270.52.30919, 8537347.
    • (1995) J Biol Chem , vol.270 , pp. 30919-30926
    • Burbelo, P.D.1    Miyamoto, S.2    Utani, A.3    Brill, S.4    Yamada, K.M.5    Hall, A.6    Yamada, Y.7
  • 11
    • 54149096498 scopus 로고    scopus 로고
    • Coordination of Rho and Rac GTPase function via p190B RhoGAP
    • 10.1016/j.cub.2008.09.019, 18948007
    • Bustos RI, Forget MA, Settleman JE, Hansen SH. Coordination of Rho and Rac GTPase function via p190B RhoGAP. Curr Biol 2008, 18:1606-1611. 10.1016/j.cub.2008.09.019, 18948007.
    • (2008) Curr Biol , vol.18 , pp. 1606-1611
    • Bustos, R.I.1    Forget, M.A.2    Settleman, J.E.3    Hansen, S.H.4
  • 12
    • 34548127049 scopus 로고    scopus 로고
    • Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development
    • 10.1016/j.ydbio.2007.07.002, 17662267
    • Heckman BM, Chakravarty G, Vargo-Gogola T, Gonzales-Rimbau M, Hadsell DL, Lee AV, Settleman J, Rosen JM. Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development. Dev Biol 2007, 309:137-149. 10.1016/j.ydbio.2007.07.002, 17662267.
    • (2007) Dev Biol , vol.309 , pp. 137-149
    • Heckman, B.M.1    Chakravarty, G.2    Vargo-Gogola, T.3    Gonzales-Rimbau, M.4    Hadsell, D.L.5    Lee, A.V.6    Settleman, J.7    Rosen, J.M.8
  • 13
    • 0038517913 scopus 로고    scopus 로고
    • P190-B RhoGAP regulates mammary ductal morphogenesis
    • 10.1210/me.2002-0428, 12637587
    • Chakravarty G, Hadsell D, Buitrago W, Settleman J, Rosen JM. p190-B RhoGAP regulates mammary ductal morphogenesis. Mol Endocrinol 2003, 17:1054-1065. 10.1210/me.2002-0428, 12637587.
    • (2003) Mol Endocrinol , vol.17 , pp. 1054-1065
    • Chakravarty, G.1    Hadsell, D.2    Buitrago, W.3    Settleman, J.4    Rosen, J.M.5
  • 14
    • 33744469039 scopus 로고    scopus 로고
    • P190-B Rho GTPase-activating protein overexpression disrupts ductal morphogenesis and induces hyperplastic lesions in the developing mammary gland
    • 10.1210/me.2005-0426, 16469769
    • Vargo-Gogola T, Heckman BM, Gunther EJ, Chodosh LA, Rosen JM. P190-B Rho GTPase-activating protein overexpression disrupts ductal morphogenesis and induces hyperplastic lesions in the developing mammary gland. Mol Endocrinol 2006, 20:1391-1405. 10.1210/me.2005-0426, 16469769.
    • (2006) Mol Endocrinol , vol.20 , pp. 1391-1405
    • Vargo-Gogola, T.1    Heckman, B.M.2    Gunther, E.J.3    Chodosh, L.A.4    Rosen, J.M.5
  • 16
    • 0037363715 scopus 로고    scopus 로고
    • Protein carbonyl groups as biomarkers of oxidative stress
    • 10.1016/S0009-8981(03)00003-2, 12589963
    • Dalle-Donne I, Rossi R, Giustarini D, Milzani A, Colombo R. Protein carbonyl groups as biomarkers of oxidative stress. Clin Chim Acta 2003, 329:23-38. 10.1016/S0009-8981(03)00003-2, 12589963.
    • (2003) Clin Chim Acta , vol.329 , pp. 23-38
    • Dalle-Donne, I.1    Rossi, R.2    Giustarini, D.3    Milzani, A.4    Colombo, R.5
  • 17
    • 0023713558 scopus 로고
    • Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene
    • 10.1016/0092-8674(88)90184-5, 2898299
    • Muller WJ, Sinn E, Pattengale PK, Wallace R, Leder P. Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene. Cell 1988, 54:105-115. 10.1016/0092-8674(88)90184-5, 2898299.
    • (1988) Cell , vol.54 , pp. 105-115
    • Muller, W.J.1    Sinn, E.2    Pattengale, P.K.3    Wallace, R.4    Leder, P.5
  • 18
    • 0036187113 scopus 로고    scopus 로고
    • A novel doxycycline-inducible system for the transgenic analysis of mammary gland biology
    • 10.1096/fj.01-0551com, 11874978
    • Gunther EJ, Belka GK, Wertheim GB, Wang J, Hartman JL, Boxer RB, Chodosh LA. A novel doxycycline-inducible system for the transgenic analysis of mammary gland biology. FASEB J 2002, 16:283-292. 10.1096/fj.01-0551com, 11874978.
    • (2002) FASEB J , vol.16 , pp. 283-292
    • Gunther, E.J.1    Belka, G.K.2    Wertheim, G.B.3    Wang, J.4    Hartman, J.L.5    Boxer, R.B.6    Chodosh, L.A.7
  • 19
    • 33745260929 scopus 로고    scopus 로고
    • A critical role for the inflammatory response in a mouse model of preneoplastic progression
    • 10.1158/0008-5472.CAN-05-3781, 16740705
    • Schwertfeger KL, Xian W, Kaplan AM, Burnett SH, Cohen DA, Rosen JM. A critical role for the inflammatory response in a mouse model of preneoplastic progression. Cancer Res 2006, 66:5676-5685. 10.1158/0008-5472.CAN-05-3781, 16740705.
    • (2006) Cancer Res , vol.66 , pp. 5676-5685
    • Schwertfeger, K.L.1    Xian, W.2    Kaplan, A.M.3    Burnett, S.H.4    Cohen, D.A.5    Rosen, J.M.6
  • 20
    • 0037603113 scopus 로고    scopus 로고
    • Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures
    • 10.1016/S1046-2023(03)00032-X, 12798140
    • Debnath J, Muthuswamy SK, Brugge JS. Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods 2003, 30:256-268. 10.1016/S1046-2023(03)00032-X, 12798140.
    • (2003) Methods , vol.30 , pp. 256-268
    • Debnath, J.1    Muthuswamy, S.K.2    Brugge, J.S.3
  • 23
    • 31044433663 scopus 로고    scopus 로고
    • Macrophages: obligate partners for tumor cell migration, invasion, and metastasis
    • 10.1016/j.cell.2006.01.007, 16439202
    • Condeelis J, Pollard JW. Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell 2006, 124:263-266. 10.1016/j.cell.2006.01.007, 16439202.
    • (2006) Cell , vol.124 , pp. 263-266
    • Condeelis, J.1    Pollard, J.W.2
  • 24
    • 69549096143 scopus 로고    scopus 로고
    • Cell biology of the movement of breast cancer cells: intracellular signalling and the actin cytoskeleton
    • 10.1016/j.canlet.2009.02.034, 19303207
    • Jiang P, Enomoto A, Takahashi M. Cell biology of the movement of breast cancer cells: intracellular signalling and the actin cytoskeleton. Cancer Lett 2009, 284:122-130. 10.1016/j.canlet.2009.02.034, 19303207.
    • (2009) Cancer Lett , vol.284 , pp. 122-130
    • Jiang, P.1    Enomoto, A.2    Takahashi, M.3
  • 25
    • 0028903247 scopus 로고
    • An essential role for Rac in Ras transformation
    • 10.1038/374457a0, 7700355
    • Qiu RG, Chen J, Kirn D, McCormick F, Symons M. An essential role for Rac in Ras transformation. Nature 1995, 374:457-459. 10.1038/374457a0, 7700355.
    • (1995) Nature , vol.374 , pp. 457-459
    • Qiu, R.G.1    Chen, J.2    Kirn, D.3    McCormick, F.4    Symons, M.5
  • 26
    • 56649124726 scopus 로고    scopus 로고
    • Tiam1-deficiency impairs mammary tumor formation in MMTV-c-neu but not in MMTV-c-myc mice
    • 10.1007/s00432-008-0437-8, 18592271
    • Strumane K, Rygiel T, van der Valk M, Collard JG. Tiam1-deficiency impairs mammary tumor formation in MMTV-c-neu but not in MMTV-c-myc mice. J Cancer Res Clin Oncol 2009, 135:69-80. 10.1007/s00432-008-0437-8, 18592271.
    • (2009) J Cancer Res Clin Oncol , vol.135 , pp. 69-80
    • Strumane, K.1    Rygiel, T.2    van der Valk, M.3    Collard, J.G.4
  • 27
    • 5644272705 scopus 로고    scopus 로고
    • Invasive potential induced under long-term oxidative stress in mammary epithelial cells
    • 10.1158/0008-5472.CAN-04-1725, 15492271
    • Mori K, Shibanuma M, Nose K. Invasive potential induced under long-term oxidative stress in mammary epithelial cells. Cancer Res 2004, 64:7464-7472. 10.1158/0008-5472.CAN-04-1725, 15492271.
    • (2004) Cancer Res , vol.64 , pp. 7464-7472
    • Mori, K.1    Shibanuma, M.2    Nose, K.3
  • 29
    • 51649102877 scopus 로고    scopus 로고
    • Inhibition of MMP-3 or -9 suppresses lipopolysaccharide-induced expression of proinflammatory cytokines and iNOS in microglia
    • 10.1111/j.1471-4159.2008.05430.x, 18419763
    • Woo MS, Park JS, Choi IY, Kim WK, Kim HS. Inhibition of MMP-3 or -9 suppresses lipopolysaccharide-induced expression of proinflammatory cytokines and iNOS in microglia. J Neurochem 2008, 106:770-780. 10.1111/j.1471-4159.2008.05430.x, 18419763.
    • (2008) J Neurochem , vol.106 , pp. 770-780
    • Woo, M.S.1    Park, J.S.2    Choi, I.Y.3    Kim, W.K.4    Kim, H.S.5
  • 30
    • 44449178868 scopus 로고    scopus 로고
    • Rho GTPases in cancer cell biology
    • 10.1016/j.febslet.2008.04.039, 18460342
    • Vega FM, Ridley AJ. Rho GTPases in cancer cell biology. FEBS Lett 2008, 582:2093-2101. 10.1016/j.febslet.2008.04.039, 18460342.
    • (2008) FEBS Lett , vol.582 , pp. 2093-2101
    • Vega, F.M.1    Ridley, A.J.2
  • 31
    • 68549126922 scopus 로고    scopus 로고
    • The cytoskeleton and cancer
    • 10.1007/s10555-008-9166-3, 19153674
    • Hall A. The cytoskeleton and cancer. Cancer Metastasis Rev 2009, 28:5-14. 10.1007/s10555-008-9166-3, 19153674.
    • (2009) Cancer Metastasis Rev , vol.28 , pp. 5-14
    • Hall, A.1
  • 32
    • 0034659739 scopus 로고    scopus 로고
    • Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b
    • 10.1038/sj.onc.1203621, 10871853
    • Schnelzer A, Prechtel D, Knaus U, Dehne K, Gerhard M, Graeff H, Harbeck N, Schmitt M, Lengyel E. Rac1 in human breast cancer: overexpression, mutation analysis, and characterization of a new isoform, Rac1b. Oncogene 2000, 19:3013-3020. 10.1038/sj.onc.1203621, 10871853.
    • (2000) Oncogene , vol.19 , pp. 3013-3020
    • Schnelzer, A.1    Prechtel, D.2    Knaus, U.3    Dehne, K.4    Gerhard, M.5    Graeff, H.6    Harbeck, N.7    Schmitt, M.8    Lengyel, E.9
  • 33
    • 33747423320 scopus 로고    scopus 로고
    • Rac1 links integrin-mediated adhesion to the control of lactational differentiation in mammary epithelia
    • 10.1083/jcb.200601059, 2063893, 16754961
    • Akhtar N, Streuli CH. Rac1 links integrin-mediated adhesion to the control of lactational differentiation in mammary epithelia. J Cell Biol 2006, 173:781-793. 10.1083/jcb.200601059, 2063893, 16754961.
    • (2006) J Cell Biol , vol.173 , pp. 781-793
    • Akhtar, N.1    Streuli, C.H.2
  • 34
    • 0037102190 scopus 로고    scopus 로고
    • MEK1 signaling mediates transformation and metastasis of EpH4 mammary epithelial cells independent of an epithelial to mesenchymal transition
    • Pinkas J, Leder P. MEK1 signaling mediates transformation and metastasis of EpH4 mammary epithelial cells independent of an epithelial to mesenchymal transition. Cancer Res 2002, 62:4781-4790.
    • (2002) Cancer Res , vol.62 , pp. 4781-4790
    • Pinkas, J.1    Leder, P.2
  • 36
    • 27944452744 scopus 로고    scopus 로고
    • Pleiotropic effects of FGFR1 on cell proliferation, survival, and migration in a 3 D mammary epithelial cell model
    • 10.1083/jcb.200505098, 2171554, 16301332
    • Xian W, Schwertfeger KL, Vargo-Gogola T, Rosen JM. Pleiotropic effects of FGFR1 on cell proliferation, survival, and migration in a 3 D mammary epithelial cell model. J Cell Biol 2005, 171:663-673. 10.1083/jcb.200505098, 2171554, 16301332.
    • (2005) J Cell Biol , vol.171 , pp. 663-673
    • Xian, W.1    Schwertfeger, K.L.2    Vargo-Gogola, T.3    Rosen, J.M.4
  • 37
    • 0034691562 scopus 로고    scopus 로고
    • Potential prognostic value of mitogen-activated protein kinase activity for disease-free survival of primary breast cancer patients
    • 10.1002/1097-0215(20000720)89:4<384::AID-IJC11>3.0.CO;2-R, 10956414
    • Mueller H, Flury N, Eppenberger-Castori S, Kueng W, David F, Eppenberger U. Potential prognostic value of mitogen-activated protein kinase activity for disease-free survival of primary breast cancer patients. Int J Cancer 2000, 89:384-388. 10.1002/1097-0215(20000720)89:4<384::AID-IJC11>3.0.CO;2-R, 10956414.
    • (2000) Int J Cancer , vol.89 , pp. 384-388
    • Mueller, H.1    Flury, N.2    Eppenberger-Castori, S.3    Kueng, W.4    David, F.5    Eppenberger, U.6
  • 38
    • 23844494402 scopus 로고    scopus 로고
    • The duration, magnitude and compartmentalization of ERK MAP kinase activity: mechanisms for providing signaling specificity
    • 10.1242/jcs.02505, 16014377
    • Ebisuya M, Kondoh K, Nishida E. The duration, magnitude and compartmentalization of ERK MAP kinase activity: mechanisms for providing signaling specificity. J Cell Sci 2005, 118:2997-3002. 10.1242/jcs.02505, 16014377.
    • (2005) J Cell Sci , vol.118 , pp. 2997-3002
    • Ebisuya, M.1    Kondoh, K.2    Nishida, E.3
  • 39
    • 33646429471 scopus 로고    scopus 로고
    • Activated ERK1/2 and phosphorylated oestrogen receptor alpha are associated with improved breast cancer survival in women treated with tamoxifen
    • 10.1016/j.ejca.2006.01.028, 16603346
    • Bergqvist J, Elmberger G, Ohd J, Linderholm B, Bjohle J, Hellborg H, Nordgren H, Borg AL, Skoog L, Bergh J. Activated ERK1/2 and phosphorylated oestrogen receptor alpha are associated with improved breast cancer survival in women treated with tamoxifen. Eur J Cancer 2006, 42:1104-1112. 10.1016/j.ejca.2006.01.028, 16603346.
    • (2006) Eur J Cancer , vol.42 , pp. 1104-1112
    • Bergqvist, J.1    Elmberger, G.2    Ohd, J.3    Linderholm, B.4    Bjohle, J.5    Hellborg, H.6    Nordgren, H.7    Borg, A.L.8    Skoog, L.9    Bergh, J.10
  • 40
    • 21744453318 scopus 로고    scopus 로고
    • ERK phosphorylation is linked to VEGFR2 expression and Ets-2 phosphorylation in breast cancer and is associated with tamoxifen treatment resistance and small tumours with good prognosis
    • 10.1038/sj.onc.1208626, 15806151
    • Svensson S, Jirstrom K, Ryden L, Roos G, Emdin S, Ostrowski MC, Landberg G. ERK phosphorylation is linked to VEGFR2 expression and Ets-2 phosphorylation in breast cancer and is associated with tamoxifen treatment resistance and small tumours with good prognosis. Oncogene 2005, 24:4370-4379. 10.1038/sj.onc.1208626, 15806151.
    • (2005) Oncogene , vol.24 , pp. 4370-4379
    • Svensson, S.1    Jirstrom, K.2    Ryden, L.3    Roos, G.4    Emdin, S.5    Ostrowski, M.C.6    Landberg, G.7
  • 41
    • 22044438114 scopus 로고    scopus 로고
    • Expression and prognostic relevance of activated extracellular-regulated kinases (ERK1/2) in breast cancer
    • 10.1038/sj.bjc.6602655, 2361826, 15928662
    • Milde-Langosch K, Bamberger AM, Rieck G, Grund D, Hemminger G, Muller V, Loning T. Expression and prognostic relevance of activated extracellular-regulated kinases (ERK1/2) in breast cancer. Br J Cancer 2005, 92:2206-2215. 10.1038/sj.bjc.6602655, 2361826, 15928662.
    • (2005) Br J Cancer , vol.92 , pp. 2206-2215
    • Milde-Langosch, K.1    Bamberger, A.M.2    Rieck, G.3    Grund, D.4    Hemminger, G.5    Muller, V.6    Loning, T.7
  • 42
    • 0031026132 scopus 로고    scopus 로고
    • Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways
    • 231857, 9032259
    • Westwick JK, Lambert QT, Clark GJ, Symons M, Van Aelst L, Pestell RG, Der CJ. Rac regulation of transformation, gene expression, and actin organization by multiple, PAK-independent pathways. Mol Cell Biol 1997, 17:1324-1335. 231857, 9032259.
    • (1997) Mol Cell Biol , vol.17 , pp. 1324-1335
    • Westwick, J.K.1    Lambert, Q.T.2    Clark, G.J.3    Symons, M.4    Van Aelst, L.5    Pestell, R.G.6    Der, C.J.7
  • 44
    • 33846002372 scopus 로고    scopus 로고
    • Computational model explains high activity and rapid cycling of Rho GTPases within protein complexes
    • 10.1371/journal.pcbi.0020172, 1676031,1676031, 17140284
    • Goryachev AB, Pokhilko AV. Computational model explains high activity and rapid cycling of Rho GTPases within protein complexes. PLoS Comput Biol 2006, 2:e172. 10.1371/journal.pcbi.0020172, 1676031,1676031, 17140284.
    • (2006) PLoS Comput Biol , vol.2
    • Goryachev, A.B.1    Pokhilko, A.V.2
  • 45
    • 0033551698 scopus 로고    scopus 로고
    • Specific contributions of the small GTPases Rho, Rac, and Cdc42 to Dbl transformation
    • 10.1074/jbc.274.33.23633, 10438546
    • Lin R, Cerione RA, Manor D. Specific contributions of the small GTPases Rho, Rac, and Cdc42 to Dbl transformation. J Biol Chem 1999, 274:23633-23641. 10.1074/jbc.274.33.23633, 10438546.
    • (1999) J Biol Chem , vol.274 , pp. 23633-23641
    • Lin, R.1    Cerione, R.A.2    Manor, D.3
  • 46
    • 33746933848 scopus 로고    scopus 로고
    • Influencing cellular transformation by modulating the rates of GTP hydrolysis by Cdc42
    • 10.1021/bi060365h, 16784226
    • Fidyk N, Wang JB, Cerione RA. Influencing cellular transformation by modulating the rates of GTP hydrolysis by Cdc42. Biochemistry 2006, 45:7750-7762. 10.1021/bi060365h, 16784226.
    • (2006) Biochemistry , vol.45 , pp. 7750-7762
    • Fidyk, N.1    Wang, J.B.2    Cerione, R.A.3
  • 47
    • 34547122752 scopus 로고    scopus 로고
    • Matrix metalloproteinase 7 mediates mammary epithelial cell tumorigenesis through the ErbB4 receptor
    • 10.1158/0008-5472.CAN-07-0026, 17638887
    • Lynch CC, Vargo-Gogola T, Martin MD, Fingleton B, Crawford HC, Matrisian LM. Matrix metalloproteinase 7 mediates mammary epithelial cell tumorigenesis through the ErbB4 receptor. Cancer Res 2007, 67:6760-6767. 10.1158/0008-5472.CAN-07-0026, 17638887.
    • (2007) Cancer Res , vol.67 , pp. 6760-6767
    • Lynch, C.C.1    Vargo-Gogola, T.2    Martin, M.D.3    Fingleton, B.4    Crawford, H.C.5    Matrisian, L.M.6
  • 49
    • 44449162944 scopus 로고    scopus 로고
    • The Rac activator Tiam1 prevents keratinocyte apoptosis by controlling ROS-mediated ERK phosphorylation
    • 10.1242/jcs.017194, 18349077
    • Rygiel TP, Mertens AE, Strumane K, van der Kammen R, Collard JG. The Rac activator Tiam1 prevents keratinocyte apoptosis by controlling ROS-mediated ERK phosphorylation. J Cell Sci 2008, 121:1183-1192. 10.1242/jcs.017194, 18349077.
    • (2008) J Cell Sci , vol.121 , pp. 1183-1192
    • Rygiel, T.P.1    Mertens, A.E.2    Strumane, K.3    van der Kammen, R.4    Collard, J.G.5
  • 50
    • 10544246489 scopus 로고    scopus 로고
    • Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability
    • 10.1172/JCI119076, 507715, 8958220
    • Rajagopalan S, Meng XP, Ramasamy S, Harrison DG, Galis ZS. Reactive oxygen species produced by macrophage-derived foam cells regulate the activity of vascular matrix metalloproteinases in vitro. Implications for atherosclerotic plaque stability. J Clin Invest 1996, 98:2572-2579. 10.1172/JCI119076, 507715, 8958220.
    • (1996) J Clin Invest , vol.98 , pp. 2572-2579
    • Rajagopalan, S.1    Meng, X.P.2    Ramasamy, S.3    Harrison, D.G.4    Galis, Z.S.5
  • 51
    • 0037036399 scopus 로고    scopus 로고
    • Activation of matrix metalloproteinase-2 by overexpression of manganese superoxide dismutase in human breast cancer MCF-7 cells involves reactive oxygen species
    • 10.1074/jbc.M109801200, 11929863
    • Zhang HJ, Zhao W, Venkataraman S, Robbins ME, Buettner GR, Kregel KC, Oberley LW. Activation of matrix metalloproteinase-2 by overexpression of manganese superoxide dismutase in human breast cancer MCF-7 cells involves reactive oxygen species. J Biol Chem 2002, 277:20919-20926. 10.1074/jbc.M109801200, 11929863.
    • (2002) J Biol Chem , vol.277 , pp. 20919-20926
    • Zhang, H.J.1    Zhao, W.2    Venkataraman, S.3    Robbins, M.E.4    Buettner, G.R.5    Kregel, K.C.6    Oberley, L.W.7
  • 52
    • 0034680344 scopus 로고    scopus 로고
    • P190-A, a human tumor suppressor gene, maps to the chromosomal region 19q13.3 that is reportedly deleted in some gliomas
    • 10.1016/S0378-1119(00)00387-5, 11054565
    • Tikoo A, Czekay S, Viars C, White S, Heath JK, Arden K, Maruta H. p190-A, a human tumor suppressor gene, maps to the chromosomal region 19q13.3 that is reportedly deleted in some gliomas. Gene 2000, 257:23-31. 10.1016/S0378-1119(00)00387-5, 11054565.
    • (2000) Gene , vol.257 , pp. 23-31
    • Tikoo, A.1    Czekay, S.2    Viars, C.3    White, S.4    Heath, J.K.5    Arden, K.6    Maruta, H.7
  • 53
    • 0030943968 scopus 로고    scopus 로고
    • The GTPase and Rho GAP domains of p190, a tumor suppressor protein that binds the M(r) 120,000 Ras GAP, independently function as anti-Ras tumor suppressors
    • Wang DZ, Nur EKMS, Tikoo A, Montague W, Maruta H. The GTPase and Rho GAP domains of p190, a tumor suppressor protein that binds the M(r) 120,000 Ras GAP, independently function as anti-Ras tumor suppressors. Cancer Res 1997, 57:2478-2484.
    • (1997) Cancer Res , vol.57 , pp. 2478-2484
    • Wang, D.Z.1    Nur, E.K.M.S.2    Tikoo, A.3    Montague, W.4    Maruta, H.5
  • 54
    • 0037442818 scopus 로고    scopus 로고
    • P190RhoGAP can act to inhibit PDGF-induced gliomas in mice: a putative tumor suppressor encoded on human chromosome 19q13.3
    • 10.1101/gad.1040003, 196001, 12600941
    • Wolf RM, Draghi N, Liang X, Dai C, Uhrbom L, Eklof C, Westermark B, Holland EC, Resh MD. p190RhoGAP can act to inhibit PDGF-induced gliomas in mice: a putative tumor suppressor encoded on human chromosome 19q13.3. Genes Dev 2003, 17:476-487. 10.1101/gad.1040003, 196001, 12600941.
    • (2003) Genes Dev , vol.17 , pp. 476-487
    • Wolf, R.M.1    Draghi, N.2    Liang, X.3    Dai, C.4    Uhrbom, L.5    Eklof, C.6    Westermark, B.7    Holland, E.C.8    Resh, M.D.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.