p190RhoGAP can act to inhibit PDGF-induced gliomas in mice: A putative tumor suppressor encoded on human Chromosome 19q13.3

Genes and Development

Volumn 17, Issue 4, 2003, Pages 476-487

  Wolf, Rebecca M ^a,b   Draghi, Nicole ^a,b   Liang, Xiquan ^a   Dai, Chengkai ^a,b   Uhrbom, Lene ^a,c   Eklöf, Charlotta ^c   Westermark, Bengt ^c   Holland, Eric C ^a,b   Resh, Marilyn D ^a,b  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b Weill Cornell Medical Center   (United States)

^c UPPSALA UNIVERSITY   (Sweden)

Author keywords

Glioma; p190RhoGAP; RhoA

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; GENE PRODUCT; NESTIN; PHOSPHOTRANSFERASE INHIBITOR; PLATELET DERIVED GROWTH FACTOR; PROTEIN P190RHOGAP; RETROVIRUS VECTOR; RHO KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CELL CULTURE; CELL PROLIFERATION; CHROMOSOME 19Q; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; EMBRYO; ENZYME INHIBITION; GENE ACTIVITY; GENE DELETION; GENE EXPRESSION REGULATION; GENE INSERTION; GENE LOCUS; GENETIC CODE; GLIOMA; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NERVE CELL DIFFERENTIATION; NEWBORN; NONHUMAN; OLIGODENDROGLIA; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; TUMOR SUPPRESSOR GENE;

ANIMALS; BRAIN NEOPLASMS; CELL DIFFERENTIATION; CELLS, CULTURED; CHROMOSOMES, HUMAN, PAIR 19; DNA-BINDING PROTEINS; DOWN-REGULATION; GENES, TUMOR SUPPRESSOR; GLIOMA; GTPASE-ACTIVATING PROTEINS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; INTERMEDIATE FILAMENT PROTEINS; MICE; MICE, INBRED STRAINS; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; OLIGODENDROGLIOMA; PHTHALAZINES; PLATELET-DERIVED GROWTH FACTOR; PYRIDINES; REPRESSOR PROTEINS; RETROVIRIDAE;

ANIMALIA; UNIDENTIFIED RETROVIRUS;

EID: 0037442818     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1040003     Document Type: Article

References (47)

1. Altschul, S.F., Madden, T.L., Schaffer, A.A., Zhang, J., Zhang, Z., Miller, W., and Lipman, D.J. 1997. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs. Nucleic Acids Res. 25: 3389-3402.
2. Arthur, W.T. and Burridge, K. 2001. RhoA inactivation by p190RhoGAP regulates cell spreading and migration by promoting membrane protrusion and polarity. Mol. Biol. Cell 12: 2711-2720.
3. Arthur, W.T., Petch, L.A., and Burridge, K. 2000. Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism. Curr. Biol. 10: 719-722.
4. Bello, M.J., Vaquero, J., de Campos, J.M., Kusak, M.E., Sarasa, J.L., Saez-Castresana, J., Pestana, A., and Rey, J.A. 1994. Molecular analysis of chromosome 1 abnormalities in human gliomas reveals frequent loss of 1p in oligodendroglial tumors. Intl. J. Cancer 57: 172-175.
5. Boerner, J.L., Danielsen, A., McManus, M.J., and Maihle, N.J. 2001. Activation of Rho is required for ligand-independent oncogenic signaling by a mutant epidermal growth factor receptor. J. Biol. Chem. 276: 3691-3695.
6. Bogler, O., Wren, D., Barnett, S.C., Land, H., and Noble, M. 1990. Cooperation between two growth factors promotes extended self-renewal and inhibits differentiation of oligodendrocyte-type-2 astrocyte (O-2A) progenitor cells. Proc. Natl. Acad. Sci. 87: 6368-6372.
7. Burge, C. and Karlin, S. 1997. Prediction of complete gene structures in human genomic DNA. J. Mol. Biol. 268: 78-94.
8. Cairncross, J.G., Ueki, K., Zlatescu, M.C., Lisle, D.K., Finkelstein, D.M., Hammond, R.R., Silver, J.S., Stark, P.C., Macdonald, D.R., Ino, Y., et al. 1998. Specific genetic predictors of chemotherapeutic response and survival in patients with anaplastic oligodendrogliomas. J. Natl. Cancer Inst. 90: 1473-1479.
9. Chang, J.H., Gill, S., Settleman, J., and Parsons, S.J. 1995. c-Src regulates the simultaneous rearrangement of actin cytoskeleton, p190RhoGAP, and p120RasGAP following epidermal growth factor stimulation. J. Cell Biol. 130: 355-368.
10. Coso, O.A., Chiariello, M., Yu, J.C., Teramoto, H., Crespo, P., Xu, N., Miki, T., and Gutkind, J.S. 1995. The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81: 1137-1146.
11. Dai, C., Celestino, J.C., Okada, Y., Louis, D.N., Fuller, G.N., and Holland, E.C. 2001. PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo. Genes & Dev. 15: 1913-1925.
12. Danen, E.H., Sonneveld, P., Sonnenberg, A., and Yamada, K.M. 2000. Dual stimulation of Ras/mitogen-activated protein kinase and RhoA by cell adhesion to fibronectin supports growth factor-stimulated cell cycle progression. J. Cell Biol. 151: 1413-1422.
13. Denoyelle, C., Vasse, M., Korner, M., Mishal, Z., Ganne, F., Vannier, J.P., Soria, J., and Soria, C. 2001. Cerivastatin, an inhibitor of HMG-CoA reductase, inhibits the signaling pathways involved in the invasiveness and metastatic properties of highly invasive breast cancer cell lines: An in vitro study. Carcinogenesis 22: 1139-1148.
14. Dupont, H. and Blancq, M. 1999. Formation of complexes involving RasGAP and p190 RhoGAP during morphogenetic events of the gastrulation in Xenopus. Eur. J. Biochem. 265: 530-538.
15. Guha, A., Dashner, K., Black, P.M., Wagner, J.A., and Stiles, C.D. 1995. Expression of PDGF and PDGF receptors in human astrocytoma operation specimens supports the existence of an autocrine loop. Intl. J. Cancer 60: 168-173.
16. Haskell, M.D., Nickles, A.L., Agati, J.M., Su, L., Dukes, B.D., and Parsons, S.J. 2001. Phosphorylation of p190 on Tyr1105 by c-Src is necessary but not sufficient for EGF-induced actin disassembly in C3H10T1/2 fibroblasts. J. Cell Sci. 114: 1699-1708.
17. Heldin, C.H. and Westermark, B. 1999. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol. Rev. 79: 1283-1316.
18. Hogarty, M.D., Maris, J.M., White, P.S., Guo, C., and Brodeur, G.M. 2001. Analysis of genomic imprinting at 1p35-36 in neuroblastoma. Med. Pediatr. Oncol. 36: 52-55.
19. Holland, E.C. 2000. Glioblastoma multiforme: The terminator. Proc. Natl. Acad. Sci. 97: 6242-6244.
20. -. 2001. Gliomagenesis: Genetic alterations and mouse models. Nat. Rev. Genet. 2:120-129.
21. 1 cell-cycle arrest pathways to induce glioma-like lesions in mice. Genes & Dev. 12: 3675-3685.
22. Holland, E.C., Celestino, J., Dai, C., Schaefer, L., Sawaya, R.E., and Fuller, G.N. 2000. Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice. Nat. Genet. 25: 55-57.
23. Jonkers, J. and Berns, A. 1996. Retroviral insertional mutagenesis as a strategy to identify cancer genes. Biochim. Biophys. Acta 1287: 29-57.
24. Kulkarni, S.V., Gish, G., van der Geer, P., Henkemeyer, M., and Pawson, T. 2000. Role of p120 Ras-GAP in directed cell movement. J. Cell Biol. 149: 457-470.
25. Liet, J.M., Piloquet, H., Marchini, J.S., Maugere, P., Bobin, C., Roze, J.C., and Darmaun, D. 1999. Leucine metabolism in preterm infants receiving parenteral nutrition with medium-chain compared with long-chain triacylglycerol emulsions. Am. J. Clin. Nutr. 69: 539-543.
26. McKinnon, R.D., Matsui, T., Dubois-Dalcq, M., and Aaronson, S.A. 1990. FGF modulates the PDGF-driven pathway of oligodendrocyte development. Neuron 5: 603-614.
27. McLaughlin, M.E. and Jacks, T. 2002. Thinking beyond the tumor cell: Nf1 haploinsufficiency in the tumor environment. Cancer Cell 1: 408-410.
28. Mora, J., Cheung, N.K., Chen, L., Qin, J., and Gerald, W. 2001. Loss of heterozygosity at 19q13.3 is associated with locally aggressive neuroblastoma. Clin. Cancer Res. 7: 1358-1361.
29. Olson, M.F., Paterson, H.F., and Marshall, C.J. 1998. Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1. Nature 394: 295-299.
30. Osterhout, D.J., Wolven, A., Wolf, R.M., Resh, M.D., and Chao, M.V. 1999. Morphological differentiation of oligodendrocytes requires activation of Fyn tyrosine kinase. J. Cell Biol. 145: 1209-1218.
31. Reifenberger, J., Reifenberger, G., Liu, L., James, C.D., Wechsler, W., and Collins, V.P. 1994. Molecular genetic analysis of oligodendroglial tumors shows preferential allelic deletions on 19q and lp. Am. J. Pathol. 145: 1175-1190.
32. Ridley, A.J., Self, A.J., Kasmi, F., Paterson, H.F., Hall, A., Marshall, C.J., and Ellis, C. 1993. Rho family GTPase activating proteins p190, bcr and rho GAP show distinct specificities in vitro and in vivo. EMBO J. 12: 5151-5160.
33. Sahai, E., Olson, M.F., and Marshall, C.J. 2001. Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility. EMBO J. 20: 755-766.
34. Settleman, J., Albright, C.F., Foster, L.C., and Weinberg, R.A. 1992. Association between GTPase activators for Rho and Ras families. Nature 359: 153-154.
35. Sharma, S.V. 1998. Rapid recruitment of p120RasGAP and its associated protein, p190RhoGAP to the cytoskeleton during integrin mediated cell-substrate interaction. Oncogene 17: 271-281.
36. Smith, J.S. and Jenkins, R.B. 2000. Genetic alterations in adult diffuse glioma: Occurrence, significance, and prognostic implications. Front Biosci. 5: D213-D231.
37. Tang, D.G., Tokumoto, Y.M., and Raff, M.C. 2000. Long-term culture of purified postnatal oligodendrocyte precursor cells. Evidence for an intrinsic maturation program that plays out over months. J. Cell Biol. 148: 971-984.
38. Tikoo, A., Czekay, S., Viars, C., White, S., Heath, J.K., Arden, K., and Maruta, H. 2000. p190-A, a human tumor suppressor gene, maps to the chromosomal region 19q13.3 that is reportedly deleted in some gliomas. Gene 257: 23-31.
39. Uhrbom, L., Hesselager, G., Nister, M., and Westermark, B. 1998. Induction of brain tumors in mice using a recombinant platelet-derived growth factor B-chain retrovirus. Cancer Res. 58: 5275-5279.
40. van Golen, K.L., Wu, Z.F., Qiao, X.T., Bao, L.W., and Merajver, S.D. 2000. RhoC GTPase, a novel transforming oncogene for human mammary epithelial cells that partially recapitulates the inflammatory breast cancer phenotype. Cancer Res. 60: 5832-5838.
41. van Leeuwen, F. and Nusse, R. 1995. Oncogene activation and oncogene cooperation in MMTV-induced mouse mammary cancer. Semin. Cancer Biol. 6: 127-133.
42. Venkatachalam, S., Shi, Y.P., Jones, S.N., Vogel, H., Bradley, A., Pinkel, D., and Donehower, L.A. 1998. Retention of wild-type p53 in tumors from p53 heterozygous mice: Reduction of p53 dosage can promote cancer formation. EMBO J. 17: 4657-4667.
43. Wang, D.Z., Nur, E.K.M.S., Tikoo, A., Montague, W., and Maruta, H. 1997. The GTPase and Rho GAP domains of p190, a tumor suppressor protein that binds the M(r) 120,000 Ras GAP, independently function as anti-Ras tumor suppressors. Cancer Res. 57: 2478-2484.
44. Wetmore, C., Eberhart, D.E., and Curran, T. 2000. The normal patched allele is expressed in medulloblastomas from mice with heterozygous germ-line mutation of patched. Cancer Res. 60: 2239-2246.
45. Wolf, R.M., Wilkes, J.J., Chao, M.V., and Resh, M.D. 2001. Tyrosine phosphorylation of p190 RHOGAP by Fyn regulates oligodendrocyte differentiation. J. Neurobiol. 49: 62-78.
46. Wood, J.M., Bold, G., Buchdunger, E., Cozens, R., Ferrari, S., Frei, J., Hofmann, F., Mestan, J., Mett, H., O'Reilly, T., et al. 2000. PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration. Cancer Res. 60: 2178-2189.
47. Zrihan-Licht, S., Fu, Y., Settleman, J., Schinkmann, K., Shaw, L., Keydar, I., Avraham, S., and Avraham, H. 2000. RAFTK/ Pyk2 tyrosine kinase mediates the association of p190 RhoGAP with RasGAP and is involved in breast cancer cell invasion. Oncogene 19: 1318-1328.