Computational model explains high activity and rapid cycling of Rho GTPases within protein complexes

PLoS Computational Biology

Volumn 2, Issue 12, 2006, Pages 1511-1521

  Goryachev, Andrew B ^a,b   Pokhilko, Alexandra V ^a,b  

^a BIOINFORMATICS INSTITUTE   (Singapore)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; COMPUTATION THEORY; COMPUTATIONAL METHODS; PROTEINS;

CELLULAR MEMBRANES; COMPUTATIONAL MODELLING; GTPASES; HIGH ACTIVITY; MULTI-PROTEIN COMPLEX; PROTEIN COMPLEXES; RAPID CYCLING; RHO GTPASES; SMALL GTPASE; TURNOVER RATE;

CHEMICAL ACTIVATION;

PROTEIN; RAB PROTEIN; RHO FACTOR; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; GUANOSINE TRIPHOSPHATE; MULTIPROTEIN COMPLEX;

ARTICLE; CELL CYCLE; CELL CYCLE REGULATION; IN VITRO STUDY; IN VIVO STUDY; TURNOVER TIME; AMINO ACID SEQUENCE; BIOLOGICAL MODEL; CHEMICAL MODEL; CHEMISTRY; COMPUTER SIMULATION; ENZYME ACTIVATION; FEEDBACK SYSTEM; GENE EXPRESSION REGULATION; METABOLISM; MOLECULAR GENETICS; PHYSIOLOGY; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; COMPUTER SIMULATION; ENZYME ACTIVATION; FEEDBACK; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GTPASE-ACTIVATING PROTEINS; GUANOSINE TRIPHOSPHATE; MODELS, BIOLOGICAL; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; MULTIPROTEIN COMPLEXES; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION;

EID: 33846002372     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.0020172.eor     Document Type: Article

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