The nuclear inclusion a (NIa) protease of turnip mosaic virus (TuMV) cleaves amyloid-β

PLoS ONE

Volumn 5, Issue 12, 2010, Pages

  Han, Hye Eun ^a   Sellamuthu, Saravanan ^a   Shin, Bae Hyun ^a   Lee, Yong Jae ^a   Song, Sungmin ^b   Seo, Ji Seon ^c   Baek, In Sun ^c   Bae, Jeomil ^a   Kim, Hannah ^c   Yoo, Yung Joon ^a   Jung, Yong Keun ^b   Song, Woo Keun ^a   Han, Pyung Lim ^c   Park, Woo Jin ^a  

^a Gwangju Institute of Science and Technology (GIST)   (South Korea)

^b Seoul National University   (South Korea)

^c Ewha Womans University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; NUCLEAR INCLUSION A PROTEASE; PROTEINASE; UNCLASSIFIED DRUG; NUCLEAR INCLUSION PROTEIN A, MOSAIC VIRUSES; VIRUS PROTEIN;

ANIMAL CELL; ANIMAL CELL CULTURE; APOPTOSIS; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; ENZYME ACTIVITY; ENZYME LOCALIZATION; IN VITRO STUDY; NEUROBLASTOMA CELL; NONHUMAN; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; RAT; TURNIP YELLOW MOSAIC VIRUS; AMINO ACID SEQUENCE; ANIMAL; CELL FRACTIONATION; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DISEASE COURSE; ENZYME SPECIFICITY; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR GENETICS; MOSAIC VIRUS; MOUSE; NERVE CELL; RAPESEED; TRANSGENIC MOUSE; TUMOR CELL LINE; VIROLOGY;

MUS MUSCULUS; NIA; TURNIP MOSAIC VIRUS;

AMINO ACID SEQUENCE; AMYLOID BETA-PEPTIDES; ANIMALS; BRASSICA NAPUS; CELL LINE, TUMOR; CELL SURVIVAL; CYTOPLASM; DISEASE PROGRESSION; ENDOPEPTIDASES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MOSAIC VIRUSES; NEURONS; RATS; SUBCELLULAR FRACTIONS; SUBSTRATE SPECIFICITY; VIRAL PROTEINS;

EID: 78650906716     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0015645     Document Type: Article

References (46)

1. LaFerla FM, Green KN, Oddo S (2007) Intracellular amyloid-beta in Alzheimer's disease. Nat Rev Neurosci 8: 499-509.
2. Blennow K, de Leon MJ, Zetterberg H (2006) Alzheimer's disease. Lancet 368: 387-403.
3. Dahlgren KN, Manelli AM, Stine WB, Baker LK, Krafft GA, et al. (2002) Oligomeric and fibrillar species of amyloid-beta peptides differentially affect neuronal viability. J Biol Chem 277: 32046-32053.
4. Ono K, Condron MM, Teplow DB (2009) Structure-neurotoxicity relationships of amyloid beta-protein oligomers. Proc Natl Acad Sci USA 106: 14745-14750.
5. Masters CL, Simms G, Weinman NA, Multhaup G, McDonald BL, et al. (1985) Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci U S A 82: 4245-4249.
6. Pike CJ, Burdick D, Walencewicz AJ, Glabe CG, Cotman CW (1993) Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state. J Neurosci 13: 1676-1687.
7. Wirths O, Multhaup G, Bayer T (2004) A modified beta-amyloid hypothesis: intraneuronal accumulation of the beta-amyloid peptide-the first step of a fatal cascade. J Neurochem 91: 513-520.
8. Mori C, Spooner ET, Wisniewsk KE, Wisniewski TM, Yamaguch H, et al. (2002) Intraneuronal Abeta42 accumulation in Down syndrome brain. Amyloid 9: 88-102.
9. Grant SM, Ducatenzeiler A, Szyf M, Cuello AC (2000) Abeta immunoreactive material is present in several intracellular compartments in transfected, neuronally differentiated, P19 cells expressing the human amyloid beta-protein precursor. J Alzheimers Dis 2: 207-222.
10. Billings LM, Oddo S, Green KN, McGaugh JL, LaFerla FM (2005) Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron 45: 675-688.
11. Zhang Y, McLaughlin R, Goodyer C, LeBlanc A (2002) Selective cytotoxicity of intracellular amyloid beta peptide1-42 through p53 and Bax in cultured primary human neurons. J Cell Biol 156: 519-529.
12. Ohyagi Y, Asahara H, Chui DH, Tsuruta Y, Sakae N, et al. (2005) Intracellular Abeta42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's disease. Faseb J 19: 255-257.
13. Wang X, Su B, Perry G, Smith MA, Zhu X (2007) Insights into amyloid-beta-induced mitochondrial dysfunction in Alzheimer disease. Free Radic Biol Med 43: 1569-1573.
14. Oddo S, Billings L, Kesslak JP, Cribbs DH, LaFerla FM (2004) Abeta immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome. Neuron 43: 321-332.
15. Oddo S, Caccamo A, Smith IF, Green KN, LaFerla FM (2006) A dynamic relationship between intracellular and extracellular pools of Abeta. Am J Pathol 168: 184-194.
16. Selkoe DJ (2001) Clearing the brain's amyloid cobwebs. Neuron 32: 177-180.
17. Mouri A, Zou LB, Iwata N, Saido TC, Wang D, et al. (2006) Inhibition of neprilysin by thiorphan (i.c.v.) causes an accumulation of amyloid beta and impairment of learning and memory. Behav Brain Res 168: 83-91.
18. Farris W, Schutz SG, Cirrito JR, Shankar GM, Sun X, et al. (2007) Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy. Am J Pathol 171: 241-251.
19. Marr RA, Rockenstein E, Mukherjee A, Kindy MS, Hersh LB, et al. (2003) Neprilysin gene transfer reduces human amyloid pathology in transgenic mice. J Neurosci 23: 1992-1996.
20. Leissring MA, Farris W, Chang AY, Walsh DM, Wu X, et al. (2003) Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death. Neuron 40: 1087-1093.
21. Meilandt WJ, Cisse M, Ho K, Wu T, Esposito LA, et al. (2009) Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Abeta oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice. J Neurosci 29: 1977-1986.
22. Kang H, Lee YJ, Goo JH, Park WJ (2001) Determination of the substrate specificity of turnip mosaic virus NIa protease using a genetic method. J Gen Virol 82: 3115-7.
23. Kim DH, Park YS, Kim SS, Lew J, Nam HG, et al. (1995) Expression, purification, and identification of a novel self-cleavage site of the Nla C-terminal 27-kDa protease of turnip mosaic potyvirus C5. Virology 213: 517-525.
24. Stine WB, Dahlgren KN, Krafft GA, LaDu MJ (2003) In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis. J Biol Chem 278: 11612-11622.
25. Lee EK, Park YW, Shin DY, Mook-Jung I, Yoo YJ (2006) Cytosolic amyloid-beta peptide 42 escaping from degradation induces cell death. Biochem Biophys Res Commun 344: 471-477.
26. Hansson Petersen CA, Alikhani N, Behbahani H, Wiehager B, Pavlov PF, et al. (2008) The amyloid beta-peptide is imported into mitochondria via the TOM import machinery and localized to mitochondrial cristae. Proc Natl Acad Sci U S A 105: 13145-13150.
27. Chafekar SM, Baas F, Scheper W (2008) Oligomer-specific Abeta toxicity in cell models is mediated by selective uptake. Biochim Biophys Acta 1782: 523-31.
28. Almeida CG, Takahashi RH, Gouras GK (2006) Beta-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system. J Neurosci 26: 4277-4288.
29. Takuma K, Fang F, Zhang W, Yan S, Fukuzaki E, et al. (2009) RAGE-mediated signaling contributes to intraneuronal transport of amyloid-beta and neuronal dysfunction. Proc Natl Acad Sci U S A 106: 20021-20026.
30. Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, et al. (2002) Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416: 535-539.
31. Gyure KA, Durham R, Stewart WF, Smialek JE, Troncoso JC (2001) Intraneuronal abeta-amyloid precedes development of amyloid plaques in Down syndrome. Arch Pathol Lab Med 125: 489-492.
32. Martin BL, Schrader-Fischer G, Busciglio J, Duke M, Paganetti P, et al. (1995) Intracellular accumulation of beta-amyloid in cells expressing the Swedish mutant amyloid precursor protein. J Biol Chem 270: 26727-26730.
33. Chui DH, Tanahashi H, Ozawa K, Ikeda S, Checler F, et al. (1999) Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation. Nat Med 5: 560-564.
34. Song S, Jung YK (2004) Alzheimer's disease meets the ubiquitin-proteasome system. Trends Mol Med 10: 565-5670.
35. Oddo S (2008) The ubiquitin-proteasome system in Alzheimer's disease. J Cell Mol Med 12: 363-373.
36. Gregori L, Fuchs C, Figueiredo-Pereira ME, Van Nostrand WE, Goldgaber D (1995) Amyloid beta-protein inhibits ubiquitin-dependent protein degradation in vitro. J Biol Chem 270: 19702-19708.
37. Keller JN, Hanni KB, Markesbery WR (2000) Impaired proteasome function in Alzheimer's disease. J Neurochem 75: 436-439.
38. Marambaud P, Zhao H, Davies P (2005) Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides. J Biol Chem 280: 37377-37382.
39. Burns MP, Zhang L, Rebeck GW, Querfurth HW, Moussa CE (2009) Parkin promotes intracellular Abeta1-42 clearance. Hum Mol Genet 18: 3206-3216.
40. Rodriguez-Navarro JA, Gomez A, Rodal I, Perucho J, Martinez A, et al. (2008) Parkin deletion causes cerebral and systemic amyloidosis in human mutated tau over-expressing mice. Hum Mol Genet 17: 3128-3143.
41. Yan P, Hu X, Song H, Yin K, Bateman RJ, et al. (2006) Matrix metalloproteinase-9 degrades amyloid-beta fibrils in vitro and compact plaques in situ. J Biol Chem 281: 24566-24574.
42. Song S, Lee H, Kam TI, Tai ML, Lee JY, et al. (2008) E2-25K/Hip-2 regulates caspase-12 in ER stress-mediated Abeta neurotoxicity. J Cell Biol 182: 675-684.
43. Lehel C, Olah Z, Mischak H, Mushinski JF, Anderson WB (1994) Overexpressed protein kinase C-delta and -epsilon subtypes in NIH 3T3 cells exhibit differential subcellular localization and differential regulation of sodium-dependent phosphate uptake. J Biol Chem 269: 4761-4766.
44. Dull T, Zufferey R, Kelly M, Mandel RJ, Nguyen M, et al. (1998) A third-generation lentivirus vector with a conditional packaging system. J Virol 72: 8463-8471.
45. Jankowsky JL, Slunt HH, Ratovitski T, Jenkins NA, Copeland NG, et al. (2001) Co-expression of multiple transgenes in mouse CNS: a comparison of strategies. Biomol Eng 17: 157-165.
46. Lee KW, Kim JB, Seo JS, Kim TK, Im JY, et al. (2009) Behavioral stress accelerates plaque pathogenesis in the brain of Tg2576 mice via generation of metabolic oxidative stress. J Neurochem 108: 165-175.