α-TEA cooperates with MEK or mTOR inhibitors to induce apoptosis via targeting IRS/PI3K pathways

British Journal of Cancer

Volumn 104, Issue 1, 2011, Pages 101-109

  Tiwary, R ^a   Yu, W ^a   Sanders, B G ^a   Kline, K ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

TEA; Akt; breast cancer; ERK; IRS 1; mTOR

Indexed keywords

ACETIC ACID; ALPHA TOCOPHEROL; ANNEXIN; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; INSULIN RECEPTOR SUBSTRATE; INSULIN RECEPTOR SUBSTRATE 1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; RAPAMYCIN; SMALL INTERFERING RNA; WORTMANNIN;

APOPTOSIS; ARTICLE; BREAST CANCER; CELL STRAIN MCF 7; CONTROLLED STUDY; GENE SILENCING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 4-KINASE; ALPHA-TOCOPHEROL; ANDROSTADIENES; ANTHRACENES; ANTIOXIDANTS; APOPTOSIS; BLOTTING, WESTERN; BREAST NEOPLASMS; BUTADIENES; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; ENZYME INHIBITORS; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INSULIN RECEPTOR SUBSTRATE PROTEINS; MAP KINASE KINASE 4; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NITRILES; PHOSPHORYLATION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; SIROLIMUS; TOR SERINE-THREONINE KINASES; TUMOR CELLS, CULTURED;

EID: 78650903052     PISSN: 00070920     EISSN: 15321827     Source Type: Journal    
DOI: 10.1038/sj.bjc.6606019     Document Type: Article

References (46)

1. Anderson K, Lawson KA, Simmons-Menchaca M, Sun L, Sanders BG, Kline K (2002) a-TEA plus cisplatin reduces human cisplatin-resistant ovarian cancer cell tumor burden and metastasis. Exp Biol Med 229: 1169-1176
2. Bjornsti MA, Houghton PJ (2004) The mTOR pathway: a target for cancer therapy. Nat Rev Cancer 4: 335-348
3. Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, Frisch S, Reed JC (1998) Regulation of cell death protease caspase-9 by phosphorylation. Science 282: 1318-1321
4. Chan S (2004) Targeting the mammalian target of rapamycin (mTOR): a new approach to treating cancer. Br J Cancer 91: 1420-1424
5. Chang F, Lee JT, Navolanic PM, Steelman LS, Shelton JG, Blalock WL, Franklin RA, McCubrey JA (2003) Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy. Leukemia 17: 590-603
6. Datta SR, Dudek H, Tao X, Masters S, Fu H, Gotoh Y, Greenberg ME (1997) Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91: 231-241
7. Datta SR, Katsov A, Hu L, Petros A, Fesik SW, Yaffe MB, Greenberg ME (2000) 14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation. Mol Cell 6: 41-51
8. De Fea K, Roth RA (1997) Protein kinase C modulation of insulin receptor substrate-1 tyrosine phosphorylation requires serine 612. Biochemistry 36: 12939-12947 (Pubitemid 27465406)
9. Downward J (1999) How BAD phosphorylation is good for survival. Nat Cell Biol 1: E33-E35
10. Falasca M (2010) PI3K/Akt signaling pathway specific inhibitors: a novel strategy to sensitize cancer cells to anti-cancer drugs. Curr Pharm Des 16: 1410-1416
11. Ghayad SE, Vendrell JA, Larbi SB, Dumontet C, Bieche I, Cohen PA (2010) Endocrine resistance associated with activated ErbB system in breast cancer cells is reversed by inhibiting MAPK or PI3K/Akt signaling pathways. Int J Cancer 126: 545-562
12. Gibbons JJ, Abraham RT, Yu K (2009) Mammalian target of rapamycin: discovery of rapamycin reveals a signaling pathway important for normal and cancer cell growth. Semin Oncol 36(Suppl 3): S3-S17
13. Greene MW, Sakaue H, Wang L, Alessi DR, Roth RA (2003) Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by serine 312 phosphorylation. Biol Chem 278: 8199-8211
14. Hahn T, Fried LH, Hurley LH, Akporiaye ET (2009) Orally active a-tocopheryloxyacetic acid suppresses tumor growth and multiplicity of spontaneous murine breast cancer. Mol Cancer Ther 8: 1570-1578
15. Hahn T, Szabo L, Gold M, Ramanathapuram L, Hurley LH, Akporiaye ET (2006) Dietary administration of the proapoptotic vitamin E analogue a-tocopheryloxyacetic acid inhibits metastatic murine breast cancer. Cancer Res 66: 9374-9378
16. Hartley D, Cooper GM (2002) Role of mTOR in the degradation of IRS-1: regulation of PP2A activity. J Cell Biochem 85: 304-314
17. Hayakawa J, Ohmichi M, Kurachi H, Kanda Y, Hisamoto K, Nishio Y, Adachi K, Tasaka K, Kanzaki T, Murata Y (2000) Inhibition of BAD phosphorylation either at serine 112 via extracellular signal-regulated protein kinase cascade or at serine 136 via Akt cascade sensitizes human ovarian cancer cells to cisplatin. Cancer Res 60: 5988-5994
18. Hiratani K, Haruta T, Tani A, Kawahara J, Usui I, Kobayashi M (2005) Roles of mTOR and JNK in serine phosphorylation, translocation, and degradation of IRS-1. Biochem Biophys Res Commun 335: 836-842
19. Horike N, Takemori H, Katoh Y, Doi J, Min L, Asano T, Sun XJ, Yamamoto H, Kasayama S, Muraoka M, Nonaka Y, Okamoto M (2003) Adipose-specific expression, phosphorylation of Ser794 in insulin receptor substrate-1, and activation in diabetic animals of salt-inducible kinase-2. J Biol Chem 278: 18440-18447
20. Hynes NE, Dey JH (2009) PI3K inhibition overcomes trastuzumab resistance: blockade of ErbB2/ErbB3 is not always enough. Cancer Cell 15: 353-355
21. Jia L, Yu W, Wang P, Sanders BG, Kline K (2008a) In vivo and in vitro studies of anticancer actions of a-TEA for human prostate cancer cells. Prostate 68: 849-860
22. Jia L, Yu W, Wang P, Li J, Sanders BG, Kline K (2008b) Critical roles for JNK, c-Jun, and Fas/FasL-signaling in vitamin E analog-induced apoptosis in human prostate cancer cells. Prostate 68: 427-441
23. Jiang X, Sinnett-Smith J, Rozengurt E (2009) Carbachol induces p70S6K1 activation through an ERK-dependent but Akt-independent pathway in human colonic epithelial cells. Biochem Biophys Res Commun 387: 521-524
24. Kim H, Rafiuddin-Shah M, Tu HC, Jeffers JR, Zambetti GP, Hsieh JJ, Cheng EH (2006) Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies. Nat Cell Biol 8: 1348-1358
25. Lawson KA, Anderson K, Simmons-Menchaca M, Atkinson J, Sun L, Sanders BG, Kline K (2004) Comparison of vitamin E derivatives a-TEA and VES in reduction of mouse mammary tumor burden and metastasis. Exp Biol Med 229: 954-963
26. Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X (1997) Cytochrome c and dATP-dependent formation of Apaf-1/ caspase-9 complex initiates an apoptotic protease cascade. Cell 91: 479-489
27. Mabuchi S, Ohmichi M, Kimura A, Hisamoto K, Hayakawa J, Nishio Y, Adachi K, Takahashi K, Arimoto-Ishida E, Nakatsuji Y, Tasaka K, Murata Y (2002) Inhibition of phosphorylation of BAD and Raf-1 by Akt sensitizes human ovarian cancer cells to paclitaxel. J Biol Chem 277: 33490-33500
28. Mamay CL, Mingo-Sion AM, Wolf DM, Molina MD, Van Den Berg CL (2003) An inhibitory function for JNK in the regulation of IGF-I signaling in breast cancer. Oncogene 22(4): 602-614
29. McCubrey JA, Steelman LS, Chappell WH, Abrams SL, Wong EW, Chang F, Lehmann B, Terrian DM, Milella M, Tafuri A, Stivala F, Libra M, Basecke J, Evangelisti C, Martelli AM, Franklin RA (2007) Roles of the Raf/MEK/ ERK pathway in cell growth, malignant transformation and drug resistance. Biochim Biophys Acta 1773: 1263-1284
30. Mingo-Sion AM, Ferguson HA, Koller E, Reyland ME, Van Den Berg CL (2005) PKC delta and mTOR interact to regulate stress and IGF-I induced IRS-1 Ser312 phosphorylation in breast cancer cells. Breast Cancer Res Treat 91: 259-269
31. Nishitoh H, Matsuzawa A, Tobiume K, Saegusa K, Takeda K, Inoue K, Hori S, Kakizuka A, Ichijo H. (2002) ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev 16: 1345-1355
32. Ozes ON, Akca H, Mayo LD, Gustin JA, Maehama T, Dixon JE, Donner DB (2001) A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. Proc Natl Acad Sci USA 98: 4640-4645
33. Rui L, Aguirre V, Kim JK, Shulman GI, Lee A, Corbould A, Dunaif A, White MF (2001) Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways. J Clin Invest 107: 181-189
34. Schlessinger J (2000) Cell signaling by receptor tyrosine kinases. Cell 103: 211-225
35. Shun MC, Yu W, Gapor A, Parsons R, Atkinson J, Sanders BG, Kline K (2004) Pro-apoptotic mechanisms of action of a novel vitamin E analog (a-TEA) and a naturally occurring form of vitamin E (d-tocotrienol) in MDA-MB-435 human breast cancer cells. Nutr Cancer 48: 95-105
36. Shun MC, Yu W, Park SK, Sanders BG, Kline K (2010) Downregulation of epidermal growth factor receptor expression contributes to alpha-TEA's proapoptotic effects in human ovarian cancer cell lines. J Oncol 2010: 824571
37. Sun SY, Rosenberg LM, Wang X, Zhou Z, Yue P, Fu H, Khuri FR (2005) Activation of Akt and eIF4E survival pathways by rapamycinmediated mammalian target of rapamycin inhibition. Cancer Res 65: 7052-7058
38. Surmacz E (2000) Function of the IGF-I receptor in breast cancer. J Mammary Gland Biol Neoplasia 5: 95-105
39. Tiwary R, Yu W, Li J, Park SK, Sanders BG, Kline K (2010) Role of endoplasmic reticulum stress in alpha-TEA mediated TRAIL/DR5 death receptor dependent apoptosis. PLoS One 5(7): e11865
40. Valentinis B, Baserga R (2001) IGF-I receptor signaling in transformation and differentiation. Mol Pathol 54: 133-137
41. Vignot S, Faivre S, Aguirre D, Raymond E (2005) mTOR-targeted therapy of cancer with rapamycin derivatives. Ann Oncol 16: 525-537
42. Wan X, Harkavy B, Shen N, Grohar P, Helman LJ (2007) Rapamycin induces feedback activation of Akt signaling through an IGF-1Rdependent mechanism. Oncogene 26: 1932-1940
43. Wang P, Yu W, Hu Z, Jia L, Iyer VR, Sanders BG, Kline K (2008) Involvement of JNK/p73/NOXA in vitamin E analog-induced apoptosis of human breast cancer cells. Mol Carcinogenesis 7: 436-445
44. Xu C, Bailly-Maitre B, Reed JC (2005) Endoplasmic reticulum stress: cell life and death decisions. J Clin Invest 115: 2656-2664
45. Yu W, Tiwary R, Li J, Park SK, Jia L, Xiong A, Simmons-Menchaca M, Sanders BG, Kline K (2010) a-TEA induces apoptosis of human breast cancer cells via activation of TRAIL/DR5 death receptor pathway. Mol Carcinog 49: 964-973
46. Yu W, Shun MC, Anderson K, Chen H, Sanders BG, Kline K (2006) alpha- TEA inhibits survival and enhances death pathways in cisplatin sensitive and resistant human ovarian cancer cells. Apoptosis 11: 1813-1823