Bioactive biomaterials

Current Opinion in Biotechnology

Volumn 10, Issue 2, 1999, Pages 123-129

  Hubbell, Jeffrey A ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMATERIAL; CELL ADHESION MOLECULE; CELL ENZYME; FIBRONECTIN; GROWTH FACTOR; POLYSACCHARIDE;

CELL ADHESION; CELL MIGRATION; DRUG DEGRADATION; PHASE TRANSITION; PRIORITY JOURNAL; REVIEW;

EID: 0032994943     PISSN: 09581669     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0958-1669(99)80021-4     Document Type: Article

References (55)

1. Yamada K.M. Adhesive redognition sequences. J Biol Chem. 266:1991;12809-12812.
2. Hubbell J.A. Biomaterials in tissue engineering. Biotechnology. 13:1995;565-576.
3. Peppas N.A., Langer R. New challenges in biomaterials. Science. 263:1994;1715-1720.
4. Ratner B.D. The engineering of biomaterials exhibiting recognition and specificity. J Mol Recognit. 9:1996;617-625.
5. Langer R. Drug delivery and targeting. Nature. 392:1998;5-10.
6. 3-mediated fibroblast spreading and 140 nm for focal contact and stress fiber formation. J Cell Biol. 114:1991;1089-1100.
7. Massia S.P., Rao S.S., Hubbell J.A. Covalently immobilized laminin peptide Tyr-Ile-Gly-Ser-Arg (YIGSR) supports cell spreading and co-localization of the 67-kilodalton laminin receptor with α-actinin and vinculin. J Biol Chem. 268:1993;8053-8059.
8. Palecek S.P., Loftus J.C., Ginsberg M.H., Lauffenburger D.A., Horwitz A.F. Integrin-ligand binding properties govern cell migration speed through cell-substratum adhesiveness. Nature. 385:1997;537-540. [Published erratum appears in Nature 1997, 388:210]. This paper provides very convincing evidence of a direct link between cell adhesion strength and cell migration rates, providing for the biomaterials engineer important guidance that too much of a good thing (e.g. an adhesion ligand) can be bad (e.g. if cell migration was an important performance criterion).
9. Griffith L.G., Lopina S. Microdistribution of substratum-bound ligands affects cell function: hepatocyte spreading on PEO-tethered galactose. Biomaterials. 19:1998;979-986.
10. 1. J Biol Chem. 267:1992;14019-14026.
11. Bearinger J.P., Castner D.G., Healy K.E. Biomolecular modification of p(AAm-co-EG/AA) IPNs supports osteoblast adhesion and phenotypic expression. J Biomater Sci Polym Ed. 9:1998;629-652.
12. Meinhart J., Deutsch M., Zilla P. Eight years of clinical endothelial cell transplantation. Closing the gap between prosthetic grafts and vein grafts. ASAIO J. 43:1997;M515-521. This clinical study with endothelial cell seeded vascular grafts demonstrated that graft performance in high flow regions (where stresses on the attached endothelial cells were greatest) was better when the biomaterial matrix included the adhesion protein fibronectin. Although the study was performed with a complete protein, rather than an engineered peptide, it provides direct clinical evidence of the need, and probability of success, of such approaches.
13. Elbert D.E., Hubbell J.A. Surface treatments of polymers for biocompatibility. Annu Rev Mater Sci. 26:1996;365-394.
14. Cook A.D., Hrkach J.S., Gao N.N., Johnson I.M., Pajvani U.B., Cannizzaro S.M., Langer R. Characterization and development of RGD-peptide-modified poly(lactic acid-co-lysine) as an interactive, resorbable biomaterial. J Biomed Mater Res. 35:1997;513-523.
15. Borkenhagen M., Clemence J.F., Sigrist H., Aebischer P. Three dimensional extracellular matrix engineering in the nervous system. J Biomed Mater Res. 40:1998;392-400. The investigators employed grafted adhesion peptides from laminin to enhance the rate of neurite extension through a three-dimensional gel to which the peptide was attached. This provides an example of peptide grafting in three dimensions and evidence that clinically relevant biomaterials are likely to result.
16. Urry D.W., Pattanaik A., Xu J., Woods T.C., McPherson D.T., Parker T.M. Elastic protein-based polymers in soft tissue augmentation and generation. J Biomater Sci Polym Ed. 9:1998;1015-1048.
17. Dinbergs I.D., Brown L., Edelman E.R. Cellular response to transforming growth factor-beta1 and basic fibroblast growth factor depends on release kinetics and extracellular matrix interactions. J Biol Chem. 271:1996;29822-29829.
18. Zarge J.I., Huang P., Husak V., Kim D.U., Haudenschild C.C., Nord R.M., Greisler H.P. Fibrin glue containing fibroblast growth factor type 1 and heparin with autologous endothelial cells reduces intimal hyperplasia in a canine carotid artery balloon injury model. J Vasc Surg. 25:1997;840-848.
19. Haller M.F., Saltzman W.M. Nerve growth factor delivery systems. J Controlled Release. 53:1998;1-6.
20. Schroeder-Tefft J.A., Bentz H., Estridge T.D. Collagen and heparin matrices for growth factor delivery. J Controlled Release. 49:1997;291-298. The investigators employed the affinity of the important growth factor transforming growth factor β for heparin to develop clinically relevant bioactive biomaterials for bone regeneration. Heparin, grafted to the collagen substrate, served as a docking and release site to provide for delayed release. When cells migrate into such matrices, they may also release the growth factor by local enzymatic action, as occurs naturally in the extracellular matrix.
21. ••], provides evidence that covalently immobilised growth factor, in this case transforming growth factor β, can be presented to cells in a bioactive manner. This was not clear a priori, in that the ligand-bound receptors must presumably dimerise in the plane of the membrane in order to express biological activity.
22. ••], this demonstrates that internalisation of the ligand-bound receptors is not critical in order to express biological activity.
23. ••]. This permits amplification of the bioactivity associated with the biomaterial surface, in that the cells that come into contact with the material can continue to express the gene encoded on the plasmid DNA for an extended period of time.
24. ••].
25. Byun Y., Jacobs H.A., Kim S.W. Mechanism of thrombin inactivation by immobilized heparin. J Biomed Mater Res. 30:1996;423-427.
26. de Raucourt E., Mauray S., Chaubet F., Maiga-Revel O., Jozefowicz M., Fischer A.M. Anticoagulant activity of dextran derivatives. J Biomed Mater Res. 41:1998;49-57.
27. Maaroufi R.M., Jozefowicz M., Tapon-Bretaudiere J., Jozefonvicz J., Fischer A.M. Mechanism of thrombin inhibition by heparin cofactor II in the presence of dermatan sulphates, native or oversulphated, and a heparin-like dextran derivative. Biomaterials. 18:1997;359-366.
28. Logeart D., Prigent-Richard S., Jozefonvicz J., Letourneur D. Fucans, sulfated polysaccharides extracted from brown seaweeds, inhibit vascular smooth muscle cell proliferation. I. Comparison with heparin for antiproliferative activity, binding and internalization. Eur J Cell Biol. 74:1997;376-384.
29. Bagheri-Yarmand R., Kourbali Y., Mabilat C., Morere J.F., Martin A., Lu H., Soria C., Jozefonvicz J., Crepin M. The suppression of fibroblast growth factor 2/fibroblast growth factor 4-dependent tumour angiogenesis and growth by the anti-growth factor activity of dextran derivative (CMDB7). Br J Cancer. 78:1998;111-118.
30. Silver J.H., Hart A.P., Williams E.C., Cooper S.L., Charef S., Labarre D., Jozefowicz M. Anticoagulant effects of sulphonated polyurethanes. Biomaterials. 13:1992;339-344.
31. ••]) demonstrates that redox enzymes can be chemically conjugated into conducting polymer gels to obtain efficient electron transfer from the enzyme's active site to the gel and ultimately to a collecting electrode. This permitted extremely highly sensitive and fast transduction of a glucose concentration into an amperometric signal. This high level of bioactivity was obtained by combining several features of bioactivity in a single material.
32. ••].
33. Kuntz R.M., Saltzman W.M. Neutrophil motility in extracellular matrix gels: mesh size and adhesion affect speed of migration. Biophys J. 72:1997;1472-1480.
34. Herbert C.B., Bittner G.D., Hubbell J.A. Effects of fibrinolysis on neurite growth from dorsal root ganglia cultured in two- and three-dimensional fibrin gels. J Comp Neurol. 365:1996;380-391.
35. Schense J.C., Hubbell J.A. Cross-linked exogenous bifunctional peptides into fibrin gels with factor XIIIa. Bioconj Chem. 10:1999;75-81. Fibrin is a very important biomaterial, both in natural wound healing and as a therapeutic. It possesses only one set of biological signals, and thus obtains generally only one sort of healing response, namely a scar. The investigators present a simple approach by which to functionalise fibrin with exogenous bioactive peptide signals, by using bi-domain peptides, one peptide containing a substrate site for the coagulation transglutaminase factor XIIIa and the other containing a bioactive peptide of interest. This opens a fascile route to make fibrin clots with customised biological activity.
36. West J.L., Hubbell J.A. Polymeric biomaterials with degradation sites for proteases involved in cell migration. Macromolecules. 32:1999;241-244. This report, although preliminary in nature, provides an example of a totally synthetic biomaterial gel that can be degraded by cell-associated proteases. Given that adhesion ligands can also be incorporated into this material [37], this opens the door for synthetic materials that can be invaded and remodelled by cells in a healing response, in complete analogy with the way tissues are naturally remodelled.
37. Hern D.L., Hubbell J.A. Incorporation of adhesion peptides into nonadhesive hydrogels useful for tissue resurfacing. J Biomed Mater Res. 39:1998;266-276.
38. Hubbell J.A. In situ material transformations in tissue engineering. Mat Res Soc Bull. 21:1996;33-35.
39. Desai N.P., Hubbell J.A. Surface physical interpenetrating networks of poly(ethylene terephthalate) and poly(ethylene oxide) with biomedical applications. Macromolecules. 25:1992;226-232.
40. West J.L., Hubbell J.A. Separation of the arterial wall from blood contact using hydrogel barriers reduces intimal thickening after balloon injury in the rat: the roles of medial and luminal factors in arterial healing. Proc Natl Acad Sci USA. 93:1996;13188-13193.
41. Chowdhury S.M., Hubbell J.A. Adhesion prevention with ancrod released via a tissue-adherent hydrogel. J Surg Res. 61:1996;58-64.
42. Andreopoulos F.M., Deible C.R., Stauffer M.T., Weber S.G., Wagner W.R., Beckman E.J., Russell A.J. Photoscissable hydrogel synthesis via rapid photopolymerization of novel PEG-based polymers in the absence of photoinitiators. J Am Chem Soc. 118:1996;6235-6240.
43. Andreopoulos F.M., Beckman E.J., Russell A.J. Light-induced tailoring of PEG-hydrogel properties. Biomaterials. 19:1998;1343-1352.
44. Zhao X., Harris J.M. Novel degradable poly(ethylene glycol) hydrogels for controlled release of protein. J Pharm Sci. 87:1998;1450-1458.
45. Chen G., Hoffman A.S. Graft copolymers that exhibit temperature-induced phase transitions over a wide range of pH. Nature. 373:1995;49-52.
46. Jeong B., Bae Y.H., Lee D.S., Kim S.W. Biodegradable block copolymers as injectable drug-delivery systems. Nature. 388:1997;860-862.
47. von Recum H., Kikuchi A., Okuhara M., Sakurai Y., Okano T., Kim S.W. Retinal pigmented epithelium cultures on thermally responsive polymer porous substrates. J Biomater Sci Polym Ed. 9:1998;1241-1253.
48. Stayton P.S., Shimoboji T., Long C., Chilkoti A., Chen G., Harris J.M., Hoffman A.S. Control of protein-ligand recognition using a stimuli-responsive polymer. Nature. 378:1995;472-474.
49. Lu Z.R., Kopeckova P., Wu Z., Kopecek J. Functionalized semitelechelic poly[N-(2-hydroxypropyl)methacrylamide] for protein modification. Bioconjug Chem. 9:1998;793-804.
50. Cappello J., Crissman J.W., Crissman M., Ferrari F.A., Textor G., Wallis O., Whitledge J.R., Zhou X., Burman D., Aukerman L., Stedronsky E.R. In-situ self-assembling protein polymer gel systems for administration, delivery, and release of drugs. J Controlled Release. 53:1998;105-117.
51. Petka W.A., Harden J.L., McGrath K.P., Wirtz D., Tirrell D.A. Reversible hydrogels from self-assembling artificial proteins. Science. 28:1998;389-392.
52. Leon E.J., Verma N., Zhang S., Lauffenburger D.A., Kamm R.D. Mechanical properties of a self-assembling oligopeptide matrix. J Biomater Sci Polym Ed. 9:1998;297-312.
53. Elbert D.L., Hubbell J.A. Self-assembly and steric stabilization at heterogeneous, biological surfaces using adsorbing block copolymers. Chem Biol. 5:1998;177-183. Most drugs operate by highly specific biological recognition. In this case, a soluble bioactive polymer was developed that recognised its target with relatively low specificity, via binding of a poly(cation) to net negatively charged cell surfaces. Grafted poly(nonion) chains then sterically repelled high affinity biological interactions, providing an example of drug-like bioactivity via physicochemical mechanisms.
54. Elbert D.L., Hubbell J.A. Reduction of fibrous adhesion formation by a copolymer possessing an affinity for anionic surfaces. J Biomed Mater Res. 42:1998;55-65.
55. Deible C.R., Beckman E.J., Russell A.J., Wagner W.R. Creating molecular barriers to acute platelet deposition on damaged arteries with reactive polyethylene glycol. J Biomed Mater Res. 41:1998;251-256.