Region-specific diet-induced and leptin-induced cellular leptin resistance includes the ventral tegmental area in rats

Neuropharmacology

Volumn 60, Issue 2-3, 2011, Pages 480-487

  Matheny, M ^a   Shapiro, A ^a   Tumer N ^a,b   Scarpace, P J ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Gene therapy; High fat feeding; Leptin resistance; Voluntary wheel running

Indexed keywords

ADENOVIRUS VECTOR; LEPTIN; RECOMBINANT LEPTIN; STAT3 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DORSOMEDIAL HYPOTHALAMIC NUCLEUS; FOOD INTAKE; GENE OVEREXPRESSION; HORMONE RESISTANCE; HYPOTHALAMUS; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; LIPID DIET; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; VENTRAL TEGMENTUM; WEIGHT REDUCTION;

ANIMALS; ARCUATE NUCLEUS; CELL MEMBRANE; DIETARY FATS; DRUG RESISTANCE; EATING; INFUSIONS, INTRAVENTRICULAR; LEPTIN; MALE; MOTOR ACTIVITY; RATS; RATS, INBRED BN; RATS, INBRED F344; STAT3 TRANSCRIPTION FACTOR; VENTRAL TEGMENTAL AREA;

EID: 78650818014     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2010.11.002     Document Type: Article

References (32)

1. R.S. Ahima, and J.S. Flier Leptin Annu. Rev. Physiol. 62 2000 413 437
2. B.A. da Silva, C. Bjorbaek, S. Uotani, and J.S. Flier Functional properties of leptin receptor isoforms containing the gln->pro extracellular domain mutation of the fatty rat Endocrinology 139 1998 3681 3690
3. H. Dhillon, S.P. Kalra, V. Prima, S. Zolotukhin, P.J. Scarpace, L.L. Moldawer, N. Muzyczka, and P.S. Kalra Central leptin gene therapy suppresses body weight gain, adiposity and serum insulin without affecting food consumption in normal rats: a long-term study Regul. Pept. 99 2001 69 77
4. K. El-Haschimi, D.D. Pierroz, S.M. Hileman, C. Bjorbaek, and J.S. Flier Two defects contribute to hypothalamic leptin resistance in mice with diet-induced obesity J. Clin. Invest. 105 2000 1827 1832
5. R.C. Frederich, B. Lollmann, A. Hamann, A. Napolitano-Rosen, B.B. Kahn, B.B. Lowell, and J.S. Flier Expression of ob mRNA and its encoded protein in rodents. Impact of nutrition and obesity J. Clin. Invest. 96 1995 1658 1663
6. S. Fulton, B. Woodside, and P. Shizgal Modulation of brain reward circuitry by leptin Science 287 2000 125 128
7. J.L. Halaas, C. Boozer, J. Blair-West, N. Fidahusein, D.A. Denton, and J.M. Friedman Physiological response to long-term peripheral and central leptin infusion in lean and obese mice Proc. Natl. Acad. Sci. U.S.A. 94 1997 8878 8883
8. J.D. Hommel, R. Trinko, R.M. Sears, D. Georgescu, Z.W. Liu, X.B. Gao, J.J. Thurmon, M. Marinelli, and R.J. DiLeone Leptin receptor signaling in midbrain dopamine neurons regulates feeding Neuron 51 2006 801 810
9. M.K. Judge, J. Zhang, N. Tumer, C. Carter, M.J. Daniels, and P.J. Scarpace Prolonged hyperphagia with high-fat feeding contributes to exacerbated weight gain in rats with adult-onset obesity Am. J. Physiol. Regul. Integr. Comp. Physiol. 295 2008 R773 R780
10. S.R. Ladyman, and D.R. Grattan Region-specific reduction in leptin-induced phosphorylation of signal transducer and activator of transcription-3 (STAT3) in the rat hypothalamus is associated with leptin resistance during pregnancy Endocrinology 145 2004 3704 3711
11. B.E. Levin, and A.A. Dunn-Meynell Reduced central leptin sensitivity in rats with diet-induced obesity Am. J. Physiol. Regul. Integr. Comp. Physiol. 283 2002 R941 R948
12. T.L. Martin, T. Alquier, K. Asakura, N. Furukawa, F. Preitner, and B.B. Kahn Diet-induced obesity alters AMP kinase activity in hypothalamus and skeletal muscle J. Biol. Chem. 281 2006 18933 18941
13. M. Matheny, Y. Zhang, A. Shapiro, N. Tumer, and P.J. Scarpace Central overexpression of leptin antagonist reduces wheel running and underscores importance of endogenous leptin receptor activity in energy homeostasis Am. J. Physiol. Regul. Integr. Comp. Physiol. 297 2009 R1254 R1261
14. A.S. Metlakunta, M. Sahu, and A. Sahu Hypothalamic phosphatidylinositol 3-kinase pathway of leptin signaling is impaired during the development of diet-induced obesity in FVB/N mice Endocrinology 149 2008 1121 1128
15. C.D. Morrison, G.J. Morton, K.D. Niswender, R.W. Gelling, and M.W. Schwartz Leptin inhibits hypothalamic Npy and Agrp gene expression via a mechanism that requires phosphatidylinositol 3-OH-kinase signaling Am. J. Physiol. Endocrinol. Metab. 289 2005 E1051 E1057
16. G.J. Morton, J.E. Blevins, F. Kim, M. Matsen, and D.P. Figlewicz The action of leptin in the ventral tegmental area to decrease food intake is dependent on Jak-2 signaling Am. J. Physiol. Endocrinol. Metab. 297 2009 E202 E210
17. H. Munzberg, J.S. Flier, and C. Bjorbaek Region-specific leptin resistance within the hypothalamus of diet-induced obese mice Endocrinology 145 2004 4880 4889
18. M.G. Myers, M.A. Cowley, and H. Munzberg Mechanisms of leptin action and leptin resistance Annu. Rev. Physiol. 70 2008 537 556
19. J. Proietto, and A.W. Thorburn The therapeutic potential of leptin Expert. Opin. Investig. Drugs 12 2003 373 378
20. A. Sahu, and A.S. Metlakunta Hypothalamic phosphatidylinositol 3-kinase-phosphodiesterase 3B-cyclic AMP pathway of leptin signalling is impaired following chronic central leptin infusion J. Neuroendocrinol. 17 2005 720 726
21. P.J. Scarpace, M. Matheny, and N. Tumer Hypothalamic leptin resistance is associated with impaired leptin signal transduction in aged obese rats Neuroscience 104 2001 1111 1117
22. P.J. Scarpace, M. Matheny, N. Tumer, K.Y. Cheng, and Y. Zhang Leptin resistance exacerbates diet-induced obesity and is associated with diminished maximal leptin signalling capacity in rats Diabetologia 48 2005 1075 1083
23. P.J. Scarpace, M. Matheny, and Y. Zhang Wheel running eliminates high-fat preference and enhances leptin signaling in the ventral tegmental area Physiol. Behav. 100 2010 173 179
24. P.J. Scarpace, M. Matheny, Y. Zhang, K.Y. Cheng, and N. Tumer Leptin antagonist reveals an uncoupling between leptin receptor signal transducer and activator of transcription 3 signaling and metabolic responses with central leptin resistance J. Pharmacol. Exp. Ther. 320 2007 706 712
25. P.J. Scarpace, M. Matheny, Y. Zhang, E.W. Shek, V. Prima, S. Zolotukhin, and N. Tumer Leptin-induced leptin resistance reveals separate roles for the anorexic and thermogenic responses in weight maintenance Endocrinology 143 2002 3026 3035
26. P.J. Scarpace, M. Matheny, Y. Zhang, N. Tumer, C.D. Frase, E.W. Shek, B. Hong, V. Prima, and S. Zolotukhin Central leptin gene delivery evokes persistent leptin signal transduction in young and aged-obese rats but physiological responses become attenuated over time in aged-obese rats Neuropharmacology 42 2002 548 561
27. P.J. Scarpace, and Y. Zhang Leptin resistance: a prediposing factor for diet-induced obesity Am. J. Physiol. Regul. Integr. Comp. Physiol. 296 2009 R493 R500
28. F.C. Tinsley, G.Z. Taicher, and M.L. Heiman Evaluation of a quantitative magnetic resonance method for mouse whole body composition analysis Obes. Res. 12 2004 150 160
29. E.C. Villanueva, and M.G. Myers Jr. Leptin receptor signaling and the regulation of mammalian physiology Int. J. Obes. (Lond) 32 Suppl 7 2008 S8 12
30. P.S. Widdowson, R. Upton, R. Buckingham, J. Arch, and G. Williams Inhibition of food response to intracerebroventricular injection of leptin is attenuated in rats with diet-induced obesity Diabetes 46 1997 1782 1785
31. J. Wilsey, and P.J. Scarpace Caloric restriction reverses the deficits in leptin receptor protein and leptin signaling capacity associated with diet-induced obesity: role of leptin in the regulation of hypothalamic long-form leptin receptor expression J. Endocrinol. 181 2004 297 306
32. J. Zhang, M.K. Matheny, N. Tumer, M.K. Mitchell, and P.J. Scarpace Leptin antagonist reveals that the normalization of caloric intake and the thermic effect of food after high-fat feeding are leptin dependent Am. J. Physiol. Regul. Integr. Comp. Physiol. 292 2007 R868 R874