Central overexpression of leptin antagonist reduces wheel running and underscores importance of endogenous leptin receptor activity in energy homeostasis

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 297, Issue 5, 2009, Pages

  Matheny, Michael ^a   Zhang, Yi ^a,b   Shapiro, Alexandra ^a   Tümer, Nihal ^a,b   Scarpace, Philip J ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Gene therapy; High fat feeding; Leptin resistance; Voluntary wheel running

Indexed keywords

LEPTIN ANTAGONIST; LEPTIN RECEPTOR; MESSENGER RNA; MUTANT PROTEIN; PARVOVIRUS VECTOR; RECEPTOR BLOCKING AGENT; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; BROWN NORWAY RAT; CONTROLLED STUDY; ENERGY BALANCE; FAT INTAKE; FOOD INTAKE; GENE TARGETING; HYPOTHALAMUS; MALE; NONHUMAN; OBESITY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; RECEPTOR BLOCKING; TREADMILL; VIRAL GENE DELIVERY SYSTEM; VIRUS RECOMBINANT; WEIGHT GAIN;

ADENOVIRIDAE; ADIPOSITY; ANIMALS; BODY WEIGHT; EATING; ENERGY METABOLISM; HOMEOSTASIS; HYPOTHALAMUS; ION CHANNELS; LEPTIN; MALE; MITOCHONDRIAL PROTEINS; MODELS, ANIMAL; OBESITY; PHYSICAL CONDITIONING, ANIMAL; RATS; RATS, INBRED BN; RATS, INBRED F344; RECEPTORS, LEPTIN; RNA, MESSENGER; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 70449646769     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.90449.2008     Document Type: Article

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