Design, synthesis, and testing of an 6-O-linked series of benzimidazole based inhibitors of CDK5/p25

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 1, 2011, Pages 359-373

  Jain, Prashi ^a   Flaherty, Patrick T ^a   Yi, Shuyan ^a   Chopra, Ishveen ^a   Bleasdell, Gwenyth ^a   Lipay, Josh ^a   Ferandin, Yoan ^b   Meijer, Laurent ^b   Madura, Jeffry D ^a  

^a DUQUESNE UNIVERSITY   (United States)

^b STATION BIOLOGIQUE   (France)

Author keywords

1 Isopropyl benzimidazole; Benzimidazole; CDK5; Cyclin dependent kinase

Indexed keywords

1 ISOPROPYL 4 NITRO 6 HYDROXYBENZIMIDAZOLE; 2 (4 (BENZYLAMINO) 1 ISOPROPYL 1H BENZO[D]IMIDAZOL 6 YL; 2 (4 (BENZYLAMINO) 1 ISOPROPYL 1H BENZO[D]IMIDAZOL 6 YL OXY)ETHANOL; 2 (4 (BENZYLAMINO) 1 ISOPROPYL 1H BENZO[D]IMIDAZOL 6 YL OXY)ETHANOL HYDROCHLORID; BENZIMIDAZOLE DERIVATIVE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 5; N BENZYL 1 ISOPROPYL 6 ((1 METHYLPIPERIDIN 4 YL)METHOXY) 1H BENZO[D]IMIDAZOL 4 AMINE HYDROCHLORIDE; N BENZYL 1 ISOPROPYL 6 (1 METHOXYBUTAN 2 YLOXY) 1H BENZO[D]IMIDAZOL 4 AMINE HYDROCHLORIDE; N BENZYL 1 ISOPROPYL 6 (2 METHOXYETHOXY) 1H BENZO[D]IMIDAZOL 4 AMINE OXALATE; N BENZYL 1 ISOPROPYL 6 (PIPERIDIN 4 YLMETHOXY) 1H BENZO[D]IMIDAZOL 4 AMINE DIHYDROCHLORIDE; N BENZYL 1 ISOPROPYL 6 PROPOXY 1H BENZO[D]IMIDAZOL 4 AMINE; N BENZYL 6 (1 (DIMETHYLAMINO)BUTAN 2 YLOXY) 1 ISOPROPHYL 1H BENZO[D]IMIDAZOL 4 AMINE HYDROCHLORIDE; N BENZYL 6 BUTOXY 1 ISOPROPYL 1H BENZO[D]IMIDAZOL 4 AMINE; N BENZYL 6 ETHOXY 1 ISOPROPYL 1H BENZO[D]IMIDAZOL 4 AMINE; PROTEIN P25; ROSCOVITINE; UNCLASSIFIED DRUG;

ARTICLE; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION;

BENZIMIDAZOLES; CYCLIN-DEPENDENT KINASE 5; DRUG DESIGN; MODELS, MOLECULAR; PROTEIN KINASE INHIBITORS;

EID: 78650730994     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.11.022     Document Type: Article

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