Synthesis, anti-inflammatory, analgesic and kinase (CDK-1, CDK-5 and GSK-3) inhibition activity evaluation of benzimidazole/benzoxazole derivatives and some Schiff's bases

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 11, 2006, Pages 3758-3765

  Sondhi, Sham M ^a   Singh, Nirupma ^a   Kumar, Ashok ^b   Lozach, Olivier ^c   Meijer, Laurent ^c  

^a INDIAN INSTITUTE OF TECHNOLOGY ROORKEE   (India)

^b LLRM MEDICAL COLLEGE   (India)

^c STATION BIOLOGIQUE   (France)

Author keywords

Analgesic; Anti inflammatory; Benzimidazole derivatives; Benzoxazole derivatives; CDK 1; CDK 5 and GSK 3; Schiff's bases

Indexed keywords

1 [(2 AMINO 4(5) CHLOROPHENYLIMINO)METHYL]NAPHTHALEN 2 OL; 2 NAPHTHOL; 4,4' BIS[1 (2 AMINOPHENYLIMINO)METHYL]NAPHTHALEN 2 OL; BENZIMIDAZOLE; BENZOXAZOLE DERIVATIVE; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE 5; DIAMINE; IMIDAZOLE DERIVATIVE; SCHIFF BASE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; IC 50; IN VITRO STUDY; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; MOUSE; NONHUMAN; POLYMERIZATION; PROTON NUCLEAR MAGNETIC RESONANCE;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BENZIMIDAZOLES; BENZOXAZOLES; CDC2 PROTEIN KINASE; CYCLIN-DEPENDENT KINASE 5; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATION; FEMALE; GLYCOGEN SYNTHASE KINASE 3; MICE; PROTEIN KINASES; RATS; RATS, WISTAR; SCHIFF BASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33646481830     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.01.054     Document Type: Article

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