Advances in the structural study and molecular comprehension of the transcription mechanism of influenza virus;Avancées dans l'étude structurale et la compréhension moléculaire du mécanisme de transcription du virus de la grippe

Virologie

Volumn 14, Issue 6, 2010, Pages 435-445

  Chenavas, Sylvie ^a   Guilligay, Delphine ^a   Cusack, Stephen ^a   Hart, Darren J ^a   Ruigrok, Rob W H ^a   Crépin, Thibaut ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (France)

Author keywords

Cap; Flu; Replication; RNA polymerase; Structure; Transcription

Indexed keywords

CAP BINDING PROTEIN; ENDONUCLEASE; MESSENGER RNA; RIBONUCLEOPROTEIN; RNA POLYMERASE; VIRUS RNA;

CRYOELECTRON MICROSCOPY; CRYSTAL STRUCTURE; INFLUENZA VIRUS; NONHUMAN; REVIEW; RNA REPLICATION; RNA TRANSCRIPTION;

ORTHOMYXOVIRIDAE;

EID: 78650729609     PISSN: 12678694     EISSN: 19506961     Source Type: Journal    
DOI: 10.1684/vir.2010.0328     Document Type: Review

References (60)

1. Ruigrok RW, Crepin T, Hart DJ, Cusack S. Towards an atomic resolution understanding of the influenza virus replication machinery. Curr Opin Struct Biol 2010 ; 20 : 104-13.
2. Elton D, Digard P, Tiley L, Ortin J. Structure and function of the influenza virus RNP. In: Kawaoka Y., ed. Current topics in influenza virology. Caister Academic Press, 2006.
3. Noah DL, Krug RM. Influenza virus virulence and its molecular determinants. Adv Virus Res 2005 ; 65 : 121-45.
4. Gabriel G, Dauber B, Wolff T, Planz O, Klenk HD, Stech J. The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host. Proc Natl Acad Sci U S A 2005 ; 102 : 18590-5.
5. Naffakh N, Tomoiu A, Rameix-Welti MA, van der Werf S. Host restriction of avian influenza viruses at the level of the ribonucleoproteins. Annu Rev Microbiol 2008 ; 62 : 403-4.
6. Gong J, Fang H, Li M, Liu Y, Yang K, Xu W. Potential targets and their relevant inhibitors in anti-influenza fields. Curr Med Chem 2009 ; 16 : 3716-39.
7. Krug RM, Aramini JM. Emerging antiviral targets for influenza Avirus. Trends Pharmacol Sci 2009 ; 30 : 269-77.
8. Jorba N, Coloma R, Ortin J. Genetic trans-complementation establishes a new model for influenza virus RNA transcription and replication. PLoS Pathog 2009 ; 5 : e1000462.
9. Plotch SJ, Bouloy M, Ulmanen I, Krug RM. A unique cap(m7GpppXm)-dependent influenza virion endonuclease cleaves capped RNAs to generate the primers that initiate viral RNA transcription. Cell 1981 ; 23 : 847-58.
10. Jin H, Elliott RM. Non-viral sequences at the 5′ ends of Dugbe nairovirus S mRNAs. J Gen Virol 1993 ; 74 (Pt 10) : 2293-7.
11. Poch O, Sauvaget I, Delarue M, Tordo N. Identification of four conserved motifs among the RNA-dependent polymerase encoding elements. Embo J 1989 ; 8 : 3867-74.
12. Biswas SK, Nayak DP. Mutational analysis of the conserved motifs of influenza Avirus polymerase basic protein 1. J Virol 1994 ; 68 : 1819-26.
13. Li ML, Rao P, Krug RM. The active sites of the influenza cap-dependent endonuclease are on different polymerase subunits. Embo J 2001 ; 20 : 2078-86.
14. Guilligay D, Tarendeau F, Resa-Infante P, et al. The structural basis for cap binding by influenza virus polymerase subunit PB2. Nat Struct Mol Biol 2008 ; 15 : 500-6.
15. Dias A, Bouvier D, Crepin T, et al. The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit. Nature 2009 ; 458 : 914-8.
16. Yuan P, Bartlam M, Lou Z, et al. Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site. Nature 2009 ; 458 : 909-13.
17. Dias A, Bouvier D, Cusack S, Ruigrok RW, Crepin T. New strategy for targeting influenza virus replication. Med Sci (Paris) 2009 ; 25 : 352-4.
18. Klumpp K, Ruigrok RW, Baudin F. Roles of the influenza virus polymerase and nucleoprotein in forming a functional RNP structure. Embo J 1997 ; 16 : 1248-57.
19. Martin-Benito J, Area E, Ortega J, et al. Three-dimensional reconstruction of a recombinant influenza virus ribonucleoprotein particle. EMBO Rep 2001 ; 2 : 313-7.
20. Area E, Martin-Benito J, Gastaminza P, et al. 3D structure of the influenza virus polymerase complex: localization of subunit domains. Proc Natl Acad Sci U S A 2004 ; 101 : 308-13.
21. Coloma R, Valpuesta JM, Arranz R, Carrascosa JL, Ortin J, Martin-Benito J. The structure of a biologically active influenza virus ribonucleoprotein complex. PLoS Pathog 2009 ; 5 : e1000491.
22. Ortega J, Martin-Benito J, Zurcher T, Valpuesta JM, Carrascosa JL, Ortin J. Ultrastructural and functional analyses of recombinant influenza virus ribonucleoproteins suggest dimerization of nucleoprotein during virus amplification. J Virol 2000 ; 74 : 156-63.
23. Newcomb LL, Kuo RL, Ye Q, Jiang Y, Tao YJ, Krug RM. Interaction of the influenza a virus nucleocapsid protein with the viral RNA polymerase potentiates unprimed viral RNA replication. J Virol 2009 ; 83 : 29-36.
24. Torreira E, Schoehn G, Fernandez Y, et al. Three-dimensional model for the isolated recombinant influenza virus polymerase heterotrimer. Nucleic Acids Res 2007 ; 35 : 3774-83.
25. Ye Q, Krug RM, Tao YJ. The mechanism by which influenza Avirus nucleoprotein forms oligomers and binds RNA. Nature 2006 ; 444 : 1078-82.
26. Ng AK, Zhang H, Tan K, et al. Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine design. Faseb J 2008 ; 22 : 3638-47.
27. Albertini AA, Wernimont AK, Muziol T, et al. Crystal structure of the rabies virus nucleoprotein-RNA complex. Science 2006 ; 313 : 360-3.
28. Tawar RG, Duquerroy S, Vonrhein C, et al. Crystal structure of a nucleocapsid-like nucleoprotein-RNA complex of respiratory syncytial virus. Science 2009 ; 326 : 1279-83.
29. Rudolph MG, Kraus I, Dickmanns A, Eickmann M, Garten W, Ficner R. Crystal structure of the borna disease virus nucleoprotein. Structure 2003 ; 11 : 1219-26.
30. Ruigrok RW, Crepin T. Nucleoproteins of negative strand RNA viruses; RNA binding, oligomerisation and binding to polymerase co-factor. Viruses 2010 ; 2 : 27-32.
31. Hara K, Schmidt FI, Crow M, Brownlee GG. Amino acid residues in the N-terminal region of the PA subunit of influenza A virus RNA polymerase play a critical role in protein stability, endonuclease activity, cap binding, and virion RNA promoter binding. J Virol 2006 ; 80 : 7789-98.
32. He X, Zhou J, Bartlam M, et al. Crystal structure of the polymerase PA(C)-PB1(N) complex from an avian influenza H5N1 virus. Nature 2008 ; 454 : 1123-6.
33. Obayashi E, Yoshida H, Kawai F, et al. The structural basis for an essential subunit interaction in influenza virus RNA polymerase. Nature 2008 ; 454 : 1127-31.
34. Ghanem A, Mayer D, Chase G, et al. Peptide-mediated interference with influenza A virus polymerase. J Virol 2007 ; 81 : 7801-4.
35. Wunderlich K, Mayer D, Ranadheera C, et al. Identification of a PA-binding peptide with inhibitory activity against influenza A and B virus replication. PLoS One 2009 ; 4 : e7517.
36. Doan L, Handa B, Roberts NA, Klumpp K. Metal ion catalysis of RNA cleavage by the influenza virus endonuclease. Biochemistry 1999 ; 38 : 5612-9.
37. Crepin T, Dias A, Palencia A, Swale C, Cusack S, Ruigrok RW. Mutational and metal binding analysis of the endonuclease domain of the influenza virus polymerase PA subunit. J Virol 2010 ; 84 : 9096-104.
38. Tomassini J, Selnick H, Davies ME, et al. Inhibition of cap (m7GpppXm)-dependent endonuclease of influenza virus by 4-substituted 2,4-dioxobutanoic acid compounds. Antimicrob Agents Chemother 1994 ; 38 : 2827-37.
39. Tarendeau F, Boudet J, Guilligay D, et al. Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit. Nat Struct Mol Biol 2007 ; 14 : 229-33.
40. Angelini A, Tosi T, Mas P, et al. Expression of Helicobacter pylori CagA domains by library-based construct screening. Febs J 2009 ; 276 : 816-24.
41. Tarendeau F, Crepin T, Guilligay D, Ruigrok RW, Cusack S, Hart DJ. Host determinant residue lysine 627 lies on the surface of a discrete, folded domain of influenza virus polymerase PB2 subunit. PLoS Pathog 2008 ; 4 : e1000136.
42. Marcotrigiano J, Gingras AC, Sonenberg N, Burley SK. Cocrystal structure of the messenger RNA 5′ cap-binding protein (eIF4E) bound to 7-methyl-GDP. Cell 1997 ; 89 : 951-61.
43. Mazza C, Segref A, Mattaj IW, Cusack S. Large-scale induced fit recognition of an m(7)GpppG cap analogue by the human nuclear cap-binding complex. Embo J 2002 ; 21 : 5548-57.
44. Kuzuhara T, Kise D, Yoshida H, et al. Structural basis of the influenza Avirus RNA polymerase PB2 RNA-binding domain containing the pathogenicity- determinant lysine 627 residue. J Biol Chem 2009 ; 284 : 6855-60.
45. Sugiyama K, Obayashi E, Kawaguchi A, et al. Structural insight into the essential PB1-PB2 subunit contact of the influenza virus RNA polymerase. Embo J 2009 ; 28 : 1803-11.
46. Muller R, Poch O, Delarue M, Bishop DH, Bouloy M. Rift Valley fever virus L segment: correction of the sequence and possible functional role of newly identified regions conserved in RNA-dependent polymerases. J Gen Virol 1994 ; 75 (Pt 6) : 1345-52.
47. Ng KK, Arnold JJ, Cameron CE. Structure-function relationships among RNA-dependent RNA polymerases. Curr Top Microbiol Immunol 2008 ; 320 : 137-56.
48. Taubenberger JK, Reid AH, Lourens RM, Wang R, Jin G, Fanning TG. Characterization of the 1918 influenza virus polymerase genes. Nature 2005 ; 437 : 889-93.
49. dos Reis M, Hay AJ, Goldstein RA. Using non-homogeneous models of nucleotide substitution to identify host shift events: application to the origin of the 1918 "Spanish" influenza pandemic virus. J Mol Evol 2009 ; 69 : 333-45.
50. Jorba N, Juarez S, Torreira E, et al. Analysis of the interaction of influenza virus polymerase complex with human cell factors. Proteomics 2008 ; 8 : 2077-88.
51. Watanabe T, Watanabe S, Kawaoka Y. Cellular networks involved in the influenza virus life cycle. Cell Host Microbe 2010 ; 7 : 427-39.
52. Tamuri AU, Dos Reis M, Hay AJ, Goldstein RA. Identifying changes in selective constraints: host shifts in influenza. PLoS Comput Biol 2009 ; 5 : e1000564.
53. Miotto O, Heiny AT, Albrecht R, et al. Complete-proteome mapping of human influenza A adaptive mutations: implications for human transmissibility of zoonotic strains. PLoS One 2010 ; 5 : e9025.
54. Chen GW, Chang SC, Mok CK, et al. Genomic signatures of human versus avian influenza Aviruses. Emerg Infect Dis 2006 ; 12 : 1353-60.
55. Mehle A, Doudna JA. Adaptive strategies of the influenza virus polymerase for replication in humans. Proc Natl Acad Sci U S A 2009 ; 106 : 21312-6.
56. Li Z, Chen H, Jiao P, Deng G, et al. Molecular basis of replication of duck H5N1 influenza viruses in a mammalian mouse model. J Virol 2005 ; 79 : 12058-64.
57. Gabriel G, Herwig A, Klenk HD. Interaction of polymerase subunit PB2 and NP with importin alpha1 is a determinant of host range of influenza A virus. PLoS Pathog 2008 ; 4 : e11.
58. Resa-Infante P, Jorba N, Zamarreno N, Fernandez Y, Juarez S, Ortin J. The host-dependent interaction of alpha-importins with influenza PB2 polymerase subunit is required for virus RNA replication. PLoS One 2008 ; 3 : e3904.
59. Parkes KE, Ermert P, Fassler J, et al. Use of a pharmacophore model to discover a new class of influenza endonuclease inhibitors. J Med Chem 2003 ; 46 : 1153-64.
60. Furuta Y, Takahashi K, Shiraki K, et al. T-705 (favipiravir) and related compounds: Novel broad-spectrum inhibitors of RNA viral infections. Antiviral Res 2009 ; 82 : 95-102.