New strategy for targeting influenza virus replication;Nouvelle stratégie pour cibler la réplication du virus de la grippe

Medecine/Sciences

Volumn 25, Issue 4, 2009, Pages 352-354

  Dias, Alexandre ^a   Bouvier, Denis ^a   Cusack, Stephen ^b   Ruigrok, Rob W H ^a   Crépin, Thibaut ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (France)

^b Antenne de Grenoble   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ORTHOMYXOVIRIDAE;

2,4 DIOXO 4 PHENYLBUTANOIC ACID; 2,4-DIOXO-4-PHENYLBUTANOIC ACID; AMINOBUTYRIC ACID DERIVATIVE; ANTIVIRUS AGENT; CAPPED RNA; INFLUENZA VIRUS POLYMERASE BASIC PROTEIN 1; PA PROTEIN, INFLUENZA VIRUSES; PB2 PROTEIN, INFLUENZA VIRUS; RNA DIRECTED RNA POLYMERASE; VIRUS PROTEIN; VIRUS RNA;

BIOLOGICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG SCREENING; GENETICS; METABOLISM; NOTE; ORTHOMYXOVIRUS; PHYSIOLOGY; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; VIRUS REPLICATION;

AMINOBUTYRIC ACIDS; ANTIVIRAL AGENTS; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; MODELS, BIOLOGICAL; MODELS, MOLECULAR; ORTHOMYXOVIRIDAE; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RNA CAPS; RNA REPLICASE; RNA, VIRAL; VIRAL PROTEINS; VIRUS REPLICATION;

EID: 70349245426     PISSN: 07670974     EISSN: 19585381     Source Type: Journal    
DOI: 10.1051/medsci/2009254352     Document Type: Review

References (9)

1. Rao P, Yuan W, Krug RM. Crucial role of CA cleavage sites in the cap-snatching mechanism for initiating viral mRNA synthesis. EMBO J 2003 ; 22 : 1188-1189.
2. Guilligay D, Tarendeau F, Resa-Infante P, et al. The structural basis for cap binding by influenza virus polymerase subunit PB. Nat Struct Mol Biol 2008 ; 15 : 500-6. (Pubitemid 351653591)
3. Shi L, Summers DF, Peng Q, Galarz JM. Influenza A virus RNA polymerase subunit PB2 is the endonuclease which cleaves host cell mRNA and functions only as the trimeric enzyme. Virology 1995 ; 208 : 38-47.
4. Li ML, Rao P, Krug RM. The active sites of the influenza cap-dependent endonuclease are on different polymerase subunits. EMBO J 2001 ; 20 : 2078-2086. (Pubitemid 32397409)
5. Dias A, Bouvier D, Crépin T, et al. The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit. Nature 2009, 4 février (online).
6. Horton NC, Perona JJ. DNA cleavage by EcoRV endonuclease: two metal ions in three metal ion binding sites. Biochemistry 2004 ; 43 : 6841-6857. (Pubitemid 38720502)
7. Hara K, Schmidt FI, Crow M, Brownlee GG. Amino acid residues in the N-terminal region of the PA subunit of influenza A virus RNA polymerase play a critical role in protein stability, endonuclease activity, cap binding, and virion RNA promoter binding. J Virol 2006 ; 80 : 7789-7798. (Pubitemid 44182280)
8. Doan L, Handa B, Roberts NA, Klumpp K. Metal ion catalysis of RNA cleavage by the influenza virus endonuclease. Biochemistry 1996 ; 38 : 5612-5619.
9. Tomassini J, Selnick H, Davies ME, et al. Inhibition of cap (m7GpppXm)-dependent endonuclease of influenza virus by 4-substituted 2,4-dioxobutanoic acid compounds. Antimicrob Agents Chemother 1994 ; 38 : 2827-2837. (Pubitemid 24374443)