The structure of a biologically active influenza virus ribonucleoprotein complex

PLoS Pathogens

Volumn 5, Issue 6, 2009, Pages

  Coloma, Rocío ^a,b   Valpuesta, José M ^a   Arranz, Rocío ^a   Carrascosa, José L ^a   Ortín, Juan ^a,b   Martín Benito, Jaime ^a,b  

^a CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

MONOMER; RECOMBINANT PROTEIN; RIBONUCLEOPROTEIN; RNA POLYMERASE; VIRUS PROTEIN; VIRUS RNA; RIBONUCLEASE; RNA; RNA, RECOMBINANT;

ARTICLE; CONTROLLED STUDY; INFLUENZA VIRUS; MOLECULAR DOCKING; MUTATIONAL ANALYSIS; NONHUMAN; POLYMERIZATION; PROTEIN DOMAIN; PROTEIN PURIFICATION; PROTEIN RNA BINDING; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; VIRUS REPLICATION; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; CRYOELECTRON MICROSCOPY; GENETICS; INFLUENZA VIRUS A; ISOLATION AND PURIFICATION; METABOLISM; PROTEIN CONFORMATION;

ORTHOMYXOVIRIDAE; RNA VIRUSES;

CRYOELECTRON MICROSCOPY; INFLUENZA A VIRUS; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; PROTEIN CONFORMATION; RIBONUCLEASES; RIBONUCLEOPROTEINS; RNA; RNA, VIRAL; VIRAL PROTEINS;

EID: 67650917906     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1000491     Document Type: Article

References (40)

1. Wright PF, Neumann G, Kawaoka Y (2007) Orthomyxoviridae. In: Knipe DM, Howley PM, eds (2007) Fields Virology 5th edition. Philadelphia: Lippincott Williams & Wilkins. pp 1691-1740.
2. Horimoto T, Kawaoka Y (2005) Influenza: lessons from past pandemics, warnings from current incidents. Nat Rev Microbiol 3: 591-600. (Pubitemid 41052146)
3. Peiris JS, de Jong MD, Guan Y (2007) Avian influenza virus (H5N1): a threat to human health. Clin Microbiol Rev 20: 243-267. (Pubitemid 46709304)
4. Murti KG, Webster RG, Jones IM (1988) Localization of RNA polymerases of influenza viral ribonucleoproteins by immunogold labeling. Virology 164: 562-566.
5. Palese P, Shaw M (2006) Orthomyxoviridae: the viruses and their replication. In: Knipe DM, Howley PM, eds (2006) Fields Virology 5th edition. Philadelphia: Lippincott Williams & Wilkins. pp 1647-1689.
6. Compans RW, Content J, Duesberg PH (1972) Structure of the ribonucleoprotein of influenza virus. J Virol 4: 795-800.
7. Pons MW, Schulze IT, Hirst GK (1969) Isolation and characterization of the ribonucleoprotein of influenza virus. Virology 39: 250-259.
8. Yamanaka K, Ishihama A, Nagata K (1990) Reconstitution of influenza virus RNA-nucleoprotein complexes structurally resembling native viral ribonucleoprotein cores. J Biol Chem 265: 11151-11155. (Pubitemid 20200117)
9. Ruigrok RW, Baudin F (1995) Structure of influenza virus ribonucleoprotein particles. II. Purified RNA-free influenza virus ribonucleoprotein forms structures that are indistinguishable from the intact influenza virus ribonucleoprotein particles. J Gen Virol 76: 1009-1014.
10. González S, Ortín J (1999) Characterization of the influenza virus PB1 protein binding to vRNA: Two separate regions of the protein contribute to the interaction domain. J Virol 73: 631-637.
11. Lee MT, Klumpp K, Digard P, Tiley L (2003) Activation of influenza virus RNA polymerase by the 5′ and 3′ terminal duplex of genomic RNA. Nucleic Acids Res 31: 1624-1632. (Pubitemid 36336563)
12. Tiley LS, Hagen M, Mathews JT, Krystal M (1994) Sequence-specific binding of the influenza virus RNA polymerase to sequences located at the 5′-end of the viral RNAs. J Virol 68: 5108-5116. (Pubitemid 24226579)
13. Klumpp K, Ruigrok RW, Baudin F (1997) Roles of the influenza virus polymerase and nucleoprotein in forming a functional RNP structure. Embo J 16: 1248-1257. (Pubitemid 27136091)
14. Ortega J, Martín-Benito J, Zürcher T, Valpuesta JM, Carrascosa JL, et al. (2000) Ultrastructural and functional analyses of of recombinant influenza virus ribonucleoproteins suggest dimerization of nucleoprotein during virus amplification. J Virol 74: 156-163. (Pubitemid 30002894)
15. Martín-Benito J, Area E, Ortega J, Llorca O, Valpuesta JM, et al. (2001) Three dimensional reconstruction of a recombinant influenza virus ribonucleoprotein particle. EMBO Reports 2: 313-317. (Pubitemid 32401526)
16. Area E, Martín-Benito J, Gastaminza P, Torreira E, Valpuesta JM, et al. (2004) Three-dimensional structure of the influenza virus RNA polymerase: localization of subunit domains. Proc Natl Acad Sci USA 101: 308-313. (Pubitemid 38084246)
17. Frank J, Radermacher M, Penczek P, Zhu J, Li Y, et al. (1996) Spider and web: processing and visualization of images in 3D electron microscopy and related fields. J Struct Biol 116: 190-199. (Pubitemid 26093143)
18. Torreira E, Schoehn G, Fernández Y, Jorba N, Ruigrok RW, et al. (2007) Three-dimensional model for the isolated influenza virus polymerase heterotrimer. Nucleic Acids Res 35: 3774-3783. (Pubitemid 47244670)
19. He X, Zhou J, Bartlam M, Zhang R, Ma J, et al. (2008) Crystal structure of the polymerase PA(C)-PB1(N) complex from an avian influenza H5N1 virus. Nature 454: 1123-1126.
20. Obayashi E, Yoshida H, Kawai F, Shibayama N, Kawaguchi A, et al. (2008) The structural basis for an essential subunit interaction in influenza virus RNA polymerase. Nature 454: 1127-1131.
21. Ye Q, Krug RM, Tao YJ (2006) The mechanism by which influenza A virus nucleoprotein forms oligomers and binds RNA. Nature 444: 1078-1082. (Pubitemid 46018528)
22. Guilligay D, Tarendeau F, Resa-Infante P, Coloma R, Crepin T, et al. (2008) The structural basis for cap-binding by influenza virus polymerase subunit PB2. Nat Struct Mol Biol 15: 500-506. (Pubitemid 351653591)
23. Tarendeau F, Boudet J, Guilligay D, Mas PJ, Bougault CM, et al. (2007) Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit. Nat Struct Mol Biol 14: 229-233. (Pubitemid 46355581)
24. Tarendeau F, Crepin T, Guilligay D, Ruigrok RW, Cusack S, et al. (2008) Host determinant residue lysine 627 lies on the surface of a discrete, folded domain of influenza virus polymerase PB2 subunit. PLoS Pathog 4: e1000136. doi:10.1371/journal.ppat.1000136.
25. Elton D, Medcalf E, Bishop K, Digard P (1999) Oligomerization of the influenza virus nucleoprotein: identification of positive and negative sequence elements. Virology 260: 190-200. (Pubitemid 29391747)
26. Elton D, Medcalf L, Bishop K, Harrison D, Digard P (1999) Identification of amino acid residues of influenza virus nucleoprotein essential for RNA binding. J Virol 73: 7357-7367. (Pubitemid 29383219)
27. Albertini AA, Wernimont AK, Muziol T, Ravelli RB, Clapier CR, et al. (2006) Crystal structure of the rabies virus nucleoprotein-RNA complex. Science 313: 360-363. (Pubitemid 44480962)
28. Green TJ, Zhang X, Wertz GW, Luo M (2006) Structure of the vesicular stomatitis virus nucleoprotein-RNA complex. Science 313: 357-360. (Pubitemid 44480961)
29. Ng AK, Zhang H, Tan K, Li Z, Liu JH, et al. (2008) Structure of the influenza virus A H5N1 nucleoprotein: implications for RNA binding, oligomerization, and vaccine design. Faseb J 22: 3638-3647.
30. Albo C, Valencia A, Portela A (1995) Identification of an RNA binding region within the N-terminal third of the influenza A virus NP polypeptide. J Virol 69: 3799-3806.
31. Perales B, Ortín J (1997) The influenza A virus PB2 polymerase subunit is required for the replication of viral RNA. J Virol 71: 1381-1385. (Pubitemid 27030313)
32. Fuerst TR, Earl PL, Moss B (1987) Use of a hybrid vaccinia virus-T7 RNA polymerase system for expression of target genes. Mol Cell Biol 7: 2538-2544.
33. Bárcena J, Ochoa M, de la Luna S, Melero JA, Nieto A, et al. (1994) Monoclonal antibodies against influenza virus PB2 and NP polypeptides interfere with the initiation step of viral mRNA synthesis in vitro. J Virol 68: 6900-6909. (Pubitemid 24328738)
34. Ochoa M, Bárcena J, de la Luna S, Melero JA, Douglas AR, et al. (1995) Epitope mapping of cross-reactive monoclonal antibodies specific for the influenza A virus PA and PB2 polypeptides. Virus Res 37: 305-315.
35. Jorba N, Juarez S, Torreira E, Gastaminza P, Zamarreño N, et al. (2008) Analysis of the interaction of influenza virus polymerase complex with human cell factors. Proteomics 8: 2077-2088. (Pubitemid 351775787)
36. Mindell JA, Grigorieff N (2003) Accurate determination of local defocus and specimen tilt in electron microscopy. J Struct Biol 142: 334-347.
37. Heymann JB (2001) Bsoft: image and molecular processing in electron microscopy. J Struct Biol 133: 156-169. (Pubitemid 33586152)
38. Chacon P, Wriggers W (2002) Multi-resolution contour-based fitting of macromolecular structures. J Mol Biol 317: 375-384. (Pubitemid 34722177)
39. Sorzano CO, Marabini R, Velazquez-Muriel J, Bilbao-Castro JR, Scheres SH, et al. (2004) XMIPP: a new generation of an open-source image processing package for electron microscopy. J Struct Biol 148: 194-204. (Pubitemid 39346008)
40. Pettersen EF, Goddard TD, Huang CC, Couch GS, Greenblatt DM, et al. (2004) UCSF Chimera - a visualization system for exploratory research and analysis. J Comput Chem 25: 1605-1612.