Kv7 (KCNQ) channel openers induce hypothermia in the mouse

Neuroscience Letters

Volumn 488, Issue 2, 2011, Pages 178-182

  Kristensen, Line V ^a   Sandager Nielsen, Karin ^a   Hansen, Henrik H ^a  

^a NEUROSEARCH A S   (Denmark)

Author keywords

Hypothermia; ICA 27243; KCNQ; Kv7; Retigabine; Thermoregulation

Indexed keywords

10,10 BIS(4 PYRIDINYLMETHYL) 9(10H) ANTHRACENONE; 5 CHLORO 2,4 DIHYDROXYPYRIDINE PLUS OXONATE POTASSIUM PLUS TEGAFUR; FLINDOKALNER; FLUMAZENIL; ICA 27243; ICA 27743; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL KCNQ; POTASSIUM CHANNEL STIMULATING AGENT; RETIGABINE; UNCLASSIFIED DRUG;

ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; GABAERGIC TRANSMISSION; GENE; HYPOTHERMIA; MOUSE; NERVE CONDUCTION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RECTUM TEMPERATURE; THERMOREGULATION;

ANIMALS; ANTHRACENES; ANTICONVULSANTS; BENZAMIDES; BODY TEMPERATURE REGULATION; CARBAMATES; FEMALE; HYPOTHERMIA; INDOLES; KCNQ POTASSIUM CHANNELS; MICE; PHENYLENEDIAMINES; PROTEIN ISOFORMS; PYRIDINES;

EID: 78650709270     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2010.11.024     Document Type: Article

References (32)

1. Blackburn-Munro G., by-Brown W., Mirza N.R., Mikkelsen J.D., Blackburn-Munro R.E. Retigabine: chemical synthesis to clinical application. CNS. Drug Rev. 2005, 11:1-20.
2. Cooper E.C., Harrington E., Jan Y.N., Jan L.Y. M channel KCNQ2 subunits are localized to key sites for control of neuronal network oscillations and synchronization in mouse brain. J. Neurosci. 2001, 21:9529-9540.
3. Dalby-Brown W., Hansen H.H., Korsgaard M.P., Mirza N., Olesen S.P. K(v)7 channels: function, pharmacology and channel modulators. Curr. Top. Med. Chem. 2006, 6:999-1023.
4. Elliot E.E, White J.M. The acute effects of zolpidem compared to diazepam and lorazepam using radiotelemetry. Neuropharmacology 2001, 40:717-721.
5. Geiger J., Weber Y.G., Landwehrmeyer B., Sommer C., Lerche H. Immunohistochemical analysis of KCNQ3 potassium channels in mouse brain. Neurosci. Lett. 2006, 400:101-104.
6. Greenwood I.A., Ohya S. New tricks for old dogs: KCNQ expression and role in smooth muscle. Br. J. Pharmacol. 2009, 156:1196-1203.
7. Gribkoff V.K., Starrett J.E., Dworetzky S.I., Hewawasam P., Boissard C.G., Cook D.A., Frantz S.W., Heman K., Hibbard J.R., Huston K., Johnson G., Krishnan B.S., Kinney G.G., Lombardo L.A., Meanwell N.A., Molinoff P.B., Myers R.A., Moon S.L., Ortiz A., Pajor L., Pieschl R.L., Post-Munson D.J., Signor L.J., Srinivas N., Taber M.T., Thalody G., Trojnacki J.T., Wiener H., Yeleswaram K., Yeola S.W. Targeting acute ischemic stroke with a calcium-sensitive opener of maxi-K potassium channels. Nat. Med. 2001, 7:471-477.
8. Hansen H.H., Andreasen J.T., Weikop P., Mirza N., Scheel-Kruger J., Mikkelsen J.D. The neuronal KCNQ channel opener retigabine inhibits locomotor activity and reduces forebrain excitatory responses to the psychostimulants cocaine, methylphenidate and phencyclidine. Eur. J. Pharmacol. 2007, 570:77-88.
9. Hansen H.H, Ebbesen C., Mathiesen C., Weikop P., Ronn L.C., Waroux O., Scuvee-Moreau J., Seutin V., Mikkelsen J.D. The KCNQ channel opener retigabine inhibits the activity of mesencephalic dopaminergic systems of the rat. J. Pharmacol. Exp. Ther. 2006, 318:1006-1019.
10. Hansen H.H., Waroux O., Seutin V., Jentsch T.J., Aznar S., Mikkelsen J.D. Kv7 channels: interaction with dopaminergic and serotonergic neurotransmission in the CNS. J. Physiol. 2008, 586:1823-1832.
11. Jentsch T.J. Neuronal KCNQ potassium channels: physiology and role in disease. Nat. Rev. Neurosci. 2000, 1:21-30.
12. Joshi S., Sedivy V., Hodyc D., Herget J., Gurney A.M. KCNQ modulators reveal a key role for KCNQ potassium channels in regulating the tone of rat pulmonary artery smooth muscle. J. Pharmacol. Exp. Ther. 2009, 329:368-376.
13. Korsgaard M.P., Hartz B.P., Brown W.D., Ahring P.K., Strobaek D., Mirza N.R. Anxiolytic effects of maxipost (BMS-204352) and retigabine via activation of neuronal Kv7 channels. J. Pharmacol. Exp. Ther. 2005, 314:282-292.
14. Lipton J.M., Clark W.G. Neurotransmitters in temperature control. Annu. Rev. Physiol. 1986, 48:613-623.
15. Mackie A.R., Brueggemann L.I., Henderson K.K., Shiels A.J., Cribbs L.L., Scrogin K.E., Byron K.L. Vascular KCNQ potassium channels as novel targets for the control of mesenteric artery constriction by vasopressin, based on studies in single cells, pressurized arteries, and in vivo measurements of mesenteric vascular resistance. J. Pharmacol. Exp. Ther. 2008, 325:475-483.
16. Morrison S.F, Nakamura K., Madden C.J. Central control of thermogenesis in mammals. Exp. Physiol. 2008, 93:773-797.
17. Olivier B., Zethof T., Pattij T., van Boogaert M., van Oorschot R., Leahy C., Oosting R., Bouwknecht A., Veening J., van der Gugten J., Groenink L. Stress-induced hyperthermia and anxiety: pharmacological validation. Eur. J. Pharmacol. 2003, 463:117-132.
18. Redrobe J.P., Nielsen A.N. Effects of neuronal Kv7 potassium channel activators on hyperactivity in a rodent model of mania. Behav. Brain Res. 2009, 198:481-485.
19. Roeloffs R., Wickenden A.D., Crean C., Werness S., McNaughton-Smith G., Stables J., McNamara J.O., Ghodadra N., Rigdon G.C. In vivo profile of ICA-27243 [N-(6-chloro-pyridin-3-yl)-3 4-difluoro-benzamide], a potent and selective KCNQ2/Q3 (Kv7. 2/Kv7. 3) activator in rodent anticonvulsant models. J. Pharmacol. Exp. Ther. 2008, 326:818-828.
20. Rostock A., Tober C., Rundfeldt C., Bartsch R., Engel J., Polymeropoulos E.E., Kutscher B., Loscher W., Honack D., White H.S., Wolf H.H. D-23129: a new anticonvulsant with a broad spectrum activity in animal models of epileptic seizures. Epilepsy Res. 1996, 23:211-223.
21. Rundfeldt C., Netzer R. Investigations into the mechanism of action of the new anticonvulsant retigabine. Interaction with GABAergic and glutamatergic neurotransmission and with voltage gated ion channels. Arzneimittelforschung 2000, 50:1063-1070.
22. Saganich M.J., Machado E., Rudy B. Differential expression of genes encoding subthreshold-operating voltage-gated K+ channels in brain. J. Neurosci. 2001, 21:4609-4624.
23. Sotty F., Damgaard T., Montezinho L.P., Mork A., Olsen C.K., Bundgaard C., Husum H. Antipsychotic-like effect of retigabine [N-(2-Amino-4-(fluorobenzylamino)-phenyl)carbamic acid ester], a KCNQ potassium channel opener, via modulation of mesolimbic dopaminergic neurotransmission. J. Pharmacol. Exp. Ther. 2009, 328:951-962.
24. Tang A.H., Code R.A., Himes C.S. Antagonism of hypothermia produced by benzodiazepine-related compounds by U-78875 in mice. Eur. J. Pharmacol. 1993, 236:1-5.
25. Vinkers C.H., van Bogaert M.J., Klanker M., Korte S.M., Oosting R., Hanania T., Hopkins S.C., Olivier B., Groenink L. Translational aspects of pharmacological research into anxiety disorders: the stress-induced hyperthermia (SIH) paradigm. Eur. J. Pharmacol. 2008, 585:407-425.
26. Weber Y.G., Geiger J., Kampchen K., Landwehrmeyer B., Sommer C., Lerche H. Immunohistochemical analysis of KCNQ2 potassium channels in adult and developing mouse brain. Brain Res. 2006, 1077:1-6.
27. Wickenden A.D., Krajewski J.L., London B., Wagoner P.K., Wilson W.A., Clark S., Roeloffs R., McNaughton-Smith G., Rigdon G.C. N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator. Mol. Pharmacol. 2008, 73:977-986.
28. Wu Y.J., Boissard C.G., Greco C., Gribkoff V.K., Harden D.G., He H., L'Heureux A., Kang S.H., Kinney G.G., Knox R.J., Natale J., Newton A.E., Lehtinen-Oboma S., Sinz M.W., Sivarao D.V., Starrett J.E., Sun L.Q., Tertyshnikova S., Thompson M.W., Weaver D., Wong H.S., Zhang L., Dworetzky S.I. (S)-N-[1-(3-morpholin-4-ylphenyl)ethyl]-3-phenylacrylamide: an orally bioavailable KCNQ2 opener with significant activity in a cortical spreading depression model of migraine. J. Med. Chem. 2003, 46:3197-3200.
29. Wu Y.J., He H., Sun L.Q., L'Heureux A., Chen J., Dextraze P., Starrett J.E., Boissard C.G., Gribkoff V.K., Natale J., Dworetzky S.I. Synthesis and structure-activity relationship of acrylamides as KCNQ2 potassium channel openers. J. Med. Chem. 2004, 47:2887-2896.
30. Yeung S., Schwake M., Pucovsky V., Greenwood I. Bimodal effects of the Kv7 channel activator retigabine on vascular K+ currents. Br. J. Pharmacol. 2008, 155:62-72.
31. Yeung S.Y., Pucovsky V., Moffatt J.D., Saldanha L., Schwake M., Ohya S., Greenwood I.A. Molecular expression and pharmacological identification of a role for K(v)7 channels in murine vascular reactivity. Br. J. Pharmacol. 2007, 151:758-770.
32. Zhang W., Wang D., Liu X.H., Kosala W.R., Rajapaksha J.S., Fisher T.E. An osmosensitive voltage-gated K+ current in rat supraoptic neurons. Eur. J. Neurosci. 2009, 29:2335-2346.