(S)-N-[1-(3-morpholin-4-ylphenyl)ethyl]-3-phenylacrylamide: An orally bioavailable KCNQ2 opener with significant activity in a cortical spreading depression model of migraine

Journal of Medicinal Chemistry

Volumn 46, Issue 15, 2003, Pages 3197-3200

  Wu, Yong Jin ^a   Boissard, Christopher G ^a   Greco, Corinne ^a   Gribkoff, Valentin K ^a   Harden, David G ^a   He, Huan ^a   L'Heureux, Alexandre ^a   Kang, Shing Hong ^a   Kinney, Gene G ^a   Knox, Ronald J ^a   Natale, Joanne ^a   Newton, Amy E ^a   Lehtinen Oboma, Sanna ^a   Sinz, Michael W ^a   Sivarao, Digavalli V ^a   Starrett Jr , John E ^a   Sun, Li Qiang ^a   Tertyshnikova, Svetlana ^a   Thompson, Mark W ^a   Weaver, David ^a   Wong, Henry S ^a   Zhang, Lei ^a   Dworetzky, Steven I ^a   more..

^a Department of Neuroscience Chemistry ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MORPHOLINE DERIVATIVE; N [1 (3 MORPHOLIN 4 YLPHENYL)ETHYL] 3 PHENYLACRYLAMIDE; POTASSIUM CHANNEL; POTASSIUM CHLORIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG EFFECT; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; MIGRAINE; NONHUMAN; RAT; SPREADING CORTICAL DEPRESSION;

ACRYLAMIDES; ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CELL LINE; CEREBRAL CORTEX; DISEASE MODELS, ANIMAL; DOGS; HUMANS; ION CHANNEL GATING; KCNQ2 POTASSIUM CHANNEL; MIGRAINE DISORDERS; MORPHOLINES; OOCYTES; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

EID: 0038493792     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm034073f     Document Type: Article

References (19)

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