Differential gene expression in mutant mice overexpressing or deficient in the serotonin transporter: A focus on urocortin 1

European Neuropsychopharmacology

Volumn 21, Issue 1, 2011, Pages 33-44

  Fabre, Véronique ^a,b   Massart, Renaud ^a,b   Rachalski, Adeline ^a,b   Jennings, Katie ^c   Brass, Andrew ^d   Sharp, Trevor ^c   Lesch, Klaus Peter ^e   Lanfumey, Laurence ^a,b   Hamon, Michel ^a,b  

^a SORBONNE UNIVERSITÉ   (France)

^b INSERM   (France)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

^e UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Anxiety; Edinger Westphal nucleus; ; Gene expression; ; Serotonin transporter; ; Serotonin; ; Urocortin1;

Indexed keywords

COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PEPTIDE; SEROTONIN TRANSPORTER; TRANSCRIPTOME; UROCORTIN I;

ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; DOWN REGULATION; EDINGER WESTPHAL NUCLEUS; GENE LOCATION; GENE OVEREXPRESSION; MALE; MOUSE; MOUSE MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAPHE NUCLEUS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UNINDEXED SEQUENCE; UPREGULATION;

ANIMALS; ANXIETY; AUTORADIOGRAPHY; BEHAVIOR, ANIMAL; DEPRESSIVE DISORDER; DISEASE MODELS, ANIMAL; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROARRAY ANALYSIS; NERVE TISSUE PROTEINS; RAPHE NUCLEI; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; UROCORTINS;

EID: 78650679618     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2010.10.004     Document Type: Article

References (58)

1. Adamec R., Burton P., Blundell J., Murphy D.L., Holmes A. Vulnerability to mild predator stress in serotonin transporter knockout mice. Behav. Brain Res. 2006, 170:126-140.
2. Arango V., Underwood M.D., Boldrini M., Tamir H., Kassir S.A., Hsiung S., Chen J.J., Mann J.J. Serotonin 1A receptors, serotonin transporter binding and serotonin transporter mRNA expression in the brainstem of depressed suicide victims. Neuropsychopharmacology 2001, 25:892-903.
3. Bale T.L., Contarino A., Smith G.W., Chan R., Gold L.H., Sawchenko P.E., Koob G.F., Vale W.W., Lee K.F. Mice deficient for corticotropin-releasing hormone receptor-2 display anxiety-like behaviour and are hypersensitive to stress. Nat. Genet. 2000, 24:410-414.
4. Bengel D., Murphy D.L., Andrews A.M., Wichems C.H., Feltner D., Heils A., Moessner R., Westphal H., Lesch K.P. Altered brain serotonin homeostasis and locomotor insensitivity to 3, 4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice. Mol. Pharmacol. 1998, 53:649-655.
5. Bittencourt J.C., Vaughan J., Arias C., Rissman R.A., Vale W.W., Sawchenko P.E. Urocortin expression in rat brain: evidence against a pervasive relationship of urocortin-containing projections with targets bearing type 2 CRF receptors. J. Comp. Neurol. 1999, 415:285-312.
6. Blakely R.D., Berson H.E., Fremeau R.T., Caron M.G., Peek M.M., Prince H.K., Bradley C.C. Cloning and expression of a functional serotonin transporter from rat brain. Nature 1991, 354:66-70.
7. Bolstad B.M., Irizarry R.A., Astrand M., Speed T.P. A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 2003, 19:185-193.
8. Caspi A., Sugden K., Moffitt T.E., Taylor A., Craig I.W., Harrington H., McClay J., Mill J., Martin J., Braithwaite A., Poulton R. Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene. Science 2003, 301:386-389.
9. Clements J.R., Beitz A.J., Fletcher T.F., Mullett M.A. Immunocytochemical localization of serotonin in the rat periaqueductal gray: a quantitative light and electron microscopic study. J. Comp. Neurol. 1985, 236:60-70.
10. Dandekar M.P., Singru P.S., Kokare D.M., Subhedar N.K. Cocaine- and amphetamine-regulated transcript peptide plays a role in the manifestation of depression: social isolation and olfactory bulbectomy models reveal unifying principles. Neuropsychopharmacology 2009, 34:1288-1300.
11. Delgado P.L., Charney D.S., Price L.H., Aghajanian G.K., Landis H., Heninger G.R. Serotonin function and the mechanism of antidepressant action. Reversal of antidepressant-induced remission by rapid depletion of plasma tryptophan. Arch. Gen. Psychiatry 1990, 47:411-418.
12. Dunning M.J., Smith M.L., Ritchie M.E., Tavare S. Beadarray: R classes and methods for Illumina bead-based data. Bioinformatics 2007, 23:2183-2184.
13. Fabre V., Beaufour C., Evrard A., Rioux A., Hanoun N., Lesch K.P., Murphy D.L., Lanfumey L., Hamon M., Martres M.P. Altered expression and functions of serotonin 5-HT1A and 5-HT1B receptors in knock-out mice lacking the 5-HT transporter. Eur. J. Neurosci. 2000, 12:2299-2310.
14. Franklin K.B., Paxinos G. The Mouse Brain in Stereotaxic Coordinates 2008, Academic Press, New York. Third ed.
15. Gaszner B., Csernus V., Kozicz T. Urocortinergic neurons respond in a differentiated manner to various acute stressors in the Edinger-Westphal nucleus in the rat. J. Comp. Neurol. 2004, 480:170-179.
16. Greenberg B.D., Tolliver T.J., Huang S.J., Li Q., Bengel D., Murphy D.L. Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. Am. J. Med. Genet. 1999, 88:83-87.
17. Hamon M. Dissection of the Brain (Rat and Mouse) 2006, Newmood & Universiteit Maastricht, www.sciencevision.unimaas.nl.
18. Hariri A.R., Holmes A. Genetics of emotional regulation: the role of the serotonin transporter in neural function. Trends Cogn. Sci. 2006, 10:182-191.
19. Holmes A., Lit Q., Murphy D.L., Gold E., Crawley J.N. Abnormal anxiety-related behavior in serotonin transporter null mutant mice: the influence of genetic background. Genes Brain Behav. 2003, 2:365-380.
20. Horn A.K., Eberhorn A., Hartig W., Ardeleanu P., Messoudi A., Buttner-Ennever J.A. Perioculomotor cell groups in monkey and man defined by their histochemical and functional properties: reappraisal of the Edinger-Westphal nucleus. J. Comp. Neurol. 2008, 507:1317-1335.
21. Jennings K.A., Loder M.K., Sheward W.J., Pei Q., Deacon R.M., Benson M.A., Olverman H.J., Hastie N.D., Harmar A.J., Shen S., Sharp T. Increased expression of the 5-HT transporter confers a low-anxiety phenotype linked to decreased 5-HT transmission. J. Neurosci. 2006, 26:8955-8964.
22. Kitamura Y., Tanaka H., Motoike T., Ishii M., Williams S.C., Yanagisawa M., Sakurai T. Distribution of neuropeptide W immunoreactivity and mRNA in adult rat brain. Brain Res. 2006, 1093:123-134.
23. Korosi A., Schotanus S., Olivier B., Roubos E.W., Kozicz T. Chronic ether stress-induced response of urocortin 1 neurons in the Edinger-Westphal nucleus in the mouse. Brain Res. 2005, 1046:172-179.
24. Kozicz T. Neurons colocalizing urocortin and cocaine and amphetamine-regulated transcript immunoreactivities are induced by acute lipopolysaccharide stress in the Edinger-Westphal nucleus in the rat. Neuroscience 2003, 116:315-320.
25. Kozicz T. On the role of urocortin 1 in the non-preganglionic Edinger-Westphal nucleus in stress adaptation. Gen. Comp. Endocrinol. 2007, 153:235-240.
26. Kozicz T., Yanaihara H., Arimura A. Distribution of urocortin-like immunoreactivity in the central nervous system of the rat. J. Comp. Neurol. 1998, 391:1-10.
27. Kozicz T., Li M., Areviura A. The activation of urocortin immunoreactive neurons in the Edinger-Westphal nucleus following acute pain stress in rats. Stress 2001, 4:85-90.
28. Kozicz T., Bordewin L.A., Czéh B., Fuchs E., Roubos E.W. Chronic psychosocial stress affects corticotropin-releasing factor in the paraventricular nucleus and central extended amygdala as well as urocortin 1 in the non-preganglionic Edinger-Westphal nucleus of the tree shrew. Psychoneuroendocrinology 2008, 33:741-754.
29. Kozicz T., Tilburg-Ouwens D., Faludi G., Palkovits M., Roubos E. Gender-related urocortin 1 and brain-derived neurotrophic factor expression in the adult human midbrain of suicide victims with major depression. Neuroscience 2008, 152:1015-1023.
30. Lee H.J., Lee M.S., Kang R.H., Kim H., Kim S.D., Kee B.S., Kim Y.H., Kim Y.K., Kim J.B., Yeon B.K., Oh K.S., Oh B.H., Yoon J.S., Lee C., Jung H.Y., Chee I.S., Paik I.H. Influence of the serotonin transporter promoter gene polymorphism on susceptibility to posttraumatic stress disorder. Depress. Anxiety 2005, 21:135-139.
31. Lesch K.P., Bengel D., Heils A., Sabol S.Z., Greenberg B.D., Petri S., Benjamin J., Muller C.R., Hamer D.H., Murphy D.L. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996, 274:1527-1531.
32. Linden A.M., Greene S.J., Bergeron M., Schoepp D.D. Anxiolytic activity of the MGLU2/3 receptor agonist LY354740 on the elevated plus maze is associated with the suppression of stress-induced c-Fos in the hippocampus and increases in c-Fos induction in several other stress-sensitive brain regions. Neuropsychopharmacology 2004, 29:502-513.
33. 123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane and single photon emission computed tomography. Biol. Psychiatry 1998, 44:1090-1098.
34. Mathews T.A., Fedele D.E., Coppelli F.M., Avila A.M., Murphy D.L., Andrews A.M. Gene dose-dependent alterations in extraneuronal serotonin but not dopamine in mice with reduced serotonin transporter expression. J. Neurosci. Meth. 2004, 140:169-181.
35. Miraglia del Giudice E., Santoro N., Fiumani P., Dominguez G., Kuhar M.J., Perrone L. Adolescents carrying a missense mutation in the CART gene exhibit increased anxiety and depression. Depress. Anxiety 2006, 23:90-92.
36. Murphy D.L., Lesch K.P. Targeting the murine serotonin transporter: insights into human neurobiology. Nat. Rev. Neurosci. 2008, 9:85-96.
37. Nemeroff C.B., Owens M.J. Treatment of mood disorders. Nat. Neurosci. 2002, 5(Suppl):1068-1070.
38. Neufeld-Cohen A., Evans A.K., Getselter D., Spyroglou A., Hill A., Gil S., Tsoory M., Beuschlein F., Lowry C.A., Vale W., Chen A. Urocortin-1 and -2 double-deficient mice show robust anxiolytic phenotype and modified serotonergic activity in anxiety circuits. Mol. Psychiatry 2009, 15:426-441.
39. Okere B., Xu L., Roubos E.W., Sonetti D., Kozicz T. Restraint stress alters the secretory activity of neurons co-expressing urocortin-1, cocaine- and amphetamine-regulated transcript peptide and nesfatin-1 in the mouse Edinger-Westphal nucleus. Brain Res. 2010, 1317:92-99.
40. Oquendo M.A., Hastings R.S., Huang Y.Y., Simpson N., Ogden R.T., Hu X.Z., Goldman D., Arango V., Van Heertum R.L., Mann J.J., Parsey R.V. Brain serotonin transporter binding in depressed patients with bipolar disorder using positron emission tomography. Arch. Gen. Psychiatry 2007, 64:201-208.
41. Pringle A., Jennings K.A., Line S., Bannerman D.M., Higgs S., Sharp T. Mice overexpressing the 5-hydroxytryptamine transporter show no alterations in feeding behaviour and increased non-feeding responses to fenfluramine. Psychopharmacology (Berl) 2008, 200:291-300.
42. Rattray M., Liu X., Sanguinetti G., Milo M., Lawrence N.D. Propagating uncertainty in microarray data analysis. Brief. Bioinform. 2006, 7:37-47.
43. Ravary A., Muzerelle A., Darmon M., Murphy D.L., Moessner R., Lesch K.P., Gaspar P. Abnormal trafficking and subcellular localization of an N-terminally truncated serotonin transporter protein. Eur. J. Neurosci. 2001, 13:1349-1362.
44. Risch N., Herrell R., Lehner T., Liang K.Y., Eaves L., Hoh J., Griem A., Kovacs M., Ott J., Merikangas K.R. Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. Jama 2009, 301:2462-2471.
45. Rogge G., Jones D., Hubert G.W., Lin Y., Kuhar M.J. CART peptides: regulators of body weight, reward and other functions. Nat. Rev. Neurosci. 2008, 9:747-758.
46. Schinka J.A., Busch R.M., Robichaux-Keene N. A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety. Mol. Psychiatry 2004, 9:197-202.
47. Schmittgen T.D., Livak K.J. Analyzing real-time PCR data by the comparative C(T) method. Nat. Protoc. 2008, 3:1101-1108.
48. Sen S., Burmeister M., Ghosh D. Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2004, 127B:85-89.
49. Skelton K.H., Nemeroff C.B., Knight D.L., Owens M.J. Chronic administration of the triazolobenzodiazepine alprazolam produces opposite effects on corticotropin-releasing factor and urocortin neuronal systems. J. Neurosci. 2000, 20:1240-1248.
50. Stanek L.M. Cocaine- and amphetamine related transcript (CART) and anxiety. Peptides 2006, 27:2005-2011.
51. Tjurmina O.A., Armando I., Saavedra J.M., Goldstein D.S., Murphy D.L. Exaggerated adrenomedullary response to immobilization in mice with targeted disruption of the serotonin transporter gene. Endocrinology 2002, 143:4520-4526.
52. Uher R., McGuffin P. The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis. Mol. Psychiatry 2008, 13:131-146.
53. Vaughan J., Donaldson C., Bittencourt J., Perrin M.H., Lewis K., Sutton S., Chan R., Turnbull A.V., Lovejoy D., Rivier C., Rivier J., Sawchenko P.E., Vale W. Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor. Nature 1995, 378:287-292.
54. Vetter D.E., Li C., Zhao L., Contarino A., Liberman M.C., Smith G.W., Marchuk Y., Koob G.F., Heinemann S.F., Vale W., Lee K.F. Urocortin-deficient mice show hearing impairment and increased anxiety-like behavior. Nat. Genet. 2002, 31:363-369.
55. Weitemier A.Z., Tsivkovskaia N.O., Ryabinin A.E. Urocortin 1 distribution in mouse brain is strain-dependent. Neuroscience 2005, 132:729-740.
56. Wellman C.L., Izquierdo A., Garrett J.E., Martin K.P., Carroll J., Millstein R., Lesch K.P., Murphy D.L., Holmes A. Impaired stress-coping and fear extinction and abnormal corticolimbic morphology in serotonin transporter knock-out mice. J. Neurosci. 2007, 27:684-691.
57. Weninger S.C., Peters L.L., Majzoub J.A. Urocortin expression in the Edinger-Westphal nucleus is up-regulated by stress and corticotropin-releasing hormone deficiency. Endocrinology 2000, 141:256-263.
58. Zalutskaya A.A., Arai M., Bounoutas G.S., Abou-Samra A.B. Impaired adaptation to repeated restraint and decreased response to cold in urocortin 1 knockout mice. Am. J. Physiol. Endocrinol. Metab. 2007, 293:E259-E263.