Transport of 5,5-diphenylbarbituric acid and its precursors and their effect on P-gp, MRP2 and CYP3A4 in Caco-2 and LS180 cells

European Journal of Pharmaceutical Sciences

Volumn 42, Issue 1-2, 2011, Pages 19-29

  Fan, J ^a   Maeng, H J ^a   Du, Y ^a   Kwan, D ^a   Pang, K S ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

5,5 Diphenylbarbituric acid; CYP3A4; Induction; MDR1; Metabolism; MRP2; P gp; Precursor; PXR; Transport

Indexed keywords

1,3 DIMETHOXYMETHYL 5,5 DIPHENYLBARBITURIC ACID; 5,5 DIPHENYLBARBITURIC ACID; 6BETA HYDROXYTESTOSTERONE; BARBITURIC ACID DERIVATIVE; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 3A4; DIGOXIN; GLYCOPROTEIN P; MESSENGER RNA; MONOMETHOXYMETHYL 5,5 DIPHENYLBARBITURIC ACID; MULTIDRUG RESISTANCE PROTEIN 2; PREGNANE X RECEPTOR; RHODAMINE 123; RIFAMPICIN; SMALL INTERFERING RNA; TESTOSTERONE; TESTOSTERONE DERIVATIVE; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

ARTICLE; CELL STRAIN CACO 2; CONTROLLED STUDY; DRUG EFFECT; DRUG TRANSPORT; ENZYME ACTIVITY; HUMAN; HUMAN CELL; NUCLEOTIDE SEQUENCE; PERMEABILITY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; STEROID HYDROXYLATION; WESTERN BLOTTING;

BIOLOGICAL TRANSPORT; BIOTRANSFORMATION; BLOTTING, WESTERN; CACO-2 CELLS; CELL CULTURE TECHNIQUES; CELL MEMBRANE PERMEABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP3A; HUMANS; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; MOLECULAR STRUCTURE; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEIN; PHENOBARBITAL; PRODRUGS; RECEPTORS, CALCITRIOL; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 78650676789     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2010.10.001     Document Type: Article

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