Persistence of DNA double-strand breaks in normal human cells induced by radiation-induced bystander effect

Radiation Research

Volumn 175, Issue 1, 2011, Pages 90-96

  Ojima, Mitsuaki ^a   Furutani, Asahi ^a   Ban, Nobuhiko ^a   Kai, Michiaki ^a  

^a OITA UNIVERSITY OF NURSING AND HEALTH SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; DOUBLE STRANDED DNA; LINDANE;

ARTICLE; BYSTANDER EFFECT; COCULTURE; CONTROLLED STUDY; DOUBLE STRANDED DNA BREAK; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN PHOSPHORYLATION; RADIATION DOSE; RADIATION RESPONSE; X IRRADIATION;

BYSTANDER EFFECT; CELL CYCLE PROTEINS; CELLS, CULTURED; DNA BREAKS, DOUBLE-STRANDED; DNA-BINDING PROTEINS; HUMANS; KINETICS; LINDANE; LINEAR ENERGY TRANSFER; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEINS; X-RAYS;

ATAXIA TELANGIECTASIA;

EID: 78650587293     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR2223.1     Document Type: Article

References (52)

1. J. H. J. Hoeijmakers, Genome maintenance mechanisms for preventing cancer. Nature 411, 366-374 (2001)
2. G. L. Dianov, P. O'Neill and D. T. Goodhead, Securing genome stability by orchestrating DNA repair: removal of radiation-induced clustered lesions in DNA. Bioessays 23, 745-749 (2001)
3. Y. Shiloh, ATM and related protein kinase: Safeguarding genome integrity. Nat. Rev. Cancer 3, 155-168 (2003)
4. L. H. Thompson and D. Schild, Recombinational DNA repair and human disease. Mutat. Res. 509, 49-78 (2003)
5. C. Chen and R. D. Kolodner, Gross chromosomal rearrangements in Saccharomyces cerevisiae replication and recombination defective mutants. Nat. Genet. 23, 81-85 (1999)
6. R. D. Johnson and M. Jasin, Sister chromatid gene conversion is a prominent double-strand break repair pathway in mammalian cells. EMBO J. 19, 3398-3407 (2000)
7. E. P. Rogakou, C. Boon, C. Redon and W. M. Bonner, Megabase chromatin domains involved in DNA double-strand breaks in vivo. J. Cell Biol. 146, 905-915 (1999)
8. T. T. Paull, E. P. Rogakou, V. Yamazaki, C. U. Kirchgessner, M. Gellert and W. M. Bonner, A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr. Biol. 10, 886-895 (2000)
9. 125IdU-induced DNA double-strand breaks with c-H2AX antibody. Radiat. Res. 158, 486-492 (2002)
10. K. Rothkamm and M. Löbrich, Evidence for a lack of DNA double-strand break repair in human cells exposed to very low X-ray doses. Proc. Natl. Acad. Sci. USA 100, 5057-5062 (2003)
11. H. Nagasawa and J. B. Little, Induction of sister chromatid exchanges by extremely low doses of alpha-particles. Cancer Res. 52, 6394-6396 (1992)
12. A. Deshpande, E. H. Goodwin, S. M. Bailey, B. L. Marrone and B. E. Lehnert, Alpha-particle-induced sister chromatid exchange in normal human lung fibroblasts: evidence for an extranuclear target. Radiat. Res. 145, 260-267 (1996)
13. H. Nagasawa and J. B. Little, Unexpected sensitivity to the induction of mutations by very low doses of alpha-particle radiation: evidence for a bystander effect. Radiat. Res. 152, 552-557 (1999)
14. H. Zhou, G. Randers-Pehrson, C. A. Waldren, D. Vannais, E. J. Hall and T. K. Hei, Induction of a bystander mutagenic effect of alpha particles in mammalian cells. Proc. Natl. Acad. Sci. USA 97, 2099-2104 (2000)
15. H. Nagasawa, L. Huo and J. B. Little, Increased bystander mutagenic effect in DNA double-strand break repair-deficient mammalian cells. Int. J. Radiat. Biol. 79, 3-41 (2003)
16. R. Persaud, H. Zhou, S. E. Baker, T. K. Hei and E. J. Hall, Assessment of low linear energy transfer radiation-induced bystander mutagenesis in a three-dimensional culture model. Cancer Res. 65, 9876-9882 (2005)
17. M. V. Sokolov, J. S. Dickey, W. M. Bonner and O. A. Sedelnikova, c-H2AX in bystander cells. Cell Cycle 6, 2210-2212 (2007)
18. J. S. Dickey, B. J. Baird, C. E. Redon, M. V. Sokolov, O. A. Sedelnikova and W. M. Bonner, Intercellular communication of cellular stress monitored by gamma-H2AX induction. Carcinogenesis 10, 1686-1695 (2009)
19. H. Nagasawa and J. B. Little, Bystander effect for chromosomal aberrations induced in wild-type and repair deficient CHO cells by low fluences of alpha particles. Mutat. Res. 508, 121-129 (2002)
20. C. Shao, M. Aoki and Y. Furusawa, Medium-mediated bystander effects on HSG cells co-cultivated with cells irradiated by X-rays or a 290 MeV/u carbon beam. J. Radiat. Res. 42, 305-316 (2001)
21. M. Suzuki, H. Zhou, T. K. Hei, C. Tsuruoka and K. Fujitaka, Induction of a bystander chromosomal damage of He-ion microbeams in mammalian cells. Biol. Sci. Space. 17, 251-252 (2003)
22. C. B. Seymour and C. Mothersill, Relative contribution of bystander and targeted cell killing to the low-dose region of the radiation dose-response curve. Radiat. Res. 153, 508-511 (2000)
23. D. A. Lewis, B. M. Maylugh, Y. Qin, K. Trott and M. S. Mendonca, Production of delayed death and neoplastic transformation in CGL1 cells by radiation-induced bystander effects. Radiat. Res. 156, 251-258 (2001)
24. G. Schettino, M. Folkard, K. M. Prise, B. Vojnovic, K. D. Held and B. D. Michael, Low-dose studies of bystander cell killing with targeted soft X rays. Radiat. Res. 160, 505-511 (2003)
25. S. G. Sawant, G. Randers-Pehrson, C. R. Geard, D. J. Brenner and E. J. Hall, The bystander effect in radiation oncogenesis: I. Transformation in C3H 10TK cells in vitro can be initiated in the unirradiated neighbors of irradiated cells. Radiat. Res. 155, 397-401 (2001)
26. C. Shao, Y. Furusawa, M. Aoki and K. Ando, Role of gap junctional intercellular communication in radiation-induced bystander effects in human fibroblasts. Radiat. Res. 160, 318-323 (2003)
27. E. I. Azzam, S. M. de Toledo and J. B. Little, Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha-particle irradiated to nonirradiated cells. Proc. Natl. Acad. Sci. USA 98, 473-478 (2001)
28. E. I. Azzam, S. M. de Toledo, T. Gooding and J. B. Little, Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles. Radiat. Res. 150, 497-504 (1998)
29. K. Suzuki, S. Kodama and M. Watanabe, Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation. J. Biol. Chem. 274, 25571-25575 (1999)
30. S. Burma, B. P. Chen, M. Murphy, A. Kurimasa and D. J. Chen, ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J. Biol. Chem. 276, 42462-42467 (2001)
31. T. Stiff, M. O'Driscoll, N. Rief, K. Iwabuchi, M. Löbrich and P. A. Jeggo, ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res. 64, 2390-2396 (2004)
32. K. Suzuki, H. Okada, M. Yamauchi, Y. Oka, S. Kodama and M. Watanabe, Qualitative and quantitative analysis of phos-phorylated ATM foci induced by low-dose ionizing radiation. Radiat. Res. 165, 499-504 (2006)
33. M. F. Lavin, G. Birrell, P. Chen, S. Kozlov, S. Scott and N. Gueven, ATM signaling and genomic stability in response to DNA damage. Mutat. Res. 569, 123-132 (2005)
34. M. Ojima, N. Ban and M. Kai, DNA double-strand breaks induced by very low X-ray doses are largely due to bystander effects. Radiat. Res. 170, 365-371 (2008)
35. B. Hu, L. Wu, W. Han, L. Zhang, S. Chen, A. Xu, T. K. Hei and Z. Yu, The time and spatial effects of bystander response in mammalian cells induced by low dose radiation. Carcinogenesis 27, 245-251 (2006)
36. C. Mothersill and C. B. Seymour, Radiation-induced bystander effects: Past history and future directions. Radiat. Res. 155, 759-767 (2001)
37. H. Matsumoto, N. Hamada, A. Takahashi, Y. Kobayashi and T. Ohnishi, Vanguards of paradigm shift in radiation biology: radiation-induced adaptive and bystander responses. J. Radiat. Res. 48, 97-106 (2007)
38. S. Burdak-Rothkamm, S. C. Short, M. Folkard, K. Rothkamm and K. M. Prise, ATR-dependent radiation-induced cH2AX foci in bystander primary human astrocytes and glioma cells. Oncogene 26, 993-1002 (2007)
39. L. Huo, H. Nagasawa and J. B. Little, HPRT mutants induced in bystander cells by very low fluences of alpha particles result primarily from point mutations. Radiat. Res. 156, 521-525 (2001)
40. M. Suzuki, H. Zhou, T. K. Hei, C. Tsuruoka and K. Fujitaka, Effects of irradiated medium on chromatid aberrations in mammalian cells using double Mylar dishes. Biol. Sci. Space 18, 110-111 (2004)
41. M. Suzuki, H. Zhou, C. R. Geard and T. K. Hei, Effect on chromatin damage in bystander mammalian cells. Radiat. Res. 162, 264-269 (2004)
42. G. Olivieri, J. Bodycote and S. Wolff, Adaptive response of human lymphocytes to low concentrations of radioactive thymidine. Science 223, 594-597 (1984)
43. T. Ikusima, Chromosomal response to ionizing radiation reminiscent of an adaptive response in cultured Chinese hamster cells. Mutat. Res. 180, 215 (1987)
44. M. Ojima, K. Ishii, T. Hayashi and A. Ito, Induction of radio-adaptive response in colony formation by low dose X-ray irradiation. Physiol. Chem. Phys. Med. NMR 33, 41-48 (2001)
45. H. Matsumoto, S. Hayashi, M. Hatashita, K. Ohnishi, H. Shioura, T. Ohtsubo, R. Kitai, T. Ohnishi and E. Kano, Induction of radioresistance by a nitric oxide-mediated bystander effect. Radiat. Res. 155, 387-396 (2001)
46. B. Iyer and B. E. Lehnert, Alpha-particle-induced increases in the radioresistance of normal human bystander cells. Radiat. Res. 157, 3-7 (2002)
47. S. A. Mitchell, S. A. Marino, D. J. Brenner and E. J. Hall, Bystander effect and adaptive response in C3H10T1/2 cells. Int. J. Radiat. Biol. 80, 465-472 (2004)
48. T. Groesser, B. Cooper and B. Rydberg, Lack of bystander effects from high-LET radiation for early cytogenetic end points. Radiat. Res. 170, 794-802 (2008)
49. C. Fournier, P. Barberet, T. Pouthier, S. Ritter, B. Fischer, K. O. Voss, T. Funayama, N. Hamada, Y. Kobayashi and G. Taucher-Scholz, No evidence for DNA and early cytogenetic damage in bystander cells after heavy-ion microirradiation at two facilities. Radiat. Res. 171, 530-540 (2009)
50. S. G. Sawant, W. Zheng, K. M. Hopkins, G. Randers-Pehrson, H. B. Lieberman and E. J. Hall, The radiation-induced bystander effect for clonogenic survival. Radiat. Res. 157, 361-364 (2002)
51. M. B. Sowa, W. Goetz, J. E. Baulch, D. N. Pyles, J. Dziegielewski, S. Yovino, A. R. Snyder, S. M. de Toledo, E. I. Azzam and W. F. Morgan, Lack of evidence for low-LET radiation induced bystander response in normal human fibroblasts and colon carcinoma cells. Int. J. Radiat. Biol. 86, 102-113 (2010)
52. H. Yang, N. Asaad and K. D. Held, Medium-mediated intercellular communication is involved in bystander responses of X-ray-irradiated normal human fibroblasts. Oncogene 24, 2096-2103 (2005)