Lack of evidence for low-LET radiation induced bystander response in normal human fibroblasts and colon carcinoma cells

International Journal of Radiation Biology

Volumn 86, Issue 2, 2010, Pages 102-113

  Sowa, Marianne B ^a   Goetz, Wilfried ^b   Baulch, Janet E ^b   Pyles, Dinah N ^c   Dziegielewski, Jaroslaw ^c   Yovino, Susannah ^b   Snyder, Andrew R ^d   De Toledo, Sonia M ^e   Azzam, Edouard I ^e   Morgan, William F ^a,b  

^a PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

^d Targanox   (United States)

^e RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

Bystander effects; Human cells; Ionising radiation; Low LET

Indexed keywords

HISTONE H2A;

ARTICLE; BYSTANDER EFFECT; CANCER CELL CULTURE; CELL COMMUNICATION; CELL JUNCTION; CELL SURVIVAL; CLONOGENESIS; COLON CARCINOMA; CONTROLLED STUDY; DNA DAMAGE; FIBROBLAST; HUMAN; HUMAN CELL; ION THERAPY; IRRADIATION; LINEAR ENERGY TRANSFER; MICRONUCLEUS; PRIORITY JOURNAL; RADIATION DOSE; RADIATION FIELD;

BYSTANDER EFFECT; CELL LINE; CELL LINE, TUMOR; COLONIC NEOPLASMS; COLONY-FORMING UNITS ASSAY; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, RADIATION; FIBROBLASTS; GAP JUNCTIONS; HISTONES; HUMANS; LINEAR ENERGY TRANSFER; MICRONUCLEUS TESTS; TUMOR STEM CELL ASSAY;

EID: 77249135874     PISSN: 09553002     EISSN: 13623095     Source Type: Journal    
DOI: 10.3109/09553000903419957     Document Type: Article

References (54)

1. Anzenberg V, Chandiramani S, Coderre JA. 2008. LET-dependent bystander effects caused by irradiation of human prostate carcinoma cells with X rays or alpha particles. Radiation Research 170:467-476.
2. Aydarous AS, Darley PJ, Charles MW. 2001. A wide dynamic range, high-spatial-resolution scanning system for radiochromic dye films. Physics in Medicine and Biology 46: 1379-1389.
3. Azzam EI, de Toledo SM, Gooding T, Little JB. 1998. Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles. Radiation Research 150: 497-504.
4. Azzam EI, de Toledo SM, Little JB. 2001. Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alphaparticle irradiated to nonirradiated cells. Proceedings of the National Academy of Science of the USA 98:473-478.
5. Burdak-Rothkamm S, Short SC, Folkard M, Rothkamm K, Prise KM. 2007. ATR-dependent radiation-induced gamma H2AX foci in bystander primary human astrocytes and glioma cells. Oncogene 26:993-1002.
6. Chapman KL, Kelly JW, Lee R, Goodwin EH, Kadhim MA. 2008. Tracking genomic instability within irradiated and bystander populations. Journal of Pharmacy and Pharmacology 60:959-968.
7. Cucinotta FA, Wu H, Shavers MR, George K. 2003. Radiation dosimetry and biophysical models of space radiation effects. Gravitational and Space Biology Bulletin 16:11-18.
8. Dahlberg WK, Azzam EI, Yu Y, Little JB. 1999. Response of human tumor cells of varying radiosensitivity and radiocurability to fractionated irradiation. Cancer Research 59: 5365-5369.
9. Fenech M. 1993. The cytokinesis-block micronucleus technique: A detailed description of the method and its application to genotoxicity studies in human populations. Mutation Research 285:35-44.
10. Folkard M, Vojnovic B, Hollis KJ, Bowey AG, Watts SJ, Schettino G, Prise KM, Michael BD. 1997a. A chargedparticle microbeam: II. A single-particle micro-collimation and detection system. International Journal of Radiation Biology 72:387-395.
11. Folkard M, Vojnovic B, Prise KM, Bowey AG, Locke RJ, Schettino G, Michael BD. 1997b. A charged-particle microbeam: I. Development of an experimental system for targeting cells individually with counted particles. International Journal of Radiation Biology 72:375-385.
12. Fournier C, Barberet P, Pouthier T, Ritter S, Fischer B, Voss KO, Funayama T, Hamada N, Kobayashi Y, Taucher-Scholz G. 2009. No evidence for DNA and early cytogenetic damage in bystander cells after heavy-ion microirradiation at two facilities. Radiation Research 171:530-540.
13. Frankenberg D, Greif KD, Giesen U. 2006. Radiation response of primary human skin fibroblasts and their bystander cells after exposure to counted particles at low and high LET. International Journal of Radiation Biology 82:59-67.
14. Gerashchenko BI, Howell RW. 2003. Cell proximity is a prerequisite for the proliferative response of bystander cells co-cultured with cells irradiated with gamma-rays. Cytometry A 56:71-80.
15. Groesser T, Cooper B, Rydberg B. 2008. Lack of bystander effects from High-LET radiation for early cytogenetic end points. Radiation Research 170:794-802.
16. Hamada N. 2009. Recent insights into the biological action of heavy-ion radiation. Journal of Radiation Research (Tokyo) 50: 1-9.
17. Hei TK, Zhou H, Ivanov VN, Hong M, Lieberman HB, Brenner DJ, Amundson SA, Geard CR. 2008. Mechanism of radiation-induced bystander effects: A unifying model. Journal of Pharmacy and Pharmacology 60:943-950.
18. Hu B, Wu L, Han W, Zhang L, Chen S, Xu A, Hei TK, Yu Z. 2006. The time and spatial effects of bystander response in mammalian cells induced by low dose radiation. Carcinogenesis 27:245-251.
19. Huang L, Grim S, Smith LE, Kim PM, Nickoloff JA, Goloubeva OG, Morgan WF. 2004. Ionizing radiation induces delayed hyperrecombination in Mammalian cells. Molecular Cell Biology 24:5060-5068.
20. Huang L, Kim PM, Nickoloff JA, Morgan WF. 2007. Targeted and nontargeted effects of low-dose ionizing radiation on delayed genomic instability in human cells. Cancer Research 67:1099-1104.
21. Lorimore SA, Coates PJ, Wright EG. 2003. Radiation-induced genomic instability and bystander effects: Inter-related nontargeted effects of exposure to ionizing radiation. Oncogene 22: 7058-7069.
22. Mendonca MS, Temples TM, Farrington DL, Bloch C. 1998. Evidence for a role of delayed death and genomic instability in radiation-induced neoplastic transformation of human hybrid cells. International Journal of Radiation Biology 74:755-764.
23. Miller JH, Sowa Resat M, Metting NF, Wei K, Lynch DJ, Wilson WE. 2000. Monte Carlo simulation of single-cell irradiation by an electron microbeam. Radiation and Environmental Biophysics 39:173-177.
24. Mitchell SA, Randers-Pehrson G, Brenner DJ, Hall EJ. 2004. The bystander response in C3H 10T1/2 cells: The influence of cellto-cell contact. Radiation Research 161:397-401.
25. Morgan WF. 2003a. Non-targeted and delayed effects of exposure to ionizing radiation: I. Radiation-induced genomic instability and bystander effects in vitro. Radiation Research 159: 567-580.
26. Morgan WF. 2003b. Non-targeted and delayed effects of exposure to ionizing radiation: II. Radiation-induced genomic instability and bystander effects in vivo, clastogenic factors and transgenerational effects. Radiation Research 159:581-596.
27. Morgan WF, Sowa MB. 2005. Effects of ionizing radiation in nonirradiated cells. Proceedings of the National Academy of Science of the USA 102:14127-14128.
28. Mothersill C, Rea D, Wright EG, Lorimore SA, Murphy D, Seymour CB, O'Malley K. 2001. Individual variation in the production of a 'bystander signal' following irradiation of primary cultures of normal human urothelium. Carcinogenesis 22:1465-1471.
29. Mothersill C, Seymour C. 1997. Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells. International Journal of Radiation Biology 71:421-427.
30. Mothersill C, Seymour C. 2001. Radiation-induced bystander effects: Past history and future directions. Radiation Research 155:759-767.
31. Mothersill C, Seymour C. 2003a. Low-dose radiation effects: Experimental hematology and the changing paradigm. Experimental Hematology 31:437-445.
32. Mothersill C, Seymour C. 2003b. Radiation-induced bystander effects, carcinogenesis and models. Oncogene 22: 7028-7033.
33. Mothersill C, Seymour CB. 1998. Cell-cell contact during gamma irradiation is not required to induce a bystander effect in normal human keratinocytes: Evidence for release during irradiation of a signal controlling survival into the medium. Radiation Research 149:256-262.
34. Nagar S, Smith LE, Morgan WF. 2003. Characterization of a novel epigenetic effect of ionizing radiation: The deathinducing effect. Cancer Research 63:324-328.
35. Nagasawa H, Little JB. 1992. Induction of sister chromatid exchanges by extremely low doses of alpha-particles. Cancer Research 52:6394-6396.
36. Niroomand-Rad A, Blackwell CR, Coursey BM, Gall KP, Galvin JM, McLaughlin WL, Meigooni AS, Nath R, Rodgers JE, Soares CG. 1998. Radiochromic film dosimetry: Recommendations of AAPM Radiation Therapy Committee Task Group 55. Medical Physics 25:2093-2115.
37. Prise KM, Folkard M, Micheals BD. 2003. Bystander responses induced by low LET radiation. Oncogene 22:7043-7049.
38. Randers-Pehrson G, Geard CR, Johnson G, Elliston CD, Brenner DJ. 2001. The Columbia University single-ion microbeam. Radiation Research 156:210-214.
39. Sawant SG, Zheng W, Hopkins KM, Randers-Pehrson G, Lieberman HB, Hall EJ. 2002. The radiation-induced bystander effect for clonogenic survival. Radiation Research 157:361-364.
40. Seymour CB, Mothersill C. 1997. Delayed expression of lethal mutations and genomic instability in the progeny of human epithelial cells that survived in a bystander-killing environment. Radiation Oncology Investigations 5:106-110.
41. Shao C, Aoki M, Furusawa Y. 2003a. Bystander effect on cell growth stimulation in neoplastic HSGc cells induced by heavyion irradiation. Radiation and Environmental Biophysics 42: 183-187.
42. Shao C, Folkard M, Michael BD, Prise KM. 2004. Targeted cytoplasmic irradiation induces bystander responses. Proceedings of the National Academy of Science of the USA 101: 13495-13500.
43. Shao C, Furusawa Y, Aoki M, Matsumoto H, Ando K. 2002. Nitric oxide-mediated bystander effect induced by heavy-ions in human salivary gland tumour cells. International Journal of Radiation Biology 78:837-844.
44. Shao C, Furusawa Y, Kobayashi Y, Funayama T, Wada S. 2003b. Bystander effect induced by counted high-LET particles in confluent human fibroblasts: A mechanistic study. The Journal for the Federation of American Societies for Experimental Biology 17:1422-1427.
45. Sowa MB, Kathmann LE, Holben BA, Thrall BD, Kimmel GA. 2005a. Low-LET microbeam investigation of the track-end dependence of electron-induced damage in normal human diploid fibroblasts. Radiation Research 164:677-679.
46. Sowa MB, Murphy MK, Miller JH, McDonald JC, Strom DJ, Kimmel GA. 2005b. A variable-energy electron microbeam: A unique modality for targeted low-LET radiation. Radiation Research 164:695-700.
47. Sowa Resat M, Morgan WF. 2004a. Microbeam developments and applications: A low linear energy transfer perspective. Cancer and Metastasis Review 23:323-331.
48. Sowa Resat MB,Morgan WF. 2004b. Radiation-induced genomic instability: A role for secreted soluble factors in communicating the radiation response to non-irradiated cells. Journal of Cell Biochemistry 92:1013-1019.
49. Suzuki M, Zhou H, Geard CR, Hei TK. 2004. Effect of medium on chromatin damage in bystander mammalian cells. Radiation Research 162:264-269.
50. Wu LJ, Randers-Pehrson G, Xu A, Waldren CA, Geard CR, Yu Z, Hei TK. 1999. Targeted cytoplasmic irradiation with alpha particles induces mutations in mammalian cells. Proceeding of the National Academy of Science of the USA 96: 4959-4964.
51. Yang H, Anzenberg V, Held KD. 2007a. Effects of heavy ions and energetic protons on normal skin fibroblasts. Radiatsionnaia Biologiia, Radioecologiia 47:302-306.
52. Yang H, Anzenberg V, Held KD. 2007b. The time dependence of bystander responses induced by iron-ion radiation in normal human skin fibroblasts. Radiation Research 168:292-298.
53. Yang H, Asaad N, Held KD. 2005. Medium-mediated intercellular communication is involved in bystander responses of X-ray-irradiated normal human fibroblasts. Oncogene 24: 2096-2103.
54. Zeitlin C, Heilbronn L, Miller J. 1998. Detailed characterization of the 1087 MeV/nucleon iron-56 beam used for radiobiology at the alternating gradient synchrotron. Radiation Research 149: 560-569.