Role of gap junctional intercellular communication in radiation-induced bystander effects in human fibroblasts

Radiation Research

Volumn 160, Issue 3, 2003, Pages 318-323

  Shao, Chunlin ^a   Furusawa, Yoshiya ^a   Aoki, Mizuho ^a   Ando, Koichi ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON; CYCLIC AMP; DIMETHYL SULFOXIDE; LINDANE; REACTIVE OXYGEN METABOLITE; SCAVENGER;

ARTICLE; BYSTANDER EFFECT; CELL COMMUNICATION; CELL CYCLE G1 PHASE; CELL SURVIVAL; FIBROBLAST; GAP JUNCTION; HUMAN; HUMAN CELL; IRRADIATION; MICRONUCLEUS; PRIORITY JOURNAL; RADIATION; RADIATION DOSE; RADIOSENSITIVITY;

8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; BYSTANDER EFFECT; CELL CYCLE; CELL NUCLEUS; CELL SURVIVAL; CYCLIC AMP; DIMETHYL SULFOXIDE; DOSE-RESPONSE RELATIONSHIP, RADIATION; FIBROBLASTS; FLUORESCENT DYES; GAP JUNCTIONS; HUMANS; INTERCELLULAR JUNCTIONS; ISOQUINOLINES; LINDANE; MICRONUCLEI, CHROMOSOME-DEFECTIVE; REACTIVE OXYGEN SPECIES;

EID: 0041317777     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR3044     Document Type: Article

References (27)

1. R. Iyer and B. E. Lehnert, Effects of ionizing radiation in targeted and nontargeted cells. Arch. Biochem. Biophys. 376, 14-25 (2000).
2. C. Mothersill and C. Seymour, Radiation-induced bystander effects: Past history and future directions. Radiat. Res. 155, 759-767 (2001).
3. H. Nagasawa and J. B. Little, Induction of sister chromatid exchanges by extremely low doses of alpha-particles. Cancer Res. 52, 6394-6396 (1992).
4. A. Deshpande, E. H. Goodwin, S. M. Bailey, B. L. Marrone and B. E. Lehnert, Alpha-particle-induced sister chromatid exchange in normal human lung fibroblasts: Evidence for an extranuclear target. Radiat. Res. 145, 260-267 (1996).
5. P. K. Narayanan, E. H. Goodwin and B. E. Lehnert, Alpha particles initiate biological production of superoxide anions and hydrogen peroxide in human cells. Cancer Res. 57, 3963-3971 (1997).
6. R. Iyer and B. E. Lehnert, Factors underlying the cell growth-related bystander responses to alpha particles. Cancer Res. 60, 1290-1298 (2000).
7. C. Shao, M. Aoki and Y. Furusawa, Medium-mediated bystander effects on HSG cells co-cultivated with cells irradiated by X-rays or a 290 MeV/u carbon beam. J. Radiat. Res. 42, 305-316 (2001).
8. C. Shao, Y. Furusawa, M. Aoki, H. Matsumoto and K. Ando, Nitric oxide-mediated bystander effect induced by heavy-ions in human salivary gland tumour cells. Int. J. Radiat. Biol. 78, 837-844 (2002).
9. J. D. Pitts, Cancer gene therapy: A bystander effect using the gap junctional pathway. Mol. Carcinog. 11, 127-130 (1994).
10. F. L. Moolten, Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: Paradigm for a prospective cancer control strategy. Cancer Res. 46, 5276-5281 (1986).
11. H. Zhou, G. Randers-Pehrson, C. A. Waldren, D. Vannais, E. J. Hall and T. K. Hei, Induction of a bystander mutagenic effect of alpha particles in mammalian cells. Proc. Natl. Acad. Sci. USA 97, 2099-2104 (2000).
12. H. Zhou, M. Suzuki, G. Randers-Pehrson, D. Vannais, G. Chen, J. E. Trosko, C. A. Waldren and T. K. Hei, Radiation risk to low fluences of alpha particles may be greater than we thought. Proc. Natl. Acad. Sci. USA 98, 14410-14415 (2001).
13. H. Moussa, S. A. Mitchell, R. Grenman and M. C. Joiner, Cell-cell contact increases radioresistance in head and neck carcinoma cell lines. Int. J. Radiat. Biol. 76, 1245-1253 (2000).
14. A. Bishayee, D. V. Rao and R. W. Howell, Evidence for pronounced bystander effects caused by nonuniform distributions of radioactivity using a novel three-dimensional tissue culture model. Radiat. Res. 152, 88-97 (1999).
15. A. Bishayee, H. Z. Hill, D. Stein, D. V. Rao and R. W. Howell, Free radical-initiated and gap junction-mediated bystander effect due to nonuniform distribution of incorporated radioactivity in a three-dimensional tissue culture model. Radiat. Res. 155, 335-344 (2001).
16. E. I. Azzam, S. M. de Toledo, T. Gooding and J. B. Little, Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles. Radiat. Res. 150, 497-504 (1998).
17. 1 checkpoint in human diploid fibroblasts. Cancer Res. 60, 2623-2631 (2000).
18. E. I. Azzam, S. M. de Toledo and J. B. Little, Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha-particle irradiated to nonirradiated cells. Proc. Natl. Acad. Sci. USA 98, 473-478 (2001).
19. G. D. Carystinos, M. M. Katabi, D. W. Laird, J. Galipeau, H. Chan, M. A. Alaoui-Jamali and G. Batist, Cyclic-AMP induction of gap junctional intercellular communication increases bystander effect in suicide gene therapy. Clin. Cancer Res. 5, 61-68 (1999).
20. A. F. Paulson, P. D. Lampe, R. A. Meyer, E. TenBroek, M. M. Atkinson, T. F. Walseth and R. G. Johnson, Cyclic AMP and LDL trigger a rapid enhancement in gap junction assembly through a stimulation of connexin trafficking. J. Cell Sci. 113, 3037-3049 (2000).
21. R. Li and J. P. Mather, Lindane, an inhibitor of gap junction formation, abolishes oocyte directed follicle organizing activity in vitro. Endocrinology 138, 4477-4480 (1997).
22. M. H. El-Fouly, J. E. Trosko and C. C. Chang, Scrape-loading and dye transfer. A rapid and simple technique to study gap junctional intercellular communication. Exp. Cell Res. 168, 422-430 (1987).
23. M. Fenech and A. A. Morley, Cytokinesis-block micronucleus method in human lymphocytes: Effect of in vivo ageing and low dose X-irradiation. Mutat. Res. 161, 193-198 (1986).
24. M. Fenech, The cytokinesis-block micronucleus technique and its application to genotoxicity studies in human populations. Environ. Health Perspect. 101 (Suppl. 3), 101-107 (1993).
25. J. F. Ward, C. L. Limoli, P. M. Calabro-Jones and J. Aguilera, An examination of the repair saturation hypothesis for describing shouldered survival curves. Radiat. Res. 127, 90-96 (1991).
26. L. J. Wu, G. Randers-Pehrson, A. Xu, C. A. Waldren, C. R. Geard, Z. Yu and T. K. Hei, Targeted cytoplasmic irradiation with alpha particles induces mutations in mammalian cells. Proc. Natl. Acad. Sci. USA 96, 4959-4964 (1999).
27. P. K. Narayanan, K. E. LaRue, E. H. Goodwin and B. E. Lehnert, Alpha particles induce the production of interleukin-8 by human cells. Radiat. Res. 152, 57-63 (1999).