DNA double-strand breaks induced by very low X-ray doses are largely due to bystander effects

Radiation Research

Volumn 170, Issue 3, 2008, Pages 365-371

  Ojima, Mitsuaki ^a   Ban, Nobuhiko ^a   Kai, Michiaki ^a  

^a OITA UNIVERSITY OF NURSING AND HEALTH SCIENCES   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; DOUBLE STRANDED DNA; LINDANE;

ARTICLE; BYSTANDER EFFECT; CONTROLLED STUDY; DNA STRAND BREAKAGE; DOSE RESPONSE; FIBROBLAST; GAP JUNCTION; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; IMMUNOFLUORESCENCE; NORMAL HUMAN; PRIORITY JOURNAL; RADIATION BEAM; RADIATION DOSE; X IRRADIATION;

BYSTANDER EFFECT; CELL CYCLE PROTEINS; CELL LINE; DNA; DNA DAMAGE; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, RADIATION; FIBROBLASTS; HUMANS; PROTEIN-SERINE-THREONINE KINASES; RADIATION DOSAGE; TUMOR SUPPRESSOR PROTEINS; X-RAYS;

EID: 51649119854     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR1255.1     Document Type: Article

References (36)

1. United Nations Scientific Committee on the Effects of Atomic Radiation, Sources and Effects of Ionizing Radiation, 2000 Report to the General Assembly, with Science Annexes, Vol. 2. United Nations, New York, 2000.
2. ICRP, Recommendations of the International Commission on Radiological Protection. Publication 60, Annals of the ICRP, Vol. 21, El-sevier Science, New York, 1991.
3. NCRP. Limitations of Exposure to Ionizing Radiation. Report No. 116, National Council on Radiation Protection and Measurements, Bethesda, MD, 1993.
4. NRPB, Risk of Radiation-Induced Cancer at Low Doses and Low Dose Rates for Radiation Protection Purposes. Documents of the NRPB, Vol. 6, No. 1, National Radiological Protection Board, Chilton, UK, 1995.
5. Advisory Committee on Radiological Protection. Biological Effects of Low Doses of Radiation at Low Dose Rate. ACRP-18, lnfo-0654, Atomic Energy Control Board of Canada, Ottawa, 1996.
6. W. K. Sinclair. The linear no-threshold response: Why not linearity. Med. Phys. 25, 285-290 (1998).
7. D. J. Brenner, R. Doll, D. T. Goodhead, E. J. Hall, C. E. Land, J. B. Little. J. H. Lubin, D. L. Preston, R. J. Preston and M. Zaider, Cancer risks attributable to low doses of ionizing radiation: assessing what we really know. Proc. Natl. Acad. Sci. USA 100, 13761-13766 (2003).
8. H. Nagasawa and J. B. Little, Induction of sister chromatid exchanges by extremely low doses of alpha-particles. Cancer Res. 52, 6394-6396 (1992).
9. A. Deshpande, E. H. Goodwin, S. M. Bailey, B. L. Marrone and B. E. Lehnert, Alpha-particle-induced sister chromatid exchange in normal human lung fibroblasts: Evidence for an extranuclear target. Radiat. Res. 145, 260-267 (1996).
10. K. M. Prise, O. V. Belyakov, M. Folkard and B. D. Michael, Studies of bystander effects in human fibroblasts using a charged particle microbeam. Int. J. Radiat. Biol. 74, 793-798 (1998).
11. G. Schettino, M. Folkard, K. M. Prise, B. Vojnovic, K. D. Held and B. D. Michael, Low-dose studies of bystander cell killing with targeted soft X rays. Radiat. Res. 160, 505-511 (2004).
12. C. Shao, Y. Furusawa, M. Aoki and K. Ando, Role of gap junctional intercellular communication in radiation-induced bystander effects in human fibroblasts. Radiat. Res. 160, 318-323 (2003).
13. H. Zhou, G. Randers-Pehrson, C. A. Waldren, D. Vannais, E. J. Hall and T. K. Hei, Induction of a bystander mutagenic effect of alpha particles in mammalian cells. Proc. Natl. Acad. Sci. USA 97, 2099-2104 (2000).
14. B. Hu, L. Wu, W. Han, L. Zhang, S. Chen, A. Xu, T. K. Hei and Z. Yu, The time and spatial effects of bystander response in mammalian cells induced by low dose radiation. Carcinogenesis 27, 245-251 (2006).
15. E. I. Azzam, S. M. de Toledo, T. Gooding and J. B. Little, Intercellular communication is involved in the bystander regulation of gene expression in human cells exposed to very low fluences of alpha particles. Radiat. Res. 150, 497-504 (1998).
16. E. I. Azzam, S. M. de Toledo, A. J. Waker and J. B. Little, High and low fluences of alpha-particles induce a G1 checkpoint in human diploid fibroblasts. Cancer Res. 60, 2623-2631 (2000).
17. E. I. Azzam, S. M. de Toledo and J. B. Little, Direct evidence for the participation of gap junction-mediated intercellular communication in the transmission of damage signals from alpha-particle irradiated to nonirradiated cells. Proc. Natl. Acad. Sci. USA 98, 473-478 (2001).
18. K. Suzuki, S. Kodama and M. Watanabe, Recruitment of ATM protein to double strand DNA irradiated with ionizing radiation. J. Biol. Chem. 274, 25571-25575 (1999).
19. S. Burma, B. P. Chen, M. Murphy, A. Kurimasa and D. J. Chen, ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J. Biol. Chem. 276, 42462-42467 (2001).
20. T. Stiff, M. O'Driscoll, N. Rief, K. Iwabuchi, M. Löbrich and P. A. Jeggo, ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res. 64, 2390-2396 (2004).
21. K. Suzuki, H. Okada, M. Yamauchi, Y. Oka, S. Kodama and M. Watanabe, Qualitative and quantitative analysis of phosphorylated ATM foci induced by low-dose ionizing radiation. Radiat. Res. 165, 499-504 (2006).
22. M. F. Lavin, G. Birrell, P. Chen, S. Kozlov, S. Scott and N. Gueven, ATM signaling and genomic stability in response to DNA damage. Mutat. Res. 569, 123-132 (2005).
23. J. H. J. Hoeijmakers, Genome maintenance mechanisms for preventing cancer. Nature 411, 366-374 (2001).
24. G. L. Dianov, P. O'Neill and D. T. Goodhead, Securing genome stability by orchestrating DNA repair: removal of radiation-induced clustered lesions in DNA. Bioessays 23, 745-749 (2001).
25. K. Rothkamm and M. Löbrich, Evidence for a lack of DNA double-strand break repair in human cells exposed to very low X-ray doses. Proc. Natl. Acad. Sci. USA 100, 5057-5062 (2003).
26. T. Miyazaki, Y. Hayakawa, K. Suzuki, M. Suzuki and M. Watanabe, Radioprotective effects of dimethyl sulfoxide in golden hamster embryo cells exposed to gamma rays at 77 K. I. Radical formation as studied by electron spin resonance. Radiat. Res. 124, 66-72 (1990).
27. M. Watanabe, M. Suzuki, K. Suzuki, Y. Hayakawa and T. Miyazaki, Radioprotective effects of dimethyl sulfoxide in golden hamster embryo cells exposed to gamma rays at 77 K. II. Protection from lethal, chromosomal, and DNA damage. Radiat. Res. 124, 73-78 (1990).
28. C. M. deLara, T. J. Jenner, K. M. Townsend, S. J. Marsden and P. O'Neill, The effect of dimethyl sulfoxide on the induction of DNA double-strand breaks in V79-4 mammalian cells by alpha particles. Radiat. Res. 144, 43-49 (1995).
29. L. E. Feinendegen, The cell dose concept; potential application in radiation protection. Phys. Med. Biol. 35, 597-612 (1990).
30. P. K. Narayanan, E. H. Goodwin and B. E. Lehnert, Alpha particles initiate biological production of superoxide anions and hydrogen peroxide in human cells. Cancer Res. 57, 3963-3971 (1997).
31. H. Matsumoto, S. Hayashi, M. Hatashita, K. Ohnishi, H. Shioura, X Ohtsubo, R. Kitai, T. Ohnishi and E. Kano, Induction of radioresistance by a nitric oxide-mediated bystander effect. Radiat. Res. 155, 387-396 (2001).
32. C. Shao, Y. Furusawa, M. Aoki, H. Matsumoto and K. Ando, Nitric oxide-mediated bystander effect induced by heavy-ions in human salivary gland tumour cells. Int. J. Radiat. Biol. 78, 837-844 (2002).
33. P. Sonveaux, C. Dessy, A. Brouet, B. F. lordan, V. Gregoire, B. Ga1-lez, J. L. Balligand and O. Feron, Modulation of the tumor vasculature functionality by ionizing radiation accounts for tumor radio-sensitization and promotes gene delivery. FASEB J. 16, 1979-1981 (2002).
34. E. J. Ehrhart, P. Segarini, M. L. Tsang, A. G. Carroll and M. H. Barcellos-Hoff, Latent transforming growth factor betal activation in situ: quantitative and functional evidence after low-dose gamma-irradiation. FASEB J. 11, 991-1002 (1997).
35. R. Iyer, B. E. Lehnert and R. Svensson, Factors underlying the cell growth-related bystander responses to alpha particles. Cancer Res. 60, 1290-1298 (2000).
36. C. B. Seymour and C. Mothersill, Relative contribution of bystander and targeted cell killing to the low-dose region of the radiation dose-response curve. Radiat. Res. 153, 508-511 (2000).