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Volumn 60, Issue 4, 2010, Pages 387-406

Genetic polymorphisms in diabetes: Influence on therapy with oral antidiabetics

Author keywords

Oral antidiabetics; Pharmacogenetics

Indexed keywords

ACARBOSE; ACETOHEXOMIDE; CHLORPROPAMIDE; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; GLIBENCLAMIDE; GLICLAZIDE; GLIMEPIRIDE; GLIPIZIDE; GLUCOKINASE; GLUCOSE; HEMOGLOBIN A1C; HEPATOCYTE NUCLEAR FACTOR 1ALPHA; HEPATOCYTE NUCLEAR FACTOR 1BETA; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; METFORMIN; MIGLITOL; NATEGLINIDE; OCTAMER TRANSCRIPTION FACTOR 1; OCTAMER TRANSCRIPTION FACTOR 2; ORAL ANTIDIABETIC AGENT; PIOGLITAZONE; REPAGLINIDE; ROSIGLITAZONE; SULFONYLUREA; SULFONYLUREA RECEPTOR 1; TOLAZAMIDE; TOLBUTAMIDE; TRANSCRIPTION FACTOR 7 LIKE 2; UNCLASSIFIED DRUG;

EID: 78650578778     PISSN: 13300075     EISSN: 18469558     Source Type: Journal    
DOI: 10.2478/v10007-010-0040-9     Document Type: Article
Times cited : (16)

References (68)
  • 1
    • 17044386953 scopus 로고    scopus 로고
    • Type 2 diabetes: Principles of pathogenesis and therapy
    • DOI: 10.1016/S0140-6736(05)61032-X
    • M. Stumvoll, B. J. Goldstein and T. W. Haeften, Type 2 diabetes: principles of pathogenesis and therapy, Lancet 365 (2005) 1333-1346; DOI: 10.1016/S0140-6736(05)61032-X.
    • (2005) Lancet , vol.365 , pp. 1333-1346
    • Stumvoll, M.1    Goldstein, B.J.2    Haeften, T.W.3
  • 2
    • 49249107690 scopus 로고    scopus 로고
    • Problems in differential diagnosis of diabetes types
    • M. Maiecki and J. Skupieñ, Problems in differential diagnosis of diabetes types, Pol. Arch. Med. Wewn. 118 (2008) 435-440.
    • (2008) Pol. Arch. Med. Wewn. , vol.118 , pp. 435-440
    • Maiecki, M.1    Skupien, J.2
  • 3
    • 0035106310 scopus 로고    scopus 로고
    • Putting the genes for type II diabetes on the map
    • DOI 10.1038/85405
    • K. Almind, A. Doria and C. R. Kahn, Putting the genes for type 2 diabetes on the map, Nat Med. 7 (2001) 277-279; DOI: 10.1038/85405. (Pubitemid 32224333)
    • (2001) Nature Medicine , vol.7 , Issue.3 , pp. 277-279
    • Almind, K.1    Doria, A.2    Kahn, C.R.3
  • 5
    • 41149084500 scopus 로고    scopus 로고
    • Clinical implications of a molecular genetic classification of monogenic beta-cell diabetes
    • DOI: 10.1038/ ncpendmet0778
    • R. Murphy, S. Ellard and A. T. Hattersley, Clinical implications of a molecular genetic classification of monogenic beta-cell diabetes, Nat. Clin. Pract. Endocr. Metab. 4 (2008) 200-213; DOI: 10.1038/ ncpendmet0778.
    • (2008) Nat. Clin. Pract. Endocr. Metab. , vol.4 , pp. 200-213
    • Murphy, R.1    Ellard, S.2    Hattersley, A.T.3
  • 7
    • 48949102448 scopus 로고    scopus 로고
    • Neonatal and late-onset diabetes mellitus caused by failure of pancreatic development: Report of 4 more cases and a review of the literature.
    • DOI: 10.1542/peds.2007-3543
    • C. Rongrong, H. Khalid and A. A. Maryam, Neonatal and late-onset diabetes mellitus caused by failure of pancreatic development: Report of 4 more cases and a review of the literature. Pediatrics 121 (2008) 1541-1547; DOI: 10.1542/peds.2007-3543.
    • (2008) Pediatrics , vol.121 , pp. 1541-1547
    • Rongrong, C.1    Khalid, H.2    Maryam, A.A.3
  • 8
    • 43549102666 scopus 로고    scopus 로고
    • Neonatal diabetes mellitus
    • DOI 10.1210/er.2007-0029
    • L. Aguilar-Bryan and J. Bryan, Neonatal diabetes mellitus, Endocr. Rev. 29 (2008) 265-291; DOI: 10.1210/er.2007-0029. (Pubitemid 351679699)
    • (2008) Endocrine Reviews , vol.29 , Issue.3 , pp. 265-291
    • Aguilar-Bryan, L.1    Bryan, J.2
  • 9
    • 34247880183 scopus 로고    scopus 로고
    • Neonatal diabetes mellitus: A disease linked to multiple mechanisms
    • DOI: 10.1186/1750-1172-2-12
    • M. Polak and H. Cavé, Neonatal diabetes mellitus: a disease linked to multiple mechanisms, Orphanet J. Rare Dis. 2 (2007) 12; DOI: 10.1186/1750-1172-2-12.
    • (2007) Orphanet J. Rare Dis. , vol.2 , pp. 12
    • Polak, M.1    Cavé, H.2
  • 10
    • 0037421590 scopus 로고    scopus 로고
    • Pharmacogenomics - Drug disposition, drug targets, and side effects
    • DOI 10.1056/NEJMra020526
    • W. E. Evans and H. L. McLeod, Pharmacogenomics - drug disposition, drug targets and side effects, N. Engl. J. Med. 6 (2003) 538-549; DOI: 10.1056/NEJMra020526. (Pubitemid 36159890)
    • (2003) New England Journal of Medicine , vol.348 , Issue.6 , pp. 538-549
    • Evans, W.E.1    McLeod, H.L.2
  • 11
    • 0037421584 scopus 로고    scopus 로고
    • Inheritance and drug response
    • DOI: 10.1056/ NEJMra020021
    • R.Weinshilboum, Inheritance and drug response, N. Engl. J. Med. 348 (2003) 529-537; DOI: 10.1056/ NEJMra020021.
    • (2003) N. Engl. J. Med. , vol.348 , pp. 529-537
    • Weinshilboum, R.1
  • 12
    • 0033569516 scopus 로고    scopus 로고
    • Pharmacogenomics: Translating functional genomics into rational therapeutics
    • DOI: 10.1126/science.286.5439.487
    • W. E. Evans and M. V. Relling, Pharmacogenomics: Translating functional genomics into rational therapeutics, Science 286 (1999) 487-491; DOI: 10.1126/science.286.5439.487.
    • (1999) Science , vol.286 , pp. 487-491
    • Evans, W.E.1    Relling, M.V.2
  • 13
    • 49949106373 scopus 로고    scopus 로고
    • Pharmacogenomics and drug toxicity
    • DOI: 10.1056/NEJMe0805136
    • Y. Nakamura, Pharmacogenomics and drug toxicity, N. Engl. J. Med. 8 (2008) 856-858; DOI: 10.1056/NEJMe0805136.
    • (2008) N. Engl. J. Med. , vol.8 , pp. 856-858
    • Nakamura, Y.1
  • 14
    • 35748961114 scopus 로고    scopus 로고
    • Identifying genetic risk factors for serious adverse drug reactions: Current progress and challenges
    • DOI 10.1038/nrd2423, PII NRD2423
    • R. A. Wilke, D. W. Lin, D. M. Roden, P. B. Watkins, D. Flockhart, I. Zineh, K. M. Giacomini and R. M. Krauss, Identifying genetic risk factors for serious adverse drug reactions: Current progress and challenges, Nat. Rev. Drug. Discov. 6 (2007) 904-916; DOI: 10.1038/nrd2423. (Pubitemid 350042398)
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.11 , pp. 904-916
    • Wilke, R.A.1    Lin, D.W.2    Roden, D.M.3    Watkins, P.B.4    Flockhart, D.5    Zineh, I.6    Giacomini, K.M.7    Krauss, R.M.8
  • 15
    • 69949151636 scopus 로고    scopus 로고
    • Frequency of C3435 MDR1 and A6896G CYP3A5 single nucleotide polymorphism in an Iranian population and comparison with other ethnic groups
    • N. Azarpira and M. H. Aghdaie, Frequency of C3435 MDR1 and A6896G CYP3A5 single nucleotide polymorphism in an Iranian population and comparison with other ethnic groups, Mod. J. Ist. Rep. Iran 20 (2006) 131-136.
    • (2006) Mod. J. Ist. Rep. Iran , vol.20 , pp. 131-136
    • Azarpira, N.1    Aghdaie, M.H.2
  • 16
    • 85176850633 scopus 로고    scopus 로고
    • Oral Pharmacological Agents for Type 2 Diabetes: Oral Agents, Incretions and other Non-Insulin Pharmacologic Interventions for Diabetes
    • Diabetes Manager (Eds. I. D. Goldfine and R. J. Rushakoff) last author version May 2010; access date Nov
    • J. L. Evans and R. J. Rushakoff, Oral Pharmacological Agents for Type 2 Diabetes: Oral Agents, Incretions and other Non-Insulin Pharmacologic Interventions for Diabetes, Endo Text. Org. - The Endocrine Source, Diabetes Manager (Eds. I. D. Goldfine and R. J. Rushakoff) last author version May 2010; http://diabetesmanager.pbworks.com/w/page/17680289/Oral-Pharmacological- Agents-for-Type-2-Diabetes, access date Nov. 5, 2010.
    • (2010) Endo Text. Org. - The Endocrine Source , vol.5
    • Evans, J.L.1    Rushakoff, R.J.2
  • 19
    • 70350517412 scopus 로고    scopus 로고
    • Type 2 diabetes: Where we are today: An overview of disease burden, current treatments, and treatment strategies
    • DOI: 10.1331/ JAPhA.2009.09077
    • R. K. Campbell, Type 2 diabetes: Where we are today: An overview of disease burden, current treatments, and treatment strategies, J. Am. Pharm. Assoc. 49 (Suppl 1) (2009) S3-S9; DOI: 10.1331/ JAPhA.2009.09077.
    • (2009) J. Am. Pharm. Assoc. , vol.49 , Issue.SUPPL. 1
    • Campbell, R.K.1
  • 20
    • 34248138844 scopus 로고    scopus 로고
    • Pharmacogenetics of metformin response: A step in the path toward personalized medicine
    • DOI 10.1172/JCI32133
    • M. L. Reitman and E. E. Schadt, Pharmacogenetics of metformin response: a step in the path toward personalized medicine, J. Clin. Invest. 117 (2007) 1226-1229; DOI: 10.1172/JCI32133. (Pubitemid 46718410)
    • (2007) Journal of Clinical Investigation , vol.117 , Issue.5 , pp. 1226-1229
    • Reitman, M.L.1    Schadt, E.E.2
  • 21
    • 58149335251 scopus 로고    scopus 로고
    • Learning from molecular genetics. Novel insights arising from the definition of genes for monogenic and type 2 diabetes
    • DOI: 10.2337/db08-0343
    • M. I. McCarthy and A. T. Hattersley, Learning from molecular genetics. Novel insights arising from the definition of genes for monogenic and type 2 diabetes, Diabetes 57 (2008) 2889-2898; DOI: 10.2337/db08-0343.
    • (2008) Diabetes , vol.57 , pp. 2889-2898
    • McCarthy, M.I.1    Hattersley, A.T.2
  • 22
    • 4043096481 scopus 로고    scopus 로고
    • Unlocking the secrets of the pancreatic β cell: Man and mouse provide the key
    • DOI 10.1172/JCI200422506
    • A. T. Hattersley, Unlocking the secrets of the pancreatic b cell: Man and mouse provide the key, J. Clin. Invest. 114 (2004) 314-316; DOI: 10.1172/JCI200422506. (Pubitemid 39071601)
    • (2004) Journal of Clinical Investigation , vol.114 , Issue.3 , pp. 314-316
    • Hattersley, A.T.1
  • 23
    • 33646778478 scopus 로고    scopus 로고
    • Minireview: Pharmacogenetics and beyond: The interaction of therapeutic response, β-cell physiology, and genetics in diabetes
    • DOI 10.1210/en.2006-0152
    • A. T. Hattersley and E. R. Pearson, Minireview: Pharmacogenetics and beyond: The interaction of therapeutic response, b-cell physiology, and genetics in diabetes, Endocrinology 147 (2006) 2657-2663; DOI: 10.1210/en.2006-0152. (Pubitemid 43764600)
    • (2006) Endocrinology , vol.147 , Issue.6 , pp. 2657-2663
    • Hattersley, A.T.1    Pearson, E.R.2
  • 24
    • 67649400464 scopus 로고    scopus 로고
    • Screening of mutations in the GCK gene in Jordanian maturity-onset diabetes of the young type 2 (MODY2) patients
    • DOI: 10.4238/vol8-2gmr597
    • R. Khalil, F. Al-Sheyab, E. Khamaiseh, M. A. Halaweh and H. A. Abder-Rahman, Screening of mutations in the GCK gene in Jordanian maturity-onset diabetes of the young type 2 (MODY2) patients, Genet. Mol. Res. 8 (2009) 500-506; DOI: 10.4238/vol8-2gmr597.
    • (2009) Genet. Mol. Res. , vol.8 , pp. 500-506
    • Khalil, R.1    Al-Sheyab, F.2    Khamaiseh, E.3    Halaweh, M.A.4    Abder-Rahman, H.A.5
  • 27
    • 0035122350 scopus 로고    scopus 로고
    • B-Cell genes and diabetes: Quantitative and qualitative differences in the pathophysiology of hepatic nuclear factor-1a and glucokinase mutations
    • DOI: 10.2337/diabetes.50.2007.S101
    • E. R. Pearson, G. Velho, P. Clark, A. Stride, M. Shepherd, T. M. Frayling, M. P. Bulman, S. Ellard, P. Froguel and A. T. Hattersley, b-Cell genes and diabetes: Quantitative and qualitative differences in the pathophysiology of hepatic nuclear factor-1a and glucokinase mutations, Diabetes 50 (2001) S101-S107; DOI: 10.2337/diabetes.50.2007.S101.
    • (2001) Diabetes , vol.50
    • Pearson, E.R.1    Velho, G.2    Clark, P.3    Stride, A.4    Shepherd, M.5    Frayling, T.M.6    Bulman, M.P.7    Ellard, S.8    Froguel, P.9    Hattersley, A.T.10
  • 28
    • 21544451980 scopus 로고    scopus 로고
    • β-cell dysfunction, insulin sensitivity, and glycosuria precede diabetes in hepatocyte nuclear factor-1α mutation carriers
    • DOI 10.2337/diacare.28.7.1751
    • A. Stride, S. Ellard, P. Clark, L. Shakespeare, M. Salzmann, M. Shepherd and A. T. Hattersley, b-Cell dysfunction, insulin sensitivity, and glycosuria precede diabetes in hepatocyte nuclear factor-1a mutation carriers, Diabetes Care 28 (2005) 1751-1756; DOI: 10.2337/diacare.28.7.1751. (Pubitemid 40923088)
    • (2005) Diabetes Care , vol.28 , Issue.7 , pp. 1751-1756
    • Stride, A.1    Ellard, S.2    Clark, P.3    Shakespeare, L.4    Salzmann, M.5    Shepherd, M.6    Hattersley, A.T.7
  • 31
    • 0034663750 scopus 로고    scopus 로고
    • Molecular targets of a human HNF1a mutation responsible for pancreatic b-cell dysfunction
    • DOI: 10.1093/emboj/19.16.4257
    • H. Wang, P. A. Antinozzi, K. A. Hagenfeldt, P. Maechler and C. B. Wollheim, Molecular targets of a human HNF1a mutation responsible for pancreatic b-cell dysfunction, EMBO J. 19 (2000) 4257-4264; DOI: 10.1093/emboj/19.16.4257.
    • (2000) EMBO J. , vol.19 , pp. 4257-4264
    • Wang, H.1    Antinozzi, P.A.2    Hagenfeldt, K.A.3    Maechler, P.4    Wollheim, C.B.5
  • 32
    • 0033847575 scopus 로고    scopus 로고
    • Sensitivity to sulphonylureas in patients with hepatocyte nuclear factor-1α gene mutations: Evidence for pharmacogenetics in diabetes
    • DOI 10.1046/j.1464-5491.2000.00305.x
    • E. R. Pearson, W. G. Liddell, M. Shepherd, R. J. Corrall and A. T. Hattersley, Sensitivity to sulphonylureas in patients with hepatocyte nuclear factor 1a gene mutations: Evidence for pharmacogenetics in diabetes, Diabetic Med. 17 (2000) 543-545; DOI: 10.1046/j.1464-5491.2000.00305.x. (Pubitemid 30660158)
    • (2000) Diabetic Medicine , vol.17 , Issue.7 , pp. 543-545
    • Pearson, E.R.1    Liddell, W.G.2    Shepherd, M.3    Corrall, R.J.4    Hattersley, A.T.5
  • 33
    • 0142186278 scopus 로고    scopus 로고
    • Genetic cause of hyperglycaemia and response to treatment in diabetes
    • DOI 10.1016/S0140-6736(03)14571-0
    • E. R. Pearson, B. J. Starkey, R. J. Powell, F. M. Gribble, P. M. Clark and A. T. Hattersley, Genetic cause of hyperglycaemia and response to treatment in diabetes, Lancet 362 (2003) 1275-1281; DOI: 10.1016/S0140-6736(03)14571-0. (Pubitemid 37324255)
    • (2003) Lancet , vol.362 , Issue.9392 , pp. 1275-1281
    • Pearson, E.R.1    Starkey, B.J.2    Powell, R.J.3    Gribble, F.M.4    Clark, P.M.5    Hattersley, A.T.6
  • 34
    • 0036895595 scopus 로고    scopus 로고
    • Decreased glibenclamide uptake in hepatocytes of hepatocyte nuclear factor-1a-deficient mice. A mechanism for hypersensitivity to sulfonylurea therapy in patients with Maturity-Onset Diabetes of the Young, Type 3 (MODY3)
    • DOI: 10.2337/diabetes.51.2007.S343
    • P. Boileau, C. Wolfrum, D. Q. Shih, T. A. Yang, A. W. Wolkoff and M. Stoffel1, Decreased glibenclamide uptake in hepatocytes of hepatocyte nuclear factor-1a-deficient mice. A mechanism for hypersensitivity to sulfonylurea therapy in patients with Maturity-Onset Diabetes of the Young, Type 3 (MODY3), Diabetes 51 (2002) 343-348; DOI: 10.2337/diabetes.51.2007.S343.
    • (2002) Diabetes , vol.51 , pp. 343-348
    • Boileau, P.1    Wolfrum, C.2    Shih, D.Q.3    Yang, T.A.4    Wolkoff, A.W.5    Stoffell, M.6
  • 35
    • 0032923404 scopus 로고    scopus 로고
    • A case of hepatocyte nuclear factor-1 diabetes/MODY3 masquerading as type 1 diabetes in a Mexican-American adolescent and responsive to a low dose of sulfonylurea [15]
    • DOI 10.2337/diacare.22.5.867
    • E. H. Hathout, B. N. Cockburn, J. W. Mace, J. Sharkney, J. Chen-Daniel and G. I. Bell, A case of hepatocyte nuclear factor-1a diabetes/MODY 3 masquerading as type 1 diabetes in a Mexican-American adolescent and responsive to a low dose of sulphonylurea (letter), Diabetes Care 22 (1999) 867-868; DOI: 10.2337/diacare.22.5.867. (Pubitemid 29220807)
    • (1999) Diabetes Care , vol.22 , Issue.5 , pp. 867-868
    • Hathout, E.H.1    Cockburn, B.N.2    MacE, J.W.3    Sharkey, J.4    Chen-Daniel, J.5    Bell, G.I.6
  • 36
    • 0037923100 scopus 로고    scopus 로고
    • Identifying hepatic nuclear factor 1α mutations in children and young adults with a clinical diagnosis of type 1 diabetes
    • DOI 10.2337/diacare.26.2.333
    • A. P. Lambert, S. Ellard, L. I. Allen, I. W. Gallen, K. M. Gillespie, P. Bingley and A. T. Hattersley, Identifying hepatic nuclear factor 1a mutations in children and young adults with a clinical diagnosis of type 1 diabetes, Diabetes Care 26 (2003) 333-337; DOI: 10.2337/diacare.26.2.333. (Pubitemid 36929051)
    • (2003) Diabetes Care , vol.26 , Issue.2 , pp. 333-337
    • Lambert, A.P.1    Ellard, S.2    Allen, L.I.S.3    Gallen, I.W.4    Gillespie, K.M.5    Bingley, P.J.6    Hattersley, A.T.7
  • 37
    • 0242363725 scopus 로고    scopus 로고
    • No deterioration in glycemic control in HNF-1a maturity-onset diabetes of the young following transfer from long-term insulin to sulphonylureas
    • DOI: 10.2337/diacare. 26.11.3191-a
    • M. Shepherd, E. R. Pearson, J. Houghton, G. Salt, S. Ellard and A. T. Hattersley, No deterioration in glycemic control in HNF-1a maturity-onset diabetes of the young following transfer from long-term insulin to sulphonylureas, Diabetes Care 26 (2003) 3191-3192; DOI: 10.2337/diacare. 26.11.3191-a.
    • (2003) Diabetes Care , vol.26 , pp. 3191-3192
    • Shepherd, M.1    Pearson, E.R.2    Houghton, J.3    Salt, G.4    Ellard, S.5    Hattersley, A.T.6
  • 38
    • 0032836391 scopus 로고    scopus 로고
    • A novel syndrome of diabetes mellitus, renal dysfunction and genital malformation associated with a partial deletion of the pseudo-POU domain of hepatocyte nuclear factor-1β
    • DOI 10.1093/hmg/8.11.2001
    • T. H. Lindner, P. R. Njolstad, Y. Horikawa, L. Bostad, G. I. Bell and O. Sovik, A novel syndrome of diabetes mellitus, renal dysfunction and genital malformation associated with a partial deletion of the pseudo-POU domain of hepatocyte nuclear factor-1b, Hum. Mol. Genet. 8 (1999) 2001-2008; DOI: 10.1093/hmg/8.11.2001. (Pubitemid 29458726)
    • (1999) Human Molecular Genetics , vol.8 , Issue.11 , pp. 2001-2008
    • Lindner, T.H.1    Njolstad, P.R.2    Horikawa, Y.3    Bostad, L.4    Bell, G.I.5    Sovik, O.6
  • 39
    • 2342472176 scopus 로고    scopus 로고
    • Contrasting Diabetes Phenotypes Associated with Hepatocyte Nuclear Factor-1α and -1β Mutations
    • DOI 10.2337/diacare.27.5.1102
    • E. R. Pearson, M. K. Badman, C. R. Lockwood, P. M. Clark, S. Ellard, C. Bingham and A. T. Hattersley, Contrasting diabetes phenotypes associated with hepatocyte nuclear factor-1a and -1b mutations, Diabetes Care 27 (2004) 1102-1107; DOI: 10.2337/diacare.27.5.1102. (Pubitemid 38579773)
    • (2004) Diabetes Care , vol.27 , Issue.5 , pp. 1102-1107
    • Pearson, E.R.1    Badman, M.K.2    Lockwood, C.R.3    Clark, P.M.4    Ellard, S.5    Bingham, C.6    Hattersley, A.T.7
  • 41
    • 33847025257 scopus 로고    scopus 로고
    • An ATP-binding mutation (G334D) in KCNJ11 is associated with a sulfonylurea-insensitive form of developmental delay, epilepsy, and neonatal diabetes
    • DOI: 10.2337/ db06-1275
    • R. Masia, J. C. Koster, S. Tumini, F. Chiarelli, C. Colombo, C. G. Nichols and F. Barbetti, An ATP-binding mutation (G334D) in KCNJ11 is associated with a sulfonylurea-insensitive form of developmental delay, epilepsy, and neonatal diabetes, Diabetes 56 (2007) 328-336; DOI: 10.2337/ db06-1275.
    • (2007) Diabetes , vol.56 , pp. 328-336
    • Masia, R.1    Koster, J.C.2    Tumini, S.3    Chiarelli, F.4    Colombo, C.5    Nichols, C.G.6    Barbetti, F.7
  • 42
    • 33746681908 scopus 로고    scopus 로고
    • ATP-sensitive potassium channels - Neonatal diabetes mellitus and beyond
    • DOI 10.1056/NEJMe068142
    • M. A. Sperling, ATP-sensitive potassium channels - neonatal diabetes mellitus and beyond, N. Engl. J. Med. 355 (2006) 507-510; DOI: 10.1056/NEJMe068142. (Pubitemid 44162279)
    • (2006) New England Journal of Medicine , vol.355 , Issue.5 , pp. 507-510
    • Sperling, M.A.1
  • 43
    • 0242415358 scopus 로고    scopus 로고
    • ATP Channels: Function Fits Form
    • DOI 10.1085/jgp.200308878
    • D. Enkvetchakul and C. G. Nichols, Gating mechanism of KATP channels: Function fits form, J. Gen. Physiol. 5 (2003) 471-480; DOI: 10.1085/jgp. 200308878. (Pubitemid 37420843)
    • (2003) Journal of General Physiology , vol.122 , Issue.5 , pp. 471-480
    • Enkvetchakul, D.1    Nichols, C.G.2
  • 46
    • 24144456153 scopus 로고    scopus 로고
    • + channels in neonatal diabetes: Implications for pharmacogenomic therapy
    • DOI 10.2337/diabetes.54.9.2645
    • J. C. Koster, M. S. Remedi, C. Dao and C. G. Nichols, ATP and sulfonylurea sensitivity of mutant ATP-sensitive K+ channels in neonatal diabetes: Implications for pharmacogenomic therapy, Diabetes 54 (2005) 2645-2654; DOI: 10.2337/diabetes.54.9.2645. (Pubitemid 41233586)
    • (2005) Diabetes , vol.54 , Issue.9 , pp. 2645-2654
    • Koster, J.C.1    Remedi, M.S.2    Dao, C.3    Nichols, C.G.4
  • 49
    • 8744262895 scopus 로고    scopus 로고
    • Glibenclamide treatment in permanent neonatal diabetes mellitus due to an activating mutation in Kir6.2
    • DOI 10.1210/jc.2004-1241
    • A. Zung, B. Glaser, R. Nimri and Z. Zadik, Glibenclamide treatment in permanent neonatal diabetes mellitus due to an activating mutation in Kir6.2, J. Clin. Endocrinol. Metab. 89 (2004) 5504-5507; DOI: 10.1210/jc.2004-1241. (Pubitemid 39518433)
    • (2004) Journal of Clinical Endocrinology and Metabolism , vol.89 , Issue.11 , pp. 5504-5507
    • Zung, A.1    Glaser, B.2    Nimri, R.3    Zadik, Z.4
  • 50
    • 55949116427 scopus 로고    scopus 로고
    • Chronic antidiabetic sulfonylureas in vivo: Reversible effects on mouse pancreatic b-cells
    • DOI: 10.1371/journal.pmed.0050206
    • M. S. Remedi and C. G. Nichols, Chronic antidiabetic sulfonylureas in vivo: Reversible effects on mouse pancreatic b-cells, PLoS Med. 5 (2008) e206; DOI: 10.1371/journal.pmed.0050206.
    • (2008) PLoS Med. , vol.5
    • Remedi, M.S.1    Nichols, C.G.2
  • 51
    • 33744965950 scopus 로고    scopus 로고
    • The E23K variant of KCNJ11 encoding the pancreatic β-cell adenosine 5′-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes
    • DOI 10.1210/jc.2005-2323
    • G. Sesti, E. Laratta, M. Cardellini, F. Andreozzi, S. Del Guerra, C. Irace, A. Gnasso, M. Grupillo, R. Lauro, M. L. Hribal, F. Perticone and P. Marchetti, The E23K variant of KCNJ11 encoding the pancreatic b-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes, J. Clin. Endocr. Metab. 91 (2006) 2334-2339; DOI: 10.1210/jc.2005- 2323. (Pubitemid 43855025)
    • (2006) Journal of Clinical Endocrinology and Metabolism , vol.91 , Issue.6 , pp. 2334-2339
    • Sesti, G.1    Laratta, E.2    Cardellini, M.3    Andreozzi, F.4    Del Guerra, S.5    Irace, C.6    Gnasso, A.7    Grupillo, M.8    Lauro, R.9    Hribal, M.L.10    Perticone, F.11    Marchetti, P.12
  • 52
    • 29244482237 scopus 로고    scopus 로고
    • Effect of genetic polymorphisms in cytochrome P450 (CYP) 2C9 and CYP2C8 on the pharmacokinetics of oral antidiabetic drugs: Clinical relevance
    • DOI 10.2165/00003088-200544120-00002
    • J. Kirchheiner, I. Roots, M. Goldammer, B. Rosenkranz and J. Brockmöller, Effect of genetic polymorphisms in cytochrome p450 (CYP) 2C9 and CYP2C8 on the pharmacokinetics of oral antidiabetic drugs: Clinical relevance, Clin. Pharmacokin. 44 (2005) 1209-1225; DOI: 10.2165/00003088- 200544120-00002. (Pubitemid 41832564)
    • (2005) Clinical Pharmacokinetics , vol.44 , Issue.12 , pp. 1209-1225
    • Kirchheiner, J.1    Roots, I.2    Goldammer, M.3    Rosenkranz, B.4    Brockmoller, J.5
  • 53
    • 21744439005 scopus 로고    scopus 로고
    • Association between CYP2C9 slow metabolizer genotypes and severe hypoglycaemia on medication with sulphonylurea hypoglycaemic agents
    • DOI 10.1111/j.1365-2125.2005.02379.x
    • A. Holstein, A. Plaschke, M. Ptak, E. H. Egberts, J. El-Din, J. Brockmöller and J. Kirchheiner, Association between CYP2C9 slow metabolizer genotypes and severe hypoglycaemia on medication with sulphonylurea hypoglycaemic agents, Br. J. Clin. Pharmacol. 60 (2005) 103-106; DOI: 10.1111/j.1365-2125.2005.02379.x. (Pubitemid 40942788)
    • (2005) British Journal of Clinical Pharmacology , vol.60 , Issue.1 , pp. 103-106
    • Holstein, A.1    Plaschke, A.2    Ptak, M.3    Egberts, E.-H.4    El-Din, J.5    Brockmoller, J.6    Kirchheiner, J.7
  • 54
    • 0036231580 scopus 로고    scopus 로고
    • Impact of CYP2C9 amino acid polymorphisms on glyburide kinetics and on the insulin and glucose response in healthy volunteers
    • DOI 10.1067/mcp.2002.122476
    • J. Kirchheiner, J. Brockmöller, I. Meineke, S. Bauer, W. Rohde, C. Meisel and I. Roots, Impact of CYP2C9 amino acid polymorphisms on glyburide kinetics and on the insulin and glucose response in healthy volunteers, Clin. Pharmacol. Ther. 71 (2002) 286-296; DOI: 10.1067/mcp.2002. 122476. (Pubitemid 34311458)
    • (2002) Clinical Pharmacology and Therapeutics , vol.71 , Issue.4 , pp. 286-296
    • Kirchheiner, J.1    Brockmoller, J.2    Meineke, I.3    Bauer, S.4    Rohde, W.5    Meisel, C.6    Roots, I.7
  • 55
    • 0036220552 scopus 로고    scopus 로고
    • Impact of CYP2C9 and CYP2C19 polymorphisms on tolbutamide kinetics and the insulin and glucose response in healthy volunteers
    • DOI 10.1097/00008571-200203000-00004
    • J. Kirchheiner, S. Bauer, I. Meineke, W. Rohde, V. Prang, C. Meisel, I. Roots and J. Brockmöller, Impact of CYP2C9 and CYP2C19 polymorphisms on tolbutamide kinetics and on the insulin and glucose response in healthy volunteers, Pharmacogenetics 12 (2002) 101-109; DOI: 10.1067/ mcp.2002.122476. (Pubitemid 34298914)
    • (2002) Pharmacogenetics , vol.12 , Issue.2 , pp. 101-109
    • Kirchheiner, J.1    Bauer, S.2    Meineke, I.3    Rohde, W.4    Prang, V.5    Meisel, C.6    Roots, I.7    Brockmoller, J.8
  • 56
    • 1842505044 scopus 로고    scopus 로고
    • Influence of CYP2C9 and CYP2D6 polymorphisms on the pharmacokinetics of nateglinide in genotyped healthy volunteers
    • DOI 10.2165/00003088-200443040-00005
    • J. Kirchheiner, I. Meineke, G. Müller, S. Bauer, W. Rohde, C. Meisel, I. Roots and J. Brockmöller, Influence of CYP2C9 and CYP2D6 polymorphisms on pharmacokinetics of nateglinide in genotyped healthy volunteers, J. Clin. Pharmacokin. 43 (2004) 267-278; DOI: 10.2165/00003088- 200443040-00005. (Pubitemid 38429306)
    • (2004) Clinical Pharmacokinetics , vol.43 , Issue.4 , pp. 267-278
    • Kirchheiner, J.1    Meineke, I.2    Muller, G.3    Bauer, S.4    Rohde, W.5    Meisel, C.6    Roots, I.7    Brockmoller, J.8
  • 57
    • 77953258349 scopus 로고    scopus 로고
    • IGF2BP2 variations influence repaglinide response and risk of type 2 diabetes in Chinese population
    • DOI: 10.1038/aps.2010.47
    • Q. Huang, J. Y. Yin, X. P. Dai, Q. Pei, M. Dong, Z. G. Zhou, X. Huang, M. Yu, H. H. Zhou and Z. Q. Liu, IGF2BP2 variations influence repaglinide response and risk of type 2 diabetes in Chinese population, Acta Pharmacol. Sin. 31 (2010) 709-717; DOI: 10.1038/aps.2010.47.
    • (2010) Acta Pharmacol. Sin. , vol.31 , pp. 709-717
    • Huang, Q.1    Yin, J.Y.2    Dai, X.P.3    Pei, Q.4    Dong, M.5    Zhou, Z.G.6    Huangc, X.7    Yu, M.8    Zhou, H.H.9    Liu, Z.Q.10
  • 61
    • 33644664085 scopus 로고    scopus 로고
    • Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1
    • DOI: 10.2133/dmpk.20.379
    • N. Kimura, S. Masuda, Y. Tanihara, H. Ueo, M. Okuda, T. Katsura and K. Inui, Metformin is a superior substrate for renal organic cation transporter OCT2 rather than hepatic OCT1, Drug Metab. Pharmacokin. 20 (2005) 379-386; DOI: 10.2133/dmpk.20.379.
    • (2005) Drug Metab. Pharmacokin. , vol.20 , pp. 379-386
    • Kimura, N.1    Masuda, S.2    Tanihara, Y.3    Ueo, H.4    Okuda, M.5    Katsura, T.6    Inui, K.7
  • 63
    • 33644669582 scopus 로고    scopus 로고
    • Sequence variation in PPARG may underlie differential response to troglitazone
    • DOI 10.2337/diabetes.54.11.3319
    • J. K. Wolford, K. A. Yeatts, S. K. Dhanjal, M. H. Black, A. H. Xiang, T. A. Buchanan and R. M. Watanabe, Sequence variation in PPARG may underlie differential response to troglitazone, Diabetes 54 (2005) 3319-3325; DOI: 10.2337/diabetes.54.11.3319. (Pubitemid 43334389)
    • (2005) Diabetes , vol.54 , Issue.11 , pp. 3319-3325
    • Wolford, J.K.1    Yeatts, K.A.2    Dhanjal, S.K.3    Black, M.H.4    Xiang, A.H.5    Buchanan, T.A.6    Watanabe, R.M.7
  • 64
    • 2542443906 scopus 로고    scopus 로고
    • Troglitazone in prevention of diabetes (TRIPOD) study, Changes in insulin sensitivity in response to troglitazone do not differ between subjects with and without the common, functional Pro12Ala PPAR-g-2 gene variant: Results from the troglitazone in prevention of diabetes (TRIPOD) study
    • DOI: 10.2337/diacare. 27.6.1365
    • S. Snitker, R. M. Watanabe, I. Ani, A. H. Xiang, A. Marroquin, C. Ochoa, J. Goico, A. R. Shuldiner and T. A. Buchanan, Troglitazone in prevention of diabetes (TRIPOD) study, Changes in insulin sensitivity in response to troglitazone do not differ between subjects with and without the common, functional Pro12Ala PPAR-g-2 gene variant: Results from the troglitazone in prevention of diabetes (TRIPOD) study, Diabetes Care 27 (2004) 1365-1368; DOI: 10.2337/diacare. 27.6.1365.
    • (2004) Diabetes Care , vol.27 , pp. 1365-1368
    • Snitker, S.1    Watanabe, R.M.2    Ani, I.3    Xiang, A.H.4    Marroquin, A.5    Ochoa, C.6    Goico, J.7    Shuldiner, A.R.8    Buchanan, T.A.9
  • 65
    • 18344417084 scopus 로고    scopus 로고
    • Analysis of the relationship between the Pro12Ala variant in the PPAR-γ2 gene and the response rate to therapy with pioglitazone in patients with type 2 diabetes
    • DOI 10.2337/diacare.26.3.825
    • M. Blüher, G. Lübben and R. Paschke, Analysis of the relationship between the Pro12Ala variant in the PPAR-g2 gene and the response rate to therapy with pioglitazone in patients with type 2 diabetes, Diabetes Care 26 (2003) 825-831; DOI: 10.2337/diacare.26.3.825. (Pubitemid 36929350)
    • (2003) Diabetes Care , vol.26 , Issue.3 , pp. 825-831
    • Bluher, M.1    Lubben, G.2    Paschke, R.3
  • 66
    • 78650571748 scopus 로고    scopus 로고
    • Effects of the peroxisome proliferator activated receptor-g coactivator-1a (PGC-1a) Thr394Thr and Gly482Ser polymorphisms on rosiglitazone response in Chinese patients with type 2 diabetes mellitus
    • DOI: 10.1177/0091270009355159
    • K. H. Zhang, Q. Huang, X. P. Dai, J. Y. Yin, W. Zhang, G. Zhou, H. H. Zhou and Z. Q. Liu, Effects of the peroxisome proliferator activated receptor-g coactivator-1a (PGC-1a) Thr394Thr and Gly482Ser polymorphisms on rosiglitazone response in Chinese patients with type 2 diabetes mellitus, J. Clin. Pharmacol. 50 (2010) 1022-1030; DOI: 10.1177/0091270009355159.
    • (2010) J. Clin. Pharmacol. , vol.50 , pp. 1022-1030
    • Zhang, K.H.1    Huang, Q.2    Dai, X.P.3    Yin, J.Y.4    Zhang, W.5    Zhou, G.6    Zhou, H.H.7    Liu, Z.Q.8
  • 67
    • 20044366932 scopus 로고    scopus 로고
    • Pharmacogenetic analysis of rosiglitazone-induced hepatosteatosis in new mouse models of type 2 diabetes
    • DOI 10.2337/diabetes.54.6.1854
    • H. J. Pan, P. Reifsnyder, D. E. Vance, Q. Xiao and E. H. Leiter, Pharmacogenetic analysis of rosiglitazone- induced hepatosteatosis in new mouse models of type 2 diabetes, Diabetes 54 (2005) 1854-1862; DOI: 10.2337/diabetes.54.6.1854. (Pubitemid 40770777)
    • (2005) Diabetes , vol.54 , Issue.6 , pp. 1854-1862
    • Pan, H.-J.1    Reifsnyder, P.2    Vance, D.E.3    Xiao, Q.4    Leiter, E.H.5
  • 68
    • 8744241615 scopus 로고    scopus 로고
    • Targeted deletion of hepatic CTP:phosphocholine cytidylyltransferase α in mice decreases plasma high density and very low density lipoproteins
    • DOI 10.1074/jbc.M404027200
    • R. L. Jacobs, C. Devlin, I. Tabas and D. E. Vance, Targeted deletion of hepatic CTP: phosphocholine cytidyltransferase a in mice decreases plasma high density and very low density lipoproteins, J. Biol. Chem. 279 (2004) 47402-47410; DOI: 10.1074/jbc.M404027200. (Pubitemid 39518397)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.45 , pp. 47402-47410
    • Jacobs, R.L.1    Devlin, C.2    Tabas, I.3    Vance, D.E.4


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