-
1
-
-
57749188299
-
Targeting cancer with small molecule kinase inhibitors
-
Zhang J, Yang PL, Gray NS: Targeting cancer with small molecule kinase inhibitors. Nat. Rev. Cancer 9, 28-39 (2009).
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 28-39
-
-
Zhang, J.1
Yang, P.L.2
Gray, N.S.3
-
2
-
-
77954623320
-
Tyrosine kinase inhibitors: The first decade
-
Agrawal M, Garg RJ, Cortes J, Quintás-Cardama A: Tyrosine kinase inhibitors: the first decade. Curr. Hematol. Malig. Rep. 5, 70-80 (2010).
-
(2010)
Curr. Hematol. Malig. Rep.
, vol.5
, pp. 70-80
-
-
Agrawal, M.1
Garg, R.J.2
Cortes, J.3
Quintás-Cardama, A.4
-
3
-
-
77949957365
-
Cell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agents
-
Sharma SV, Haber DA, Settleman J: Cell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agents. Nat. Rev. Cancer 10, 241-253 (2010).
-
(2010)
Nat. Rev. Cancer
, vol.10
, pp. 241-253
-
-
Sharma, S.V.1
Haber, D.A.2
Settleman, J.3
-
4
-
-
75149130051
-
Targeting the cancer kinome through polypharmacology
-
Summary of US FDA-approved TKIs and their targets
-
Knight ZA, Lin H, Shokat KM: Targeting the cancer kinome through polypharmacology. Nat. Rev. Cancer 10, 130-137 (2010). n Summary of US FDA-approved TKIs and their targets.
-
(2010)
Nat. Rev. Cancer
, vol.10
, pp. 130-137
-
-
Knight, Z.A.1
Lin, H.2
Shokat, K.M.3
-
5
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
DOI 10.1056/NEJM200104053441401
-
Druker BJ, Talpaz M, Resta DJ et al.: Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N. Engl. J. Med. 344, 1031-1037 (2001). (Pubitemid 32267972)
-
(2001)
New England Journal of Medicine
, vol.344
, Issue.14
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.J.3
Peng, B.4
Buchdunger, E.5
Ford, J.M.6
Lydon, N.B.7
Kantarjian, H.8
Capdeville, R.9
Ohno-Jones, S.10
Sawyers, C.L.11
-
6
-
-
0037103424
-
Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors
-
DOI 10.1056/NEJMoa020461
-
Demetri GD, von Mehren M, Blanke CD et al.: Efficacy and safety of imatinib mesylate in advanced gastrointestinal stromal tumors. N. Engl. J. Med. 347, 472-480 (2002). (Pubitemid 34879334)
-
(2002)
New England Journal of Medicine
, vol.347
, Issue.7
, pp. 472-480
-
-
Demetri, G.D.1
Von Mehren, M.2
Blanke, C.D.3
Van Den Abbeele, A.D.4
Eisenberg, B.5
Roberts, P.J.6
Heinrich, M.C.7
Tuveson, D.A.8
Singer, S.9
Janicek, M.10
Fletcher, J.A.11
Silverman, S.G.12
Silberman, S.L.13
Capdeville, R.14
Kiese, B.15
Peng, B.16
Dimitrijevic, S.17
Druker, B.J.18
Corless, C.19
Fletcher, C.D.M.20
Joensuu, H.21
more..
-
7
-
-
0035960428
-
European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group. Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: A Phase I study
-
van Oosterom AT, Judson I, Verweij J et al.: European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group. Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: a Phase I study. Lancet 358, 1421-1423 (2001).
-
(2001)
Lancet
, vol.358
, pp. 1421-1423
-
-
Van Oosterom, A.T.1
Judson, I.2
Verweij, J.3
-
8
-
-
0029947186
-
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
-
DOI 10.1038/nm0596-561
-
Druker BJ, Tamura S, Buchdunger E et al.: Effects of s selective inhibitor of the Abl tyrosine kinase on the growth of BCR-ABL positive cells. Nat. Med. 2, 561-566 (1996). (Pubitemid 26151518)
-
(1996)
Nature Medicine
, vol.2
, Issue.5
, pp. 561-566
-
-
Druker, B.J.1
Tamura, S.2
Buchdunger, E.3
Ohno, S.4
Segal, G.M.5
Fanning, S.6
Zimmermann, J.7
Lydon, N.B.8
-
9
-
-
33846621955
-
Small molecule tyrosine kinase inhibitors in the treatment of solid tumors: An update of recent developments
-
DOI 10.1245/s10434-006-9227-1
-
Steeghs N, Nortier JW, Gelderblom H: Small molecule tyrosine kinase inhibitors in the treatment of solid tumors: an update of recent developments. Ann. Surg. Oncol. 14, 942-953 (2007). (Pubitemid 46175346)
-
(2007)
Annals of Surgical Oncology
, vol.14
, Issue.2
, pp. 942-953
-
-
Steeghs, N.1
Nortier, J.W.R.2
Gelderblom, H.3
-
10
-
-
38649129787
-
New developments in multitargeted therapy for patients with solid tumours
-
DOI 10.1016/j.ctrv.2007.09.003, PII S0305737207001375
-
Le Tourneau C, Faivre S, Raymond E: New developments in multitargeted therapy for patients with solid tumours. Cancer Treat. Rev. 34, 37-48 (2008). (Pubitemid 351168610)
-
(2008)
Cancer Treatment Reviews
, vol.34
, Issue.1
, pp. 37-48
-
-
Le Tourneau, C.1
Faivre, S.2
Raymond, E.3
-
11
-
-
63449112585
-
Therapeutic protein kinase inhibitors
-
Grant SK: Therapeutic protein kinase inhibitors. Cell Mol. Life Sci. 66, 1163-1177 (2009).
-
(2009)
Cell Mol. Life Sci.
, vol.66
, pp. 1163-1177
-
-
Grant, S.K.1
-
12
-
-
0012381722
-
Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer
-
DOI 10.1200/JCO.2003.10.038
-
Fukuoka M, Yano S, Giaccone G et al.: Multi-institutional randomized Phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (the IDEAL 1 trial). J. Clin. Oncol. 21, 2237-2246 (2003). (Pubitemid 46621858)
-
(2003)
Journal of Clinical Oncology
, vol.21
, Issue.12
, pp. 2237-2246
-
-
Fukuoka, M.1
Yano, S.2
Giaccone, G.3
Tamura, T.4
Nakagawa, K.5
Douillard, J.-Y.6
Nishiwaki, Y.7
Vansteenkiste, J.8
Kudoh, S.9
Rischin, D.10
Eek, R.11
Horai, T.12
Noda, K.13
Takata, I.14
Smit, E.15
Averbuch, S.16
Macleod, A.17
Feyereislova, A.18
Dong, R.-P.19
Baselga, J.20
more..
-
13
-
-
0142055937
-
Efficacy of Gefitinib, an Inhibitor of the Epidermal Growth Factor Receptor Tyrosine Kinase, in Symptomatic Patients with Non-Small Cell Lung Cancer: A Randomized Trial
-
DOI 10.1001/jama.290.16.2149
-
Kris MG, Natale RB, Herbst RS et al.: Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial. JAMA 290, 2149-2158 (2003). (Pubitemid 37432975)
-
(2003)
Journal of the American Medical Association
, vol.290
, Issue.16
, pp. 2149-2158
-
-
Kris, M.G.1
Natale, R.B.2
Herbst, R.S.3
Lynch Jr., T.J.4
Prager, D.5
Belani, C.P.6
Schiller, J.H.7
Kelly, K.8
Spiridonidis, H.9
Sandler, A.10
Albain, K.S.11
Cella, D.12
Wolf, M.K.13
Averbuch, S.D.14
Ochs, J.J.15
Kay, A.C.16
-
14
-
-
22044445517
-
Clinical Trials Group. Erlotinib in previously treated non-small-cell lung cancer
-
Shepherd FA, Rodrigues Pereira J, Ciuleanu T et al.: Clinical Trials Group. Erlotinib in previously treated non-small-cell lung cancer. N. Engl. J. Med. 353, 123-132 (2005).
-
(2005)
N. Engl. J. Med.
, vol.353
, pp. 123-132
-
-
Shepherd, F.A.1
Rodrigues Pereira, J.2
Ciuleanu, T.3
-
15
-
-
33846148701
-
Sorafenib in advanced clear-cell renal-cell carcinoma
-
DOI 10.1056/NEJMoa060655
-
Escudier B, Eisen T, Stadler WM et al.: Sorafenib in advanced clear-cell renal-cell carcinoma. N. Engl. J. Med. 356, 125-134 (2007). (Pubitemid 46089673)
-
(2007)
New England Journal of Medicine
, vol.356
, Issue.2
, pp. 125-134
-
-
Escudier, B.1
Eisen, T.2
Stadler, W.M.3
Szczylik, C.4
Oudard, S.5
Siebels, M.6
Negrier, S.7
Chevreau, C.8
Solska, E.9
Desai, A.A.10
Rolland, F.11
Demkow, T.12
Hutson, T.E.13
Gore, M.14
Freeman, S.15
Schwartz, B.16
Shan, M.17
Simantov, R.18
Bukowski, R.M.19
-
16
-
-
47949116252
-
Sorafenib in advanced hepatocellular carcinoma
-
Llovet JM, Ricci S, Mazzaferro V et al.: Sorafenib in advanced hepatocellular carcinoma. N. Engl. J. Med. 359, 378-390 (2008).
-
(2008)
N. Engl. J. Med.
, vol.359
, pp. 378-390
-
-
Llovet, J.M.1
Ricci, S.2
Mazzaferro, V.3
-
17
-
-
33846181370
-
Sunitinib versus interferon alfa in metastatic renal-cell carcinoma
-
DOI 10.1056/NEJMoa065044
-
Motzer RJ, Hutson TE, Tomczak P et al.: Sunitinib versus interferon a in metastatic renal-cell carcinoma. N. Engl. J. Med. 356, 115-124 (2007). (Pubitemid 46089672)
-
(2007)
New England Journal of Medicine
, vol.356
, Issue.2
, pp. 115-124
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
Michaelson, D.4
Bukowski, R.M.5
Rixe, O.6
Oudard, S.7
Negrier, S.8
Szczylik, C.9
Kim, S.T.10
Chen, I.11
Bycott, P.W.12
Baum, C.M.13
Figlin, R.A.14
-
18
-
-
68949145218
-
Overall survival and updated results for sunitinib compared with interferon a in patients with metastatic renal cell carcinoma
-
Motzer RJ, Hutson TE, Tomczak P et al.: Overall survival and updated results for sunitinib compared with interferon a in patients with metastatic renal cell carcinoma. J. Clin. Oncol. 27, 3584-3590 (2009).
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 3584-3590
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
-
19
-
-
0035800507
-
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
-
DOI 10.1126/science.1062538
-
Gorre ME, Mohammed M, Ellwood K et al.: Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 293, 876-880 (2001). (Pubitemid 32743979)
-
(2001)
Science
, vol.293
, Issue.5531
, pp. 876-880
-
-
Gorre, M.E.1
Mohammed, M.2
Ellwood, K.3
Hsu, N.4
Paquette, R.5
Nagesh Rao, P.6
Sawyers, C.L.7
-
20
-
-
20844448396
-
A new mutation in the KIT ATP pocket causes acquired resistance to imatinib in a gastrointestinal stromal tumor patient
-
DOI 10.1053/j.gastro.2004.02.021, PII S0016508504002203
-
Tamborini E, Bonadiman L, Greco A et al.: A new mutation in the Kit ATP pocket causes acquired resistance to imatinib in a gastrointestinal stromal tumor patient. Gastroenterology 127, 294-299 (2004). (Pubitemid 38962296)
-
(2004)
Gastroenterology
, vol.127
, Issue.1
, pp. 294-299
-
-
Tamborini, E.1
Bonadiman, L.2
Greco, A.3
Albertini, V.4
Negri, T.5
Gronchi, A.6
Bertulli, R.7
Colecchia, M.8
Casali, P.G.9
Pierotti, M.A.10
Pilotti, S.11
-
21
-
-
18244371651
-
Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
-
DOI 10.1371/journal.pmed.0020073, e73
-
Pao W, Miller VA, Politi KA et al.: Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med. 2, E73 (2005). (Pubitemid 40629469)
-
(2005)
PLoS Medicine
, vol.2
, Issue.3
, pp. 0225-0235
-
-
Pao, W.1
Miller, V.A.2
Politi, K.A.3
Riely, G.J.4
Somwar, R.5
Zakowski, M.F.6
Kris, M.G.7
Varmus, H.8
-
22
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
DOI 10.1126/science.1141478
-
Engelman JA, Zejnullahu K, Mitsudomi T et al.: MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 316, 1039-1043 (2007). n Demonstrates the resistance mechanism of TKI. (Pubitemid 46799492)
-
(2007)
Science
, vol.316
, Issue.5827
, pp. 1039-1043
-
-
Engelman, J.A.1
Zejnullahu, K.2
Mitsudomi, T.3
Song, Y.4
Hyland, C.5
Joon, O.P.6
Lindeman, N.7
Gale, C.-M.8
Zhao, X.9
Christensen, J.10
Kosaka, T.11
Holmes, A.J.12
Rogers, A.M.13
Cappuzzo, F.14
Mok, T.15
Lee, C.16
Johnson, B.E.17
Cantley, L.C.18
Janne, P.A.19
-
23
-
-
33846552656
-
Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3
-
DOI 10.1038/nature05474, PII NATURE05474
-
Sergina NV, Rausch M, Wang D et al.: Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3. Nature 445, 437-441 (2007). (Pubitemid 46160912)
-
(2007)
Nature
, vol.445
, Issue.7126
, pp. 437-441
-
-
Sergina, N.V.1
Rausch, M.2
Wang, D.3
Blair, J.4
Hann, B.5
Shokat, K.M.6
Moasser, M.M.7
-
24
-
-
56449089812
-
Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations
-
Yano S, Wang W, Li Q et al.: Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations. Cancer Res. 68, 9479-9487 (2008).
-
(2008)
Cancer Res.
, vol.68
, pp. 9479-9487
-
-
Yano, S.1
Wang, W.2
Li, Q.3
-
25
-
-
34547820876
-
+ myeloid cells
-
DOI 10.1038/nbt1323, PII NBT1323
-
+ myeloid cells. (Pubitemid 47236916)
-
(2007)
Nature Biotechnology
, vol.25
, Issue.8
, pp. 911-920
-
-
Shojaei, F.1
Wu, X.2
Malik, A.K.3
Zhong, C.4
Baldwin, M.E.5
Schanz, S.6
Fuh, G.7
Gerber, H.-P.8
Ferrara, N.9
-
26
-
-
66149092730
-
G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models
-
Describes the relationship of anti-VEGF therapy and myeloid cells
-
Shojaei F, Wu X, Qu X et al.: G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models. Proc. Natl Acad. Sci. USA 106, 6742-6747 (2009). n Describes the relationship of anti-VEGF therapy and myeloid cells.
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 6742-6747
-
-
Shojaei, F.1
Wu, X.2
Qu, X.3
-
27
-
-
77951754469
-
Direct and differential suppression of myeloid-derived suppressor cell subsets by sunitinib is compartmentally constrained
-
Novel finding regarding the role of granulocyte-macrophage-colony stimulating factor in the effects of sunitinib on myeloid-derived suppressor cells (MDSCs
-
Ko JS, Rayman P, Ireland J et al.: Direct and differential suppression of myeloid-derived suppressor cell subsets by sunitinib is compartmentally constrained. Cancer Res. 70, 3526-3536 (2010). nn Novel finding regarding the role of granulocyte-macrophage-colony stimulating factor in the effects of sunitinib on myeloid-derived suppressor cells (MDSCs).
-
(2010)
Cancer Res.
, vol.70
, pp. 3526-3536
-
-
Ko, J.S.1
Rayman, P.2
Ireland, J.3
-
28
-
-
3042844293
-
Cancer immunotherapy: A treatment for the masses
-
Blattman JN, Greenberg PD: Cancer immunotherapy: a treatment for the masses. Science 305, 200-205 (2004).
-
(2004)
Science
, vol.305
, pp. 200-205
-
-
Blattman, J.N.1
Greenberg, P.D.2
-
29
-
-
51349123892
-
Cancer immunotherapy by dendritic cells
-
Representative review of cancer immunotherapy with dendritic cells (DCs
-
Melief CJ: Cancer immunotherapy by dendritic cells. Immunity 29, 372-383 (2008). n Representative review of cancer immunotherapy with dendritic cells (DCs).
-
(2008)
Immunity
, vol.29
, pp. 372-383
-
-
Melief, C.J.1
-
30
-
-
34848837386
-
Taking dendritic cells into medicine
-
DOI 10.1038/nature06175, PII NATURE06175
-
Steinman RM, Banchereau J: Taking dendritic cells into medicine. Nature 449, 419-426 (2007). (Pubitemid 47509552)
-
(2007)
Nature
, vol.449
, Issue.7161
, pp. 419-426
-
-
Steinman, R.M.1
Banchereau, J.2
-
31
-
-
35748978808
-
Taming cancer by inducing immunity via dendritic cells
-
DOI 10.1111/j.1600-065X.2007.00575.x
-
Palucka AK, Ueno H, Fay JW, Banchereau J: Taming cancer by inducing immunity via dendritic cells. Immunol. Rev. 220, 129-150 (2007). (Pubitemid 350045575)
-
(2007)
Immunological Reviews
, vol.220
, Issue.1
, pp. 129-150
-
-
Palucka, A.K.1
Ueno, H.2
Fay, J.W.3
Banchereau, J.4
-
32
-
-
27144538614
-
Natural killer-dendritic cell cross-talk in cancer immunotherapy
-
DOI 10.1517/14712598.5.10.1303
-
Kalinski P, Mailliard RB, Giermasz A et al.: Natural killer-dendritic cell cross-talk in cancer immunotherapy. Expert. Opin. Biol. Ther. 5, 1303-1315 (2005). (Pubitemid 41503042)
-
(2005)
Expert Opinion on Biological Therapy
, vol.5
, Issue.10
, pp. 1303-1315
-
-
Kalinski, P.1
Mailliard, R.B.2
Giermasz, A.3
Zeh, H.J.4
Basse, P.5
Bartlett, D.L.6
Kirkwood, J.M.7
Lotze, M.T.8
Herberman, R.B.9
-
34
-
-
0033566984
-
Induction of systemic and therapeutic antitumor immunity using intratumoral injection of dendritic cells genetically modified to express interleukin 12
-
Nishioka Y, Hirao M, Robbins PD, Lotze MT, Tahara H: Induction of systemic and therapeutic antitumor immunity using intratumoral injection of dendritic cells genetically modified to express interleukin-12. Cancer Res. 59, 4035-4041 (1999). (Pubitemid 29393574)
-
(1999)
Cancer Research
, vol.59
, Issue.16
, pp. 4035-4041
-
-
Nishioka, Y.1
Hirao, M.2
Robbins, P.D.3
Lotze, M.T.4
Tahara, H.5
-
35
-
-
0039782448
-
The use of dendritic cells in cancer therapy
-
DOI 10.1016/S1470-2045(00)00389-2, PII S1470204500003892
-
Jefford M, Maraskovsky E, Cebon J, Davis ID: The use of dendritic cells in cancer therapy. Lancet Oncol. 2, 343-353 (2001). (Pubitemid 33585939)
-
(2001)
Lancet Oncology
, vol.2
, Issue.6
, pp. 343-353
-
-
Jefford, M.1
Maraskovsky, E.2
Cebon, J.3
Davis, I.D.4
-
36
-
-
0035889647
-
Active immunization against cancer with dendritic cells: The near future
-
DOI 10.1002/ijc.1503
-
Steinman RM, Dhodapkar M: Active immunization against cancer with dendritic cells: the near future. Int. J. Cancer 94, 459-473 (2001). n Summary of DC-based immunotherapy. (Pubitemid 32979535)
-
(2001)
International Journal of Cancer
, vol.94
, Issue.4
, pp. 459-473
-
-
Steinman, R.M.1
Dhodapkar, M.2
-
37
-
-
4644324025
-
Cancer immunotherapy: Moving beyond current vaccines
-
DOI 10.1038/nm1100
-
Rosenberg SA, Yang JC, Restifo NP: Cancer immunotherapy: moving beyond current vaccines. Nat. Med. 10, 909-915 (2004). n Important summary of clinical trials in cancer immunotherapy. (Pubitemid 39273730)
-
(2004)
Nature Medicine
, vol.10
, Issue.9
, pp. 909-915
-
-
Rosenberg, S.A.1
Yang, J.C.2
Restifo, N.P.3
-
38
-
-
54849437711
-
Review of clinical studies on dendritic cell-based vaccination of patients with malignant melanoma: Assessment of correlation between clinical response and vaccine parameters
-
Engell-Noerregaard L, Hansen TH, Andersen MH, Thor Straten P, Svane IM: Review of clinical studies on dendritic cell-based vaccination of patients with malignant melanoma: assessment of correlation between clinical response and vaccine parameters. Cancer Immunol. Immunother. 58, 1-14 (2009).
-
(2009)
Cancer Immunol. Immunother.
, vol.58
, pp. 1-14
-
-
Engell-Noerregaard, L.1
Hansen, T.H.2
Andersen, M.H.3
Thor Straten, P.4
Svane, I.M.5
-
39
-
-
0029150110
-
Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor a-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
-
Early report concerning the discovery of regulatory T (Treg) cells
-
Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M: Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor a-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155, 1151-1164 (1995). n Early report concerning the discovery of regulatory T (Treg) cells.
-
(1995)
J. Immunol
, vol.155
, pp. 1151-1164
-
-
Sakaguchi, S.1
Sakaguchi, N.2
Asano, M.3
Itoh, M.4
Toda, M.5
-
41
-
-
16844378209
-
Natural regulatory T cells and self-tolerance
-
DOI 10.1038/ni1184
-
Schwartz R: Natural regulatory T cells and self-tolerance. Nat. Immunol. 6, 327-330 (2005). (Pubitemid 41716768)
-
(2005)
Nature Immunology
, vol.6
, Issue.4
, pp. 327-330
-
-
Schwartz, R.H.1
-
42
-
-
43949105866
-
Regulatory T cells and immune tolerance
-
DOI 10.1016/j.cell.2008.05.009, PII S0092867408006247
-
Sakaguchi S, Yamaguchi T, Nomura T, Ono M: Regulatory T cells and immune tolerance. Cell 133, 775-787 (2008). n Representative review of Treg cells. (Pubitemid 351707693)
-
(2008)
Cell
, vol.133
, Issue.5
, pp. 775-787
-
-
Sakaguchi, S.1
Yamaguchi, T.2
Nomura, T.3
Ono, M.4
-
43
-
-
74049164847
-
Regulatory T cells exert checks and balances on self tolerance and autoimmunity
-
Wing K, Sakaguchi S: Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat. Immunol. 11, 7-13 (2010).
-
(2010)
Nat. Immunol.
, vol.11
, pp. 7-13
-
-
Wing, K.1
Sakaguchi, S.2
-
44
-
-
45849099077
-
The significance of Treg cells in defective tumor immunity
-
Kosmaczewska A, Ciszak L, Potoczek S, Frydecka I: The significance of Treg cells in defective tumor immunity. Arch. Immunol. Ther. Exp. (Warsz.) 56, 181-191 (2008).
-
(2008)
Arch. Immunol. Ther. Exp. (Warsz.)
, vol.56
, pp. 181-191
-
-
Kosmaczewska, A.1
Ciszak, L.2
Potoczek, S.3
Frydecka, I.4
-
45
-
-
0035874949
-
+ T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer
-
+ T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer. Cancer Res. 61, 4766-4772 (2001).
-
(2001)
Cancer Res.
, vol.61
, pp. 4766-4772
-
-
Woo, E.Y.1
Chu, C.S.2
Goletz, T.J.3
-
46
-
-
0036569127
-
Cutting edge: Regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation
-
Woo EY, Yeh H, Chu CS et al.: Cutting edge: regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation. J. Immunol. 168, 4272-4276 (2002). (Pubitemid 34441324)
-
(2002)
Journal of Immunology
, vol.168
, Issue.9
, pp. 4272-4276
-
-
Woo, E.Y.1
Yeh, H.2
Chu, C.S.3
Schlienger, K.4
Carroll, R.G.5
Riley, J.L.6
Kaiser, L.R.7
June, C.H.8
-
47
-
-
0037312480
-
Increase of regulatory T cells in the peripheral blood of cancer patients
-
Wolf AM, Wolf D, Steurer M, Gastl G, Gunsilius E, Grubeck-Loebenstein B: Increase of regulatory T cells in the peripheral blood of cancer patients. Clin. Cancer Res. 9, 606-612 (2003). (Pubitemid 36182591)
-
(2003)
Clinical Cancer Research
, vol.9
, Issue.2
, pp. 606-612
-
-
Wolf, A.M.1
Wolf, D.2
Steurer, M.3
Gastl, G.4
Gunsilius, E.5
Grubeck-Loebenstein, B.6
-
48
-
-
0141891466
-
Increased populations of regulatory T cells in peripheral blood and tumor-infiltrating lymphocytes in patients with gastric and esophageal cancers
-
Ichihara F, Kono K, Takahashi A, Kawaida H, Sugai H, Fujii H: Increased populations of regulatory T cells in peripheral blood and tumor-infiltrating lymphocytes in patients with gastric and esophageal cancers. Clin. Cancer Res. 9, 4404-4408 (2003). (Pubitemid 37248397)
-
(2003)
Clinical Cancer Research
, vol.9
, Issue.12
, pp. 4404-4408
-
-
Ichihara, F.1
Kono, K.2
Takahashi, A.3
Kawaida, H.4
Sugai, H.5
Fujii, H.6
-
49
-
-
0036721629
-
Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma
-
Liyanage UK, Moore TT, Joo HG et al.: Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma. J. Immunol. 169, 2756-2761 (2002).
-
(2002)
J. Immunol.
, vol.169
, pp. 2756-2761
-
-
Liyanage, U.K.1
Moore, T.T.2
Joo, H.G.3
-
50
-
-
16844378685
-
Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma
-
DOI 10.1158/0008-5472.CAN-04-3232
-
Ormandy LA, Hillemann T, Wedemeyer H, Manns MP, Greten TF, Korangy F: Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma. Cancer Res. 65, 2457-2464 (2005). n Representative report of Treg cells in cancer patients. (Pubitemid 40490158)
-
(2005)
Cancer Research
, vol.65
, Issue.6
, pp. 2457-2464
-
-
Ormandy, L.1
Hillemann, T.2
Wedemeyer, H.3
Manns, M.P.4
Greten, T.F.5
Korangy, F.6
-
51
-
-
0041386189
-
+ regulatory T cells in patients with gastrointestinal malignancies: Possible involvement of regulatory T cells in disease progression
-
DOI 10.1002/cncr.11618
-
+ regulatory T cells in patients with gastrointestinal malignancies: possible involvement of regulatory T cells in disease progression. Cancer 98, 1089-1099 (2003). (Pubitemid 37022112)
-
(2003)
Cancer
, vol.98
, Issue.5
, pp. 1089-1099
-
-
Sasada, T.1
Kimura, M.2
Yoshida, Y.3
Kanai, M.4
Takabayashi, A.5
-
52
-
-
13944260193
-
high regulatory T-cells in tumor-draining lymph nodes in patients with gastric cancer
-
DOI 10.1016/j.jss.2004.10.004
-
+CD25high regulatory T-cells in tumor-draining lymph nodes in patients with gastric cancer. J. Surg. Res. 124, 151-157 (2005). (Pubitemid 40269816)
-
(2005)
Journal of Surgical Research
, vol.124
, Issue.1
, pp. 151-157
-
-
Kawaida, H.1
Kono, K.2
Takahashi, A.3
Sugai, H.4
Mimura, K.5
Miyagawa, N.6
Omata, H.7
Ooi, A.8
Fujii, H.9
-
53
-
-
33744457276
-
high regulatory T cells increase with tumor stage in patients with gastric and esophageal cancers
-
DOI 10.1007/s00262-005-0092-8
-
+CD25high regulatory T cells increase with tumor stage in patients with gastric and esophageal cancers. Cancer Immunol. Immunother. 55, 1064-1071 (2005). (Pubitemid 43800721)
-
(2006)
Cancer Immunology, Immunotherapy
, vol.55
, Issue.9
, pp. 1064-1071
-
-
Kono, K.1
Kawaida, H.2
Takahashi, A.3
Sugai, H.4
Mimura, K.5
Miyagawa, N.6
Omata, H.7
Fujii, H.8
-
54
-
-
0037026003
-
+ human thymocytes
-
DOI 10.1084/jem.20020110
-
+ human thymocytes. J. Exp. Med. 196, 379-387 (2002). nn Summary of immunosuppressive mechanisms by Treg cells. (Pubitemid 34879113)
-
(2002)
Journal of Experimental Medicine
, vol.196
, Issue.3
, pp. 379-387
-
-
Annunziato, F.1
Cosmi, L.2
Liotta, F.3
Lazzeri, E.4
Manetti, R.5
Vanini, V.6
Romagnani, P.7
Maggi, E.8
Romagnani, S.9
-
55
-
-
0035801335
-
+ regulatory T cells is mediated by cell surface-bound transforming growth factor β
-
DOI 10.1084/jem.194.5.629
-
+ regulatory T cells is mediated by cell surface-bound transforming growth factorβ. J. Exp. Med. 194, 629-644 (2001). n One of the studies demonstrating the mechanism of immunosuppressive functions of Treg cells. (Pubitemid 32844773)
-
(2001)
Journal of Experimental Medicine
, vol.194
, Issue.5
, pp. 629-644
-
-
Nakamura, K.1
Kitani, A.2
Strober, W.3
-
56
-
-
0142219250
-
Transforming Growth Factor (TGF)-β1-producing Regulatory T Cells Induce Smad-mediated Interleukin 10 Secretion That Facilitates Coordinated Immunoregulatory Activity and Amelioration of TGF-β1-mediated Fibrosis
-
DOI 10.1084/jem.20030917
-
Kitani A, Fuss I, Nakamura K, Kumaki F, Usui T, Strober W: Transforming growth factor (TGF)-b1-producing regulatory T cells induce Smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-β1-mediated fibrosis. J. Exp. Med. 198, 1179-1188 (2003). n One of the studies demonstrating the mechanism of immunosuppressive functions of Treg cells. (Pubitemid 37323383)
-
(2003)
Journal of Experimental Medicine
, vol.198
, Issue.8
, pp. 1179-1188
-
-
Kitani, A.1
Fuss, I.2
Nakamura, K.3
Kumaki, F.4
Usui, T.5
Strober, W.6
-
57
-
-
0034679567
-
+ regulatory cells that control intestinal inflammation
-
DOI 10.1084/jem.192.2.295
-
+ regulatory cells that control intestinal inflammation. J. Exp. Med. 192, 295-302 (2000). n One of the studies demonstrating the mechanism of immunosuppressive functions of Treg cells. (Pubitemid 30470312)
-
(2000)
Journal of Experimental Medicine
, vol.192
, Issue.2
, pp. 295-302
-
-
Read, S.1
Malmstrom, V.2
Powrie, F.3
-
58
-
-
0035869432
-
IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo
-
Hara M, Kingsley CI, Niimi M et al.: IL-10 is required for regulatory T cells to mediate tolerance to alloantigens in vivo. J. Immunol. 166, 3789-3796 (2001). (Pubitemid 32224903)
-
(2001)
Journal of Immunology
, vol.166
, Issue.6
, pp. 3789-3796
-
-
Hara, M.1
Kingsley, C.I.2
Niimi, M.3
Read, S.4
Turvey, S.E.5
Bushell, A.R.6
Morris, P.J.7
Powrie, F.8
Wood, K.J.9
-
59
-
-
33645506145
-
Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-β
-
Ostroukhova M, Qi Z, Oriss TB, Dixon-McCarthy B, Ray P, Ray A: Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-β. J. Clin. Invest. 116, 996-1004 (2006).
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 996-1004
-
-
Ostroukhova, M.1
Qi, Z.2
Oriss, T.B.3
Dixon-McCarthy, B.4
Ray, P.5
Ray, A.6
-
60
-
-
61349100687
-
Myeloid-derived suppressor cells as regulators of the immune system
-
Critical review of MDSCs
-
Gabrilovich DI, Nagaraj S: Myeloid-derived suppressor cells as regulators of the immune system. Nat. Rev. Immunol. 9, 162-174 (2009). nn Critical review of MDSCs.
-
(2009)
Nat. Rev. Immunol.
, vol.9
, pp. 162-174
-
-
Gabrilovich, D.I.1
Nagaraj, S.2
-
61
-
-
65249138393
-
Myeloid-derived suppressor cells: Linking inflammation and cancer
-
Ostrand-Rosenberg S, Sinha P: Myeloid-derived suppressor cells: linking inflammation and cancer. J. Immunol. 182, 4499-4506 (2009).
-
(2009)
J. Immunol.
, vol.182
, pp. 4499-4506
-
-
Ostrand-Rosenberg, S.1
Sinha, P.2
-
62
-
-
41149119143
-
Tumor-induced tolerance and immune suppression by myeloid derived suppressor cells
-
DOI 10.1111/j.1600-065X.2008.00602.x
-
Marigo I, Dolcetti L, Serafini P, Zanovello P, Bronte V: Tumor-induced tolerance and immune suppression by myeloid derived suppressor cells. Immunol. Rev. 222, 162-179 (2008). (Pubitemid 351430364)
-
(2008)
Immunological Reviews
, vol.222
, Issue.1
, pp. 162-179
-
-
Marigo, I.1
Dolcetti, L.2
Serafini, P.3
Zanovello, P.4
Bronte, V.5
-
63
-
-
10244279184
-
Mechanisms and functional significance of tumour-induced dendritic-cell defects
-
DOI 10.1038/nri1498
-
Gabrilovich D: Mechanisms and functional significance of tumor-induced dendritic-cell defects. Nat. Rev. Immunol. 4, 941-952 (2004). nn Critical review of tumor-induced immunosuppression for DC functions. (Pubitemid 39620069)
-
(2004)
Nature Reviews Immunology
, vol.4
, Issue.12
, pp. 941-952
-
-
Gabrilovich, D.1
-
64
-
-
0035164478
-
Increased production of immature myeloid cells in cancer patients: A mechanism of immunosuppression in cancer
-
Almand B, Clark JI, Nikitina E et al.: Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancer. J. Immunol. 166, 678-689 (2001). n Early report of MDSCs. (Pubitemid 32038493)
-
(2001)
Journal of Immunology
, vol.166
, Issue.1
, pp. 678-689
-
-
Almand, B.1
Clark, J.I.2
Nikitina, E.3
Van Beynen, J.4
English, N.R.5
Knight, S.C.6
Carbone, D.P.7
Gabrilovich, D.I.8
-
65
-
-
43249130187
-
Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity
-
Movahedi K, Guilliams M, Van den Bossche J et al.: Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity. Blood 111, 4233-4244 (2008).
-
(2008)
Blood
, vol.111
, pp. 4233-4244
-
-
Movahedi, K.1
Guilliams, M.2
Van Den Bossche, J.3
-
67
-
-
77950829023
-
Mechanism of T cell tolerance induced by myeloid-derived suppressor cells
-
Describes the immunosuppresive mechanisms of MDSCs
-
Nagaraj S, Schrum AG, Cho HI, Celis E, Gabrilovich DI: Mechanism of T cell tolerance induced by myeloid-derived suppressor cells. J. Immunol. 184, 3106-3116 (2010). n Describes the immunosuppresive mechanisms of MDSCs.
-
(2010)
J. Immunol.
, vol.184
, pp. 3106-3116
-
-
Nagaraj, S.1
Schrum, A.G.2
Cho, H.I.3
Celis, E.4
Gabrilovich, D.I.5
-
68
-
-
47949090079
-
The role of myeloid cells in the promotion of tumour angiogenesis
-
Critical review of myeloid cell-mediated tumor angiogenesis
-
Murdoch C, Muthana M, Coffelt SB, Lewis CE: The role of myeloid cells in the promotion of tumour angiogenesis. Nat. Rev. Cancer 8, 618-631 (2008). nn Critical review of myeloid cell-mediated tumor angiogenesis.
-
(2008)
Nat. Rev. Cancer
, vol.8
, pp. 618-631
-
-
Murdoch, C.1
Muthana, M.2
Coffelt, S.B.3
Lewis, C.E.4
-
69
-
-
77953487609
-
Myeloid cells in the tumor microenvironment: Modulation of tumor angiogenesis and tumor inflammation
-
Epub ahead of print DOI: 10.1155/2010/201026
-
Schmid MC, Varner JA: Myeloid cells in the tumor microenvironment: modulation of tumor angiogenesis and tumor inflammation. J. Oncol. DOI: 10.1155/2010/201026. (2010) (Epub ahead of print).
-
(2010)
J. Oncol.
-
-
Schmid, M.C.1
Varner, J.A.2
-
70
-
-
36849013036
-
Bv8 regulates myeloid-cell-dependent tumour angiogenesis
-
DOI 10.1038/nature06348, PII NATURE06348
-
Shojaei F, Wu X, Zhong C et al.: Bv8 regulates myeloid-cell-dependent tumour angiogenesis. Nature 450, 825-831 (2007). (Pubitemid 350231321)
-
(2007)
Nature
, vol.450
, Issue.7171
, pp. 825-831
-
-
Shojaei, F.1
Wu, X.2
Zhong, C.3
Yu, L.4
Liang, X.-H.5
Yao, J.6
Blanchard, D.7
Bais, C.8
Peale, F.V.9
Van Bruggen, N.10
Ho, C.11
Ross, J.12
Tan, M.13
Carano, R.A.D.14
Meng, Y.G.15
Ferrara, N.16
-
71
-
-
5444225991
-
Expansion of myeloid immune suppressor Gr+CD11b+ cells in tumor-bearing host directly promotes tumor angiogenesis
-
DOI 10.1016/j.ccr.2004.08.031, PII S1535610804002703
-
+ cells in tumor-bearing host directly promotes tumor angiogenesis. Cancer Cell 6, 409-421 (2004). n Direct evidence regarding the relationship between MDSCs and tumor angiogenesis. (Pubitemid 39361441)
-
(2004)
Cancer Cell
, vol.6
, Issue.4
, pp. 409-421
-
-
Yang, L.1
DeBusk, L.M.2
Fukuda, K.3
Fingleton, B.4
Green-Jarvis, B.5
Shyr, Y.6
Matrisian, L.M.7
Carbone, D.P.8
Lin, P.C.9
-
72
-
-
0344987881
-
A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome
-
DOI 10.1056/NEJMoa025217
-
Cools J, DeAngelo DJ, Gotlib J et al.: A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N. Engl. J. Med. 348, 1201-1214 (2003). (Pubitemid 36359296)
-
(2003)
New England Journal of Medicine
, vol.348
, Issue.13
, pp. 1201-1214
-
-
Cools, J.1
DeAngelo, D.J.2
Gotlib, J.3
Stover, E.H.4
Legare, R.D.5
Cortes, J.6
Kutok, J.7
Clark, J.8
Galinsky, I.9
Griffin, J.D.10
Cross, N.C.P.11
Tefferi, A.12
Malone, J.13
Alam, R.14
Schrier, S.L.15
Schmid, J.16
Rose, M.17
Vandenberghe, P.18
Verhoef, G.19
Boogaerts, M.20
Wlodarska, I.21
Kantarjian, H.22
Marynen, P.23
Coutre, S.E.24
Stone, R.25
Gilliland, D.G.26
more..
-
73
-
-
16344368251
-
Effects of imatinib on monocyte-derived dendritic cells are mediated by inhibition of nuclear factor-κB and Akt signaling pathways
-
DOI 10.1158/1078-0432.CCR-04-1713
-
Appel S, Rupf A, Week MM et al.: Effects of imatinib on monocyte-derived dendritic cels are mediated by inhibition of nuclear factor-kB and Akt signaling pathway. Clin. Cancer Res. 11, 1928-1940 (2005). (Pubitemid 40471859)
-
(2005)
Clinical Cancer Research
, vol.11
, Issue.5
, pp. 1928-1940
-
-
Appel, S.1
Rupf, A.2
Weck, M.M.3
Schoor, O.4
Brummendorf, T.H.5
Weinschenk, T.6
Grunebach, F.7
Brossart, P.8
-
74
-
-
15244351682
-
Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner
-
DOI 10.1182/blood-2004-07-2527
-
Seggewiss R, Loré K, Greiner E et al.: Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner. Blood 105, 2473-2479 (2005). (Pubitemid 40387048)
-
(2005)
Blood
, vol.105
, Issue.6
, pp. 2473-2479
-
-
Seggewiss, R.1
Lore, K.2
Greiner, E.3
Magnusson, M.K.4
Price, D.A.5
Douek, D.C.6
Dunbar, C.E.7
Wiestner, A.8
-
75
-
-
3843119865
-
Imatinib mesylate inhibits T-cell proliferation in vitro and delayed-type hypersensitivity in vivo
-
DOI 10.1182/blood-2003-12-4266
-
Dietz AB, Souan L, Knutson GJ, Bulur PA, Litzow MR, Vuk-Pavlovic S: Imatinib mesylate inhibits T-cell proliferation in vitro and delayed-type hypersensitivity in vivo. Blood 104, 1094-1099 (2004). n Report of the immunosuppresive effects of imatinib. (Pubitemid 39038030)
-
(2004)
Blood
, vol.104
, Issue.4
, pp. 1094-1099
-
-
Dietz, A.B.1
Souan, L.2
Knutson, G.J.3
Bulur, P.A.4
Litzow, M.R.5
Vuk-Pavlovic, S.6
-
76
-
-
3042802079
-
+ peripheral blood progenitor cells
-
DOI 10.1182/blood-2003-03-0975
-
+ peripheral blood progenitor cells. Blood 103, 538-544 (2004). (Pubitemid 38140084)
-
(2004)
Blood
, vol.103
, Issue.2
, pp. 538-544
-
-
Appel, S.1
Boehmler, A.M.2
Grunebach, F.3
Muller, M.R.4
Rupf, A.5
Weck, M.M.6
Hartmann, U.7
Reichardt, V.L.8
Kanz, L.9
Brummendorf, T.H.10
Brossart, P.11
-
77
-
-
1442331705
-
Imatinib impairs Flt3L-mediated dendritic cell expansion and antitumor effects in vivo
-
Taieb J, Maruyama K, Borg C et al.: Imatinib impairs Flt3L-mediated dendritic cell expansion and antitumor effects in vivo. Blood 103, 1966-1967 (2004).
-
(2004)
Blood
, vol.103
, pp. 1966-1967
-
-
Taieb, J.1
Maruyama, K.2
Borg, C.3
-
78
-
-
33746418579
-
+ and normal monocyte-derived dendritic cells but strongly inhibits T cell expansion despite reciprocal dendritic cell-T cell activation
-
DOI 10.1189/jlb.0705419
-
+ and normal monocyte-derived dendritic cells but strongly inhibits T cell expansion despite reciprocal dendritic cell-T cell activation. J. Leukoc. Biol. 79, 747-756 (2006) (Pubitemid 44835607)
-
(2006)
Journal of Leukocyte Biology
, vol.79
, Issue.4
, pp. 747-756
-
-
Boissel, N.1
Rousselot, P.2
Raffoux, E.3
Cayuela, J.-M.4
Soulier, J.5
Mooney, N.6
Charron, D.7
Dombret, H.8
Toubert, A.9
Rea, D.10
-
79
-
-
2942625414
-
Imatinib and plasmacytoid dendritic cell function in patients with chronic myeloid leukemia
-
DOI 10.1182/blood-2003-09-3220
-
Mohty M, jourdan F, Mami NB et al.: Imatinib and plasmocytoid dendritic cell function in patients with chronic myelogenous leukemia. Blood 103, 4666-4668 (2004). (Pubitemid 38746000)
-
(2004)
Blood
, vol.103
, Issue.12
, pp. 4666-4668
-
-
Mohty, M.1
Jourdan, E.2
Mami, N.B.3
Vey, N.4
Damaj, G.5
Blaise, D.6
Isnardon, D.7
Olive, D.8
Gaugler, B.9
-
80
-
-
10744232318
-
The effects of STI571 on antigen presentation of dendritic cells generated from patients with chronic myelogenous leukemia
-
DOI 10.1002/hon.705
-
Sato N, Narita M, Takahashi M et al.: The effects of STI571 on antigen-presentation of dendritic cells generated from patients with chironic myelogenous leukemia. Hematol. Oncol. 21, 67-75 (2003). (Pubitemid 36717431)
-
(2003)
Hematological Oncology
, vol.21
, Issue.2
, pp. 67-75
-
-
Sato, N.1
Narita, M.2
Takahashi, M.3
Yagisawa, K.4
Liu, A.5
Abe, T.6
Nikkuni, K.7
Furukawa, T.8
Toba, K.9
Aizawa, Y.10
-
81
-
-
12844265929
-
+ T-cell tolerance
-
DOI 10.1182/blood-2004-01-0027
-
+ T-cell tolerance. Blood 105, 1135-1143 (2005). (Pubitemid 40170886)
-
(2005)
Blood
, vol.105
, Issue.3
, pp. 1135-1143
-
-
Wang, H.1
Cheng, F.2
Cuenca, A.3
Horna, P.4
Zheng, Z.5
Bhalla, K.6
Sotomayor, E.M.7
-
82
-
-
4043134677
-
Novel mode of action of c-kit tyrosine kinase inhibitors leading to NK cell-dependent antitumor effects
-
DOI 10.1172/JCI200421102
-
Borg C, Terme M, Taïeb J et al.: Novel mode of action of c-Kit tyrosine kinase inhibitors leading to NK cell-dependent antitumor effects. J. Clin. Invest. 114, 379-388 (2004). nn Early report regarding the effects of imatinib on NK cell activity. (Pubitemid 39071610)
-
(2004)
Journal of Clinical Investigation
, vol.114
, Issue.3
, pp. 379-388
-
-
Borg, C.1
Terme, M.2
Taieb, J.3
Menard, C.4
Flament, C.5
Robert, C.6
Maruyama, K.7
Wakasugi, H.8
Angevin, E.9
Thielemans, K.10
Le Cesne, A.11
Chung-Scott, V.12
Lazar, V.13
Tchou, I.14
Crepineau, F.15
Lemoine, F.16
Bernard, J.17
Fletcher, J.A.18
Turhan, A.19
Blay, J.-Y.20
Spatz, A.21
Emile, J.-F.22
Heinrich, M.C.23
Mecheri, S.24
Tursz, T.25
Zitvogel, L.26
more..
-
83
-
-
17044403497
-
Macrophage colony-stimulating factor receptor c-fms is a novel target of imatinib
-
DOI 10.1182/blood-2004-10-3967
-
Dewar AL, Cambareri AC, Zannettino AC et al.: Macrophage colony-stimulating factor receptor c-Fms is a novel target of imatinib. Blood 105, 3127-3132 (2005). (Pubitemid 40504330)
-
(2005)
Blood
, vol.105
, Issue.8
, pp. 3127-3132
-
-
Dewar, A.L.1
Cambareri, A.C.2
Zannettino, A.C.W.3
Miller, B.L.4
Doherty, K.V.5
Hughes, T.P.6
Bruce Lyons, A.7
-
84
-
-
30044449181
-
FMS receptor for M-CSF (CSF-1) is sensitive to the kinase inhibitor imatinib and mutation of Asp-802 to Val confers resistance
-
DOI 10.1111/j.1365-277X.2006.00674.x
-
Taylor JR, Brownlow N, Domin J, Dibb NJ: FMS receptor for M-CSF (CSF-1) is sensitive to the kinase inhibitor imatinib and mutation of Asp-802 to Val confers resistance. Oncogene 25, 147-151 (2006). (Pubitemid 43050013)
-
(2006)
Oncogene
, vol.25
, Issue.1
, pp. 147-151
-
-
Taylor, J.R.1
Brownlow, N.2
Domin, J.3
Dibb, N.J.4
-
85
-
-
0029842830
-
Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells
-
DOI 10.1038/nm1096-1096
-
Gabrilovich DI, Chen HL, Girgis KR et al.: Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells. Nat. Med. 2, 1096-1103 (1996). nn First report regarding VEGF-mediated suppression of DC function. (Pubitemid 26338628)
-
(1996)
Nature Medicine
, vol.2
, Issue.10
, pp. 1096-1103
-
-
Gabrilovich, D.I.1
Chen, H.L.2
Girgis, K.R.3
Cunningham, H.T.4
Meny, G.M.5
Nadaf, S.6
Kavanaugh, D.7
Carbone, D.P.8
-
86
-
-
0033568001
-
Effect of vascular endothelial growth factor and FLT3 ligand on dendritic cell generation in vivo
-
Ohm JE, Shurin MR, Esche C, Lotze MT, Carbone DP, Gabrilovich DI: Effect of vascular endothelial growth factor and Flt3 ligand on dendritic cell generation in vivo. J. Immunol. 163, 3260-3268 (1999). (Pubitemid 29431827)
-
(1999)
Journal of Immunology
, vol.163
, Issue.6
, pp. 3260-3268
-
-
Ohm, J.E.1
Shurin, M.R.2
Esche, C.3
Lotze, M.T.4
Carbone, D.P.5
Gabrilovich, D.I.6
-
87
-
-
0031892785
-
Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-κB activation in hemopoietic progenitor cells
-
Oyama T, Ran S, Ishida T et al.: Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-kB activation in hemopoietic progenitor cells. J. Immunol. 160, 1224-1232 (1998). (Pubitemid 28093419)
-
(1998)
Journal of Immunology
, vol.160
, Issue.3
, pp. 1224-1232
-
-
Oyama, T.1
Ran, S.2
Ishida, T.3
Nadaf, S.4
Kerr, L.5
Carbone, D.P.6
Gabrilovich, D.I.7
-
88
-
-
0032211082
-
Defective function of langerhans cells in tumor-bearing animals is the result of defective maturation from hemopoietic progenitors
-
Ishida T, Oyama T, Carbone DP, Gabrilovich DI: Defective function of Langerhans cells in tumor-bearing animals is the result of defective maturation from hemopoietic progenitors. J. Immunol. 161, 4842-4851 (1998). (Pubitemid 28492062)
-
(1998)
Journal of Immunology
, vol.161
, Issue.9
, pp. 4842-4851
-
-
Ishida, T.1
Oyama, T.2
Carbone, D.P.3
Gabrilovich, D.I.4
-
89
-
-
0032741283
-
Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function
-
Gabrilovich DI, Ishida T, Nadaf S, Ohm JE, Carbone DP: Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function. Clin. Cancer Res. 5, 2963-2970 (1999). (Pubitemid 29493976)
-
(1999)
Clinical Cancer Research
, vol.5
, Issue.10
, pp. 2963-2970
-
-
Gabrilovich, D.I.1
Ishida, T.2
Nadaf, S.3
Ohm, J.E.4
Carbone, D.P.5
-
91
-
-
47049127786
-
Sorafenib, but not sunitinib, affects function of dendritic cells and induction of primary immune responses
-
Describes the immunomodulatory effects of sorafenib and sunitinib
-
Hipp MM, Hilf N, Walter S et al.: Sorafenib, but not sunitinib, affects function of dendritic cells and induction of primary immune responses. Blood 111, 5610-5620 (2008). nn Describes the immunomodulatory effects of sorafenib and sunitinib.
-
(2008)
Blood
, vol.111
, pp. 5610-5620
-
-
Hipp, M.M.1
Hilf, N.2
Walter, S.3
-
92
-
-
45149084681
-
Sorafenib inhibits activation of human peripheral blood T cells by targeting LCK phosphorylation
-
DOI 10.1038/leu.2008.58, PII LEU200858
-
Zhao W, Gu YH, Song R, Qu BQ, Xu Q: Sorafenib inhibits activation of human peripheral blood T cells by targeting Lck phosphorylation. Leukemia 22, 1226-1233 (2008). (Pubitemid 351833791)
-
(2008)
Leukemia
, vol.22
, Issue.6
, pp. 1226-1233
-
-
Zhao, W.1
Gu, Y.H.2
Song, R.3
Qu, B.Q.4
Xu, Q.5
-
93
-
-
65549141834
-
The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies
-
Report on the immunostimulatory effects of sunitinib
-
Ozao-Choy J, Ma G, Kao J et al.: The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies. Cancer Res. 69, 2514-2522 (2009). n Report on the immunostimulatory effects of sunitinib.
-
(2009)
Cancer Res.
, vol.69
, pp. 2514-2522
-
-
Ozao-Choy, J.1
Ma, G.2
Kao, J.3
-
94
-
-
38049181485
-
Reversion of immune tolerance in advanced malignancy: Modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor function
-
Novel mechanism to block MDSC development
-
Pan PY, Wang GX, Yin B et al.: Reversion of immune tolerance in advanced malignancy: modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor function. Blood 111, 219-228 (2008). n Novel mechanism to block MDSC development.
-
(2008)
Blood
, vol.111
, pp. 219-228
-
-
Pan, P.Y.1
Wang, G.X.2
Yin, B.3
-
95
-
-
65549129226
-
Sunitinib inhibition of STAT3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells
-
Xin H, Zhang C, Herrmann A, Du Y, Figlin R, Yu H: Sunitinib inhibition of STAT3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells. Cancer Res. 69, 2506-2513 (2009).
-
(2009)
Cancer Res.
, vol.69
, pp. 2506-2513
-
-
Xin, H.1
Zhang, C.2
Herrmann, A.3
Du, Y.4
Figlin, R.5
Yu, H.6
-
96
-
-
63549105681
-
Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients
-
Representative report describing the immunostimulatory effects of sunitinib in cancer patients
-
Ko JS, Zea AH, Rini BI et al.: Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients. Clin. Cancer Res. 15, 2148-2157 (2009). nn Representative report describing the immunostimulatory effects of sunitinib in cancer patients.
-
(2009)
Clin. Cancer Res.
, vol.15
, pp. 2148-2157
-
-
Ko, J.S.1
Zea, A.H.2
Rini, B.I.3
-
97
-
-
19944428353
-
Discovery of N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays
-
DOI 10.1021/jm049486a
-
Lombardo LJ, Lee FY, Chen P et al.: Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)-piperazin-1-yl) -2-methylpyrimidin-4-ylamino) thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays. J. Med. Chem. 47, 6658-6661 (2004). (Pubitemid 40053752)
-
(2004)
Journal of Medicinal Chemistry
, vol.47
, Issue.27
, pp. 6658-6661
-
-
Lombardo, L.J.1
Lee, F.Y.2
Chen, P.3
Norris, D.4
Barrish, J.C.5
Behnia, K.6
Castaneda, S.7
Cornelius, L.A.M.8
Das, J.9
Doweyko, A.M.10
Fairchild, C.11
Hunt, J.T.12
Inigo, I.13
Johnston, K.14
Kamath, A.15
Kan, D.16
Klei, H.17
Marathe, P.18
Pang, S.19
Peterson, R.20
Pitt, S.21
Schieven, G.L.22
Schmidt, R.J.23
Tokarski, J.24
Wen, M.-L.25
Wityak, J.26
Borzilleri, R.M.27
more..
-
98
-
-
33745102555
-
Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias
-
DOI 10.1056/NEJMoa055229
-
Talpaz M, Shah NP, Kantarjian H et al.: Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias. N. Engl. J. Med. 354, 2531-2541 (2006). (Pubitemid 43882349)
-
(2006)
New England Journal of Medicine
, vol.354
, Issue.24
, pp. 2531-2541
-
-
Talpaz, M.1
Shah, N.P.2
Kantarjian, H.3
Donato, N.4
Nicoll, J.5
Paquette, R.6
Cortes, J.7
O'Brien, S.8
Nicaise, C.9
Bleickardt, E.10
Blackwood-Chirchir, M.A.11
Iyer, V.12
Chen, T.-T.13
Huang, F.14
Decillis, A.P.15
Sawyers, C.L.16
-
99
-
-
46849114097
-
Association between imatinib-resistant BCR-ABL mutation-negative leukemia and persistent activation of LYN kinase
-
DOI 10.1093/jnci/djn188
-
Wu J, Meng F, Kong LY et al.: Association between imatinib-resistant BCR-ABL mutation-negative leukemia and persistent activation of LYN kinase. J. Natl Cancer Inst. 100, 926-939 (2008). (Pubitemid 351957515)
-
(2008)
Journal of the National Cancer Institute
, vol.100
, Issue.13
, pp. 926-939
-
-
Wu, J.1
Meng, F.2
Kong, L.-Y.3
Peng, Z.4
Ying, Y.5
Bornmann, W.G.6
Darnay, B.G.7
Lamothe, B.8
Sun, H.9
Talpaz, M.10
Donato, N.J.11
-
100
-
-
42249088418
-
Profound inhibition of antigen-specific T-cell effector functions by dasatinib
-
DOI 10.1158/1078-0432.CCR-07-4393
-
Weichsel R, Dix C, Wooldridge L et al.: Profound inhibition of antigen-specific T-cell effector functions by dasatinib. Clin. Cancer Res. 14, 2488-2491 (2008). (Pubitemid 351551084)
-
(2008)
Clinical Cancer Research
, vol.14
, Issue.8
, pp. 2484-2491
-
-
Weichsel, R.1
Dix, C.2
Wooldridge, L.3
Clement, M.4
Fenton-May, A.5
Sewell, A.K.6
Zezula, J.7
Greiner, E.8
Gostick, E.9
Price, D.A.10
Einsele, H.11
Seggewiss, R.12
-
101
-
-
58149181387
-
+ T-cell responses and NK-cell cytolytic activity in vitro and in vivo
-
+ T-cell responses and NK-cell cytolytic activity in vitro and in vivo. Exp. Hematol. 37, 256-265 (2009).
-
(2009)
Exp. Hematol.
, vol.37
, pp. 256-265
-
-
Fraser, C.K.1
Blake, S.J.2
Diener, K.R.3
-
102
-
-
70449411507
-
Dasatinib inhibits the secretion of TNF-α following TLR stimulation in vitro and in vivo
-
Fraser CK, Lousberg EL, Kumar R, Hughes TP, Diener KR, Hayball JD: Dasatinib inhibits the secretion of TNF-α following TLR stimulation in vitro and in vivo. Exp. Hematol. 37, 1435-1444 (2009).
-
(2009)
Exp. Hematol.
, vol.37
, pp. 1435-1444
-
-
Fraser, C.K.1
Lousberg, E.L.2
Kumar, R.3
Hughes, T.P.4
Diener, K.R.5
Hayball, J.D.6
-
104
-
-
62849094732
-
Selectivity and therapeutic inhibition of kinases: To be or not to be?
-
Ghoreschi K, Laurence A, O'Shea JJ: Selectivity and therapeutic inhibition of kinases: to be or not to be? Nat. Immunol. 10, 56-360 (2009).
-
(2009)
Nat. Immunol.
, vol.10
, pp. 56-360
-
-
Ghoreschi, K.1
Laurence, A.2
O'Shea, J.J.3
-
105
-
-
38549162640
-
Inflammation, inflammatory cells and angiogenesis: Decisions and indecisions
-
Representative review of myeloid cell-mediated angiogenesis
-
Noonan DM, De Lerma Barbaro A, Vannini N, Mortara L, Albini A: Inflammation, inflammatory cells and angiogenesis: decisions and indecisions. Cancer Metastasis Rev. 27, 31-40 (2008). nn Representative review of myeloid cell-mediated angiogenesis.
-
(2008)
Cancer Metastasis Rev.
, vol.27
, pp. 31-40
-
-
Noonan, D.M.1
De Lerma Barbaro, A.2
Vannini, N.3
Mortara, L.4
Albini, A.5
-
106
-
-
77954753261
-
Anti-inflammatory M2 type macrophages characterize metastasized and tyrosine kinase inhibitor-treated gastrointestinal stromal tumors
-
van Dongen M, Savage ND, Jordanova ES et al.: Anti-inflammatory M2 type macrophages characterize metastasized and tyrosine kinase inhibitor-treated gastrointestinal stromal tumors. Int. J. Cancer. 127, 899-909 (2010).
-
(2010)
Int. J. Cancer.
, vol.127
, pp. 899-909
-
-
Van Dongen, M.1
Savage, N.D.2
Jordanova, E.S.3
-
107
-
-
38049068004
-
Myeloid cells functioning in tumor vascularization as a novel therapeutic target
-
Review of myeloid cell-mediated angiogenesis
-
McLean K, Buckanovich RJ: Myeloid cells functioning in tumor vascularization as a novel therapeutic target. Transl. Res. 151, 59-67 (2008). nn Review of myeloid cell-mediated angiogenesis.
-
(2008)
Transl. Res.
, vol.151
, pp. 59-67
-
-
McLean, K.1
Buckanovich, R.J.2
-
108
-
-
77952299622
-
Tumor growth and angiogenesis are dependent on the presence of immature dendritic cells
-
Direct demonstration of the contribution of immature DCs to angiogenesis
-
Fainaru O, Almog N, Yung CW et al.: Tumor growth and angiogenesis are dependent on the presence of immature dendritic cells. FASEB J. 24, 1411-1418 (2010). nn Direct demonstration of the contribution of immature DCs to angiogenesis.
-
(2010)
FASEB J.
, vol.24
, pp. 1411-1418
-
-
Fainaru, O.1
Almog, N.2
Yung, C.W.3
-
109
-
-
4644345036
-
Tumor-infiltrating dendritic cell precursors recruited by a β-defensin contribute to vasculogenesis under the influence of Vegf-A
-
DOI 10.1038/nm1097
-
Conejo-Garcia JR, Benencia F, Courreges MC et al.: Tumor-infiltrating dendritic cell precursors recruited by a β-defensin contribute to vasculogenesis under the influence of VEGF-A. Nat. Med. 10, 950-958 (2004). n First report describing the role of DCs in vasculogenesis. (Pubitemid 39273736)
-
(2004)
Nature Medicine
, vol.10
, Issue.9
, pp. 950-958
-
-
Conejo-Garcia, J.R.1
Benencia, F.2
Courreges, M.-C.3
Kang, E.4
Mohamed-Hadley, A.5
Buckanovich, R.J.6
Holtz, D.O.7
Jenkins, A.8
Na, H.9
Zhang, L.10
Wagner, D.S.11
Katsaros, D.12
Caroll, R.13
Coukos, G.14
-
110
-
-
76249091676
-
Expression of soluble vascular endothelial growth factor receptor-1 in human monocyte-derived mature dendritic cells contributes to their antiangiogenic property
-
Kishuku M, Nishioka Y, Abe S et al.: Expression of soluble vascular endothelial growth factor receptor-1 in human monocyte-derived mature dendritic cells contributes to their antiangiogenic property. J. Immunol. 183, 8176-8185 (2009).
-
(2009)
J. Immunol.
, vol.183
, pp. 8176-8185
-
-
Kishuku, M.1
Nishioka, Y.2
Abe, S.3
-
111
-
-
18044391683
-
The role of dendritic cell precursors in tumour vasculogenesis
-
DOI 10.1038/sj.bjc.6602476
-
Coukos G, Benencia F, Buckanovich RJ, Conejo-Garcia JR: The role of dendritic cell precursors in tumour vasculogenesis. Br. J. Cancer. 92, 1182-1187 (2005). n Concise review of the role of DCs in angiogenesis. (Pubitemid 40604389)
-
(2005)
British Journal of Cancer
, vol.92
, Issue.7
, pp. 1182-1187
-
-
Coukos, G.1
Benencia, F.2
Buckanovich, R.J.3
Conejo-Garcia, J.R.4
|