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Volumn 3, Issue 1, 2011, Pages 107-116

Role of tyrosine kinase inhibitors in tumor immunology

Author keywords

dendritic cell; myeloid derived suppressor cell; regulatory T cell; tyrosine kinase inhibitor

Indexed keywords

4 [N [1 (2 CYANO 1 OXOETHYL) 4 METHYL 3 PIPERIDINYL] N METHYLAMINO]PYRROLO[2,3 D]PYRIMIDINE; DASATINIB; DENDRITIC CELL VACCINE; IMATINIB; PLATELET DERIVED GROWTH FACTOR A; PLATELET DERIVED GROWTH FACTOR B; PLATELET DERIVED GROWTH FACTOR RECEPTOR; PROTEIN TYROSINE KINASE INHIBITOR; SORAFENIB; SUNITINIB;

EID: 78650569157     PISSN: 1750743X     EISSN: None     Source Type: Journal    
DOI: 10.2217/imt.10.79     Document Type: Review
Times cited : (13)

References (111)
  • 1
    • 57749188299 scopus 로고    scopus 로고
    • Targeting cancer with small molecule kinase inhibitors
    • Zhang J, Yang PL, Gray NS: Targeting cancer with small molecule kinase inhibitors. Nat. Rev. Cancer 9, 28-39 (2009).
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 28-39
    • Zhang, J.1    Yang, P.L.2    Gray, N.S.3
  • 3
    • 77949957365 scopus 로고    scopus 로고
    • Cell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agents
    • Sharma SV, Haber DA, Settleman J: Cell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agents. Nat. Rev. Cancer 10, 241-253 (2010).
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 241-253
    • Sharma, S.V.1    Haber, D.A.2    Settleman, J.3
  • 4
    • 75149130051 scopus 로고    scopus 로고
    • Targeting the cancer kinome through polypharmacology
    • Summary of US FDA-approved TKIs and their targets
    • Knight ZA, Lin H, Shokat KM: Targeting the cancer kinome through polypharmacology. Nat. Rev. Cancer 10, 130-137 (2010). n Summary of US FDA-approved TKIs and their targets.
    • (2010) Nat. Rev. Cancer , vol.10 , pp. 130-137
    • Knight, Z.A.1    Lin, H.2    Shokat, K.M.3
  • 7
    • 0035960428 scopus 로고    scopus 로고
    • European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group. Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: A Phase I study
    • van Oosterom AT, Judson I, Verweij J et al.: European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group. Safety and efficacy of imatinib (STI571) in metastatic gastrointestinal stromal tumours: a Phase I study. Lancet 358, 1421-1423 (2001).
    • (2001) Lancet , vol.358 , pp. 1421-1423
    • Van Oosterom, A.T.1    Judson, I.2    Verweij, J.3
  • 9
    • 33846621955 scopus 로고    scopus 로고
    • Small molecule tyrosine kinase inhibitors in the treatment of solid tumors: An update of recent developments
    • DOI 10.1245/s10434-006-9227-1
    • Steeghs N, Nortier JW, Gelderblom H: Small molecule tyrosine kinase inhibitors in the treatment of solid tumors: an update of recent developments. Ann. Surg. Oncol. 14, 942-953 (2007). (Pubitemid 46175346)
    • (2007) Annals of Surgical Oncology , vol.14 , Issue.2 , pp. 942-953
    • Steeghs, N.1    Nortier, J.W.R.2    Gelderblom, H.3
  • 10
    • 38649129787 scopus 로고    scopus 로고
    • New developments in multitargeted therapy for patients with solid tumours
    • DOI 10.1016/j.ctrv.2007.09.003, PII S0305737207001375
    • Le Tourneau C, Faivre S, Raymond E: New developments in multitargeted therapy for patients with solid tumours. Cancer Treat. Rev. 34, 37-48 (2008). (Pubitemid 351168610)
    • (2008) Cancer Treatment Reviews , vol.34 , Issue.1 , pp. 37-48
    • Le Tourneau, C.1    Faivre, S.2    Raymond, E.3
  • 11
    • 63449112585 scopus 로고    scopus 로고
    • Therapeutic protein kinase inhibitors
    • Grant SK: Therapeutic protein kinase inhibitors. Cell Mol. Life Sci. 66, 1163-1177 (2009).
    • (2009) Cell Mol. Life Sci. , vol.66 , pp. 1163-1177
    • Grant, S.K.1
  • 14
    • 22044445517 scopus 로고    scopus 로고
    • Clinical Trials Group. Erlotinib in previously treated non-small-cell lung cancer
    • Shepherd FA, Rodrigues Pereira J, Ciuleanu T et al.: Clinical Trials Group. Erlotinib in previously treated non-small-cell lung cancer. N. Engl. J. Med. 353, 123-132 (2005).
    • (2005) N. Engl. J. Med. , vol.353 , pp. 123-132
    • Shepherd, F.A.1    Rodrigues Pereira, J.2    Ciuleanu, T.3
  • 16
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • Llovet JM, Ricci S, Mazzaferro V et al.: Sorafenib in advanced hepatocellular carcinoma. N. Engl. J. Med. 359, 378-390 (2008).
    • (2008) N. Engl. J. Med. , vol.359 , pp. 378-390
    • Llovet, J.M.1    Ricci, S.2    Mazzaferro, V.3
  • 18
    • 68949145218 scopus 로고    scopus 로고
    • Overall survival and updated results for sunitinib compared with interferon a in patients with metastatic renal cell carcinoma
    • Motzer RJ, Hutson TE, Tomczak P et al.: Overall survival and updated results for sunitinib compared with interferon a in patients with metastatic renal cell carcinoma. J. Clin. Oncol. 27, 3584-3590 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , pp. 3584-3590
    • Motzer, R.J.1    Hutson, T.E.2    Tomczak, P.3
  • 19
    • 0035800507 scopus 로고    scopus 로고
    • Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
    • DOI 10.1126/science.1062538
    • Gorre ME, Mohammed M, Ellwood K et al.: Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science 293, 876-880 (2001). (Pubitemid 32743979)
    • (2001) Science , vol.293 , Issue.5531 , pp. 876-880
    • Gorre, M.E.1    Mohammed, M.2    Ellwood, K.3    Hsu, N.4    Paquette, R.5    Nagesh Rao, P.6    Sawyers, C.L.7
  • 21
    • 18244371651 scopus 로고    scopus 로고
    • Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain
    • DOI 10.1371/journal.pmed.0020073, e73
    • Pao W, Miller VA, Politi KA et al.: Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain. PLoS Med. 2, E73 (2005). (Pubitemid 40629469)
    • (2005) PLoS Medicine , vol.2 , Issue.3 , pp. 0225-0235
    • Pao, W.1    Miller, V.A.2    Politi, K.A.3    Riely, G.J.4    Somwar, R.5    Zakowski, M.F.6    Kris, M.G.7    Varmus, H.8
  • 23
    • 33846552656 scopus 로고    scopus 로고
    • Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3
    • DOI 10.1038/nature05474, PII NATURE05474
    • Sergina NV, Rausch M, Wang D et al.: Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3. Nature 445, 437-441 (2007). (Pubitemid 46160912)
    • (2007) Nature , vol.445 , Issue.7126 , pp. 437-441
    • Sergina, N.V.1    Rausch, M.2    Wang, D.3    Blair, J.4    Hann, B.5    Shokat, K.M.6    Moasser, M.M.7
  • 24
    • 56449089812 scopus 로고    scopus 로고
    • Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations
    • Yano S, Wang W, Li Q et al.: Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutations. Cancer Res. 68, 9479-9487 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 9479-9487
    • Yano, S.1    Wang, W.2    Li, Q.3
  • 26
    • 66149092730 scopus 로고    scopus 로고
    • G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models
    • Describes the relationship of anti-VEGF therapy and myeloid cells
    • Shojaei F, Wu X, Qu X et al.: G-CSF-initiated myeloid cell mobilization and angiogenesis mediate tumor refractoriness to anti-VEGF therapy in mouse models. Proc. Natl Acad. Sci. USA 106, 6742-6747 (2009). n Describes the relationship of anti-VEGF therapy and myeloid cells.
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 6742-6747
    • Shojaei, F.1    Wu, X.2    Qu, X.3
  • 27
    • 77951754469 scopus 로고    scopus 로고
    • Direct and differential suppression of myeloid-derived suppressor cell subsets by sunitinib is compartmentally constrained
    • Novel finding regarding the role of granulocyte-macrophage-colony stimulating factor in the effects of sunitinib on myeloid-derived suppressor cells (MDSCs
    • Ko JS, Rayman P, Ireland J et al.: Direct and differential suppression of myeloid-derived suppressor cell subsets by sunitinib is compartmentally constrained. Cancer Res. 70, 3526-3536 (2010). nn Novel finding regarding the role of granulocyte-macrophage-colony stimulating factor in the effects of sunitinib on myeloid-derived suppressor cells (MDSCs).
    • (2010) Cancer Res. , vol.70 , pp. 3526-3536
    • Ko, J.S.1    Rayman, P.2    Ireland, J.3
  • 28
    • 3042844293 scopus 로고    scopus 로고
    • Cancer immunotherapy: A treatment for the masses
    • Blattman JN, Greenberg PD: Cancer immunotherapy: a treatment for the masses. Science 305, 200-205 (2004).
    • (2004) Science , vol.305 , pp. 200-205
    • Blattman, J.N.1    Greenberg, P.D.2
  • 29
    • 51349123892 scopus 로고    scopus 로고
    • Cancer immunotherapy by dendritic cells
    • Representative review of cancer immunotherapy with dendritic cells (DCs
    • Melief CJ: Cancer immunotherapy by dendritic cells. Immunity 29, 372-383 (2008). n Representative review of cancer immunotherapy with dendritic cells (DCs).
    • (2008) Immunity , vol.29 , pp. 372-383
    • Melief, C.J.1
  • 30
    • 34848837386 scopus 로고    scopus 로고
    • Taking dendritic cells into medicine
    • DOI 10.1038/nature06175, PII NATURE06175
    • Steinman RM, Banchereau J: Taking dendritic cells into medicine. Nature 449, 419-426 (2007). (Pubitemid 47509552)
    • (2007) Nature , vol.449 , Issue.7161 , pp. 419-426
    • Steinman, R.M.1    Banchereau, J.2
  • 31
    • 35748978808 scopus 로고    scopus 로고
    • Taming cancer by inducing immunity via dendritic cells
    • DOI 10.1111/j.1600-065X.2007.00575.x
    • Palucka AK, Ueno H, Fay JW, Banchereau J: Taming cancer by inducing immunity via dendritic cells. Immunol. Rev. 220, 129-150 (2007). (Pubitemid 350045575)
    • (2007) Immunological Reviews , vol.220 , Issue.1 , pp. 129-150
    • Palucka, A.K.1    Ueno, H.2    Fay, J.W.3    Banchereau, J.4
  • 33
    • 0034812545 scopus 로고    scopus 로고
    • + blood dendritic cells enhance NK cell-mediated cytotoxicity
    • DOI 10.1002/1521-4141(200109)31:9<2633::AID-IMMU2633>3.0.CO;2-2
    • 3+ blood dendritic cells enhance NK cell-mediated cytotoxicity. Eur. J. Immunol. 31, 2633-2641 (2001). (Pubitemid 32898730)
    • (2001) European Journal of Immunology , vol.31 , Issue.9 , pp. 2633-2641
    • Nishioka, Y.1    Nishimura, N.2    Suzuki, Y.3    Sone, S.4
  • 34
    • 0033566984 scopus 로고    scopus 로고
    • Induction of systemic and therapeutic antitumor immunity using intratumoral injection of dendritic cells genetically modified to express interleukin 12
    • Nishioka Y, Hirao M, Robbins PD, Lotze MT, Tahara H: Induction of systemic and therapeutic antitumor immunity using intratumoral injection of dendritic cells genetically modified to express interleukin-12. Cancer Res. 59, 4035-4041 (1999). (Pubitemid 29393574)
    • (1999) Cancer Research , vol.59 , Issue.16 , pp. 4035-4041
    • Nishioka, Y.1    Hirao, M.2    Robbins, P.D.3    Lotze, M.T.4    Tahara, H.5
  • 35
    • 0039782448 scopus 로고    scopus 로고
    • The use of dendritic cells in cancer therapy
    • DOI 10.1016/S1470-2045(00)00389-2, PII S1470204500003892
    • Jefford M, Maraskovsky E, Cebon J, Davis ID: The use of dendritic cells in cancer therapy. Lancet Oncol. 2, 343-353 (2001). (Pubitemid 33585939)
    • (2001) Lancet Oncology , vol.2 , Issue.6 , pp. 343-353
    • Jefford, M.1    Maraskovsky, E.2    Cebon, J.3    Davis, I.D.4
  • 36
    • 0035889647 scopus 로고    scopus 로고
    • Active immunization against cancer with dendritic cells: The near future
    • DOI 10.1002/ijc.1503
    • Steinman RM, Dhodapkar M: Active immunization against cancer with dendritic cells: the near future. Int. J. Cancer 94, 459-473 (2001). n Summary of DC-based immunotherapy. (Pubitemid 32979535)
    • (2001) International Journal of Cancer , vol.94 , Issue.4 , pp. 459-473
    • Steinman, R.M.1    Dhodapkar, M.2
  • 37
    • 4644324025 scopus 로고    scopus 로고
    • Cancer immunotherapy: Moving beyond current vaccines
    • DOI 10.1038/nm1100
    • Rosenberg SA, Yang JC, Restifo NP: Cancer immunotherapy: moving beyond current vaccines. Nat. Med. 10, 909-915 (2004). n Important summary of clinical trials in cancer immunotherapy. (Pubitemid 39273730)
    • (2004) Nature Medicine , vol.10 , Issue.9 , pp. 909-915
    • Rosenberg, S.A.1    Yang, J.C.2    Restifo, N.P.3
  • 38
    • 54849437711 scopus 로고    scopus 로고
    • Review of clinical studies on dendritic cell-based vaccination of patients with malignant melanoma: Assessment of correlation between clinical response and vaccine parameters
    • Engell-Noerregaard L, Hansen TH, Andersen MH, Thor Straten P, Svane IM: Review of clinical studies on dendritic cell-based vaccination of patients with malignant melanoma: assessment of correlation between clinical response and vaccine parameters. Cancer Immunol. Immunother. 58, 1-14 (2009).
    • (2009) Cancer Immunol. Immunother. , vol.58 , pp. 1-14
    • Engell-Noerregaard, L.1    Hansen, T.H.2    Andersen, M.H.3    Thor Straten, P.4    Svane, I.M.5
  • 39
    • 0029150110 scopus 로고
    • Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor a-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases
    • Early report concerning the discovery of regulatory T (Treg) cells
    • Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M: Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor a-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 155, 1151-1164 (1995). n Early report concerning the discovery of regulatory T (Treg) cells.
    • (1995) J. Immunol , vol.155 , pp. 1151-1164
    • Sakaguchi, S.1    Sakaguchi, N.2    Asano, M.3    Itoh, M.4    Toda, M.5
  • 41
    • 16844378209 scopus 로고    scopus 로고
    • Natural regulatory T cells and self-tolerance
    • DOI 10.1038/ni1184
    • Schwartz R: Natural regulatory T cells and self-tolerance. Nat. Immunol. 6, 327-330 (2005). (Pubitemid 41716768)
    • (2005) Nature Immunology , vol.6 , Issue.4 , pp. 327-330
    • Schwartz, R.H.1
  • 42
    • 43949105866 scopus 로고    scopus 로고
    • Regulatory T cells and immune tolerance
    • DOI 10.1016/j.cell.2008.05.009, PII S0092867408006247
    • Sakaguchi S, Yamaguchi T, Nomura T, Ono M: Regulatory T cells and immune tolerance. Cell 133, 775-787 (2008). n Representative review of Treg cells. (Pubitemid 351707693)
    • (2008) Cell , vol.133 , Issue.5 , pp. 775-787
    • Sakaguchi, S.1    Yamaguchi, T.2    Nomura, T.3    Ono, M.4
  • 43
    • 74049164847 scopus 로고    scopus 로고
    • Regulatory T cells exert checks and balances on self tolerance and autoimmunity
    • Wing K, Sakaguchi S: Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat. Immunol. 11, 7-13 (2010).
    • (2010) Nat. Immunol. , vol.11 , pp. 7-13
    • Wing, K.1    Sakaguchi, S.2
  • 45
    • 0035874949 scopus 로고    scopus 로고
    • + T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer
    • + T cells in tumors from patients with early-stage non-small cell lung cancer and late-stage ovarian cancer. Cancer Res. 61, 4766-4772 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 4766-4772
    • Woo, E.Y.1    Chu, C.S.2    Goletz, T.J.3
  • 48
    • 0141891466 scopus 로고    scopus 로고
    • Increased populations of regulatory T cells in peripheral blood and tumor-infiltrating lymphocytes in patients with gastric and esophageal cancers
    • Ichihara F, Kono K, Takahashi A, Kawaida H, Sugai H, Fujii H: Increased populations of regulatory T cells in peripheral blood and tumor-infiltrating lymphocytes in patients with gastric and esophageal cancers. Clin. Cancer Res. 9, 4404-4408 (2003). (Pubitemid 37248397)
    • (2003) Clinical Cancer Research , vol.9 , Issue.12 , pp. 4404-4408
    • Ichihara, F.1    Kono, K.2    Takahashi, A.3    Kawaida, H.4    Sugai, H.5    Fujii, H.6
  • 49
    • 0036721629 scopus 로고    scopus 로고
    • Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma
    • Liyanage UK, Moore TT, Joo HG et al.: Prevalence of regulatory T cells is increased in peripheral blood and tumor microenvironment of patients with pancreas or breast adenocarcinoma. J. Immunol. 169, 2756-2761 (2002).
    • (2002) J. Immunol. , vol.169 , pp. 2756-2761
    • Liyanage, U.K.1    Moore, T.T.2    Joo, H.G.3
  • 50
    • 16844378685 scopus 로고    scopus 로고
    • Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma
    • DOI 10.1158/0008-5472.CAN-04-3232
    • Ormandy LA, Hillemann T, Wedemeyer H, Manns MP, Greten TF, Korangy F: Increased populations of regulatory T cells in peripheral blood of patients with hepatocellular carcinoma. Cancer Res. 65, 2457-2464 (2005). n Representative report of Treg cells in cancer patients. (Pubitemid 40490158)
    • (2005) Cancer Research , vol.65 , Issue.6 , pp. 2457-2464
    • Ormandy, L.1    Hillemann, T.2    Wedemeyer, H.3    Manns, M.P.4    Greten, T.F.5    Korangy, F.6
  • 51
    • 0041386189 scopus 로고    scopus 로고
    • + regulatory T cells in patients with gastrointestinal malignancies: Possible involvement of regulatory T cells in disease progression
    • DOI 10.1002/cncr.11618
    • + regulatory T cells in patients with gastrointestinal malignancies: possible involvement of regulatory T cells in disease progression. Cancer 98, 1089-1099 (2003). (Pubitemid 37022112)
    • (2003) Cancer , vol.98 , Issue.5 , pp. 1089-1099
    • Sasada, T.1    Kimura, M.2    Yoshida, Y.3    Kanai, M.4    Takabayashi, A.5
  • 55
    • 0035801335 scopus 로고    scopus 로고
    • + regulatory T cells is mediated by cell surface-bound transforming growth factor β
    • DOI 10.1084/jem.194.5.629
    • + regulatory T cells is mediated by cell surface-bound transforming growth factorβ. J. Exp. Med. 194, 629-644 (2001). n One of the studies demonstrating the mechanism of immunosuppressive functions of Treg cells. (Pubitemid 32844773)
    • (2001) Journal of Experimental Medicine , vol.194 , Issue.5 , pp. 629-644
    • Nakamura, K.1    Kitani, A.2    Strober, W.3
  • 56
    • 0142219250 scopus 로고    scopus 로고
    • Transforming Growth Factor (TGF)-β1-producing Regulatory T Cells Induce Smad-mediated Interleukin 10 Secretion That Facilitates Coordinated Immunoregulatory Activity and Amelioration of TGF-β1-mediated Fibrosis
    • DOI 10.1084/jem.20030917
    • Kitani A, Fuss I, Nakamura K, Kumaki F, Usui T, Strober W: Transforming growth factor (TGF)-b1-producing regulatory T cells induce Smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-β1-mediated fibrosis. J. Exp. Med. 198, 1179-1188 (2003). n One of the studies demonstrating the mechanism of immunosuppressive functions of Treg cells. (Pubitemid 37323383)
    • (2003) Journal of Experimental Medicine , vol.198 , Issue.8 , pp. 1179-1188
    • Kitani, A.1    Fuss, I.2    Nakamura, K.3    Kumaki, F.4    Usui, T.5    Strober, W.6
  • 57
    • 0034679567 scopus 로고    scopus 로고
    • + regulatory cells that control intestinal inflammation
    • DOI 10.1084/jem.192.2.295
    • + regulatory cells that control intestinal inflammation. J. Exp. Med. 192, 295-302 (2000). n One of the studies demonstrating the mechanism of immunosuppressive functions of Treg cells. (Pubitemid 30470312)
    • (2000) Journal of Experimental Medicine , vol.192 , Issue.2 , pp. 295-302
    • Read, S.1    Malmstrom, V.2    Powrie, F.3
  • 59
    • 33645506145 scopus 로고    scopus 로고
    • Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-β
    • Ostroukhova M, Qi Z, Oriss TB, Dixon-McCarthy B, Ray P, Ray A: Treg-mediated immunosuppression involves activation of the Notch-HES1 axis by membrane-bound TGF-β. J. Clin. Invest. 116, 996-1004 (2006).
    • (2006) J. Clin. Invest. , vol.116 , pp. 996-1004
    • Ostroukhova, M.1    Qi, Z.2    Oriss, T.B.3    Dixon-McCarthy, B.4    Ray, P.5    Ray, A.6
  • 60
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • Critical review of MDSCs
    • Gabrilovich DI, Nagaraj S: Myeloid-derived suppressor cells as regulators of the immune system. Nat. Rev. Immunol. 9, 162-174 (2009). nn Critical review of MDSCs.
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2
  • 61
    • 65249138393 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells: Linking inflammation and cancer
    • Ostrand-Rosenberg S, Sinha P: Myeloid-derived suppressor cells: linking inflammation and cancer. J. Immunol. 182, 4499-4506 (2009).
    • (2009) J. Immunol. , vol.182 , pp. 4499-4506
    • Ostrand-Rosenberg, S.1    Sinha, P.2
  • 62
    • 41149119143 scopus 로고    scopus 로고
    • Tumor-induced tolerance and immune suppression by myeloid derived suppressor cells
    • DOI 10.1111/j.1600-065X.2008.00602.x
    • Marigo I, Dolcetti L, Serafini P, Zanovello P, Bronte V: Tumor-induced tolerance and immune suppression by myeloid derived suppressor cells. Immunol. Rev. 222, 162-179 (2008). (Pubitemid 351430364)
    • (2008) Immunological Reviews , vol.222 , Issue.1 , pp. 162-179
    • Marigo, I.1    Dolcetti, L.2    Serafini, P.3    Zanovello, P.4    Bronte, V.5
  • 63
    • 10244279184 scopus 로고    scopus 로고
    • Mechanisms and functional significance of tumour-induced dendritic-cell defects
    • DOI 10.1038/nri1498
    • Gabrilovich D: Mechanisms and functional significance of tumor-induced dendritic-cell defects. Nat. Rev. Immunol. 4, 941-952 (2004). nn Critical review of tumor-induced immunosuppression for DC functions. (Pubitemid 39620069)
    • (2004) Nature Reviews Immunology , vol.4 , Issue.12 , pp. 941-952
    • Gabrilovich, D.1
  • 65
    • 43249130187 scopus 로고    scopus 로고
    • Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity
    • Movahedi K, Guilliams M, Van den Bossche J et al.: Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity. Blood 111, 4233-4244 (2008).
    • (2008) Blood , vol.111 , pp. 4233-4244
    • Movahedi, K.1    Guilliams, M.2    Van Den Bossche, J.3
  • 67
    • 77950829023 scopus 로고    scopus 로고
    • Mechanism of T cell tolerance induced by myeloid-derived suppressor cells
    • Describes the immunosuppresive mechanisms of MDSCs
    • Nagaraj S, Schrum AG, Cho HI, Celis E, Gabrilovich DI: Mechanism of T cell tolerance induced by myeloid-derived suppressor cells. J. Immunol. 184, 3106-3116 (2010). n Describes the immunosuppresive mechanisms of MDSCs.
    • (2010) J. Immunol. , vol.184 , pp. 3106-3116
    • Nagaraj, S.1    Schrum, A.G.2    Cho, H.I.3    Celis, E.4    Gabrilovich, D.I.5
  • 68
    • 47949090079 scopus 로고    scopus 로고
    • The role of myeloid cells in the promotion of tumour angiogenesis
    • Critical review of myeloid cell-mediated tumor angiogenesis
    • Murdoch C, Muthana M, Coffelt SB, Lewis CE: The role of myeloid cells in the promotion of tumour angiogenesis. Nat. Rev. Cancer 8, 618-631 (2008). nn Critical review of myeloid cell-mediated tumor angiogenesis.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 618-631
    • Murdoch, C.1    Muthana, M.2    Coffelt, S.B.3    Lewis, C.E.4
  • 69
    • 77953487609 scopus 로고    scopus 로고
    • Myeloid cells in the tumor microenvironment: Modulation of tumor angiogenesis and tumor inflammation
    • Epub ahead of print DOI: 10.1155/2010/201026
    • Schmid MC, Varner JA: Myeloid cells in the tumor microenvironment: modulation of tumor angiogenesis and tumor inflammation. J. Oncol. DOI: 10.1155/2010/201026. (2010) (Epub ahead of print).
    • (2010) J. Oncol.
    • Schmid, M.C.1    Varner, J.A.2
  • 74
    • 15244351682 scopus 로고    scopus 로고
    • Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner
    • DOI 10.1182/blood-2004-07-2527
    • Seggewiss R, Loré K, Greiner E et al.: Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner. Blood 105, 2473-2479 (2005). (Pubitemid 40387048)
    • (2005) Blood , vol.105 , Issue.6 , pp. 2473-2479
    • Seggewiss, R.1    Lore, K.2    Greiner, E.3    Magnusson, M.K.4    Price, D.A.5    Douek, D.C.6    Dunbar, C.E.7    Wiestner, A.8
  • 75
    • 3843119865 scopus 로고    scopus 로고
    • Imatinib mesylate inhibits T-cell proliferation in vitro and delayed-type hypersensitivity in vivo
    • DOI 10.1182/blood-2003-12-4266
    • Dietz AB, Souan L, Knutson GJ, Bulur PA, Litzow MR, Vuk-Pavlovic S: Imatinib mesylate inhibits T-cell proliferation in vitro and delayed-type hypersensitivity in vivo. Blood 104, 1094-1099 (2004). n Report of the immunosuppresive effects of imatinib. (Pubitemid 39038030)
    • (2004) Blood , vol.104 , Issue.4 , pp. 1094-1099
    • Dietz, A.B.1    Souan, L.2    Knutson, G.J.3    Bulur, P.A.4    Litzow, M.R.5    Vuk-Pavlovic, S.6
  • 77
    • 1442331705 scopus 로고    scopus 로고
    • Imatinib impairs Flt3L-mediated dendritic cell expansion and antitumor effects in vivo
    • Taieb J, Maruyama K, Borg C et al.: Imatinib impairs Flt3L-mediated dendritic cell expansion and antitumor effects in vivo. Blood 103, 1966-1967 (2004).
    • (2004) Blood , vol.103 , pp. 1966-1967
    • Taieb, J.1    Maruyama, K.2    Borg, C.3
  • 79
    • 2942625414 scopus 로고    scopus 로고
    • Imatinib and plasmacytoid dendritic cell function in patients with chronic myeloid leukemia
    • DOI 10.1182/blood-2003-09-3220
    • Mohty M, jourdan F, Mami NB et al.: Imatinib and plasmocytoid dendritic cell function in patients with chronic myelogenous leukemia. Blood 103, 4666-4668 (2004). (Pubitemid 38746000)
    • (2004) Blood , vol.103 , Issue.12 , pp. 4666-4668
    • Mohty, M.1    Jourdan, E.2    Mami, N.B.3    Vey, N.4    Damaj, G.5    Blaise, D.6    Isnardon, D.7    Olive, D.8    Gaugler, B.9
  • 84
    • 30044449181 scopus 로고    scopus 로고
    • FMS receptor for M-CSF (CSF-1) is sensitive to the kinase inhibitor imatinib and mutation of Asp-802 to Val confers resistance
    • DOI 10.1111/j.1365-277X.2006.00674.x
    • Taylor JR, Brownlow N, Domin J, Dibb NJ: FMS receptor for M-CSF (CSF-1) is sensitive to the kinase inhibitor imatinib and mutation of Asp-802 to Val confers resistance. Oncogene 25, 147-151 (2006). (Pubitemid 43050013)
    • (2006) Oncogene , vol.25 , Issue.1 , pp. 147-151
    • Taylor, J.R.1    Brownlow, N.2    Domin, J.3    Dibb, N.J.4
  • 85
    • 0029842830 scopus 로고    scopus 로고
    • Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells
    • DOI 10.1038/nm1096-1096
    • Gabrilovich DI, Chen HL, Girgis KR et al.: Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells. Nat. Med. 2, 1096-1103 (1996). nn First report regarding VEGF-mediated suppression of DC function. (Pubitemid 26338628)
    • (1996) Nature Medicine , vol.2 , Issue.10 , pp. 1096-1103
    • Gabrilovich, D.I.1    Chen, H.L.2    Girgis, K.R.3    Cunningham, H.T.4    Meny, G.M.5    Nadaf, S.6    Kavanaugh, D.7    Carbone, D.P.8
  • 86
    • 0033568001 scopus 로고    scopus 로고
    • Effect of vascular endothelial growth factor and FLT3 ligand on dendritic cell generation in vivo
    • Ohm JE, Shurin MR, Esche C, Lotze MT, Carbone DP, Gabrilovich DI: Effect of vascular endothelial growth factor and Flt3 ligand on dendritic cell generation in vivo. J. Immunol. 163, 3260-3268 (1999). (Pubitemid 29431827)
    • (1999) Journal of Immunology , vol.163 , Issue.6 , pp. 3260-3268
    • Ohm, J.E.1    Shurin, M.R.2    Esche, C.3    Lotze, M.T.4    Carbone, D.P.5    Gabrilovich, D.I.6
  • 87
    • 0031892785 scopus 로고    scopus 로고
    • Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-κB activation in hemopoietic progenitor cells
    • Oyama T, Ran S, Ishida T et al.: Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-kB activation in hemopoietic progenitor cells. J. Immunol. 160, 1224-1232 (1998). (Pubitemid 28093419)
    • (1998) Journal of Immunology , vol.160 , Issue.3 , pp. 1224-1232
    • Oyama, T.1    Ran, S.2    Ishida, T.3    Nadaf, S.4    Kerr, L.5    Carbone, D.P.6    Gabrilovich, D.I.7
  • 88
    • 0032211082 scopus 로고    scopus 로고
    • Defective function of langerhans cells in tumor-bearing animals is the result of defective maturation from hemopoietic progenitors
    • Ishida T, Oyama T, Carbone DP, Gabrilovich DI: Defective function of Langerhans cells in tumor-bearing animals is the result of defective maturation from hemopoietic progenitors. J. Immunol. 161, 4842-4851 (1998). (Pubitemid 28492062)
    • (1998) Journal of Immunology , vol.161 , Issue.9 , pp. 4842-4851
    • Ishida, T.1    Oyama, T.2    Carbone, D.P.3    Gabrilovich, D.I.4
  • 89
    • 0032741283 scopus 로고    scopus 로고
    • Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function
    • Gabrilovich DI, Ishida T, Nadaf S, Ohm JE, Carbone DP: Antibodies to vascular endothelial growth factor enhance the efficacy of cancer immunotherapy by improving endogenous dendritic cell function. Clin. Cancer Res. 5, 2963-2970 (1999). (Pubitemid 29493976)
    • (1999) Clinical Cancer Research , vol.5 , Issue.10 , pp. 2963-2970
    • Gabrilovich, D.I.1    Ishida, T.2    Nadaf, S.3    Ohm, J.E.4    Carbone, D.P.5
  • 91
    • 47049127786 scopus 로고    scopus 로고
    • Sorafenib, but not sunitinib, affects function of dendritic cells and induction of primary immune responses
    • Describes the immunomodulatory effects of sorafenib and sunitinib
    • Hipp MM, Hilf N, Walter S et al.: Sorafenib, but not sunitinib, affects function of dendritic cells and induction of primary immune responses. Blood 111, 5610-5620 (2008). nn Describes the immunomodulatory effects of sorafenib and sunitinib.
    • (2008) Blood , vol.111 , pp. 5610-5620
    • Hipp, M.M.1    Hilf, N.2    Walter, S.3
  • 92
    • 45149084681 scopus 로고    scopus 로고
    • Sorafenib inhibits activation of human peripheral blood T cells by targeting LCK phosphorylation
    • DOI 10.1038/leu.2008.58, PII LEU200858
    • Zhao W, Gu YH, Song R, Qu BQ, Xu Q: Sorafenib inhibits activation of human peripheral blood T cells by targeting Lck phosphorylation. Leukemia 22, 1226-1233 (2008). (Pubitemid 351833791)
    • (2008) Leukemia , vol.22 , Issue.6 , pp. 1226-1233
    • Zhao, W.1    Gu, Y.H.2    Song, R.3    Qu, B.Q.4    Xu, Q.5
  • 93
    • 65549141834 scopus 로고    scopus 로고
    • The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies
    • Report on the immunostimulatory effects of sunitinib
    • Ozao-Choy J, Ma G, Kao J et al.: The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies. Cancer Res. 69, 2514-2522 (2009). n Report on the immunostimulatory effects of sunitinib.
    • (2009) Cancer Res. , vol.69 , pp. 2514-2522
    • Ozao-Choy, J.1    Ma, G.2    Kao, J.3
  • 94
    • 38049181485 scopus 로고    scopus 로고
    • Reversion of immune tolerance in advanced malignancy: Modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor function
    • Novel mechanism to block MDSC development
    • Pan PY, Wang GX, Yin B et al.: Reversion of immune tolerance in advanced malignancy: modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor function. Blood 111, 219-228 (2008). n Novel mechanism to block MDSC development.
    • (2008) Blood , vol.111 , pp. 219-228
    • Pan, P.Y.1    Wang, G.X.2    Yin, B.3
  • 95
    • 65549129226 scopus 로고    scopus 로고
    • Sunitinib inhibition of STAT3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells
    • Xin H, Zhang C, Herrmann A, Du Y, Figlin R, Yu H: Sunitinib inhibition of STAT3 induces renal cell carcinoma tumor cell apoptosis and reduces immunosuppressive cells. Cancer Res. 69, 2506-2513 (2009).
    • (2009) Cancer Res. , vol.69 , pp. 2506-2513
    • Xin, H.1    Zhang, C.2    Herrmann, A.3    Du, Y.4    Figlin, R.5    Yu, H.6
  • 96
    • 63549105681 scopus 로고    scopus 로고
    • Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients
    • Representative report describing the immunostimulatory effects of sunitinib in cancer patients
    • Ko JS, Zea AH, Rini BI et al.: Sunitinib mediates reversal of myeloid-derived suppressor cell accumulation in renal cell carcinoma patients. Clin. Cancer Res. 15, 2148-2157 (2009). nn Representative report describing the immunostimulatory effects of sunitinib in cancer patients.
    • (2009) Clin. Cancer Res. , vol.15 , pp. 2148-2157
    • Ko, J.S.1    Zea, A.H.2    Rini, B.I.3
  • 101
    • 58149181387 scopus 로고    scopus 로고
    • + T-cell responses and NK-cell cytolytic activity in vitro and in vivo
    • + T-cell responses and NK-cell cytolytic activity in vitro and in vivo. Exp. Hematol. 37, 256-265 (2009).
    • (2009) Exp. Hematol. , vol.37 , pp. 256-265
    • Fraser, C.K.1    Blake, S.J.2    Diener, K.R.3
  • 104
    • 62849094732 scopus 로고    scopus 로고
    • Selectivity and therapeutic inhibition of kinases: To be or not to be?
    • Ghoreschi K, Laurence A, O'Shea JJ: Selectivity and therapeutic inhibition of kinases: to be or not to be? Nat. Immunol. 10, 56-360 (2009).
    • (2009) Nat. Immunol. , vol.10 , pp. 56-360
    • Ghoreschi, K.1    Laurence, A.2    O'Shea, J.J.3
  • 105
    • 38549162640 scopus 로고    scopus 로고
    • Inflammation, inflammatory cells and angiogenesis: Decisions and indecisions
    • Representative review of myeloid cell-mediated angiogenesis
    • Noonan DM, De Lerma Barbaro A, Vannini N, Mortara L, Albini A: Inflammation, inflammatory cells and angiogenesis: decisions and indecisions. Cancer Metastasis Rev. 27, 31-40 (2008). nn Representative review of myeloid cell-mediated angiogenesis.
    • (2008) Cancer Metastasis Rev. , vol.27 , pp. 31-40
    • Noonan, D.M.1    De Lerma Barbaro, A.2    Vannini, N.3    Mortara, L.4    Albini, A.5
  • 106
    • 77954753261 scopus 로고    scopus 로고
    • Anti-inflammatory M2 type macrophages characterize metastasized and tyrosine kinase inhibitor-treated gastrointestinal stromal tumors
    • van Dongen M, Savage ND, Jordanova ES et al.: Anti-inflammatory M2 type macrophages characterize metastasized and tyrosine kinase inhibitor-treated gastrointestinal stromal tumors. Int. J. Cancer. 127, 899-909 (2010).
    • (2010) Int. J. Cancer. , vol.127 , pp. 899-909
    • Van Dongen, M.1    Savage, N.D.2    Jordanova, E.S.3
  • 107
    • 38049068004 scopus 로고    scopus 로고
    • Myeloid cells functioning in tumor vascularization as a novel therapeutic target
    • Review of myeloid cell-mediated angiogenesis
    • McLean K, Buckanovich RJ: Myeloid cells functioning in tumor vascularization as a novel therapeutic target. Transl. Res. 151, 59-67 (2008). nn Review of myeloid cell-mediated angiogenesis.
    • (2008) Transl. Res. , vol.151 , pp. 59-67
    • McLean, K.1    Buckanovich, R.J.2
  • 108
    • 77952299622 scopus 로고    scopus 로고
    • Tumor growth and angiogenesis are dependent on the presence of immature dendritic cells
    • Direct demonstration of the contribution of immature DCs to angiogenesis
    • Fainaru O, Almog N, Yung CW et al.: Tumor growth and angiogenesis are dependent on the presence of immature dendritic cells. FASEB J. 24, 1411-1418 (2010). nn Direct demonstration of the contribution of immature DCs to angiogenesis.
    • (2010) FASEB J. , vol.24 , pp. 1411-1418
    • Fainaru, O.1    Almog, N.2    Yung, C.W.3
  • 110
    • 76249091676 scopus 로고    scopus 로고
    • Expression of soluble vascular endothelial growth factor receptor-1 in human monocyte-derived mature dendritic cells contributes to their antiangiogenic property
    • Kishuku M, Nishioka Y, Abe S et al.: Expression of soluble vascular endothelial growth factor receptor-1 in human monocyte-derived mature dendritic cells contributes to their antiangiogenic property. J. Immunol. 183, 8176-8185 (2009).
    • (2009) J. Immunol. , vol.183 , pp. 8176-8185
    • Kishuku, M.1    Nishioka, Y.2    Abe, S.3
  • 111
    • 18044391683 scopus 로고    scopus 로고
    • The role of dendritic cell precursors in tumour vasculogenesis
    • DOI 10.1038/sj.bjc.6602476
    • Coukos G, Benencia F, Buckanovich RJ, Conejo-Garcia JR: The role of dendritic cell precursors in tumour vasculogenesis. Br. J. Cancer. 92, 1182-1187 (2005). n Concise review of the role of DCs in angiogenesis. (Pubitemid 40604389)
    • (2005) British Journal of Cancer , vol.92 , Issue.7 , pp. 1182-1187
    • Coukos, G.1    Benencia, F.2    Buckanovich, R.J.3    Conejo-Garcia, J.R.4


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