Crystal structure of hexokinase KlHxk1 of kluyveromyces lactis: A molecular basis for understanding the control of yeast hexokinase functions via covalent modification and oligomerization

Journal of Biological Chemistry

Volumn 285, Issue 52, 2010, Pages 41019-41033

  Kuettner, E Bartholomeus ^a   Kettner, Karina ^b   Keim, Antje ^a   Svergun, Dmitri I ^c   Volke, Daniela ^a   Singer, David ^a   Hoffmann, Ralf ^a   Müller, Eva Christina ^d   Otto, Albrecht ^d   Kriegel, Thomas M ^b   Sträter, Norbert ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^c DESY   (Germany)

^d MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHARGED RESIDUES; COMPLEX STRUCTURE; CONSERVED RESIDUES; COVALENT MODIFICATIONS; CRYSTAL FORMS; DIMER FORMATION; ELECTROSTATIC REPULSION; FAVORABLE INTERACTIONS; GLUCOSE SIGNALING; HEXOKINASES; HOMODIMERS; INDEPENDENT CRYSTALS; KLUYVEROMYCES LACTIS; LARGE DOMAIN; MOLECULAR BASIS; MOLECULAR MODELS; MONOMERIC ENZYMES; N-TERMINALS; OPEN CONFORMATION; SMALL ANGLE X-RAY SCATTERING; SUBSTRATE BINDING; TAIL ARRANGEMENT;

AMINO ACIDS; CRYSTAL STRUCTURE; DISSOCIATION; GLUCOSE; OLIGOMERIZATION; PHOSPHORYLATION; SUBSTRATES; SUPERSONIC AERODYNAMICS; X RAY SCATTERING; YEAST;

DIMERS;

DIMER; GLUCOSE; HEXOKINASE 1; HOMODIMER; SERINE;

AMINO TERMINAL SEQUENCE; ARTICLE; CRYSTAL STRUCTURE; DIMERIZATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME BINDING; ENZYME CONFORMATION; ENZYME SUBSTRATE; ENZYME SUBUNIT; KLUYVEROMYCES LACTIS; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STATIC ELECTRICITY; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; FUNGAL PROTEINS; GLUCOSE; HEXOKINASE; KLUYVEROMYCES; MODELS, MOLECULAR; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY;

KLUYVEROMYCES LACTIS;

EID: 78650407222     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.185850     Document Type: Article

References (64)

1. Moreno, F., Ahuatzi, D., Riera, A., Palomino, C. A., and Herrero, P. (2005) Biochem. Soc. Trans. 33, 265-268
2. Rolland, F., and Sheen, J. (2005) Biochem. Soc. Trans. 33, 269-271
3. Matschinsky, F. M., Magnuson, M. A., Zelent, D., Jetton, T. L., Doliba, N., Han, Y., Taub, R., and Grimsby, J. (2006) Diabetes 55, 1-12
4. Rolland, F., Baena-Gonzalez, E., and Sheen, J. (2006) Annu. Rev. Plant Biol. 57, 675-709
5. Rolland, F., Winderickx, J., and Thevelein, J. M. (2001) Trends Biochem. Sci. 26, 310-317
6. Wilson, J. E. (2003) J. Exp. Biol. 206, 2049-2057
7. Cho, Y. H., Yoo, S. D., and Sheen, J. (2006) Cell 127, 579-589
8. Riera, A., Ahuatzi, D., Herrero, P., Garcia-Gimeno, M. A., Sanz, P., and Moreno, F. (2008) Biochem. J. 415, 233-239
9. Peláez, R., Herrero, P., and Moreno, F. (2009) J. Biol. Chem. 284, 20548-20555
10. Breunig, K. D., Bolotin-Fukuhara, M., Bianchi, M. M., Bourgarel, D., Falcone, C., Ferrero, I. I., Frontali, L., Goffrini, P., Krijger, J. J., Mazzoni, C., Milkowski, C., Steensma, H. Y., Wésolowski-Louvel, M., and Zeeman, A. M. (2000) Enzyme Microb. Technol. 26, 771-780
11. Bolotin-Fukuhara, M., Toffano-Nioche, C., Artiguenave, F., Duchateau-Nguyen, G., Lemaire, M., Marmeisse, R., Montrocher, R., Robert, C., Termier, M., Wincker, P., and Wésolowski-Louvel, M. (2000) FEBS Lett. 487, 66-70
12. Schaffrath, R., and Breunig, K. D. (2000) Fungal Genet. Biol. 30, 173-190
13. Prior, C., Mamessier, P., Fukuhara, H., Chen, X. J., and Wesolowski-Louvel, M. (1993) Mol. Cell. Biol. 13, 3882-3889
14. Milkowski, C., Krampe, S., Weirich, J., Hasse, V., Boles, E., and Breunig, K. D. (2001) J. Bacteriol. 183, 5223-5229
15. Weirich, J., Goffrini, P., Kuger, P., Ferrero, I., and Breunig, K. D. (1997) Eur. J. Biochem. 249, 248-257
16. Agius, L. (2008) Biochem. J. 414, 1-18
17. Matschinsky, F. M. (2009) Nat. Rev. Drug Discov. 8, 399-416
18. Vojtek, A. B., and Fraenkel, D. G. (1990) Eur. J. Biochem. 190, 371-375
19. Kriegel, T. M., Rush, J., Vojtek, A. B., Clifton, D., and Fraenkel, D. G. (1994) Biochemistry 33, 148-152
20. Behlke, J., Heidrich, K., Naumann, M., Müller, E. C., Otto, A., Reuter, R., and Kriegel, T. (1998) Biochemistry 37, 11989-11995
21. Golbik, R., Naumann, M., Otto, A., Müller, E., Behlke, J., Reuter, R., Hübner, G., and Kriegel, T. M. (2001) Biochemistry 40, 1083-1090
22. Kettner, K., Müller, E. C., Otto, A., Rödel, G., Breunig, K. D., and Kriegel, T. M. (2007) FEMS Yeast Res. 7, 683-692
23. Bär, D., Golbik, R., Hübner, G., Lilie, H., Müller, E. C., Naumann, M., Otto, A., Reuter, R., Breunig, K. D., and Kriegel, T. M. (2003) J. Biol. Chem. 278, 39280-39286
24. Anderson, C. M., McDonald, R. C., and Steitz, T. A. (1978) J. Mol. Biol. 123, 1-13
25. Bennett, W. S., Jr., and Steitz, T. A. (1978) Proc. Natl. Acad. Sci. U.S.A. 75, 4848-4852
26. McDonald, R. C., Steitz, T. A., and Engelman, D. M. (1979) Biochemistry 18, 338-342
27. Bennett, W. S., Jr., and Steitz, T. A. (1980) J. Mol. Biol. 140, 211-230
28. Anderson, C. M., Stenkamp, R. E., and Steitz, T. A. (1978) J. Mol. Biol. 123, 15-33
29. Kuser, P., Cupri, F., Bleicher, L., and Polikarpov, I. (2008) Proteins 72, 731-740
30. Kuser, P. R., Krauchenco, S., Antunes, O. A., and Polikarpov, I. (2000) J. Biol. Chem. 275, 20814-20821
31. Hoggett, J. G., and Kellett, G. L. (1992) Biochem. J. 287 (Pt 2), 567-572
32. Steitz, T. A., Fletterick, R. J., and Hwang, K. J. (1973) J. Mol. Biol. 78, 551-561
33. Anderson, W. F., Fletterick, R. J., and Steitz, T. A. (1974) J. Mol. Biol. 86, 261-269
34. McDonald, R. C., Engelman, D. M., and Steitz, T. A. (1979) J. Biol. Chem. 254, 2942-2943
35. Bradford, M. M. (1976) Anal. Biochem. 72, 248-254
36. Kuettner, E. B., Kriegel, T. M., Keim, A., Naumann, M., and Sträter, N. (2007) Acta Crystallogr. Sect. F Struct. Biol Cryst. Commun. 63, 430-433
37. Riboldi-Tunnicliffe, A., and Hilgenfeld, R. (1999) J. Appl. Crystallogr. 32, 1003-1005
38. Otwinowski, Z., and Minor, W. (1997) in Methods in Enzymology, Volume 276, Macromolecular Crystallography, Part A (Charles, C. W., Jr., and Sweet, R. M., eds) pp. 307-326, Academic Press, Orlando, FL
39. Collaborative Computational Project, No. 4 (1994) Acta Crystallogr. D Biol. Crystallogr. 50, 760-763
40. Weiss, M. S. (2001) J. Appl. Crystallogr. 34, 130-135
41. Kabsch, W. (1993) J. Appl. Crystallogr. 26, 795-800
42. Navaza, J. (1994) Acta Crystallogr. A 50, 157-163
43. Perrakis, A., Morris, R., and Lamzin, V. S. (1999) Nat. Struct. Biol. 6, 458-463
44. Emsley, P., and Cowtan, K. (2004) Acta Crystallogr. D Biol. Crystallogr. 60, 2126-2132
45. Winn, M. D., Isupov, M. N., and Murshudov, G. N. (2001) Acta Crystallogr. D Biol. Crystallogr. 57, 122-133
46. Cohen, G. H. (1997) J. Appl. Crystallogr. 30, 1160-1161
47. Kabsch, W., and Sander, C. (1983) Biopolymers 22, 2577-2637
48. Konarev, P. V., Volkov, V. V., Sokolova, A. V., Koch, M. H. J., and Svergun, D. I. (2008) J. Appl. Crystallogr. 36, 1277-1282
49. Svergun, D. I., Barberato, C., and Koch, M. H. J. (1995) J. Appl. Crystallogr. 28, 768-773
50. Svergun, D. I. (1992) J. Appl. Crystallogr. 25, 495-503
51. Svergun, D. I., Petoukhov, M. V., and Koch, M. H. J. (2001) Biophys. J. 80, 2946-2953
52. Kozin, M. B., and Svergun, D. I. (2001) J. Appl. Crystallogr. 34, 33-41
53. Petoukhov, M. V., and Svergun, D. I. (2005) Biophys. J 89, 1237-1250
54. Grueninger, D., Treiber, N., Ziegler, M. O., Koetter, J. W., Schulze, M. S., and Schulz, G. E. (2008) Science 319, 206-209
55. Aleshin, A. E., Kirby, C., Liu, X., Bourenkov, G. P., Bartunik, H. D., Fromm, H. J., and Honzatko, R. B. (2000) J. Mol. Biol. 296, 1001-1015
56. Hayward, S., and Lee, R. A. (2002) J. Mol. Graph. Model. 21, 181-183
57. Hayward, S., and Berendsen, H. J. (1998) Proteins 30, 144-154
58. Hayward, S. (1999) Proteins 36, 425-435
59. Mulichak, A. M., Wilson, J. E., Padmanabhan, K., and Garavito, R. M. (1998) Nat. Struct. Biol 5, 555-560
60. Tielens, A. G., van den Heuvel, J. M., van Mazijk, H. J., Wilson, J. E., and Shoemaker, C. B. (1994) J. Biol. Chem. 269, 24736-24741
61. Schmidt, J. J., and Colowick, S. P. (1973) Arch. Biochem. Biophys. 158, 471-477
62. Blume, A., Fitzen, M., Benie, A. J., and Peters, T. (2009) Carbohydr. Res. 344, 1567-1574
63. Ahuatzi, D., Riera, A., Peláez, R., Herrero, P., and Moreno, F. (2007) J. Biol. Chem. 282, 4485-4493
64. Cassart, J. P., Georis, I., Ostling, J., Ronne, H., and Vandenhaute, J. (1995) FEBS Lett. 371, 191-194