Human pancreatic β-cell glucokinase: Subcellular localization and glucose repression signalling function in the yeast cell

Biochemical Journal

Volumn 415, Issue 2, 2008, Pages 233-239

  Riera, Alberto ^a   Ahuatzi, Deifilia ^a,d   Herrero, Pilar ^a   Garcia Gimeno, Maria Adelaida ^b,c   Sanz, Pascual ^b,c   Moreno, Fernando ^a  

^a DEPARTAMENTO DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR   (Spain)

^b INSTITUTO DE BIOMEDICINA DE VALENCIA   (Spain)

^c CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE ENFERMEDADES RARAS CIBERER   (Spain)

^d INSTITUTO POLITÉCNICO NACIONAL   (Mexico)

Author keywords

Glucose repression; Hexokinase 2 (Hxk2); Multicopy inhibitor of GAL gene expression (Mig1); Pancreatic cell glucokinase; Saccharomyces cerevisiae

Indexed keywords

ANIMAL CELL CULTURE; BIOACTIVITY; BIOCHEMICAL ENGINEERING; CELLS; CYTOLOGY; GENE EXPRESSION; GLUCOSE; NETWORK PROTOCOLS; PROBABILITY DENSITY FUNCTION; SENSOR NETWORKS; SUGAR (SUCROSE); SUGARS; YEAST;

GLUCOKINASE; GLUCOSE REPRESSION; GLUCOSE REPRESSIONS; HEXOKINASE; HEXOKINASE 2 (HXK2); MULTICOPY INHIBITOR OF GAL GENE EXPRESSION (MIG1); NUCLEAR; REGULATORY; REGULATORY DOMAINS; REGULATORY PROPERTIES; S. CEREVISIAE; SACCHAROMYCES CEREVISIAE; SIGNALLING PATHWAYS; SUBCELLULAR LOCALIZATIONS; TRANSCRIPTIONAL REPRESSORS; YEAST CELLS;

MAINTENANCE OF WAY;

BINDING PROTEIN; GLUCOKINASE; GLUCOSE; PANCREAS ISLET BETA CELL GLUCOKINASE; PROTEIN MIG1; SUCROSE FERMENTATION 2 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL GROWTH; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME LOCALIZATION; GENE REPRESSION; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; YEAST CELL;

BIOLOGICAL TRANSPORT; CELL NUCLEUS; CHROMATIN IMMUNOPRECIPITATION; DNA-BINDING PROTEINS; GLUCOKINASE; GLUCOSE; HUMANS; MICROSCOPY, FLUORESCENCE; PROTEIN BINDING; REPRESSOR PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; TWO-HYBRID SYSTEM TECHNIQUES;

SACCHAROMYCES CEREVISIAE;

EID: 54049132857     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20080797     Document Type: Article

References (35)

1. Wilson, J. E. (1995) Hexokinases. Rev. Physiol. Biochem. Pharmacol. 126, 65-198
2. Agius, L., Peak, M., Newrgard, C. B., Gomez-Foix, A. M. and Guinovart, J. J. (1996) Evidence for a role of glucose-induced translocation of glucolkinase in the control of hepatic glycogen synthesis. J. Biol. Chem. 271, 30479-30486
3. Matschinsky. F. M. (2005) Glucokinase, glucose homeostasis, and diabetes mellitus. Curr. Dialb. Rep. 5, 171-176
4. de la Iglesia, N., Veiga-da-Cunha, M., Van Schaftingen, E., Guinovart, J. J. and Ferrer, J. C. (1999) Glucokinase regulatory protein is essential for the proper sulocellular localisation of liver glucokinase. FEBS Lett. 456, 332-338
5. Veiga-da-Cunha. M. and Van Schaftingen, E. (2002) Identification of fructose 6-phosphate- and fructose 1-phosphate-binding residues in the regulatory protein of glucokinase. J. Biol. Chem. 277, 8466-8473
6. Danial, N. N., Gramm, C. F., Scorrano, L., Zhang, C. Y., Krauss, S., Ranger A. M., Datta, S. R., Greenberg, M. E., Licklider, L. J., Lowell, B. B. et al. (2003) BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis. Nature 424, 952-956
7. Arden, C., Baltrusch, S. and Agius, L. (2006) Glucokinase regulatory protein is associated with mitochondria in hepatocytes. FEBS Lett. 580, 2065-2070
8. Kim, W. H., Lee, J. W., Suh, Y. H., Hong, S. H., Choi, J. S., Lim, J. H., Song. J. H., Gao, B. and Jung, M. H. (2005) Exposure to chronic high glucose induces β-cell apoptosis through decreased interaction of glucokinase with mitochondria: downregulation of glucokinase in pancreatic β-cells. Diabetes 54, 2602-2611
9. Rizzo, M. A. and Piston. D. W. (2003) Regulation of β-cell glucokinase by S-nitrosylation and association with nitric oxide synthase. J. Cell Biol. 161, 243-248
10. Arden, C., Harbottle, A., Baltrusch, S., Tiedge, M. and Agius, L. (2004) Glucokinase is an integral component of the insulin granules in glucose-responsive insulin secretory cells and does not translocate during glucose stimulation. Diabetes 53, 2346-2352
11. Randez-Gil, F., Herrero, P., Sanz, P., Prieto, J. A. and Moreno, F. (1998) Hexokinase PII has a double cytosolic-nuclear localisation in Saccharomyces cerevisiae. FEBS Lett. 425, 475-478
12. Stubbs, M., Aiston, S. and Agius, L. (2000) Subcellular localization, mobility, and kinetic activity of glucokinase in glucose-responsive insulin-secreting cells. Diabetes 49, 2048-2055
13. Ahuatzi, D., Herrero, P., de la Cera, T. and Moreno, F. (2004) The glucose-regulated nuclear localization of hexokinase 2 in Saccharomyces cerevisiae is Mig1-dependent. J. Biol. Chem. 279, 14440-14446
14. Ahuatzi, D., Riera, A., Pelaez, R., Herrero, F. and Moreno, F. (2007) Hxk2 regulates the phosphorylation state of Mig1 and therefore its nucleocytoplasmic distribution. J. Biol. Chem. 282, 4485-4493
15. Vionnet, N., Stoffel, M., Takeda, J., Yasuda, K., Bell, G. I., Zouali, H., Lesage, S., Velho, G., Iris, F, Passa, P. et al. (1992) Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus. Nature 356, 721-722
16. Njolstad, P. R., Sovik, O., Cuesta-Munoz, A., Bjorkhaug, L., Massa, O., Barbetti, F., Undlien, D. E., Shiota, C., Magnuson, M. A., Molven, A. et al. (2001) Neonatal diabetes mellitus due to complete glucokinase deficiency. N. Engl. J. Med. 344, 1588-1592
17. Nehlin, J. O. and Ronne, H. (1990) Yeast MIG1 repressor is related to the mammalian early growth response and Wilms' tumour finger proteins. EMBO J. 9, 2891-2898
18. Wallis, J. W., Chrebet, G., Brodsky, G., Rolfe, M. and Rothstein, R. (1989) A hyper-recombination mutation in S. cerevisiae identifies a novel eukaryotic topoisomerase. Cell 58, 409-419
19. Ma, H. and Botstein, D. (1986) Effects of null mutations in the hexokinase genes of Saccharomyces cerevisiae on catabolite repression. Mol. Cell. Biol. 6, 4046-4052
20. Tomas-Colbos, L. and Sanz, P (2002) Active Snf1 protein kinase inhibits expression of the Saccharomyces cerevisiae HXT1 glucose transporter gene. Biochem. J. 368, 657-663
21. Harper, J. W., Adami, G. R., Wei, N., Keyomarsi, K. and Elledge, S. J. (1993) The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75, 805-816
22. Mayordomo, I. and Sanz, P. (2001) Human pancreatic glucokinase (GIkB) complements the glucose signalling defect of Saccharomyces cerevisiae hxk2 mutants. Yeast 18, 1309-1316
23. de la Cera, T., Herrero, P., Moreno-Herrero, F., Chaves, R. S. and Moreno, F. (2002) Mediator factor Med8p interacts with the hexokinase 2: implication in the glucose signalling pathway of Saccharomyces cerevisiae. J. Mol. Biol. 319, 703-714
24. Fields, S. and Song, O. (1989) A novel genetic system to detect protein-protein interactions. Nature 340, 245-246
25. Rupp, S. (2002) LacZ assays in yeast. Methods Enzymol. 350, 112-131
26. Palomino, A., Herrero, P. and Moreno. F. (2006) Tpk3 and Snf1 protein kinases regulate Rgt1 association with Saccharomyces cerevisiae HXK2 promoter. Nucleic Acids Res. 34, 1427-1438
27. Westermann, B. and Neupert. W. (2000) Mitochondria-targeted green fluorescent proteins: convenient tools for the study of organelle biogenesis in Saccharomyces cerevisiae. Yeast 16, 1421-1427
28. DeVit, M. J., Waddle, J. A. and Johnston, M. (1997) Regulated nuclear translocation of the Mig1 glucose repressor. Mol. Biol. Cell 8, 1603-1618
29. DeVit, M. J. and Johnston, M. (1999) The nuclear exportin Msn5 is required for nuclear export of the Mig1 glucose repressor of Saccharomyces cerevisiae. Curr. Biol. 9, 1231-1241
30. Ahuatzi, D., Riera, A., Pelaez, R., Herrero, P. and Moreno, F. (2006) Hxk2 regulates the phosphorylation state of Mig1 and therefore its nucleocytoplasmic distribution. J. Biol. Chem. 282, 4485-4493
31. Herrero, P., Martinez-Campa, C. and Moreno, F. (1998) The hexokinase 2 protein participates in regulatory DNA-protein complexes necessary for glucose repression of the SUC2 gene in Saccharomyces cerevisiae. FEBS Lett. 434, 71-76
32. Moreno, F., Ahuatzi, D., Riera, A., Palomino, C. A. and Herrero, P. (2005) Glucose sensing through the Hxk2-dependent signalling pathway. Biochem. Soc, Trans. 33, 265-268
33. Hohmann, S., Winderickx, J., de Winde, J. H., Valckx, D., Cobbaert, P,, Luyten, K., de Meirsman, C., Ramos, J. and Thevelein, J. M. (1999) Novel alleles of yeast hexokinase PII with distinct effects on catalytic activity and catabolite repression of SUC2. Microbiology 145, 703-714
34. Mayordomo, I. and Sanz, P. (2001) Hexokinase PII: structural analysis and glucose signalling in the yeast Saccharomyces cerevisiae. Yeast 18, 923-930
35. Wilson, J. E. (2003) Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function. J. Exp. Biol. 206, 2049-2057