Crystal structures of mutant monomeric hexokinase I reveal multiple ADP binding sites and conformational changes revelant to allosteric regulation

Journal of Molecular Biology

Volumn 296, Issue 4, 2000, Pages 1001-1015

  Aleshin, Alexander E ^a   Kirby, Christina ^a   Liu, Xiaofeng ^a   Bourenkov, Gleb P ^b   Bartunik, Hans D ^b   Fromm, Herbert J ^a   Honzatko, Richard B ^a  

^a IOWA STATE UNIVERSITY   (United States)

^b MAX PLANCK UNIT FOR STRUCTURAL MOLECULAR BIOLOGY   (Germany)

Author keywords

Allosteric enzyme; Brain hexokinase; Glycolysis; Hexokinase I; X ray structure

Indexed keywords

HEXOKINASE; MONOMER;

ALLOSTERISM; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

EID: 0034598953     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1999.3494     Document Type: Article

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