Limiting an antimicrobial peptide to the lipid-water interface enhances its bacterial membrane selectivity: A case study of MSI-367

Biochemistry

Volumn 49, Issue 50, 2010, Pages 10595-10605

  Thennarasu, Sathiah ^a,c   Huang, Rui ^a   Lee, Dong Kuk ^a,d   Yang, Pei ^a   Maloy, Lee ^b   Chen, Zhan ^a   Ramamoorthy, Ayyalusamy ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b Genaera Pharmaceuticals   (United States)

^c CENTRAL LEATHER RESEARCH INSTITUTE   (India)

^d Seoul National University of Science and Technology   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMICROBIAL PEPTIDE; AQUEOUS BUFFER; BACTERIAL CELLS; BACTERIAL MEMBRANES; BI-LAYER; CELL TARGETING; CIRCULAR DICHROISM; DESIGN APPROACHES; HUMAN CELLS; ISOTHERMAL TITRATION CALORIMETRY; LIPID VESICLES; LIPID-PEPTIDE INTERACTION; MEMBRANE PERMEABILIZATION; MEMBRANE SELECTIVITY; MICROMOLAR CONCENTRATION; MULTI-LAMELLAR VESICLES; NMR DATA; PEPTIDE BINDING; PEPTIDE COMPLEX; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLGLYCEROLS; POTENT ACTIVITY; SUM FREQUENCY GENERATION VIBRATIONAL SPECTROSCOPIES; SYNTHETIC PEPTIDE; TURN STRUCTURE; WATER INTERFACE;

BACTERIOLOGY; BIOMATERIALS; CELL MEMBRANES; COMPLEXATION; CYTOLOGY; DEUTERIUM; DICHROISM; DIFFERENTIAL SCANNING CALORIMETRY; ESCHERICHIA COLI; EXPERIMENTS; LIPID BILAYERS; MEMBRANES; NUCLEAR MAGNETIC RESONANCE; PHASE TRANSITIONS; RESONANCE;

PEPTIDES;

1 PALMITOYL 2 OLEOYL SN GLYCERO 3 PHOSPHATIDYLCHOLINE; ALANINE; BUFFER; DEUTERIUM; LYSINE; MSI 367; PHENYLALANINE; PHOSPHATIDYLCHOLINE; POLYPEPTIDE ANTIBIOTIC AGENT; UNCLASSIFIED DRUG;

AQUEOUS SOLUTION; ARTICLE; BACTERIAL MEMBRANE; BETA TURN; BINDING AFFINITY; CANDIDA ALBICANS; CELL MEMBRANE PERMEABILITY; CELL SELECTION; CIRCULAR DICHROISM; CONTROLLED STUDY; CYTOTOXICITY; DEUTERON NUCLEAR MAGNETIC RESONANCE; DIFFERENTIAL SCANNING CALORIMETRY; ESCHERICHIA COLI; HEMOLYSIS; HYPOTHESIS; ISOTHERMAL TITRATION CALORIMETRY; LIPID VESICLE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN LIPID INTERACTION; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STATIC ELECTRICITY;

ANIMALS; ANTI-INFECTIVE AGENTS; CALORIMETRY; CALORIMETRY, DIFFERENTIAL SCANNING; CIRCULAR DICHROISM; ERYTHROCYTES; ESCHERICHIA COLI; LIPID BILAYERS; LIPIDS; MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHATIDYLETHANOLAMINES; SHEEP; WATER;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; FUNGI;

EID: 78650348571     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi101394r     Document Type: Article

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