In vivo antimalarial activities of mono- and bis quaternary ammonium salts interfering with Plasmodium phospholipid metabolism

Antimicrobial Agents and Chemotherapy

Volumn 47, Issue 8, 2003, Pages 2598-2605

  Ancelin, Marie L ^a   Calas, Michèle ^b   Bonhoure, Anne ^a   Herbute, Serge ^a   Vial, Henri J ^a  

^a CNRS   (France)

^b UNIVERSITÉ DE MONTPELLIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BISQUARTERNARY AMMONIUM DERIVATIVE; CHLOROQUINE; E 6; E 8; F 4; G 15; G 25; G 5; N (2 HYDROXYETHYL) N,N DIMETHYL 1 DODECANAMINIUM IODIDE; PHOSPHOLIPID; QUATERNARY AMMONIUM DERIVATIVE; RADIOACTIVE MATERIAL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG ELIMINATION; DRUG HALF LIFE; ERADICATION THERAPY; LD 50; MOUSE; NONHUMAN; PARASITEMIA; PHOSPHOLIPID METABOLISM; PLASMODIUM; PLASMODIUM BERGHEI; PLASMODIUM CHABAUDI; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; RECURRENT DISEASE;

ANIMALS; ANTIMALARIALS; ERYTHROCYTES; HALF-LIFE; INJECTIONS, INTRAVENOUS; INJECTIONS, SUBCUTANEOUS; LETHAL DOSE 50; MALARIA; MALE; MICE; PHOSPHOLIPIDS; PLASMODIUM; PLASMODIUM BERGHEI; PLASMODIUM CHABAUDI; PYRROLIDINES; QUATERNARY AMMONIUM COMPOUNDS;

EID: 0042594674     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.47.8.2598-2605.2003     Document Type: Article

References (29)

1. Ancelin, M. L., M. Calas, J. Bompart, G. Cordina, D. Martin, M. Ben Bari, T. Jei, P. Druilhe, and H. J. Vial. 1998. Antimalarial activity of 77 phospholipid polar head analogs: close correlation between inhibition of phospholipid metabolism and in vitro Plasmodium falciparum growth. Blood 91:1426-1437.
2. Ancelin, M. L., and H. J. Vial. 1986. Quaternary ammonium compounds efficiently inhibit Plasmodium falciparum growth in vitro by impairment of choline transport. Antimicrob. Agents Chemother. 29:814-820.
3. Ancelin, M. L., and H. J. Vial. 1989. Regulation of phosphatidylcholine biosynthesis in Plasmodium-infected erythrocytes. Biochim. Biophys. Acta 1001:82-89.
4. Ancelin, M. L., M. Calas, V. Vidal-Sailhan, S. Herbuté, P. Ringwald, and H. J. Vial. 2003. Potent inhibitors of Plasmodium phospholipid metabolism with a broad spectrum of in vitro antimalarial activities. Antimicrob. Agents Chemother. 47:2590-2597.
5. Beaute-Lafitte, A., V. Altemayer-Caillard, F. Gonnet-Gonzalez, L. Ramiaramanana, A. G. Chabaud, and I. Landau. 1994. The chemosensitivity of the rodent malarias-relationships with the biology of merozoites. Int. J. Parasitol. 24:981-986.
6. Calas, M., M. L. Ancelin, G. Cordina, P. Portefaix, G. Piquet, V. Vidal-Sailhan, and H. Vial. 2000. Antimalarial activity of compounds interfering with Plasmodium falciparum phospholipid metabolism: comparison between mono- and bisquaternary ammonium salts. J. Med. Chem. 43:505-516.
7. Calas, M., G. Cordina, J. Bompart, M. Ben Bari, T. Jei, M. L. Ancelin, and H. Vial. 1997. Antimalarial activity of molecules interfering with Plasmodium falciparum phospholipid metabolism. Structure-activity relationship analysis. J. Med. Chem. 40:3557-3566.
8. Carter, R., and D. Walliker. 1975. New observations on the malaria parasites of rodents of the Central African Republic-Plasmodium vinckei petteri subsp. nov. and Plasmodium chabaudi Landau, 1965. Ann. Trop. Med. Parasitol. 69:187-196.
9. Farenc, C., J. R. Fabreguette, and F. Bressolle. 2000. Pk-fit: a pharmacokinetic/pharmacodynamic and statistical data analysis software. Comput. Biomed. Res. 33:315-329.
10. Holz, G. G. 1977. Lipids and the malaria parasite. Bull. W. H. O. 55:237-248.
11. Landau, I., and P. Gautret. 1998. Animal models: rodents, p. 401-417. In I. W. Sherman (ed.), Malaria: parasite biology, pathogenesis, and protection. ASM Press, Washington, D.C.
12. McCall, D. L. C., J. Alexander, J. Barber, R. G. Jaouhari, A. Satoskar, and R. D. Waigh. 1994. the first protoberberine alkaloid analogue with in vivo antimalarial activity. Bioorg. Med. Chem. Lett. 4:1663-1666.
13. Navaratnam, V., S. M. Mansor, N. W. Sit, J. Grace, Q. Li, and P. Olliar. 1993. Pharmacokinetics of artemisinin-type compounds. Clin. Pharmacokinet. 39:255-270.
14. Olliaro, P. L., and Y. Yuthavong. 1999. An overview of chemotherapeutic targets for antimalarial drug discovery. Pharmacol. Ther. 81:91-110.
15. Peters, W., M. L. Chance, R. Lissner, H. Momen, and D. C. Warhurst. 1978. The chemotherapy of rodent malaria. XXX. The enigmas of the 'NS lines' of P. berghei. Ann. Trop. Med. Parasitol. 72:23-36.
16. Peters, W., J. H. Portus, and B. L. Robinson. 1975. The chemotherapy of rodent malaria. XXII. The value of drug-resistant strains of P. berghei in screening for blood schizonticidal activity. Ann. Trop. Med. Parasitol. 69:155-171.
17. Ridley, R. G. 2002. Medical need, scientific opportunity and the drive for antimalarial drugs. Nature 415:686-693.
18. Sherman, L. 1979. Biochemistry of Plasmodium (malarial parasites). Microbiol. Rev. 43:453-495.
19. Van Deenen, L. L. M., and J. De Gier. 1975. Lipids of the red cell membrane, p. 147-211. In G. Surgenor (ed.), The red blood cell. Academic Press, New York, N.Y.
20. Van Vianen, P. H., D. L. Klayman, A. J. Lin, C. B. Lugt, A. L. Van Engen, H. J. Van der Kaay, and B. Mons. 1990. Plasmodium berghei: The antimalarial action of artemisinin and sodium artelinate in vivo and in vitro, studied by flow cytometry. Exp. Parasitol. 70:115-123.
21. Vennerstrom, J. L., and D. L. Klayman. 1988. Protoberberine alkaloids as antimalarials. J. Med. Chem. 31:1084-1087.
22. Vial, H., and M. Ancelin. 1998. Malarial lipids, p. 159-175. In I. Sherman (ed.), Malaria: parasite biology, pathogenesis, and protection. ASM Press, Washington, D.C.
23. Vial, H. J., and M. L. Ancelin. 1992. Malarial lipids. An overview. Subcell. Biochem. 18:259-306.
24. Vial, H. J., and M. Calas. 2001. Inhibitors of phospholipid metabolism, p. 347-365. In P. Rosenthal (ed.), Antimalarial chemotherapy, mechanisms of action, modes of resistance, and new directions in drug development. Humana Press, Totowa, N.J.
25. Vial, H. J., M. J. Thuet, M. L. Ancelin, J. R. Philippot, and C. Chavis. 1984. Phospholipid metabolism as a new target for malaria chemotherapy. Mechanism of action of D-2-amino-1-butanol. Biochem. Pharmacol. 33:2761-2770.
26. Wengelnik, K., V. Vidal, M. L. Ancelin, A. M. Cathiard, J. L. Morgat, C. H. Kocken, M. Calas, S. Herrera, A. W. Thomas, and H. J. Vial. 2002. A class of potent antimalarials and their specific accumulation in infected erythrocytes. Science 295:1311-1314.
27. White, N. J. 1992. Antimalarial pharmacokinetics and treatment regimens. Br. J. Clin. Pharmacol. 34:1-10.
28. White, N. J. 1997. Assessment of the pharmacodynamic properties of antimalarial drugs in vivo. Antimicrob. Agents Chemother. 41:1413-1422.
29. Winstanley, P. A. 2000. Chemotherapy for falciparum malaria: the armoury, the problems and the prospects. Parasitol. Today 16:146-153.