Inhibition of proteasome activity blocks cell cycle progression at specific phase boundaries in African trypanosomes

Molecular and Biochemical Parasitology

Volumn 90, Issue 2, 1997, Pages 491-504

  Mutomba, Martha C ^a   To, Wah Yuen ^a   Hyun, William C ^a   Wang, Ching C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cell cycle; Lactacystin; LLnV; Proteasome; Trypanosoma brucei

Indexed keywords

ALOXISTATIN ACID; ANTIPARASITIC AGENT; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; LACTACYSTIN; PROTEASOME; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

AFRICAN TRYPANOSOMIASIS; ARTICLE; CELL CYCLE; CELL CYCLE G2 PHASE; CELL NUCLEUS; CONTROLLED STUDY; DNA DETERMINATION; FLAGELLATE; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; KINETOPLAST; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROTOZOON; TRYPANOSOMA BRUCEI;

ACETYLCYSTEINE; ANIMALS; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DNA, PROTOZOAN; FLOW CYTOMETRY; INTERPHASE; LEUPEPTINS; MICROSCOPY, FLUORESCENCE; MICROSCOPY, PHASE-CONTRAST; MITOSIS; MULTIENZYME COMPLEXES; PROTEASOME ENDOPEPTIDASE COMPLEX; S PHASE; TRYPANOSOMA BRUCEI BRUCEI;

ARCHAEA; INSECTA; MAMMALIA; MASTIGOPHORA (FLAGELLATES); PROTOZOA; TRYPANOSOMA; TRYPANOSOMA BRUCEI;

EID: 0031574481     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(97)00197-7     Document Type: Article

References (34)

1. Rock KL, Gramm C, Rothstein L et al. Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on the MHC Class I molecules. Cell. 78:1994;761-771.
2. Biederer T, Volkwein C, Sommer T Degradation of subunits of the Sec61p complex, an integral component of the ER membrane, by the ubiquitin-proteasome pathway. EMBO J. 15:1996;2069-2076.
3. Goldberg AL, Rock K Proteolysis, proteasomes and antigen presentation. Nature. 357:1992;375-379.
4. Tawa NJ, Kettelhut IC, Goldberg AL Dietary protein deficiency reduces lysosomal and nonlysosomal ATP-dependent proteolysis in muscle. Am J Physiol. 263:1992;E326-E334.
5. Hershko A, Ciechanover A The ubiquitin system for protein degradation. Ann Rev Biochem. 61:1992;761-807.
6. Coux O, Tanaka K, Goldberg AL Structure and functions of the 20S and 26S proteasomes. Ann Rev Biochem. 65:1996;801-847.
7. Dahlmann B, Kopp F, Kuehn L, Niedel B, Pfeifer G, Hegerl R, Baumeister W The multicatalytic proteinase (prosome) is ubiquitous from eukaryotes to archaebacteria. FEBS Lett. 251:1989;125-131.
8. Tanaka K, Yoshimura T, Kumatori A et al. Proteasome (multi-protease complexes) as 20S ring-shaped particles in a variety of eukaryotic cells. J Biol Chem. 263:1988;16209-16217.
9. Ma CP, Slaughter CA, DeMartino GN Identification, purification and characterization of a protein activator (PA28) of the 20S proteasome (macropain). J Biol Chem. 267:1992;10515-10523.
10. Dubiel W, Pratt G, Ferrell K, Rechsteiner M Purification of an 11S regulator of the multicatalytic protease. J Biol Chem. 267:1992;22369-22377.
11. Yang Y, Fruh K, Ahn K, Peterson PA In vivo assembly of the proteasomal complexes, implications for antigen processing. J Biol Chem. 270:1995;27687-27694.
12. Hua S-B, To W-Y, Nguyen TT, Wong M-L, Wang CC Purification and characterization of proteasomes from Trypanosoma brucei. Mol Biochem Parasitol. 78:1996;33-46.
13. To W-Y, Wang CC Identification and characterization of an activated 20S proteasome in Trypanosoma brucei. FEBS Lett. 404:1997;253-262.
14. Omura S, Fujimoto T, Otoguro K, Matsuzaki K, Moriguchi R, Tanaka Y, Sasaki Y Lactacystin, a novel microbial metabolite, induces neuritogenesis of neuroblastoma cells. J Antibiotics. 44:1991;113-116.
15. Fenteany G, Standaert RF, Reichard GA, Corey EJ, Schreiber SL A β-lactone related to lactacystin induces neurite outgrowth in a neuroblastoma cell line and inhibits cell cycle progression in an osteosarcoma cell line. Proc Natl Acad Sci. 91:1994;3358-3362.
16. Katagiri M, Hayashi M, Matsuzaki K, Tanaka H, Omura S The neuritogenesis inducer lactacystin arrests cell cycle at both G0/G1 and G2 phases in Neuro 2a cells. J Antibiot. 48:1995;344-346.
17. Imajoh-Ohmi S, Kawaguchi T, Sugiyama S, Tanaka K, Omura S, Kikuchi H Lactacystin, a specifc inhibitor of the proteasome, induces apoptosis in human monoblast U937 cells. Biochem Biophys Res Commun. 217:1995;1070-1077.
18. Fenteany G, Standaert RF, Lane WS, Choi S, Corey EJ, Schreiber SL Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science. 268:1995;726-731.
19. Drexler HCA Activation of the cell death program by inhibition of proteasome function. Proc Natl Acad Sci. 94:1997;855-860.
20. Gonzalez J, Ramalho-Pinto FJ, Frevert U et al. Proteasome activity is required for the stage-specific transformation of a protozoan parasite. J Exp Med. 184:1996;1900-1918.
21. Mutomba MC, Wang CC Differentiation of a culture-adapted mutant bloodstream form of Trypanosoma brucei into the procyclic form results in growth arrest of the cells. Mol Biochem Parasitol. 72:1995;215-225.
22. Barrett AJ, Kembhavi AA, Brown MA, Kirschke H, Knight CG, Tamai M, Hanada K L-trans-epoxysuccinyl-leucylamido(4-guanidino) butane (E64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L. Biochem J. 201:1982;189-198.
23. Wang C-I, Yang Q, Craik CS Isolation of a high affinity inhibitor of urokinase-type plasminogen activator by phage display of ecotin. J Biol Chem. 270:1995;12250-12256.
24. Wyllie AH Apoptosis. Br J Cancer. 67:1993;205-208.
25. Murray A Cyclin ubiquitination: the destructive end of mitosis. Cell. 81:1995;149-152.
26. King RW, Deshaies RJ, Peters J-M, Kirschner MW How proteolysis drives the cell cycle. Science. 274:1996;1652-1659.
27. CDC28 protein kinase activity from Saccharomyces cerevisiae. Science. 259:1993;216-219.
28. Nugroho TT, Mendenhall MD An inhibitor of yeast cyclin-dependent protein kinase plays an important role in ensuring the genomic intergrity of daughter cells. Mol Cell Biol. 14:1994;3320-3328.
29. Kominami K, DeMartino GN, Moomaw R et al. Nin1p, a regulatory subunit of the 26S proteasome, is necessary for activation of Cdc28p kinase of Saccharomyces cerevisiae. EMBO J. 14:1995;3105-3115.
30. Ghislain M, Udvardy A, Mann C S. cerevisiae 26S protease mutants arrest cell division in G2/metaphase. Nature. 366:1993;358-362.
31. Gordon C, McGurk G, Dillon P, Rosen C, Hastle ND Defective mitosis due to a mutation in the gene for fission yeast 26S proteasome subunit. Nature. 366:1993;355-357.
32. Affranchino JL, Gonzalez SA, Pays E Isolation of a mitotic-like cyclin homologue from the protozoan Trypanosoma brucei. Gene. 132:1993;75-82.
33. Mottram JC cdc2-related protein kinases and cell cycle control in trypanomastids. Parasitol Today. 10:1994;253-257.
34. Hua S-B, Mutomba MC, Wang CC Regulated expression of cyclin-1 during differentiation of Trypanosoma brucei from bloodstream form to procyclic form. Mol Biochem Parasitol. 84:1997;255-258.