Dipyrimidine amines: A novel class of chemokine receptor type 4 antagonists with high specificity

Journal of Medicinal Chemistry

Volumn 53, Issue 24, 2010, Pages 8556-8568

  Zhu, Aizhi ^a   Zhan, Weiqiang ^b   Liang, Zhongxing ^a   Yoon, Younghyoun ^a   Yang, Hua ^a   Grossniklaus, Hans E ^a   Xu, Jianguo ^a   Rojas, Mauricio ^a   Lockwood, Mark ^b   Snyder, James P ^b   Liotta, Dennis C ^b   Shim, Hyunsuk ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; CYCLIC AMP; MATRIGEL; PYRIMIDINE DERIVATIVE; STROMAL CELL DERIVED FACTOR 1; UNCLASSIFIED DRUG; WZ 811;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING COMPETITION; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SPECIFICITY; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; METASTASIS; MICROMETASTASIS; MOUSE; NONHUMAN; PAW EDEMA; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; UVEA MELANOMA;

AMINES; ANGIOGENESIS INHIBITORS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BINDING, COMPETITIVE; COLLAGEN; DRUG COMBINATIONS; FEMALE; INFLAMMATION; LAMININ; MELANOMA; MICE; MICE, NUDE; NEOPLASM METASTASIS; NEOVASCULARIZATION, PATHOLOGIC; PROTEOGLYCANS; PULMONARY FIBROSIS; PYRIMIDINES; RECEPTORS, CXCR4; STRUCTURE-ACTIVITY RELATIONSHIP; UVEAL NEOPLASMS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 78650336969     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100786g     Document Type: Article

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