Byakangelicin induces cytochrome P450 3A4 expression via transactivation of pregnane X receptors in human hepatocytes

British Journal of Pharmacology

Volumn 162, Issue 2, 2011, Pages 441-451

  Yang, Jian ^a,b   Luan, Xiaofei ^a   Gui, Haiyan ^a   Yan, Peng ^a   Yang, Dongfang ^b   Song, Xiulong ^b   Liu, Wei ^a   Hu, Gang ^a   Yan, Bingfang ^b  

^a NANJING MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF RHODE ISLAND   (United States)

Author keywords

byakangelicin; CYP3A4; cytochrome P450 3A4; hepatocyte; pregnane X receptor; transactivation; transcriptional regulator

Indexed keywords

ANGELICIN; CYTOCHROME P450 3A4; LUCIFERASE; PREGNANE X RECEPTOR;

ADULT; AGED; ANGELICA; ANGELICA DAHURICA; ARTICLE; CATABOLISM; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; ENZYME ACTIVITY; FEMALE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LIVER CELL; MALE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SITE DIRECTED MUTAGENESIS; TRANSCRIPTION INITIATION; WESTERN BLOTTING;

ADULT; AGED; CELL LINE, TUMOR; CELLS, CULTURED; CYTOCHROME P-450 CYP3A; DRUG INTERACTIONS; FEMALE; HEPATOCYTES; HUMANS; MALE; MIDDLE AGED; MUTAGENESIS, SITE-DIRECTED; PSORALENS; RECEPTORS, STEROID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTIONAL ACTIVATION; TRANSFECTION;

EID: 78650322764     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.01069.x     Document Type: Article

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