Ethyl acetate extract from Angelica Dahuricae Radix inhibits lipopolysaccharide-induced production of nitric oxide, prostaglandin E2 and tumor necrosis factor-α via mitogen-activated protein kinases and nuclear factor-κB in macrophages

Pharmacological Research

Volumn 55, Issue 4, 2007, Pages 263-270

  Kang, Ok Hwa ^a   Lee, Go Hoon ^a   Choi, Hyuk Joon ^a   Park, Pil Sang ^a   Chae, Hee Sung ^a   Jeong, Seung Il ^b   Kim, Youn Chul ^a   Sohn, Dong Hwan ^a   Park, Hyun ^a   Lee, John Hwa ^c   Kwon, Dong Yeul ^a  

^a Wonkwang University   (South Korea)

^b Jeonju Bio Materials Institute   (South Korea)

^c Chonbuk National University   (South Korea)

Author keywords

Angelica Dahuricae Radix; Cyclooxygenase 2; Inducible nitric oxide synthase; Mitogen activated protein kinase (MAPK); Nuclear factor B

Indexed keywords

ACETIC ACID ETHYL ESTER; ANGELICA DAHURICAE EXTRACT; CYCLOOXYGENASE 2; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; MYCOPHENOLIC ACID; NITRIC OXIDE; PLANT EXTRACT; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANGELICA; ANGELICA DAHURICAE; ANIMAL CELL; ARTICLE; CELL CULTURE; CELL LINE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG EFFECT; DRUG ISOLATION; DRUG MECHANISM; ENZYME PHOSPHORYLATION; MACROPHAGE; MOUSE; NONHUMAN; PLANT ROOT; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION;

ACETATES; ANGELICA; ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE; CELL SURVIVAL; CYCLOOXYGENASE 2; DINOPROSTONE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; I-KAPPA B PROTEINS; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PHOSPHORYLATION; PLANT EXTRACTS; PLANT ROOTS; PSORALENS; SOLVENTS; TH1 CELLS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 34047176077     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2006.12.001     Document Type: Article

References (40)

1. Chevallier A. Encyclopedia of medicinal plants (2001), Dorling Kindersley Limited, London
2. Wagner H. Arzneidrogen und ihre Inhaltsstoffe. Pharmazeutische Biologie Band 2. Wissenschaftliche Verlagsgesellschaft 1999.
3. Son J.K., Song D.K., Kim J.Y., Li G., Lee K.S., Seo C.S., et al. Agents protecting aginst sepsis from the roots of Angelca dahurica. Biol Pharm Bull 28 2 (2004) 380-382
4. Gibbons S., Lechner D., Stavri M., Oluwatuyi M., and Pereda-Miranda R. The anti-staphylococcal activity of Angelica dahurica (Bai Zhi). Phytochemistry 65 (2003) 331-335
5. Okamoto T., Kajino K., and Hino O. Hepatoprotective drugs for the treatment of virus-induced chronic hepatitis: from hypercarcinogenic state to hypocarcinogenic state. Jpn J Pharmacol 87 3 (2001) 177-180
6. Abad M.J., De las Heras B., Silvan A.M., Pascual R., Bermejo P., Rodriquez B., et al. Effects of furocoumarins from Cachrys trifida on some macrophage functions. J Pharm Pharmacol 53 8 (2001) 1163-1168
7. Palmer R.M., Ashton D.S., and Moncada S. Vascular endothelial cells synthesizenitric oxide from l-arginine. Nature 333 (1988) 664-666
8. Lowenstein C.J., Hill S.L., Lafond-Walker A., Wu J., Allen G., Landavere M., et al. Nitric oxide inhibits viral replication in murine myocarditis. J Clin Invest 97 (1996) 1837-1843
9. Hibbs J.B., Taintor R.R., and Vavrin Z. Macrophage cytotoxicity: role of l-arginine deiminase and imino nitrogen oxidation to nitrite. Science 235 (1987) 473-476
10. Moncada S., Palmer R.M., and Higgs D.A. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 43 (1992) 109-142
11. MacMicking J., Xie Q.W., and Nathan C. Nitric oxide and macrophage function. Annu Rev Immunol 15 (1997) 323-350
12. Liu R.H., and Hotchkiss J.H. Potential genotoxicity of chronically elevated nitric oxide: a review. Mutat Res 339 (1995) 73-89
13. Tunctan B., and Altug S. The use of nitric oxide synthase inhibitors in inflammatory diseases: a novel class of anti-inflammatory agents. Curr Med Chem: Anti-Inflamm Anti-Aller Agents 3 (2004) 271-301
14. Tilg H., Wilmer A., Vogel W., Herold M., Nolchen B., Judmaier G., et al. Serum levels of cytokines in chronic liver diseases. Gastroenterology 103 (1992) 264-274
15. Isomaki P., and Punnonen J. Pro and anti-inflammatory cytokines in rheumatoid arthritis. Ann Med 29 (1997) 499-507
16. Coker R.K., and Laurent G.J. Pulmonary fibrosis: cytokines in the balance. Eur Respir J 11 (1998) 1218-1221
17. Chao C.C., and Hu S. Tumor necrosis factor-a potentiates glutamate neurotoxicity in human fetal brain cell cultures. Dev Neurosci 16 (1994) 172-179
18. Dawson V.L., and Dawson T.M. Nitric oxide in neuronal degeneration. Proc Soc Exp Biol Med 211 (1996) 33-40
19. Beutler B. Regulation of cachectin biosynthesis occurs at multiple levels. Prog Clin Biol Res 349 (1990) 229-240
20. Han J., Huez G., and Beutler B. Interactive effects of the tumor necrosis factor promoter and 39-untranslated regions. J Immunol 146 (1991) 1843-1848
21. Lee J.C., Laydon J.T., McDonnel P.C., Gallagher T.F., Kumar S., Green D., et al. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 372 (1994) 739-746
22. Davis R.J. MAPKs: new JNK expands the group. Trends Biochem Sci 19 (1994) 170-173
23. CobbMH, and Goldsmith E.J. How MAP kinases are regulated. J Biol Chem 270 (1995) 14843-14846
24. Lawrence T., Gilroy D.W., Colville-Nash P.R., and Willoughby D.A. Possible new role for NF-κB in the resolution of inflammation. Nat Med 7 (2001) 1291-1297
25. Baldwin@@Jr A. The NF-kappa B and I kappa B proteins: new discoveries and insights. Annu Rev Immunol 14 (1996) 649-683
26. Makarov S.S. NF-κB as a therapeutic target in chronic inflammation: recent advances. Mol Med Today 6 (2000) 441-448
27. Renard P., and Raes M. The proinflammatory transcription factor NF-κB: a potential target for novel therapeutical strategies. Cell Biol Toxicol 15 (1999) 341-344
28. Green L.C., Wagner D.A., Glogowski J., Skipper P.L., Wishnok J.S., Tannenbaum S.R., et al. Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids. Anal Biochem 126 (1982) 131-138
29. Schoonbroodt S., Legrand-Poels S., Best-Belpomme M., and Piette J. Activation of the NF-kappaB transcription factor in a T-lymphocytic cell line by hypochlorous acid. Biochem J 321 (1997) 777-785
30. Nakano H., Shindo M., Sakon S., Nishinaka S., Mihara M., Yagita H., et al. Differential regulation of IκB kinase alpha and beta by two upstream kinases NF-κB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1. Proc Natl Acad Sci USA 95 (1998) 3537-3542
31. Xie Q.W., Kashiwabara Y., and Nathan C. Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. J Biol Chem 269 (1994) 4705-4708
32. Lowenstein C.J., Alley E.W., Raval P., Snowman A.M., Snyder S.H., Russell S.W., et al. Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide. Proc Natl Acad Sci USA 90 (1993) 9730-9734
33. Karin M. The beginning of the end: I kappa B kinase (IKK) and NF-kappa B activation. J Biol Chem 274 (1999) 27339-27342
34. May M.J., and Ghosh S. Signal transduction through NF-κB. Immunol Today 19 (1998) 80-88
35. Johnson G.L., and Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298 (2002) 1911-1912
36. Carter A.B., Knudtson K.L., Monick M.M., and Hunninghake G.W. The p38 mitogen-activated protein kinase is required for NF-kappa B-dependent gene expression. The role of TATA-binding protein (TBP). J Biol Chem 274 (1999) 30858-30863
37. Chen C., Chen Y.H., and Lin W.W. Involvement of p38 mitogenactivated protein kinase in lipopolysaccharide-induced iNOS and COX-2 expression in J774 macrophages. Immunology 97 (1999) 124-129
38. Chan E.D., and Riches D.W. Potential role of the JNK/SAPK signal transduction pathway in the induction of iNOS by TNFalpha. Biochem Biophys Res Commun 253 (1998) 790-796
39. Kim S.H., Kim J., and Sharma R.P. Inhibition of p38 and ERK MAP kinases blocks endotoxin-induced nitric oxide production and differentially modulates cytokine expression. Pharmacol Res 49 (2004) 433-439
40. Kim Y.H., Lee S.H., Lee J.Y., Choi S.W., Park J.W., Kwon T.K., et al. Triptolide inhibits murine-inducible nitric oxide synthase expression by down-regulating lipopolysaccharide-induced activity of nuclear factor-kappa B and c-Jun NH2-terminal kinase. Eur J Pharmacol 494 (2004) 1-9