메뉴 건너뛰기




Volumn 10, Issue , 2010, Pages

Polysaccharides from the root of Angelica sinensis promotes hematopoiesis and thrombopoiesis through the PI3K/AKT pathway

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ANGELICA SINENSIS EXTRACT; CASPASE 3; PHOSPHATIDYLINOSITOL 3 KINASE; POLYSACCHARIDE; PROTEIN KINASE B; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; CHROMONE DERIVATIVE; HERBACEOUS AGENT; MORPHOLINE DERIVATIVE;

EID: 78650269544     PISSN: None     EISSN: 14726882     Source Type: Journal    
DOI: 10.1186/1472-6882-10-79     Document Type: Article
Times cited : (96)

References (45)
  • 1
    • 34447106121 scopus 로고    scopus 로고
    • Cytokines for the treatment of thrombocytopenia
    • 10.1053/j.seminhematol.2007.04.005, 17631181
    • Ciurea SO, Hoffman R. Cytokines for the treatment of thrombocytopenia. Semin Hematol 2007, 44:166-182. 10.1053/j.seminhematol.2007.04.005, 17631181.
    • (2007) Semin Hematol , vol.44 , pp. 166-182
    • Ciurea, S.O.1    Hoffman, R.2
  • 2
    • 0025887024 scopus 로고
    • Advances in the pharmacological studies of radix Angelica sinensis (Oliv) Diels (Chinese Danggui)
    • Mei QB, Tao JY, Cui B. Advances in the pharmacological studies of radix Angelica sinensis (Oliv) Diels (Chinese Danggui). Chin Med J (Engl) 1991, 104:776-781.
    • (1991) Chin Med J (Engl) , vol.104 , pp. 776-781
    • Mei, Q.B.1    Tao, J.Y.2    Cui, B.3
  • 3
    • 0030132647 scopus 로고    scopus 로고
    • The effect of angelica polysaccharide on proliferation and differentiation of hematopoietic progenitor cell
    • Wang Y, Zhu B. The effect of angelica polysaccharide on proliferation and differentiation of hematopoietic progenitor cell. Zhonghua Yi Xue Za Zhi 1996, 76:363-366.
    • (1996) Zhonghua Yi Xue Za Zhi , vol.76 , pp. 363-366
    • Wang, Y.1    Zhu, B.2
  • 4
    • 67349154950 scopus 로고    scopus 로고
    • An herbal decoction of Radix astragali and Radix angelicae sinensis promotes hematopoiesis and thrombopoiesis
    • 10.1016/j.jep.2009.04.007, 19443149
    • Yang M, Chan GC, Deng R, Ng MH, Cheng SW, Lau CP, Ye JY, Wang L, Liu C. An herbal decoction of Radix astragali and Radix angelicae sinensis promotes hematopoiesis and thrombopoiesis. J Ethnopharmacol 2009, 124:87-97. 10.1016/j.jep.2009.04.007, 19443149.
    • (2009) J Ethnopharmacol , vol.124 , pp. 87-97
    • Yang, M.1    Chan, G.C.2    Deng, R.3    Ng, M.H.4    Cheng, S.W.5    Lau, C.P.6    Ye, J.Y.7    Wang, L.8    Liu, C.9
  • 6
    • 0034038623 scopus 로고    scopus 로고
    • Study of the gastrointestinal protective effects of polysaccharides from Angelica sinensis in rats
    • 10.1055/s-2000-8552, 10865452
    • Cho CH, Mei QB, Shang P, Lee SS, So HL, Guo X, Li Y. Study of the gastrointestinal protective effects of polysaccharides from Angelica sinensis in rats. Planta Med 2000, 66:348-351. 10.1055/s-2000-8552, 10865452.
    • (2000) Planta Med , vol.66 , pp. 348-351
    • Cho, C.H.1    Mei, Q.B.2    Shang, P.3    Lee, S.S.4    So, H.L.5    Guo, X.6    Li, Y.7
  • 7
    • 0035846884 scopus 로고    scopus 로고
    • Angelica sinensis modulates migration and proliferation of gastric epithelial cells
    • 10.1016/S0024-3205(00)00994-2, 11213366
    • Ye YN, Koo MW, Li Y, Matsui H, Cho CH. Angelica sinensis modulates migration and proliferation of gastric epithelial cells. Life Sci 2001, 68:961-968. 10.1016/S0024-3205(00)00994-2, 11213366.
    • (2001) Life Sci , vol.68 , pp. 961-968
    • Ye, Y.N.1    Koo, M.W.2    Li, Y.3    Matsui, H.4    Cho, C.H.5
  • 8
    • 0035371005 scopus 로고    scopus 로고
    • A mechanistic study of proliferation induced by Angelica sinensis in a normal gastric epithelial cell line
    • 10.1016/S0006-2952(01)00625-6, 11331080
    • Ye YN, Liu ES, Shin VY, Koo MW, Li Y, Wei EQ, Matsui H, Cho CH. A mechanistic study of proliferation induced by Angelica sinensis in a normal gastric epithelial cell line. Biochem Pharmacol 2001, 61:1439-1448. 10.1016/S0006-2952(01)00625-6, 11331080.
    • (2001) Biochem Pharmacol , vol.61 , pp. 1439-1448
    • Ye, Y.N.1    Liu, E.S.2    Shin, V.Y.3    Koo, M.W.4    Li, Y.5    Wei, E.Q.6    Matsui, H.7    Cho, C.H.8
  • 9
    • 0037427874 scopus 로고    scopus 로고
    • Effect of polysaccharides from Angelica sinensis on gastric ulcer healing
    • 10.1016/S0024-3205(02)02332-9, 12493573
    • Ye YN, So HL, Liu ES, Shin VY, Cho CH. Effect of polysaccharides from Angelica sinensis on gastric ulcer healing. Life Sci 2003, 72:925-932. 10.1016/S0024-3205(02)02332-9, 12493573.
    • (2003) Life Sci , vol.72 , pp. 925-932
    • Ye, Y.N.1    So, H.L.2    Liu, E.S.3    Shin, V.Y.4    Cho, C.H.5
  • 11
    • 18244390977 scopus 로고    scopus 로고
    • The antitumor effects of Angelica sinensis on malignant brain tumors in vitro and in vivo
    • 10.1158/1078-0432.CCR-04-1827, 15867250
    • Tsai NM, Lin SZ, Lee CC, Chen SP, Su HC, Chang WL, Harn HJ. The antitumor effects of Angelica sinensis on malignant brain tumors in vitro and in vivo. Clin Cancer Res 2005, 11:3475-3484. 10.1158/1078-0432.CCR-04-1827, 15867250.
    • (2005) Clin Cancer Res , vol.11 , pp. 3475-3484
    • Tsai, N.M.1    Lin, S.Z.2    Lee, C.C.3    Chen, S.P.4    Su, H.C.5    Chang, W.L.6    Harn, H.J.7
  • 12
    • 3042830471 scopus 로고    scopus 로고
    • Induction of megakaryocytopoiesis and thrombocytopoiesis by JTZ-132, a novel small molecule with thrombopoietin mimetic activities
    • 10.1182/blood-2003-10-3623, 15001470
    • Inagaki K, Oda T, Naka Y, Shinkai H, Komatsu N, Iwamura H. Induction of megakaryocytopoiesis and thrombocytopoiesis by JTZ-132, a novel small molecule with thrombopoietin mimetic activities. Blood 2004, 104:58-64. 10.1182/blood-2003-10-3623, 15001470.
    • (2004) Blood , vol.104 , pp. 58-64
    • Inagaki, K.1    Oda, T.2    Naka, Y.3    Shinkai, H.4    Komatsu, N.5    Iwamura, H.6
  • 13
    • 0035158415 scopus 로고    scopus 로고
    • Administration of plasmid DNA expressing human interleukin-6 significantly improves thrombocytopoiesis in irradiated mice
    • 10.1007/s002770100345, 11732866
    • Sun L, Liu X, Qiu L, Wang J, Liu M, Fu D, Luo Q. Administration of plasmid DNA expressing human interleukin-6 significantly improves thrombocytopoiesis in irradiated mice. Ann Hematol 2001, 80:567-572. 10.1007/s002770100345, 11732866.
    • (2001) Ann Hematol , vol.80 , pp. 567-572
    • Sun, L.1    Liu, X.2    Qiu, L.3    Wang, J.4    Liu, M.5    Fu, D.6    Luo, Q.7
  • 14
    • 34547142349 scopus 로고    scopus 로고
    • Promoting effects of serotonin on hematopoiesis: ex vivo expansion of cord blood CD34+ stem/progenitor cells, proliferation of bone marrow stromal cells, and antiapoptosis
    • 10.1634/stemcells.2007-0048, 17446559
    • Yang M, Li K, Ng PC, Chuen CK, Lau TK, Cheng YS, Liu YS, Li CK, Yuen PM, James AE, et al. Promoting effects of serotonin on hematopoiesis: ex vivo expansion of cord blood CD34+ stem/progenitor cells, proliferation of bone marrow stromal cells, and antiapoptosis. Stem Cells 2007, 25:1800-1806. 10.1634/stemcells.2007-0048, 17446559.
    • (2007) Stem Cells , vol.25 , pp. 1800-1806
    • Yang, M.1    Li, K.2    Ng, P.C.3    Chuen, C.K.4    Lau, T.K.5    Cheng, Y.S.6    Liu, Y.S.7    Li, C.K.8    Yuen, P.M.9    James, A.E.10
  • 15
    • 0033768728 scopus 로고    scopus 로고
    • Expression of interleukin (IL) 1 type I and type II receptors in megakaryocytic cells and enhancing effects of IL-1beta on megakaryocytopoiesis and NF-E2 expression
    • 10.1046/j.1365-2141.2000.02340.x, 11091227
    • Yang M, Li K, Chui CM, Yuen PM, Chan PK, Chuen CK, Li CK, Fok TF. Expression of interleukin (IL) 1 type I and type II receptors in megakaryocytic cells and enhancing effects of IL-1beta on megakaryocytopoiesis and NF-E2 expression. Br J Haematol 2000, 111:371-380. 10.1046/j.1365-2141.2000.02340.x, 11091227.
    • (2000) Br J Haematol , vol.111 , pp. 371-380
    • Yang, M.1    Li, K.2    Chui, C.M.3    Yuen, P.M.4    Chan, P.K.5    Chuen, C.K.6    Li, C.K.7    Fok, T.F.8
  • 16
    • 0035318757 scopus 로고    scopus 로고
    • Platelet-derived growth factor enhances granulopoiesis via bone marrow stromal cells
    • 10.1007/BF02981957, 11345198
    • Yang M, Li K, Lam AC, Yuen PM, Fok TF, Chesterman CN, Chong BH. Platelet-derived growth factor enhances granulopoiesis via bone marrow stromal cells. Int J Hematol 2001, 73:327-334. 10.1007/BF02981957, 11345198.
    • (2001) Int J Hematol , vol.73 , pp. 327-334
    • Yang, M.1    Li, K.2    Lam, A.C.3    Yuen, P.M.4    Fok, T.F.5    Chesterman, C.N.6    Chong, B.H.7
  • 17
    • 0034657832 scopus 로고    scopus 로고
    • The role of platelet alpha-granular proteins in the regulation of thrombopoietin messenger RNA expression in human bone marrow stromal cells
    • Sungaran R, Chisholm OT, Markovic B, Khachigian LM, Tanaka Y, Chong BH. The role of platelet alpha-granular proteins in the regulation of thrombopoietin messenger RNA expression in human bone marrow stromal cells. Blood 2000, 95:3094-3101.
    • (2000) Blood , vol.95 , pp. 3094-3101
    • Sungaran, R.1    Chisholm, O.T.2    Markovic, B.3    Khachigian, L.M.4    Tanaka, Y.5    Chong, B.H.6
  • 18
    • 0025166114 scopus 로고
    • CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein
    • 10.1126/science.1698311, 1698311
    • Wright SD, Ramos RA, Tobias PS, Ulevitch RJ, Mathison JC. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 1990, 249:1431-1433. 10.1126/science.1698311, 1698311.
    • (1990) Science , vol.249 , pp. 1431-1433
    • Wright, S.D.1    Ramos, R.A.2    Tobias, P.S.3    Ulevitch, R.J.4    Mathison, J.C.5
  • 19
    • 0033532629 scopus 로고    scopus 로고
    • MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4?
    • 10.1084/jem.189.11.1777, 2193086, 10359581
    • Shimazu R, Akashi S, Ogata H, Nagai Y, Fukudome K, Miyake K, Kimoto M. MD-2, a Molecule that Confers Lipopolysaccharide Responsiveness on Toll-like Receptor 4?. J Exp Med 1999, 189:1777-1782. 10.1084/jem.189.11.1777, 2193086, 10359581.
    • (1999) J Exp Med , vol.189 , pp. 1777-1782
    • Shimazu, R.1    Akashi, S.2    Ogata, H.3    Nagai, Y.4    Fukudome, K.5    Miyake, K.6    Kimoto, M.7
  • 20
    • 0032509295 scopus 로고    scopus 로고
    • Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene
    • 10.1126/science.282.5396.2085, 9851930
    • Poltorak A, He X, Smirnova I, Liu MY, Huffel CV, Du X, Birdwell D, Alejos E, Silva M, Galanos C, et al. Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene. Science 1998, 282:2085-2088. 10.1126/science.282.5396.2085, 9851930.
    • (1998) Science , vol.282 , pp. 2085-2088
    • Poltorak, A.1    He, X.2    Smirnova, I.3    Liu, M.Y.4    Huffel, C.V.5    Du, X.6    Birdwell, D.7    Alejos, E.8    Silva, M.9    Galanos, C.10
  • 21
    • 0345561540 scopus 로고    scopus 로고
    • Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4?Tlr4)
    • 10.1084/jem.189.4.615, 2192941, 9989976
    • Qureshi ST, Lariviere L, Leveque G, Clermont S, Moore KJ, Gros P, Malo D. Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4?Tlr4). J Exp Med 1999, 189:615-625. 10.1084/jem.189.4.615, 2192941, 9989976.
    • (1999) J Exp Med , vol.189 , pp. 615-625
    • Qureshi, S.T.1    Lariviere, L.2    Leveque, G.3    Clermont, S.4    Moore, K.J.5    Gros, P.6    Malo, D.7
  • 22
    • 0034292364 scopus 로고    scopus 로고
    • Cutting Edge: Lipopolysaccharide Induces Physical Proximity Between CD14 and Toll-Like Receptor 4 (TLR4) Prior to Nuclear Translocation of NF-{kappa}B
    • Jiang Q, Akashi S, Miyake K, Petty HR. Cutting Edge: Lipopolysaccharide Induces Physical Proximity Between CD14 and Toll-Like Receptor 4 (TLR4) Prior to Nuclear Translocation of NF-{kappa}B. J Immunol 2000, 165:3541-3544.
    • (2000) J Immunol , vol.165 , pp. 3541-3544
    • Jiang, Q.1    Akashi, S.2    Miyake, K.3    Petty, H.R.4
  • 23
    • 0035877718 scopus 로고    scopus 로고
    • Lipopolysaccharide Is in Close Proximity to Each of the Proteins in Its Membrane Receptor Complex. TRANSFER FROM CD14 TO TLR4 AND MD-2
    • 10.1074/jbc.M009164200, 11274165
    • da Silva Correia J, Soldau K, Christen U, Tobias PS, Ulevitch RJ. Lipopolysaccharide Is in Close Proximity to Each of the Proteins in Its Membrane Receptor Complex. TRANSFER FROM CD14 TO TLR4 AND MD-2. J Biol Chem 2001, 276:21129-21135. 10.1074/jbc.M009164200, 11274165.
    • (2001) J Biol Chem , vol.276 , pp. 21129-21135
    • da Silva Correia, J.1    Soldau, K.2    Christen, U.3    Tobias, P.S.4    Ulevitch, R.J.5
  • 24
    • 0141844653 scopus 로고    scopus 로고
    • Reciprocal Modulation of Toll-like Receptor-4 Signaling Pathways Involving MyD88 and Phosphatidylinositol 3-Kinase/AKT by Saturated and Polyunsaturated Fatty Acids
    • 10.1074/jbc.M305213200, 12865424
    • Lee JY, Ye J, Gao Z, Youn HS, Lee WH, Zhao L, Sizemore N, Hwang DH. Reciprocal Modulation of Toll-like Receptor-4 Signaling Pathways Involving MyD88 and Phosphatidylinositol 3-Kinase/AKT by Saturated and Polyunsaturated Fatty Acids. J Biol Chem 2003, 278:37041-37051. 10.1074/jbc.M305213200, 12865424.
    • (2003) J Biol Chem , vol.278 , pp. 37041-37051
    • Lee, J.Y.1    Ye, J.2    Gao, Z.3    Youn, H.S.4    Lee, W.H.5    Zhao, L.6    Sizemore, N.7    Hwang, D.H.8
  • 25
    • 0037290876 scopus 로고    scopus 로고
    • Mammalian Toll-like receptors
    • 10.1016/S0952-7915(02)00013-4, 12495726
    • Akira S. Mammalian Toll-like receptors. Curr Opin Immunol 2003, 15:5-11. 10.1016/S0952-7915(02)00013-4, 12495726.
    • (2003) Curr Opin Immunol , vol.15 , pp. 5-11
    • Akira, S.1
  • 26
    • 0030666222 scopus 로고    scopus 로고
    • Innate immunity: the virtues of a nonclonal system of recognition
    • 10.1016/S0092-8674(00)80412-2, 9363937
    • Medzhitov R, Janeway CA. Innate immunity: the virtues of a nonclonal system of recognition. Cell 1997, 91:295-298. 10.1016/S0092-8674(00)80412-2, 9363937.
    • (1997) Cell , vol.91 , pp. 295-298
    • Medzhitov, R.1    Janeway, C.A.2
  • 27
    • 0034457684 scopus 로고    scopus 로고
    • Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9
    • Chuang TH, Ulevitch RJ. Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9. Eur Cytokine Netw 2000, 11:372-378.
    • (2000) Eur Cytokine Netw , vol.11 , pp. 372-378
    • Chuang, T.H.1    Ulevitch, R.J.2
  • 28
    • 0034456693 scopus 로고    scopus 로고
    • Three novel mammalian toll-like receptors: gene structure, expression, and evolution
    • Du X, Poltorak A, Wei Y, Beutler B. Three novel mammalian toll-like receptors: gene structure, expression, and evolution. Eur Cytokine Netw 2000, 11:362-371.
    • (2000) Eur Cytokine Netw , vol.11 , pp. 362-371
    • Du, X.1    Poltorak, A.2    Wei, Y.3    Beutler, B.4
  • 30
    • 0035911644 scopus 로고    scopus 로고
    • Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells
    • Chuang T, Ulevitch RJ. Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells. Biochim Biophys Acta 2001, 1518:157-161.
    • (2001) Biochim Biophys Acta , vol.1518 , pp. 157-161
    • Chuang, T.1    Ulevitch, R.J.2
  • 33
    • 0034307339 scopus 로고    scopus 로고
    • The Toll receptor family and microbial recognition
    • 10.1016/S0966-842X(00)01845-X, 11044679
    • Medzhitov R, Janeway C. The Toll receptor family and microbial recognition. Trends Microbiol 2000, 8:452-456. 10.1016/S0966-842X(00)01845-X, 11044679.
    • (2000) Trends Microbiol , vol.8 , pp. 452-456
    • Medzhitov, R.1    Janeway, C.2
  • 35
    • 0034650427 scopus 로고    scopus 로고
    • Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex
    • Ohashi K, Burkart V, Flohe S, Kolb H. Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex. J Immunol 2000, 164:558-561.
    • (2000) J Immunol , vol.164 , pp. 558-561
    • Ohashi, K.1    Burkart, V.2    Flohe, S.3    Kolb, H.4
  • 38
    • 0035907302 scopus 로고    scopus 로고
    • Saturated Fatty Acids, but Not Unsaturated Fatty Acids, Induce the Expression of Cyclooxygenase-2 Mediated through Toll-like Receptor 4
    • 10.1074/jbc.M011695200, 11278967
    • Lee JY, Sohn KH, Rhee SH, Hwang D. Saturated Fatty Acids, but Not Unsaturated Fatty Acids, Induce the Expression of Cyclooxygenase-2 Mediated through Toll-like Receptor 4. J Biol Chem 2001, 276:16683-16689. 10.1074/jbc.M011695200, 11278967.
    • (2001) J Biol Chem , vol.276 , pp. 16683-16689
    • Lee, J.Y.1    Sohn, K.H.2    Rhee, S.H.3    Hwang, D.4
  • 39
    • 0034857271 scopus 로고    scopus 로고
    • The role of MyD88 and TLR4 in the LPS-mimetic activity of Taxol
    • 10.1002/1521-4141(200108)31:8<2448::AID-IMMU2448>3.0.CO;2-N, 11500829
    • Byrd-Leifer CA, Block EF, Takeda K, Akira S, Ding A. The role of MyD88 and TLR4 in the LPS-mimetic activity of Taxol. Eur J Immunol 2001, 31:2448-2457. 10.1002/1521-4141(200108)31:8<2448::AID-IMMU2448>3.0.CO;2-N, 11500829.
    • (2001) Eur J Immunol , vol.31 , pp. 2448-2457
    • Byrd-Leifer, C.A.1    Block, E.F.2    Takeda, K.3    Akira, S.4    Ding, A.5
  • 40
    • 0035909372 scopus 로고    scopus 로고
    • Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    • 10.1038/35099560, 11607032
    • Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 2001, 413:732-738. 10.1038/35099560, 11607032.
    • (2001) Nature , vol.413 , pp. 732-738
    • Alexopoulou, L.1    Holt, A.C.2    Medzhitov, R.3    Flavell, R.A.4
  • 41
    • 0037099629 scopus 로고    scopus 로고
    • Potential Role of Phosphatidylinositol 3 Kinase, rather than DNA-dependent Protein Kinase, in CpG DNA-induced Immune Activation
    • 10.1084/jem.20020773, 2193923, 12119352
    • Ishii KJ, Takeshita F, Gursel I, Gursel M, Conover J, Nussenzweig A, Klinman DM. Potential Role of Phosphatidylinositol 3 Kinase, rather than DNA-dependent Protein Kinase, in CpG DNA-induced Immune Activation. J Exp Med 2002, 196:269-274. 10.1084/jem.20020773, 2193923, 12119352.
    • (2002) J Exp Med , vol.196 , pp. 269-274
    • Ishii, K.J.1    Takeshita, F.2    Gursel, I.3    Gursel, M.4    Conover, J.5    Nussenzweig, A.6    Klinman, D.M.7
  • 42
    • 0034603994 scopus 로고    scopus 로고
    • Wortmannin inhibits activation of nuclear transcription factors NF-kappaB and activated protein-1 induced by lipopolysaccharide and phorbol ester
    • 10.1016/S0014-5793(00)01501-5, 10802070
    • Manna SK, Aggarwal BB. Wortmannin inhibits activation of nuclear transcription factors NF-kappaB and activated protein-1 induced by lipopolysaccharide and phorbol ester. FEBS Lett 2000, 473:113-118. 10.1016/S0014-5793(00)01501-5, 10802070.
    • (2000) FEBS Lett , vol.473 , pp. 113-118
    • Manna, S.K.1    Aggarwal, B.B.2
  • 43
    • 0032877517 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase knockout mice: role of p85alpha in B cell development and proliferation
    • Fruman DA, Snapper SB, Yballe CM, Alt FW, Cantley LC. Phosphoinositide 3-kinase knockout mice: role of p85alpha in B cell development and proliferation. Biochem Soc Trans 1999, 27:624-629.
    • (1999) Biochem Soc Trans , vol.27 , pp. 624-629
    • Fruman, D.A.1    Snapper, S.B.2    Yballe, C.M.3    Alt, F.W.4    Cantley, L.C.5
  • 45
    • 0037352170 scopus 로고    scopus 로고
    • Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy
    • 10.1038/sj.leu.2402824, 12646949
    • Chang F, Lee JT, Navolanic PM, Steelman LS, Shelton JG, Blalock WL, Franklin RA, McCubrey JA. Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy. Leukemia 2003, 17:590-603. 10.1038/sj.leu.2402824, 12646949.
    • (2003) Leukemia , vol.17 , pp. 590-603
    • Chang, F.1    Lee, J.T.2    Navolanic, P.M.3    Steelman, L.S.4    Shelton, J.G.5    Blalock, W.L.6    Franklin, R.A.7    McCubrey, J.A.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.