Wortmannin inhibits activation of nuclear transcription factors NF-κB and activated protein-1 induced by lipopolysaccharide and phorbol ester

FEBS Letters

Volumn 473, Issue 1, 2000, Pages 113-118

  Manna, Sunil K ^a   Aggarwal, Bharat B ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Activated protein 1; Lipopolysaccharide; Nuclear transcription factor B; Phorbol ester; Phosphatidylinositol 3 kinase; Wortmannin

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; CERAMIDE; ENZYME INHIBITOR; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; OKADAIC ACID; PHORBOL ESTER; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; WORTMANNIN;

ARTICLE; CELL LINE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; INFLAMMATION; PRIORITY JOURNAL; REPORTER GENE; TRANSCRIPTION REGULATION;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; 1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; CERAMIDES; DNA PROBES; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; GENES, REPORTER; HUMANS; HYDROGEN PEROXIDE; I-KAPPA B PROTEINS; LIPOPOLYSACCHARIDES; NF-KAPPA B; OKADAIC ACID; ORGAN SPECIFICITY; SIGNAL TRANSDUCTION; TETRADECANOYLPHORBOL ACETATE; TIME FACTORS; TRANSCRIPTION FACTOR AP-1; TUMOR CELLS, CULTURED; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034603994     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(00)01501-5     Document Type: Article

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