Location in the large bowel influences the APC mutations observed in FAP Adenomas

Familial Cancer

Volumn 9, Issue 3, 2010, Pages 389-393

  Will, O C ^a,b   Leedham, S J ^b   Elia, G ^b   Phillips, R K S ^a   Clark, S K ^a   Tomlinson, I P M ^b,c  

^a ST MARK S HOSPITAL   (United Kingdom)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

'Just right' Wnt signalling; APC; Colorectal cancer; Polyposis; Two hit hypothesis

Indexed keywords

APC PROTEIN; BETA CATENIN; CASPASE 3; KI 67 ANTIGEN; WNT PROTEIN;

ADENOMATOUS POLYP; ADULT; APOPTOSIS; ARTICLE; ASCENDING COLON; CECUM; CELL PROLIFERATION; CLINICAL ARTICLE; CODON; CRYPT CELL; DESCENDING COLON; FAMILIAL CANCER; GENE MUTATION; HETEROZYGOSITY LOSS; HUMAN; IMMUNOHISTOCHEMISTRY; LARGE INTESTINE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECTUM; SIGNAL TRANSDUCTION; TRANSVERSE COLON;

ADENOMATOUS POLYPOSIS COLI; BETA CATENIN; CASPASE 3; GENES, APC; HUMANS; IMMUNOHISTOCHEMISTRY; INTESTINE, LARGE; KI-67 ANTIGEN; LASERS; LOSS OF HETEROZYGOSITY; MICRODISSECTION; MUTATION; POLYMERASE CHAIN REACTION;

EID: 78650209725     PISSN: 13899600     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10689-010-9332-y     Document Type: Article

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