Severe imbalance of cell proliferation and apoptosis in the left colon and in the rectosigmoid tract in subjects with a history of large adenomas

Gut

Volumn 48, Issue 2, 2001, Pages 238-246

  Anti, M ^a   Gasbarrini, A ^a   Gasbarrini, G ^a   Armuzzi, A ^a   Iascone, E ^a   Pignataro, G ^a   Paolucci, M ^a   Covino, M ^a   Coco, C ^a   Vecchio, F M ^a   Morini, S ^b   Lorenzetti, R ^c  

^a CATHOLIC UNIVERSITY   (Italy)

^b NUOVO REGINA MARGHERITA HOSPITAL   (Italy)

^c San Giacomo Hospital   (Italy)

Author keywords

Apoptosis; Cell proliferation; Colon cancer risk

Indexed keywords

BROXURIDINE;

ADULT; AGED; APOPTOSIS; ARTICLE; CANCER RISK; CELL PROLIFERATION; CLINICAL ARTICLE; COLON ADENOMA; COLON BIOPSY; COLON CARCINOGENESIS; COLONOSCOPY; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LABELING INDEX; MALE; PRIORITY JOURNAL;

ADENOMA; ADULT; AGED; ANALYSIS OF VARIANCE; APOPTOSIS; BIOPSY; BROMODEOXYURIDINE; CASE-CONTROL STUDIES; CELL DIVISION; COLORECTAL NEOPLASMS; FEMALE; HUMANS; IN SITU NICK-END LABELING; INTESTINAL MUCOSA; MALE; MIDDLE AGED; STATISTICS, NONPARAMETRIC;

EID: 0035125747     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.48.2.238     Document Type: Article

References (69)

1. Genetic alterations during colorectal tumor development
2. A genetic model of colorectal tumorigenesis
3. Biomarkers of increased susceptibility to gastrointestinal cancer: New application to studies of cancer prevention in human subjects
4. Tritiated-thymidine labeling of rectal epithelial cells in "non-prep" biopsies of individuals at increased risk for colonic neoplasia
5. 3H thymidine incorporation into polyps and adjacent mucosa
6. Pattern of epithelial cell proliferation in colorectal mucosa of normal subjects and of patients with adenomatous polyps or cancer of the large bowel
7. Immunohistochemical study of epithelial cell proliferation in hyperplastic polyps, adenomas and adenocarcinomas of the large bowel
8. Rectal epithelial cell proliferation patterns as predictors of adenomatous colorectal polyp recurrence
9. Apoptosis: Mechanisms and roles in pathology
10. Apoptosis
11. Molecular regulation of apoptosis: Genetic controls on cell death
12. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
13. Cell death by apoptosis: Basic concepts and disease relevance for the gastroenterologist
14. Regulation of cell number in the mammalian gastrointestinal tract: The importance of apoptosis
15. Apoptosis in the pathogenesis and treatment of disease
16. Inhibition of apoptosis during development of colorectal cancer
17. Apoptosis and immunohistochemical bcl-2 expression in colorectal adenomas and carcinomas. Aspects of carcinogenesis and prognostic significance
18. Abnormalities of epithelial apoptosis in multistep colorectal neoplasia demonstrated by terminal deoxyuridine nick end labeling
19. Bcl-2 expression in human colorectal adenomas and carcinomas
20. Bcl-2 and p53 oncoprotein expression during colorectal tumorigenesis
21. Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas
22. Field cancerization in oral stratified squamous epithelium: Clinical implication of multicentric origin
23. Abnormal pattern of cell proliferation in the entire colonic mucosa of patients with colon adenoma or cancer
24. Proliferating cell nuclear antigen (PCNA): A new marker to study human colonic cell proliferation
25. Crypt cell production rates at various sites around the colon in Wistar rats and humans
26. Human right and left colon differ in epithelial cell apoptosis and in expression of Bak, a pro-apoptotic Bcl-2 homologue
27. Increased intestinal Bak expression results in apoptosis
28. Randomized comparison of surveillance intervals after colonoscopic removal of newly diagnosed adenomatous polyps
29. Appropriate intervals for surveillance
30. Epithelial-cell apoptosis and proliferation in Helicobacter pylori-related chronic gastritis
31. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation
32. Effects of different doses of fish oil on rectal cell proliferation in patients with sporadic colonic adenomas
33. Assessing cell proliferation: A methodological review
34. Pattern of cell kinetics in colorectal mucosa of patients with different types of adenomatous polyps of the large bowel
35. Colonic epithelial cell proliferation in hereditary non-polyposis colorectal cancer
36. Apoptosis, cell replication, and Western-style diet-induced tumorigenesis in mouse colon
37. Role of apoptosis in modulation of the growth of human colorectal tubular and villous adenomas
38. Apoptosis and APC in colorectal tumorigenesis
39. Colorectal adenoma progression and genetic changes: Is there a link?
40. Normal colonic mucosa in hereditary non-polyposis colorectal cancer shows no generalized increase in somatic mutation
41. Increased stem cell somatic mutation in the non-neoplastic colorectal mucosa of patients with familial adenomatous polyposis
42. Reduced bile acid-induced apoptosis in "normal" colorectal mucosa: A potential biological marker for cancer risk
43. Apoptosis and disease
44. Aberrant crypts: Potential preneoplastic lesions in the murine colon
45. Classification of aberrant crypt foci and microadenomas in human colon
46. Aberrant crypts: Putative neoplastic foci in human colonic mucosa
47. The significance of aberrant crypt foci in understanding the pathogenesis of colon cancer
48. Aberrant crypt foci in patients with colorectal cancer
49. Somatic APC and K-ras codon 12 mutations in aberrant crypt foci from human colons
50. APC mutations occur early during colorectal tumorigenesis
51. Inactivation of both APC alleles in an early stage of colon adenomas in a patient with familial adenomatous polyposis (FAP)
52. Mutations of the APC gene in experimental carcinogenesis induced by azoxymethane in F344 rats
53. Cell kinetic evaluation of human colonic aberrant crypts (Colorectal Cancer Study Group of the University of Modena, the Health Care District 16, Modena, Italy)
54. Increased cell proliferation of azoxymethane induced aberrant crypt foci of rat colon
55. Proliferating cell nuclear antigen as a marker of cell kinetics in aberrant crypt foci, hyperplastic polyps, adenomas, and adenocarcinomas of the human colon
56. Aberrant crypt foci in colorectal carcinogenesis. Cell and crypt dynamics
57. Resistance of aberrant crypt foci to apoptosis induced by azoxymethane in rats chronically fed cholic acid
58. Colonic cell proliferation and aberrant crypt foci formation inhibited by dairy glycosphingolipids in 1,2-dimethylydrazine treated CF1 mice
59. Inhibition of dimethylhydrazine-induced aberrant crypt foci by induction of apoptosis in rat colon following oral administration of the glucosinolate singrin
60. Dietary n-3 PUFA increases the apoptotic response to 1,2-dimethylhydrazine, reduces mitosis and suppresses the induced carcinogenesis in the rat colon
61. Lovastatin augments sulindac-induced apoptosis in colon cancer cells and potentiates chemopreventive effects of sulindac
62. Frequent and characteristic K-ras activation and absence of p53 protein accumulation in aberrant crypt loci of the colon
63. Evolution of cancer of the colon and rectum
64. Morphology, anatomic distribution and cancer potential of colonic polyps
65. Inward growth of colonic adenomatous polyps
66. What is an apoptotic index measuring? A commentary
67. Distinction of apoptotic and necrotic cell death by in situ labelling of fragmented DNA
68. In situ detection of fragmented DNA (TUNEL assay) fails to discriminate among apoptosis, necrosis and autolytic cell death: A cautionary note
69. Molecular methods for the identification of apoptosis in tissues