Distinct mechanisms of glucose lowering by specific agonists for peroxisomal proliferator activated receptor γ and retinoic acid X receptors

Journal of Biological Chemistry

Volumn 280, Issue 46, 2005, Pages 38317-38327

  Li, Xiangquan ^a   Hansen, Polly A ^b   Xi, Li ^c   Chandraratna, Roshantha A S ^d   Burant, Charles F ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b SAINT LOUIS UNIVERSITY   (United States)

^c PFIZER INC   (United States)

^d Vitae Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; DISEASES; GENES; GLUCOSE; INSULIN; RNA;

ACTIVATED RECEPTOR; ACTIVATED RECEPTORS; DIABETES; SENSITIZATION;

DISEASE CONTROL;

AGN 194204; CYCLIC AMP; FATTY ACID SYNTHASE; GLUCOSE; GUANINE NUCLEOTIDE BINDING PROTEIN; HEPATOCYTE NUCLEAR FACTOR 3BETA; HEPATOCYTE NUCLEAR FACTOR 3GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA AGONIST; RETINOID X RECEPTOR; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TROGLITAZONE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; 6 [1 (5,6,7,8 TETRAHYDRO 3,5,5,8,8 PENTAMETHYL 2 NAPHTHYL)CYCLOPROPYL]NICOTINIC ACID; CHROMAN DERIVATIVE; FOXA2 PROTEIN, MOUSE; FOXA3 PROTEIN, MOUSE; GLYCOGEN; INSULIN; INSULIN RECEPTOR SUBSTRATE 2 PROTEIN; INSULIN RECEPTOR SUBSTRATE-2 PROTEIN; LIGAND; LUCIFERASE; MESSENGER RNA; NICOTINIC ACID DERIVATIVE; PHOSPHOPROTEIN; PROTEIN KINASE B; SIGNAL PEPTIDE; TETRALIN DERIVATIVE; UNSATURATED FATTY ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; DOWN REGULATION; DRUG EFFECT; FEMALE; GENE ACTIVATION; GLUCONEOGENESIS; GLYCOGEN SYNTHESIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; CELL LINE; DIMERIZATION; DNA MICROARRAY; DOSE RESPONSE; GENE EXPRESSION REGULATION; GENETIC PROCEDURES; GENETIC TRANSFECTION; GLUCOSE BLOOD LEVEL; HUMAN; HYPERINSULINISM; LIVER; METABOLISM; MOUSE; NORTHERN BLOTTING; PATHOLOGY; POLYMERASE CHAIN REACTION; RADIOIMMUNOASSAY; SIGNAL TRANSDUCTION; SKELETAL MUSCLE; TIME; TRANSACTIVATION; TUMOR CELL LINE; WESTERN BLOTTING; ZUCKER RAT;

ANIMALS; BLOOD GLUCOSE; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELL LINE; CELL LINE, TUMOR; CHROMANS; CYCLIC AMP; DIABETES MELLITUS, TYPE 2; DIMERIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; FATTY ACID SYNTHETASE COMPLEX; FATTY ACIDS, UNSATURATED; FEMALE; GENE EXPRESSION REGULATION; GENETIC TECHNIQUES; GLUCOSE; GLYCOGEN; GTP-BINDING PROTEINS; HEPATOCYTE NUCLEAR FACTOR 3-BETA; HEPATOCYTE NUCLEAR FACTOR 3-GAMMA; HUMANS; HYPERINSULINISM; INSULIN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; LIVER; LUCIFERASES; MICE; MICE, INBRED C57BL; MODELS, BIOLOGICAL; MUSCLE, SKELETAL; NICOTINIC ACIDS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHOSPHOPROTEINS; POLYMERASE CHAIN REACTION; PPAR GAMMA; PROTO-ONCOGENE PROTEINS C-AKT; RADIOIMMUNOASSAY; RATS; RATS, ZUCKER; RETINOID X RECEPTORS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TETRAHYDRONAPHTHALENES; THIAZOLIDINEDIONES; TIME FACTORS; TRANS-ACTIVATION (GENETICS); TRANSFECTION;

EID: 33644696706     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M505853200     Document Type: Article

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