In vivo-in vitro correlations: Predicting pulmonary drug deposition from pharmaceutical aerosols

Journal of Aerosol Medicine and Pulmonary Drug Delivery

Volumn 23, Issue SUPPL. 2, 2010, Pages

  Byron, Peter R ^a   Hindle, Michael ^a   Lange, Carlos F ^b   Longest, P Worth ^a   McRobbie, Donald ^c   Oldham, Michael J ^a,d   Olsson, Bo ^e   Thiel, Charles G ^f   Wachtel, Herbert ^g   Finlay, Warren H ^b  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

^c IMPERIAL COLLEGE HEALTHCARE NHS TRUST   (United Kingdom)

^d Altria Client Services   (United States)

^e ASTRAZENECA R AND D   (Sweden)

^f 3M COMPANY   (United States)

^g BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

Author keywords

aerosol distribution; airway replicas; CFD; computational fluid dynamics; deposition modeling; gamma scintigraphy; imaging

Indexed keywords

BRONCHODILATING AGENT; NACYSTELYN; SALBUTAMOL; STEROID; TERBUTALINE; UNCLASSIFIED DRUG;

AEROSOL; ARTICLE; COMPUTATIONAL FLUID DYNAMICS; COMPUTER ASSISTED TOMOGRAPHY; COMPUTER MODEL; CORRELATION ANALYSIS; DIFFUSION WEIGHTED IMAGING; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRY POWDER; IN VITRO STUDY; IN VIVO IN VITRO CORRELATION; IN VIVO STUDY; INHALER; LUNG; NUCLEAR MAGNETIC RESONANCE IMAGING; RESPIRATORY SYSTEM; THREE DIMENSIONAL IMAGING; VALIDATION PROCESS;

ADMINISTRATION, INHALATION; AEROSOLS; ANIMALS; COMPUTER SIMULATION; DRUG DELIVERY SYSTEMS; HUMANS; HYDRODYNAMICS; MODELS, BIOLOGICAL; NEBULIZERS AND VAPORIZERS; PHARMACEUTICAL PREPARATIONS; RESEARCH; RESPIRATORY SYSTEM; TISSUE DISTRIBUTION;

EID: 78650202273     PISSN: 19412711     EISSN: 19412703     Source Type: Journal    
DOI: 10.1089/jamp.2010.0846     Document Type: Article

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