Experimental measurements of particle deposition in three proximal lung bifurcation models with an idealized mouth-throat

Journal of Aerosol Medicine: Deposition, Clearance, and Effects in the Lung

Volumn 18, Issue 4, 2005, Pages 460-473

  Zhang, Y ^a   Finlay, Warren H ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Laryngeal jet; Mouth throat; Particle deposition; Proximal lung bifurcation; Trachea

Indexed keywords

DI 2 ETHYLHEXYL SEBECATE; OIL; UNCLASSIFIED DRUG;

AEROSOL; ARTICLE; FLOW RATE; GEOMETRY; GRAVIMETRY; LUNG; MEASUREMENT; MODEL; MOUTH; THROAT; TRACHEA; VISCOSITY;

ADMINISTRATION, INHALATION; AEROSOLS; CHEMISTRY, PHARMACEUTICAL; DECANOIC ACIDS; HUMANS; LARYNX; LUNG; MODELS, ANATOMIC; MOUTH; OILS; PARTICLE SIZE; PHARYNX; RESPIRATORY MECHANICS; TRACHEA;

EID: 29844458412     PISSN: 08942684     EISSN: None     Source Type: Journal    
DOI: 10.1089/jam.2005.18.460     Document Type: Article

References (42)

1. Kelly, J.T., B. Asgharian, J.S. Kimbell, et al. 2004. Particle deposition in human nasal airway replicas manufactured by different methods. Part I. Inertial regime particles. Aerosol Sci. Technol. 38:1063-1071.
2. Chan, T.L., and M. Lippmann. 1980. Experimental measurements and empirical modeling of the regional deposition of inhaled particles in humans. Am. Ind. Hyg. Assoc. J. 41:399-409.
3. ICRP. 1994. Human respiratory tract model for radiological protection. pp. 44-48; 231-299. In Annals of the ICRP. ICRP Publication 66. Elsevier, New York.
4. Emmett, P.C., R.J. Aitken, and W.J. Hannan. 1982. Measurements of the total and regional deposition of inhaled particles in the human respiratory tract. J. Aerosol Sci. 13:549-560.
5. Foord, N., A. Black, and M. Walsh. 1978. Regional deposition of 2.57.5 μm diameter inhaled particles in healthy male nonsmokers. J. Aerosol Sci. 9:343-357.
6. Finlay, W.H. 2001. The Mechanics of Inhaled Pharmaceutical Aerosols: An Introduction. Academic Press, London.
7. Kim, C.S., and A.J. Iglesias. 1989. Deposition of inhaled particles in bifurcating airway models: I. inspiratory deposition. J. Aerosol Med. 2:2-14.
8. Kim, C.S., D.M. Fisher, D.J. Lutz, et al. 1994. Particle deposition in bifurcating airway models with varying airway geometry. J. Aerosol Sci. 25:567-581.
9. Ferron, G.A. 1977. Deposition of polydisperse aerosols in two glass models representing the upper human airways. J. Aerosol Sci. 8:409-427.
10. Martonen, T.B. 1983. Measurement of particle dose distribution in a model of a human larynx and tracheo-bronchial tree. J. Aerosol Sci. 14:11-22.
11. Kim, C.S., and D.M. Fisher. 1999. Deposition characteristics of aerosol particles in sequentially bifurcating airway models. Aerosol Sci. Technol. 31:198-220.
12. Schlesinger, R.B., and M. Lippmann. 1972. Particle deposition in casts of the human upper tracheobronchial tree. Am. Ind. Hyg. Assoc. J. 33:237-251.
13. Schlesinger, R.B., and M. Lippmann. 1976. Particle deposition in the trachea: in vivo and in hollow casts. Thorax 31:678-684.
14. Schlesinger, R.B., D.E. Bohning, T.L. Chan, et al. 1977. Particle deposition in a hollow cast of the human tracheobronchial tree. J. Aerosol Sci. 8:429-445.
15. Schlesinger, R.B., J.L. Gurman, and M. Lippmann. 1982. Particle deposition within bronchial airways: comparisons using constant and cyclic inspiratory flows. Ann. Occup. Hyg. 26:47-64.
16. Cheng, Y.S., Y. Zhou, and B.T. Chen. 1999. Particle deposition in a cast of human oral airways. Aerosol Sci. Technol. 31:286-300.
17. Scherer, P.W., L.H. Schendalman, N.M. Greene, et al. 1975. Measurement of axial diffusivities in a model of the bronchial airways. J. Appl. Physiol. 38:719-723.
18. Katz, I.M., and T.B. Martonen. 1996. Flow patterns in three-dimensional laryngeal models. J. Aerosol Med. 9:501-511.
19. Katz, I.M., B.M. Davis, and T.B. Martonen. 1999. A numerical study of particle motion within the human larynx and trachea. J. Aerosol Sci. 30:173-183.
20. Stapleton, K.W., E. Guentsch, M.K. Hoskinson, et al. 2000. On the suitability of k-ε turbulence modeling for aerosol deposition in the mouth and throat: a comparison with experiment. J. Aerosol Sci. 31(6):739-749.
21. Oldham, M.J., R.F. Phalen, and T. Heistracher. 2000. Computational fluid dynamic predictions and experimental results for particle deposition in an airway model. Aerosol Sci. Technol. 32:61-71.
22. Comer, J.K., C. Kleinstreuer, and S. Hyun. 2000. Aerosol transport and deposition in sequentially bifurcating airways. ASME J. Biomech. Eng. 122:152-158.
23. Zhang, Z., C. Kleinstreuer, and C.S. Kim. 2001. Effects of curved inlet tubes on air flow and particle deposition in bifurcating lung models. J. Biomech. 34:659-669.
24. Zhang, Z., and C. Kleinstreuer. 2001. Effect of particle inlet distributions on deposition in a triple bifurcation lung airway model. J. Aerosol Med. 14:13-29.
25. Zhang, Z., C. Kleinstreuer, and S.K. Chong. 2002. Aerosol deposition efficiencies and upstream release positions for different inhalation modes in an upper bronchial airway model. Aerosol Sci. Technol. 36:828-844.
26. Chan, T.L., and R.M. Schreck. 1980. Effect of the laryngeal jet on particle deposition in the human trachea and upper bronchial airways. J. Aerosol Sci. 11:447-459.
27. Weibel, E.R. 1963. Morphometry of the Human Lung. Academic Press, New York.
28. Horsfield, K., and G. Cumming. 1968. Morphology of the bronchial tree in man. J. Appl. Physiol. 24:373-383.
29. Horsfield, K., G. Dart, and D.E. Olson. 1971. Models of the human bronchial tree. J. Appl. Physiol. 31:207-217.
30. Finlay, W.H., C.F. Lange, M. King, et al. 2000. Lung delivery of aerosolized dextran. Am. J. Respir. Crit. Care Med. 161:91-97.
31. Phillips, C.G., S.R. Kaye, and R.C. Schroter. 1994. A diameter-based reconstruction of the branching pattern of the human bronchial tree. Part I. Description and application. Respir. Physiol. 98:193-217.
32. Haefeli-Bleuer, B., and E.R. Weibel. 1988. Morphometry of the human pulmonary acinus. Anat. Rec. 220:401-414.
33. Brancatisano, T., P.W. Collett, and L.A. Engel. 1983. Respiratory movements of the vocal cords. J. Appl. Physiol. 54:1269-1276.
34. Heenan, A.F., E.A. Matida, A. Pollard, et al. 2003. Experimental measurements and computational modeling of the flow in an idealized extrathoracic airway. Exp. Fluids 35:70-84.
35. DeHaan, W.H., and W.H. Finlay. 2001. In vitro monodisperse aerosol deposition in a mouth and throat with six different inhalation devices. J. Aerosol Med. 14:361-367.
36. Grgic, B., W.H. Finlay, P.K.P. Burnell, et al. 2004. In vitro inter-subject and intra-subject deposition measurements in realistic mouth-throat geometries. J. Aerosol Sci. 35:1025-1040.
37. Grgic, B., W.H. Finlay, and A.F. Heenan. 2004. Regional aerosol deposition and flow measurements in an idealized mouth and throat. J. Aerosol Sci. 35:21-32.
38. DeHaan, W.H., and W.H. Finlay. 2004. Predicting extrathoracic deposition from dry powder inhalers. J. Aerosol Sci. 35:309-331.
39. Willeke, K., and P.A. Baron. 1993. Aerosol Measurement. Van Nostrand Reinhold, New York.
40. Kamm, R.D., E.T. Bullister, and C. Keramids. 1986. The effect of a turbulent jet on gas transport during oscillatory flow. ASME J. Biomech. Eng. 108:266-272.
41. Corcoran, T.E., and N. Chigier. 2000. Characterization of the laryngeal jet using phase doppler interferometry. J. Aerosol Med. 13:125-137.
42. Stahlhofen, W., J. Gebhart, and J. Heyder. 1980. Experimental determination of the regional deposition of aerosol particles in the human respiratory tract. Am. Ind. Hyg. Assoc. J. 41:385-398a.