메뉴 건너뛰기




Volumn 6, Issue 6, 2010, Pages 396-405

Anticancer activity of the ascidian polyclinum indicum against cervical cancer cells (HeLa) mediated through apoptosis induction

Author keywords

Anticancer activity; Apoptosis; Ascidian; Cytotoxicity; Flow cytometry; HeLa cells; Hoechst staining; Polyclinum indicum

Indexed keywords

ANTINEOPLASTIC AGENT; METHANOL; PI 8; POLYCLINUM INDICUM EXTRACT; UNCLASSIFIED DRUG;

EID: 78650188042     PISSN: 15734064     EISSN: None     Source Type: Journal    
DOI: 10.2174/157340610793564009     Document Type: Article
Times cited : (10)

References (65)
  • 2
    • 0034641980 scopus 로고    scopus 로고
    • Apoptosis in development
    • Meier, P.; Finch, A.; Evan, G. Apoptosis in development. Nature, 2000, 407, 796-801.
    • (2000) Nature , vol.407 , pp. 796-801
    • Meier, P.1    Finch, A.2    Evan, G.3
  • 4
    • 0034641932 scopus 로고    scopus 로고
    • From bench to clinic with apoptosis-based therapeutic agents
    • Nicholson, D.W. From bench to clinic with apoptosis-based therapeutic agents. Nature, 2000, 407, 810-816.
    • (2000) Nature , vol.407 , pp. 810-816
    • Nicholson, D.W.1
  • 5
    • 0034141601 scopus 로고    scopus 로고
    • Marine natural products
    • Faulkner, D.J. Marine natural products. Nat. Prod. Rep., 2003, 17, 7-55.
    • (2003) Nat. Prod. Rep. , vol.17 , pp. 7-55
    • Faulkner, D.J.1
  • 6
    • 78650185073 scopus 로고    scopus 로고
    • Marinlit. A marine literature database maintained by the Department of Chemistry, University of Canterbury, Christchurch, New Zealand.
    • Marinlit. A marine literature database maintained by the Department of Chemistry, University of Canterbury, Christchurch, 2009. New Zealand. http://www.chem.canterbury.ac.nz/marinlit/marinlit. shtmL.
    • (2009)
  • 8
    • 78650198621 scopus 로고    scopus 로고
    • Marine natural products: A way to new drugs
    • July-September. (Accessed on 20.07.2010)
    • Stonik, V.A. Marine natural products: A way to new drugs. Acta. Nat., 2009, July-September. http://actanaturae.ru/article. aspx?id= 157 (Accessed on 20.07.2010).
    • (2009) Acta. Nat.
    • Stonik, V.A.1
  • 9
    • 54249139074 scopus 로고    scopus 로고
    • Marine Pharmacology in 2005-2006: Antitumour and cytotoxic compounds
    • Mayer, A.M.S.; Gustafson, K.R. Marine Pharmacology in 2005-6: Antitumour and cytotoxic compounds. Eur. J. Cancer, 2008, 44(16), 2357-2387.
    • (2008) Eur. J. Cancer , vol.44 , Issue.16 , pp. 2357-2387
    • Mayer, A.M.S.1    Gustafson, K.R.2
  • 10
    • 0000853969 scopus 로고
    • Ascidians: Producers of amino acid derived metabolites
    • Davidson, B.S. Ascidians: Producers of amino acid derived metabolites. Chem. Rev., 1993, 93, 1771-1791.
    • (1993) Chem. Rev. , vol.93 , pp. 1771-1791
    • Davidson, B.S.1
  • 11
    • 0037388458 scopus 로고    scopus 로고
    • Rapid and selective apoptosis in human leukemic cells induced by Aplidine through a Fas/CD95- and mitochondrial-mediated mechanism
    • Gajate, C.; An. F.; Mollinedo, F. Rapid and selective apoptosis in human leukemic cells induced by aplidine through a fas/CD95-and mitochondrial-mediated mechanism. Clin. Cancer Res., 2003, 9, 1535-1545. (Pubitemid 36418412)
    • (2003) Clinical Cancer Research , vol.9 , Issue.4 , pp. 1535-1545
    • Gajate, C.1    An, F.2    Mollinedo, F.3
  • 13
    • 0842281347 scopus 로고    scopus 로고
    • A profile of the in vitro antitumor activity of lissoclinolide
    • DOI 10.1016/j.taap.2003.10.004
    • Richardson, A.D.; Ireland, C.A. A profile of the in vitro antitumor activity of lissoclinolide. Toxicol. Appl. Pharmacol., 2004,195, 55-61. (Pubitemid 38177499)
    • (2004) Toxicology and Applied Pharmacology , vol.195 , Issue.1 , pp. 55-61
    • Richardson, A.D.1    Ireland, C.M.2
  • 14
    • 31344463235 scopus 로고    scopus 로고
    • Halocynthiaxanthin and fucoxanthinol isolated from Halocynthia roretzi induce apoptosis in human leukemia, breast and colon cancer cells
    • DOI 10.1016/j.cbpc.2005.10.005, PII S1532045605002048
    • Konishi, I.; Hosokawa, M.; Sashima, T.; Kobayashi, H.; Miyashita, K. Halocynthiaxanthin and fucoxanthinol isolated from Halocynthia roretzi induce apoptosis in human leukemia, breast and colon cancer cells. Comp. Biochem. Physiol. C Toxicol. Pharmacol., 2006, 142, 53-59. (Pubitemid 43142054)
    • (2006) Comparative Biochemistry and Physiology - C Toxicology and Pharmacology , vol.142 , Issue.1-2 , pp. 53-59
    • Konishi, I.1    Hosokawa, M.2    Sashima, T.3    Kobayashi, H.4    Miyashita, K.5
  • 15
    • 0019470678 scopus 로고
    • Structures of the didemnins, antiviral and cytotoxic depsipeptides from a Caribbean tunicate
    • Rinehart, K.; Gloer, J.; Cook, J.; Carter Jr.; Mizsak, S.; Scahill, T. Structures of the didemnins, antiviral and cytotoxic depsipeptides from a Caribbean tunicate. J. Am. Chem. Soc., 1987, 103, 1857-1859.
    • (1987) J. Am. Chem. Soc. , vol.103 , pp. 1857-1859
    • Rinehart, K.1    Gloer, J.2    Cook, J.3    Carter, Jr.4    Mizsak, S.5    Scahill, T.6
  • 16
    • 0023409608 scopus 로고
    • Grossularine-1 and grossularine-2, alpha carbolines from Dendrodoa grossularia, as possible intercalative agents
    • Helbecque, N.; Moquin, C.; Bernier, J.L.; Morel, E.; Guyot, M.; Henichart, J.P. Grossularine-1 and grossularine-2, alpha carbolines from Dendrodoa grossularia, as possible intercalative agents. Cancer Biochem. Biophys., 1987, 9, 271-279.
    • (1987) Cancer Biochem. Biophys. , vol.9 , pp. 271-279
    • Helbecque, N.1    Moquin, C.2    Bernier, J.L.3    Morel, E.4    Guyot, M.5    Henichart, J.P.6
  • 17
    • 0000416568 scopus 로고    scopus 로고
    • Biomedical potential of marine natural products
    • Carte, B.K. Biomedical potential of marine natural products. Bioscience, 1996, 46(4), 271-286. (Pubitemid 126552866)
    • (1996) BioScience , vol.46 , Issue.4 , pp. 271-286
    • Carte, B.K.1
  • 18
    • 60549097409 scopus 로고    scopus 로고
    • Marine metabolites overcoming or circumventing multidrug resistance mediated by ATP-dependent transporters: A new hope for patient with tumors resistant to conventional chemotherapy
    • Barthomeuf, C.; Bourguet-Kondracki, M.L.; Kornprobst, J.M. Marine metabolites overcoming or circumventing multidrug resistance mediated by ATP-dependent transporters: A new hope for patient with tumors resistant to conventional chemotherapy. Anticancer Agents Med. Chem., 2008, 8(8), 886-903.
    • (2008) Anticancer Agents Med. Chem. , vol.8 , Issue.8 , pp. 886-903
    • Barthomeuf, C.1    Bourguet-Kondracki, M.L.2    Kornprobst, J.M.3
  • 19
    • 78650227807 scopus 로고    scopus 로고
    • First report of a simple ascidian- Phallusia Arabica Savigny, 1816 from Tuticorin coast of India
    • Meenakshi, V.K.; Senthamarai, S. First report of a simple ascidian- Phallusia Arabica Savigny, 1816 from Tuticorin coast of India. J. Mar. Biol. Assoc. India, 2004, 46(1), 104-107.
    • (2004) J. Mar. Biol. Assoc. India , vol.46 , Issue.1 , pp. 104-107
    • Meenakshi, V.K.1    Senthamarai, S.2
  • 20
    • 23944452028 scopus 로고    scopus 로고
    • New potent cytotoxic lamellarin alkaloids from Indian ascidian Didemnum obscurum
    • DOI 10.1016/j.tet.2005.07.067, PII S0040402005012755
    • Reddy, S.M.; Srinivasulu, M.; Satyanarayana, N.; Kondapi, A.K.; Venkateswarlu, Y. New potent cytotoxic lamellarin alkaloids from Indian ascidian Didemnum obscurum. Tetrahedron, 2005, 61, 9242-9247. (Pubitemid 41206483)
    • (2005) Tetrahedron , vol.61 , Issue.39 , pp. 9242-9247
    • Reddy, S.M.1    Srinivasulu, M.2    Satyanarayana, N.3    Kondapi, A.K.4    Venkateswarlu, Y.5
  • 21
    • 0028159788 scopus 로고
    • Antimicrobial activity and surface bacterial film in marine sponges
    • Becerro, M. A.; Lopez, N. I.; Turon, X.; Uniz, M.J. Antimicrobial activity and surface bacterial film in marine sponges. J. Exp. Mar. Biol. Ecol., 1994, 179, 195-205.
    • (1994) J. Exp. Mar. Biol. Ecol. , vol.179 , pp. 195-205
    • Becerro, M.A.1    Lopez, N.I.2    Turon, X.3    Uniz, M.J.4
  • 22
    • 0031428745 scopus 로고    scopus 로고
    • Isolating bioactive compounds from marine organisms
    • Riguera, R. Isolating bioactive compounds from marine organisms. J. Mar. Biotechnol., 1997, 5, 187-193.
    • (1997) J. Mar. Biotechnol. , vol.5 , pp. 187-193
    • Riguera, R.1
  • 23
    • 9444254228 scopus 로고    scopus 로고
    • Isolation of marine natural products
    • Cannell, R.P.J., Ed.; Humana Press Inc., New Jersy, USA
    • Wright, A.E. Isolation of marine natural products. In: Methods in Biotechnology: Natural Product Isolation; Cannell, R.P.J., Ed.; Humana Press Inc., New Jersy, USA, 1998, Vol. 4, pp. 365-408.
    • (1998) Methods in Biotechnology: Natural Product Isolation , vol.4 , pp. 365-408
    • Wright, A.E.1
  • 27
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
    • Mosmann, T. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods, 1983, 16, 55-63. (Pubitemid 14203433)
    • (1983) Journal of Immunological Methods , vol.65 , Issue.1-2 , pp. 55-63
    • Mosmann, T.1
  • 28
    • 34848826514 scopus 로고    scopus 로고
    • Cytotoxicity of the ascidian Cystodytes dellechiajei against tumor cells and study of the involvement of associated microbiota in the production of cytotoxic compounds
    • DOI 10.3390/md20070006
    • Martinez-Garcia, M.; Díaz-Valdes, M.; Ramos-Espla, A.; Salvador, N.; Lopez, P.; Larriba, E.; Antón, J. Cytotoxicity of the ascidian Cystodytes dellechiajei against tumor cells and study of the involvement of associated microbiota in the production of cytotoxic compounds. Drugs, 2007a, 5, 52-70. (Pubitemid 47511033)
    • (2007) Marine Drugs , vol.5 , Issue.3 , pp. 52-70
    • Martinez-Garcia, M.1    Diaz-Valdes, M.2    Ramos-Espla, A.3    Salvador, N.4    Lopez, P.5    Larriba, E.6    Anton, J.7
  • 29
    • 34249086781 scopus 로고    scopus 로고
    • Cytotoxic and free radical scavenging activities of Zingiberaceous rhizomes
    • Zaeoung, S.; Plubrukarn, A.; Keawpradub, N. Cytotoxic and free radical scavenging activities of Zingiberaceous rhizomes. Songklanakarin J. Sci. Technol., 2005, 27(4), 800-812.
    • (2005) Songklanakarin J. Sci. Technol. , vol.27 , Issue.4 , pp. 800-812
    • Zaeoung, S.1    Plubrukarn, A.2    Keawpradub, N.3
  • 30
    • 2042533677 scopus 로고    scopus 로고
    • A modified method of fluorescent staining for the apoptosis detection from blood tumor cells
    • Zheng, C.Y.; Qu, S.P.; Hu, G.B. A modified method of fluorescent staining for the apoptosis detection from blood tumor cells. Cancer Res. Prev. Treat., 1998, 25, 432-433.
    • (1998) Cancer Res. Prev. Treat. , vol.25 , pp. 432-433
    • Zheng, C.Y.1    Qu, S.P.2    Hu, G.B.3
  • 31
    • 0020636778 scopus 로고
    • Long-term storage of samples for flow cytometric DNA analysis
    • Vindelov, L.L.; Christensen, I.J.; Keiding, N.; Spang-Thomsen, M.; Nissen, N.I. Long-term storage of samples for flow cytometric DNA analysis. Cytometry, 1983, 3, 317-322. (Pubitemid 13087608)
    • (1983) Cytometry , vol.3 , Issue.5 , pp. 317-322
    • Vindelov, L.L.1    Christensen, I.J.2    Keiding, N.3
  • 32
    • 3042741064 scopus 로고    scopus 로고
    • 2 cell cycle arrest
    • DOI 10.1158/0008-5472.CAN-03-3410
    • Wesierska-Gadek, J.; Schloffer, D.; Gueorguieva, M.; Uhl, M.; Skladanowski, A. Increased susceptibility of poly (ADP-ribose) polymerase- 1 knockout cells to antitumor triazoloacridone C-1305 is associated with permanent G2 cell cycle arrest. Cancer Res., 2004, 64, 4487-4497. (Pubitemid 38856920)
    • (2004) Cancer Research , vol.64 , Issue.13 , pp. 4487-4497
    • Wesierska-Gadek, J.1    Schloffer, D.2    Gueorguieva, M.3    Uhl, M.4    Skladanowski, A.5
  • 33
    • 0030861472 scopus 로고    scopus 로고
    • Use of flow cytometry techniques in studying mechanisms of apoptosis in leukemic cells
    • DOI 10.1002/(SICI)1097-0320(19971001)29:2<97::AID-CYTO1>3.0.CO;2-J
    • Gorman, A.M.; Samali, A.; McGowan, A.J.; Cotter, T.G. Use of flow cytometry techniques in studying mechanisms of apoptosis in leukemic cells. Cytometry, 1997, 29, 97-105. (Pubitemid 27444658)
    • (1997) Cytometry , vol.29 , Issue.2 , pp. 97-105
    • Gorman, A.M.1    Samali, A.2    McGowan, A.J.3    Cotter, T.G.4
  • 37
    • 67651180568 scopus 로고    scopus 로고
    • Antitumor potential of natural products from Mediterranean ascidians
    • Menna, M. Antitumor potential of natural products from Mediterranean ascidians. Phytochem. Rev., 2009, 8, 461-472.
    • (2009) Phytochem. Rev. , vol.8 , pp. 461-472
    • Menna, M.1
  • 38
    • 0025070774 scopus 로고
    • Ecteinascidins 729, 743, 745, 759A, 759B and 770: Potent antitumor agents from the Caribbean tunicate Ecteinascidia turbinata
    • Rinehart, K.; Holt, T.; Fregeau, N. Ecteinascidins 729, 743, 745, 759A, 759B and 770: Potent antitumor agents from the Caribbean tunicate Ecteinascidia turbinata. J. Org. Chem., 1990, 55, 4512-4515.
    • (1990) J. Org. Chem. , vol.55
    • Rinehart, K.1    Holt, T.2    Fregeau, N.3
  • 40
    • 33748094828 scopus 로고    scopus 로고
    • Cytotoxic labdane alkaloids from an ascidian Lissoclinum sp.: Isolation, structure elucidation, and structure-activity relationship
    • DOI 10.1016/j.bmc.2006.06.043, PII S0968089606005050
    • Uddin, J.; Ueda, K.; Siwu, E.R.; Kita, M.; Uemura, D. Cytotoxic labdane alkaloids from an ascidian Lissoclinum sp. Isolation, structure elucidation, and structure-activity relationship. Bioorg. Med. Chem., 2006, 14, 6954-6961. (Pubitemid 44307651)
    • (2006) Bioorganic and Medicinal Chemistry , vol.14 , Issue.20 , pp. 6954-6961
    • Uddin, J.1    Ueda, K.2    Siwu, E.R.O.3    Kita, M.4    Uemura, D.5
  • 43
    • 0037138257 scopus 로고    scopus 로고
    • A novel cytotoxic alkaloid of lamellarin class from a marine ascidian Didemnum sp
    • Ham, J.; Kang, H. A novel cytotoxic alkaloid of lamellarin class from a marine ascidian Didemnum sp. Bull. Korean Chem. Soc., 2002, 23, 163-166.
    • (2002) Bull. Korean Chem. Soc. , vol.23 , pp. 163-166
    • Ham, J.1    Kang, H.2
  • 45
    • 42949084367 scopus 로고    scopus 로고
    • Cytotoxic and apoptogenic activity of a methanolic extract from the marine invertebrate ciona intestinalis on malignant cell lines
    • DOI 10.2174/157340608783789121
    • Russo, G.L.; Ciarcia, G.; Presidente, E.; Siciliano, R.A.; Tosti, E. Cytotoxic and apoptogenic activity of a methanolic extract from the marine invertebrate Ciona intestinalis on malignant cell lines. Med. Chem., 2008, 4, 106-109. (Pubitemid 351611800)
    • (2008) Medicinal Chemistry , vol.4 , Issue.2 , pp. 106-109
    • Russo, G.L.1    Ciarcia, G.2    Presidente, E.3    Siciliano, R.A.4    Tosti, E.5
  • 46
    • 77649194451 scopus 로고    scopus 로고
    • Iodocionin a cytotoxic iodinated metabolite from the Mediterranean ascidian Ciona edwardsii
    • Aiello, A.; Fattorusso, E.; Imperatore, C.; Menna, M.; Muller, W.E.G. Iodocionin, a cytotoxic iodinated metabolite from the Mediterranean ascidian Ciona edwardsii. Mar. Drugs, 2010, 8(2), 285-291.
    • (2010) Mar. Drugs , vol.8 , Issue.2 , pp. 285-291
    • Aiello, A.1    Fattorusso, E.2    Imperatore, C.3    Menna, M.4    Muller, W.E.G.5
  • 48
    • 0001905359 scopus 로고
    • Assays related to cancer drug discovery
    • Biological Techniques, Academic Press: London
    • Suffness, M.; Pezzuto, J.M. Assays related to cancer drug discovery. In: Methods in Plant Biochemistry; Biological Techniques, Academic Press: London, 1991, Vol. 6, pp. 71-131.
    • (1991) Methods in Plant Biochemistry , vol.6 , pp. 71-131
    • Suffness, M.1    Pezzuto, J.M.2
  • 50
    • 41649117700 scopus 로고    scopus 로고
    • Cytotoxic metabolites from the Okinawan ascidian Diplosoma virens
    • Ogi, T.; Taira, J.; Margiastuti, P.; Ueda, K. Cytotoxic metabolites from the Okinawan ascidian Diplosoma virens. Molecules, 2008, 13, 595-602.
    • (2008) Molecules , vol.13 , pp. 595-602
    • Ogi, T.1    Taira, J.2    Margiastuti, P.3    Ueda, K.4
  • 51
    • 0000448995 scopus 로고    scopus 로고
    • Advances in the chemistry and pharmacology of exteinascidins, a promising new class of anticancer agents
    • Manxanares, I.; Cuevas, C.; Garcia-Nieto, R.; Marco, E.; Gago, F. Advances in the chemistry and pharmacology of exteinascidins, a promising new class of anticancer agents. Curr. Med. Chem. Anticancer Agents, 2001, 1, 257-276.
    • (2001) Curr. Med. Chem. Anticancer Agents , vol.1 , pp. 257-276
    • Manxanares, I.1    Cuevas, C.2    Garcia-Nieto, R.3    Marco, E.4    Gago, F.5
  • 52
    • 0035136529 scopus 로고    scopus 로고
    • Ecteinascidin 743 induces protein-linked DNA breaks in human colon carcinoma HCT116 cells and is cytotoxic independently of topoisomerase I expression
    • Takebayashi, Y.; Goldwasser, F.; Urasaki, Y.; Kohlhagen, G.; Pommier, Y. Ecteinascidin 743 induces protein-linked DNA breaks in human colon carcinoma HCT116 cells and is cytotoxic independently of topoisomerase I expression. Clin. Cancer Res., 2001(a), 7, 185-191. (Pubitemid 32110222)
    • (2001) Clinical Cancer Research , vol.7 , Issue.1 , pp. 185-191
    • Takebayashi, Y.1    Goldwasser, F.2    Urasaki, Y.3    Kohlhagen, G.4    Pommier, Y.5
  • 56
    • 20444452899 scopus 로고    scopus 로고
    • Induction of caspase-3-dependent apoptosis in human leukemia HL-60 cells by paclitaxel
    • Ko-Hsiu, L.; Ko-Huang, L.; Hsien-Hua, L.; Keh-Liang, L.; Jing- Gung, C. Induction of caspase-3-dependent apoptosis in human leukemia HL-60 cells by paclitaxel. Clin. Chim. Acta, 2005, 357(1), 65-73.
    • (2005) Clin. Chim. Acta , vol.357 , Issue.1 , pp. 65-73
    • Ko-Hsiu, L.1    Ko-Huang, L.2    Hsien-Hua, L.3    Keh-Liang, L.4    Jing-Gung, C.5
  • 57
    • 67651178593 scopus 로고    scopus 로고
    • Cyclic peptide antitumor agent from an ascidian
    • WO/1998/013063, April
    • Ireland, C.M.; Fernandez, A. Cyclic peptide antitumor agent from an ascidian. PCT Int. Appl. WO/1998/013063, April 1998.
    • (1998) PCT Int. Appl.
    • Ireland, C.M.1    Fernandez, A.2
  • 59
    • 0018830636 scopus 로고
    • Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
    • Wyllie, A.H. Glucorcorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature, 1980, 284, 555-556. (Pubitemid 10070336)
    • (1980) Nature , vol.284 , Issue.5756 , pp. 555-556
    • Wyllie, A.H.1
  • 62
    • 33846054483 scopus 로고    scopus 로고
    • Microbial community associated with the colonial ascidian Cystodytes dellechiajei
    • DOI 10.1111/j.1462-2920.2006.01170.x
    • Martinez-Garcia, M.; Diaz-Valdes, M.; Wanner, G.; Ramos-Espla, A.; Anton, J. Microbial community associated with the colonial ascidian Cystodytes dellechiajei. Environ. Microbiol., 2007b, 9, 521-534. (Pubitemid 46072138)
    • (2007) Environmental Microbiology , vol.9 , Issue.2 , pp. 521-534
    • Martinez-Garcia, M.1    Diaz-Valdes, M.2    Wanner, G.3    Ramos-Espla, A.4    Anton, J.5
  • 63
    • 4344718146 scopus 로고    scopus 로고
    • The microenvironment and photosynthetic performance of Prochloron sp. in symbiosis with Didemnid ascidians
    • Seckbach, J., Ed.; Kluwer Academic Publishers: Dordrecht, The Netherlands
    • Kühl, M.; Larkum, A.W. The microenvironment and photosynthetic performance of Prochloron sp. in symbiosis with Didemnid ascidians. In: Symbiosis: Mechanisms and Models; Seckbach, J., Ed.; Kluwer Academic Publishers: Dordrecht, The Netherlands, 2002; pp. 273-290.
    • (2002) Symbiosis: Mechanisms and Models , pp. 273-290
    • Kühl, M.1    Larkum, A.W.2
  • 64
    • 58149526328 scopus 로고    scopus 로고
    • Isolation and screening of marine associated bacteria from Tamil Nadu, Southeast coast of India for potential antibacterial activity
    • Vijayalakshmi, S.; Santhana Ramasamy, M.; Murugesh, S.; Murugan, A. Isolation and screening of marine associated bacteria from Tamil Nadu, Southeast coast of India for potential antibacterial activity. Ann. Microbiol., 2008, 58(4), 605-609.
    • (2008) Ann. Microbiol. , vol.58 , Issue.4 , pp. 605-609
    • Vijayalakshmi, S.1    Santhana Ramasamy, M.2    Murugesh, S.3    Murugan, A.4
  • 65
    • 0020836368 scopus 로고
    • Safranins new antitumor antibiotics. II. Physicochemical properties and chemical structure
    • Ikeda, Y.; Matsuki, H.; Ogawa, T.; Munakata, T. Safranins, new antitumor antibiotics. II. Physicochemical properties and chemical structure. J. Antibiot., 1983, 36, 1284-1289.
    • (1983) J. Antibiot. , vol.36 , pp. 1284-1289
    • Ikeda, Y.1    Matsuki, H.2    Ogawa, T.3    Munakata, T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.