Iodocionin, a cytotoxic iodinated metabolite from the Mediterranean ascidian Ciona edwardsii

Marine Drugs

Volumn 8, Issue 2, 2010, Pages 285-291

  Aiello, Anna ^a   Fattorusso, Ernesto ^a   Imperatore, Concetta ^a   Menna, Marialuisa ^a   Müller, Werner E G ^b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

Author keywords

Cytotoxic activity; Iodinated metabolites; Natural products; Structure elucidation

Indexed keywords

BROMINE DERIVATIVE; CYTOTOXIC AGENT; IODOCIONIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; ASCIDIACEA; CELL STRAIN; CIONA EDWARDSII; CONTROLLED STUDY; DRUG SELECTIVITY; DRUG STRUCTURE; IC 50; LEUKEMIA L 5178 Y; MOUSE; NONHUMAN; RAT;

ASCIDIA; CIONA; RATTUS;

EID: 77649194451     PISSN: None     EISSN: 16603397     Source Type: Journal    
DOI: 10.3390/md8020285     Document Type: Article

References (15)

1. Gribble, G.W. The diversity of naturally produced organohalogens. Chemosphere 2003, 52, 289-297.
2. Paul, V.J. Chemical defenses of benthic marine invertebrates. In Ecological Roles of Marine Natural Products; Cornell University Press: London, UK, 1992; pp. 164-181.
3. Albrizio, S.; Ciminiello, P.; Fattorusso, E.; Magno, S.; Pansini, M. Chemistry of Verongida sponges, I. Constituents of the Caribbean sponge Pseudoceratina crassa. Tetrahedron 1994, 50, 783-788.
4. Ciminiello, P.; Fattorusso, E.; Magno, S.; Pansini, M. Chemistry of Verongida sponges, III. Constituents of the Caribbean Verongula sp. J. Nat. Prod. 1994, 57, 1564-1569.
5. Ciminiello, P.; Costantino, V.; Fattorusso, E.; Magno, S.; Mangoni, A.; Pansini, M. Chemistry of Verongida Sponges, II. Constituents of the Caribbean Sponge Aplysina fistularis forma fulva. J. Nat. Prod. 1994, 57, 705-712.
6. Costantino, V.; Fattorusso, E.; Mangoni, A.; Pansini, M. Three new brominated and iodinated tyrosine derivatives from Iotrochota birotulata, a non-Verongida sponge. J. Nat. Prod. 1994, 57, 1552-1556.
7. Neidleman, S.L.; Geigert, J. Halometabolites and their sources. In Biohalogenation: Principles, Basic Roles, and Applications; Ellis Horwood Ltd.: Chichester, UK, 1986; pp. 13-45.
8. Ciminiello, P.; Dell'Aversano, C.; Fattorusso, E.; Magno, S.; Pansini, M. Chemistry of Verongida Sponges. 10. Secondary metabolite composition of the Caribbean Sponge Verongula gigantea. J. Nat. Prod. 2000, 63, 263-266.
9. Hansen, P.E. Carbon-13 NMR of polycyclic aromatic compounds. Org. Magn. Reson. 1979, 12, 109-142.
10. Sachs L. Angewandte Statistik. Anwendung statistischer Methoden; Springer-Verlag: Berlin, Germany, 1984; p. 242.
11. Müller W.E.G.; Zahn R.K. Metabolism of 1-?-D-arabinofuranosyluracil in mouse L5178Y cells. Cancer Res. 1979, 39, 1102-1107.
12. Carmichael, J.; DeGraff, W.G.; Gazdar, A.F.; Minna, J.D.; Mitchell, J.B. Evaluation of a tetrazolium-based semiautomated colorimetric assay: Assessment of radiosensitivity. Cancer Res. 1987, 47, 943-946.
13. Kreuter, M.H.; Leake, R.E.; Rinaldi, F.; Müller-Klieser, W.; Maidhof, A.; Müller, W.E.G.; Schröder, H.C. Inhibition of intrinsic protein tyrosine kinase activity of EGF-receptor kinase complex from human breast cancer cells by the marine sponge metabolite (+)-aeroplysinin-1. Comp. Biochem Physiol. 1990, 97B, 151-158.
14. Xu, J.; Kjer, J.;, Sendker, J.; Wray, V.; Guan, H.; Edrada, R.A.; Müller, W.E.G.; Bayer, M.; Lin, W.; Wu, J.; Proksch, P. Cytosporones, coumarins, and an alkaloid from the endophytic fungus Pestalotiopsis sp. isolated from the Chinese mangrove plant Rhizophora mucronata. Bioorg Med. Chem. 2009, 17, 7362-7367.
15. Neidleman, S.L.; Geigert, J. The role of halogenating enzymes and halometabolites in the marine environment. In Biohalogenation: Principles, Basic Roles, and Applications; Ellis Horwood Ltd.: Chichester, UK, 1986; pp. 113-130.