Relaxin is a candidate drug for lung preservation: Relaxin-induced protection of rat lungs from ischemia-reperfusion injury

Journal of Heart and Lung Transplantation

Volumn 29, Issue 4, 2010, Pages 454-460

  Alexiou, Konstantin ^a   Matschke, Klaus ^a   Westphal, Angelika ^b   Stangl, Karl ^b   Dschietzig, Thomas ^b  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

endothelin; ischemia; lung; rat; relaxin; reperfusion

Indexed keywords

ENDOTHELIN 1; FREE RADICAL; LEUKOCYTE ELASTASE; MALONALDEHYDE; MYELOPEROXIDASE; RELAXIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRY WEIGHT; ISCHEMIA; ISOLATED LUNG; LEUKOCYTE; LUNG CIRCULATION; LUNG INJURY; LUNG PERFUSION; LUNG WEIGHT; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; REPERFUSION INJURY; TISSUE INJURY;

ANIMALS; ENDOTHELIN-1; ENDOTHELIUM; LEUKOCYTE ELASTASE; LEUKOCYTES; LUNG; LUNG INJURY; LUNG TRANSPLANTATION; MALE; MALONDIALDEHYDE; MODELS, ANIMAL; ORGAN PRESERVATION; PEROXIDASE; RATS; RATS, WISTAR; RELAXIN; REPERFUSION INJURY;

EID: 77949567524     PISSN: 10532498     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.healun.2009.09.012     Document Type: Article

References (50)

1. Whitson B.A., Prekker M.E., Herrington C.S., et al. Primary graft dysfunction and long-term pulmonary function after lung transplantation. J Heart Lung Transplant 26 (2007) 1004-1011
2. Kirk A.J.B., Colquhoun I.W., and Dark J.H. Lung preservation: a review of current clinical practice and future directions. Ann Thorac Surg 56 (1993) 990-1000
3. Christie J.D., Sager J.S., Kimmel S.E., et al. Impact of primary graft failure on outcomes following lung transplantation. Chest 127 (2005) 161-165
4. Stammberger U., Carboni G.L., Hillinger S., Schneiter D., Weder W., and Schmid R.A. Combined treatment with endothelin- and PAF-antagonists reduces posttransplant lung ischemia/reperfusion injury. J Heart Lung Transplant 18 (1999) 862-868
5. Samuel C.S., Du X.J., Bathgate R.A., and Summers R.J. Relaxin the stiffened heart and arteries: the therapeutic potential for relaxin in the treatment of cardiovascular disease. Pharmacol Ther 112 (2006) 529-552
6. Masini E., Bani D., Bello M.G., Bigazzi M., Mannaioni P.F., and Sacchi T.B. Relaxin counteracts myocardial damage induced by ischemia-reperfusion in isolated guinea pig hearts: evidence for an involvement of nitric oxide. Endocrinology 138 (1997) 4713-4720
7. Perna A.M., Masini E., Nistri S., et al. Novel drug development opportunity for relaxin in acute myocardial infarction: evidences from a swine model. FASEB J 19 (2005) 1525-1527
8. Dschietzig T., Richter C., Bartsch C., et al. The pregnancy hormone relaxin is a player in human heart failure. FASEB J 15 (2001) 2187-2195
9. Dschietzig T., Bartsch C., Richter C., Laule M., Baumann G., and Stangl K. Relaxin, a pregnancy hormone, is a functional endothelin-1 antagonist: attenuation of endothelin-1-mediated vasoconstriction by stimulation of endothelin type-B receptor expression via ERK-1/2 and nuclear factor-kappaB. Circ Res 92 (2003) 32-40
10. Tozzia C.A., Poiania G., McHugha N.A., et al. Recombinant human relaxin reduces hypoxic pulmonary hypertension in the rat. Pulm Pharmacol Therapeut 18 (2005) 346-353
11. Yang Y.L., Huang K.L., Liou H.L., and Chen H.I. The involvement of nitric oxide, nitric oxide synthase, neutrophil elastase, myeloperoxidase and proinflammatory cytokines in the acute lung injury caused by phorbol myristate acetate. J Biomed Sci 15 (2008) 499-507
12. Mullane K.M., Kraemer R., and Smith B. Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium. J Pharmacol Methods 14 (1985) 157-167
13. Kinoshita M., Ono S., and Mochizuki H. Neutrophils mediate acute lung injury in rabbits: role of neutrophil elastase. Eur Surg Res 32 (2000) 337-346
14. Rao D.S., Cohen M.V., and Mueller H.S. Production of free radicals and lipid peroxidation in early experimental myocardial ischemia. J Mol Cell Cardiol 15 (1983) 713-714
15. Aruoma O.I., Halliwell B., Laughton M.J., Quinlan G.J., and Gutteridge J.M.C. The mechanism of initiation of lipid peroxidation: evidence against a requirement for an iron (II)-iron (III) complex. Biochem J 258 (1989) 617-620
16. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72 (1976) 248-254
17. Brunner F. Dependence of endothelin-1 secretion on Ca2+. Biochem Pharmacol 49 (1995) 1785-1791
18. Okada M., Yamashita C., Okada M., and Okada K. Contribution of endothelin-1 to warm ischemia/reperfusion injury of the rat lung. Am J Respir Crit Care Med 152 (1995) 2105-2110
19. Ishida K., Takeshige K., and Minakami S. Endothelin-1 enhances superoxide generation of human neutrophils stimulated by the chemotactic peptide N-formyl-methionyl-leucyl-phenylalanine. Biochem Biophys Res Commun 173 (1990) 496-500
20. Gommez G.D., Guerra M., Gonzalez E., et al. Aggregation of human polymorphonuclear leukocytes by endothelin: role of platelet activating factor. A. Eur J Pharmacol 224 (1992) 167-172
21. Bigazzi M., Bani D., Bani G., and Bani Sacchi T. Relaxin and the cardiocirculatory system. In: MacLennan A.H., Tregear G., and Bryant-Greenwood G.D. (Eds). Progress in relaxin research (1995), World Scientific Publishing, Singapore 499-507
22. Masini E., Bani D., Bigazzi M., Mannaioni P.F., and Bani Sacchi T. Effects of relaxin on mast cells. In vitro and in vivo studies in rats and guinea pigs. J Clin Invest 94 (1994) 1974-1980
23. Bani D., Bigazzi M., Masini E., Bani G., and Bani Sacchi T. Relaxin depresses platelet aggregation. In vitro studies on isolated human and rabbit platelets. Lab Invest 73 (1995) 709-713
24. Samuel C.S., Royce S.G., Burton M.D., Zhao C., Tregear G.W., and Tang M.L. Relaxin plays an important role in the regulation of airway structure and function. Endocrinology 148 (2007) 4259-4266
25. Kaku Y., Nanri H., Sakimura T., Ejima K., Kuroiwa A., and Ikeda M. Differential induction of constitutive and inducible nitric oxide synthases by distinct inflammatory stimuli in bovine aortic endothelial cells. Biochim Biophys Acta 1356 (1997) 43-52
26. Johnson III G., Tsao P.S., and Lefer A.M. Cardioprotective effects of authentic nitric oxide in myocardial ischemia with reperfusion. Crit Care Med 19 (1991) 244-252
27. Rubanyi G.M., Ho E.H., Cantor E.H., Lumma W.C., and Botelho L.H.P. Cytoprotective function of nitric oxide: inactivation of superoxide radicals produced by human leukocytes. Biochem Biophys Res Commun 181 (1991) 1392-1397
28. Siegfried M.R., Erhardt J., Rider T., Ma X.-L., and Lefer A.M. Cardioprotection and attenuation of endothelial dysfunction by organic nitric oxide donors in myocardial ischemia-reperfusion. J Pharmacol Exp Ther 260 (1992) 668-675
29. McCord J.M. Oxygen-derived free radicals in post-ischemic tissue injury. N Engl J Med 312 (1985) 159-163
30. Koster J.F., Biemond P., and Stam H. Lipid peroxidation and myocardial damage: cause or consequence?. In: Stam H., and van der Vusse G.J. (Eds). Lipid metabolism in the normoxic and ischemic heart (1986), Steinkhoff Verlag, Darmstadt 253-260
31. Masini E., Nistri S., Vannacci A., Bani Sacchi T., Novelli A., and Bani D. Relaxin inhibits the activation of human neutrophils: involvement of the nitric oxide pathway. Endocrinology 145 (2004) 1106-1112
32. Armstrong R. The physiological role and pharmacological potential of nitric oxide in neutrophil activation. Int Immunopharmacol 1 (2001) 1501-1512
33. Failli P., Nistri S., Quattrone S., et al. Relaxin up-regulates inducible nitric oxide synthase expression and nitric oxide generation in rat coronary endothelial cells. FASEB J 16 (2002) 252-254
34. Parsell D.A., Mak J.Y., Amento E.P., and Unemori E.N. Relaxin binds to and elicits a response from cells of the human monocytic cell line, THP-1. J Biol Chem 271 (1996) 27936-27941
35. Bani D., Masini E., Bello M.G., Bigazzi M., and Bani Sacchi T. Relaxin protects against myocardial injury caused by ischemia and reperfusion in rat heart. Am J Pathol 152 (1998) 1367-1376
36. Bani D., Ballati L., Masini E., Bigazzi M., and Bani Sacchi T. Relaxin counteracts asthma-like reaction induced by inhaled antigen in sensitized guinea pigs. Endocrinology 138 (1997) 1909-1915
37. Rao D.S., Cohen M.V., and Mueller H.S. Production of free radicals and lipid peroxidation in early experimental myocardial ischemia. J Mol Cell Cardiol 15 (1983) 713-714
38. Boulanger C., and Lüscher T.F. Endothelin is released from the porcine aorta: inhibition by endothelium-derived nitric oxide. J Clin Invest 85 (1990) 587-590
39. Tønnessen T., Giaid A., Saleh D., Naess P.A., Yanagisawa M., and Christensen G. Increased in vivo expression and production of endothelin-1 by porcine cardiomyocytes subjected to ischemia. Circ Res 76 (1995) 767-772
40. Tønnessen T., Ilebekk A., Naess P.A., and Christensen G. Inhibition of granulocyte-derived proteases reduces the increase in plasma endothelin associated with myocardial ischaemia in the pig. Basic Res Cardiol 91 (1996) 289-295
41. Gonon A.T., Gourine A.V., and Pernow J. Cardioprotection from ischemia and reperfusion injury by an endothelin A receptor antagonist in relation to nitric oxide production. J Cardiovasc Pharmacol 36 (2000) 405-412
42. Gourine A.V., Gonon A.T., and Pernow J. Involvement of nitric oxide in cardioprotective effect of endothelin receptor antagonist during ischemia-reperfusion. Am J Physiol Heart Circ Physiol 280 (2001) H1105-H1112
43. Wang Q.D., Hemsen A., Li X.S., Lundberg J.M., Uriuda Y., and Pernow J. Local overflow and enhanced tissue content of endothelin following myocardial ischemia and reperfusion in the pig: modulation by L-arginine. Cardiovasc Res 29 (1995) 44-49
44. Helset E., Lindal S., Olsen R., et al. Endothelin-1 causes sequential trapping of platelets and neutrophils in pulmonary microcirculation in rats. Am J Physiol 271 (1996) 538-546
45. Ishizaki T., Shigemori K., Nakai T., et al. Endothelin-1 potentiates leukotoxin-induced edematous lung injury. J Appl Physiol 79 (1995) 1106-1111
46. Cunningham M.E., Huribal M., Bala R.J., et al. Endothelin-1 and endothelin-4 stimulate monocyte production of cytokines. Crit Care Med 25 (1997) 958-964
47. Miyauchi T., and Masaki T. Pathophysiology of endothelin in the cardiovascular system. Annu Rev Physiol 61 (1999) 391-15.
48. Bryant-Greenwood G.D., and Schwabe C. Human relaxins: chemistry and biology. Endocr Rev 15 (1994) 5-26
49. Dschietzig T., Bartsch C., Baumann G., and Stangl K. RXFP1-inactive relaxin activates human glucocorticoid receptor: further investigations into the relaxin-GR pathway. Regul Pept 154 (2009) 77-84
50. Bahrami S., Yu Y.H., Redl H., and Schlag G. Acute lung injury by endotoxin-induced mediators: prevention by HWA 138, a new xanthine derivative. J Lab Clin Med 125 (1995) 487-492