메뉴 건너뛰기




Volumn 56, Issue 5, 2010, Pages 560-569

Chronic treatment with the cannabinoid 1 antagonist rimonabant altered vasoactive cyclo-oxygenase-derived products on arteries from obese zucker rats

Author keywords

cannabinoids; COX; endothelium; iNOS; obese Zucker rats; obesity

Indexed keywords

5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; ACETYLCHOLINE; CYCLOOXYGENASE 2; MITOGEN ACTIVATED PROTEIN KINASE P38; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; NITRIC OXIDE SYNTHASE; PHENYLEPHRINE; PROSTANOID; RIMONABANT; TUMOR NECROSIS FACTOR ALPHA;

EID: 78650171814     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/FJC.0b013e3181f7141a     Document Type: Article
Times cited : (3)

References (50)
  • 1
    • 32644441249 scopus 로고    scopus 로고
    • Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: A randomized controlled trial
    • RIO North America Study Group
    • Pi-Sunyer FX, Aronne LJ, Heshmati HM, et al; RIO North America Study Group. Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial. JAMA. 2006;295:761-775.
    • (2006) JAMA , vol.295 , pp. 761-775
    • Pi-Sunyer, F.X.1    Aronne, L.J.2    Heshmati, H.M.3
  • 2
    • 33751001942 scopus 로고    scopus 로고
    • Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: A randomised controlled study
    • RIO-Diabetes Study Group
    • Scheen AJ, Finer N, Hollander P, et al; RIO-Diabetes Study Group. Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study. Lancet. 2006;368: 1660-1672.
    • (2006) Lancet , vol.368 , pp. 1660-1672
    • Scheen, A.J.1    Finer, N.2    Hollander, P.3
  • 3
    • 17144382751 scopus 로고    scopus 로고
    • Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study
    • RIO Europe Study Group
    • Van Gaal LF, Rissanen AM, Scheen AJ, et al; RIO Europe Study Group. Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study. Lancet. 2005;365:1389-1397.
    • (2005) Lancet , vol.365 , pp. 1389-1397
    • Van Gaal, L.F.1    Rissanen, A.M.2    Scheen, A.J.3
  • 4
    • 58149138840 scopus 로고    scopus 로고
    • Should peripheral CB(1) cannabinoid receptors be selectively targeted for therapeutic gain?
    • Kunos G, Osei-Hyiaman D, Bátkai S, et al. Should peripheral CB(1) cannabinoid receptors be selectively targeted for therapeutic gain? Trends Pharmacol Sci. 2009;30:1-7.
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 1-7
    • Kunos, G.1    Osei-Hyiaman, D.2    Bátkai, S.3
  • 5
    • 0029558259 scopus 로고
    • Anandamide and delta 9-THC dilation of cerebral arterioles is blocked by indomethacin
    • Ellis EF, Moore SF, Willoughby KA. Anandamide and delta 9-THC dilation of cerebral arterioles is blocked by indomethacin. Am J Physiol. 1995;269:H1859-H1864.
    • (1995) Am J Physiol , vol.269
    • Ellis, E.F.1    Moore, S.F.2    Willoughby, K.A.3
  • 6
    • 0030798335 scopus 로고    scopus 로고
    • Production and physiological actions of anandamide in the vasculature of the rat kidney
    • Deutsch DG, Goligorsky MS, Schmid PC, et al. Production and physiological actions of anandamide in the vasculature of the rat kidney. J Clin Invest. 1997;100:1538-1546.
    • (1997) J Clin Invest , vol.100 , pp. 1538-1546
    • Deutsch, D.G.1    Goligorsky, M.S.2    Schmid, P.C.3
  • 7
    • 0033569702 scopus 로고    scopus 로고
    • The endothelial component of cannabinoid-induced relaxation in rabbit mesenteric artery depends on gap junctional communication
    • Chaytor AT, Martin PE, Evans WH, et al. The endothelial component of cannabinoid-induced relaxation in rabbit mesenteric artery depends on gap junctional communication. J Physiol. 1999;520:539-550.
    • (1999) J Physiol , vol.520 , pp. 539-550
    • Chaytor, A.T.1    Martin, P.E.2    Evans, W.H.3
  • 8
    • 0033853422 scopus 로고    scopus 로고
    • Vanilloid receptors on capsaicin-sensitive nerves mediate relaxation to methanandamide in the rat isolated mesenteric bed
    • Ralevic V, Kendall DA, Randall MD, et al. Vanilloid receptors on capsaicin-sensitive nerves mediate relaxation to methanandamide in the rat isolated mesenteric bed. Br J Pharmacol. 2000;130:1483-1488.
    • (2000) Br J Pharmacol , vol.130 , pp. 1483-1488
    • Ralevic, V.1    Kendall, D.A.2    Randall, M.D.3
  • 9
    • 35648979547 scopus 로고    scopus 로고
    • Characterization of the vasorelaxant mechanisms of the endocannabinoid anandamide in rat aorta
    • DOI 10.1038/sj.bjp.0707404, PII 0707404
    • Herradón E, Mart́in MI, López-Miranda V. Characterization of the vasorelaxant mechanisms of the endocannabinoid anandamide in rat aorta. Br J Pharmacol. 2007;152:699-708. (Pubitemid 350034972)
    • (2007) British Journal of Pharmacology , vol.152 , Issue.5 , pp. 699-708
    • Herradon, E.1    Martin, M.I.2    Lopez-Miranda, V.3
  • 10
    • 20844454912 scopus 로고    scopus 로고
    • Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension
    • Bátkai S, Pacher P, Osei-Hyiaman D, et al. Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension. Circulation. 2004;110:1996-2002.
    • (2004) Circulation , vol.110 , pp. 1996-2002
    • Bátkai, S.1    Pacher, P.2    Osei-Hyiaman, D.3
  • 11
    • 77953099666 scopus 로고    scopus 로고
    • CB1 receptor inhibition leads to decreased vascular AT1 receptor expression, inhibition of oxidative stress and improved endothelial function
    • Tiyerili V, Zimmer S, Jung S, et al. CB1 receptor inhibition leads to decreased vascular AT1 receptor expression, inhibition of oxidative stress and improved endothelial function. Basic Res Cardiol. 2010;105: 465-477.
    • (2010) Basic Res Cardiol , vol.105 , pp. 465-477
    • Tiyerili, V.1    Zimmer, S.2    Jung, S.3
  • 12
    • 77955625847 scopus 로고    scopus 로고
    • Rimonabant-mediated changes in intestinal lipid metabolism and improved renal vascular dysfunction in the JCR:LA-cp rat model of prediabetic metabolic syndrome
    • May 27 [Epub ahead of print]
    • Russell JC, Kelly SE, Diane A, et al. Rimonabant-mediated changes in intestinal lipid metabolism and improved renal vascular dysfunction in the JCR:LA-cp rat model of prediabetic metabolic syndrome. Am J Physiol Gastrointest Liver Physiol. May 27, 2010 [Epub ahead of print].
    • Am J Physiol Gastrointest Liver Physiol , pp. 2010
    • Russell, J.C.1    Kelly, S.E.2    Diane, A.3
  • 13
    • 67649790255 scopus 로고    scopus 로고
    • Effects of the CB1 antagonist rimonabant on blood pressure and vascular reactivity of obese rats
    • Mingorance C, Alvarez de Sotomayor M, Jiménez-Palacios FJ, et al. Effects of the CB1 antagonist rimonabant on blood pressure and vascular reactivity of obese rats. Obesity (Silver Spring). 2009;17:1340-1347.
    • (2009) Obesity (Silver Spring) , vol.17 , pp. 1340-1347
    • Mingorance, C.1    Alvarez De Sotomayor, M.2    Jiménez-Palacios, F.J.3
  • 14
    • 15744382273 scopus 로고    scopus 로고
    • Induction of cyclooxygenase-2 by anandamide in cerebral microvascular endothelium
    • Chen P, Hu S, Yao J, et al. Induction of cyclooxygenase-2 by anandamide in cerebral microvascular endothelium. Microvasc Res. 2005;69:28-35.
    • (2005) Microvasc Res , vol.69 , pp. 28-35
    • Chen, P.1    Hu, S.2    Yao, J.3
  • 15
    • 28144462199 scopus 로고    scopus 로고
    • The endocannabinoid arachidonyl ethanolamide (anandamide) increases pulmonary arterial pressure via cyclooxygenase-2 products in isolated rabbit lungs
    • Wahn H, Wolf J, Kram F, et al. The endocannabinoid arachidonyl ethanolamide (anandamide) increases pulmonary arterial pressure via cyclooxygenase-2 products in isolated rabbit lungs. Am J Physiol Heart Circ Physiol. 2005;289:H2491-H2496.
    • (2005) Am J Physiol Heart Circ Physiol , vol.289
    • Wahn, H.1    Wolf, J.2    Kram, F.3
  • 16
    • 61949439551 scopus 로고    scopus 로고
    • Endothelial dysfunction in diabetes: From mechanisms to therapeutic targets
    • Potenza MA, Gagliardi S, Nacci C, et al. Endothelial dysfunction in diabetes: from mechanisms to therapeutic targets. Curr Med Chem. 2009; 16:94-112.
    • (2009) Curr Med Chem , vol.16 , pp. 94-112
    • Potenza, M.A.1    Gagliardi, S.2    Nacci, C.3
  • 17
    • 50649107938 scopus 로고    scopus 로고
    • Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats
    • Rivera L, Morón R, Sánchez M, et al. Quercetin ameliorates metabolic syndrome and improves the inflammatory status in obese Zucker rats. Obesity (Silver Spring). 2008;16:2081-2087.
    • (2008) Obesity (Silver Spring) , vol.16 , pp. 2081-2087
    • Rivera, L.1    Morón, R.2    Sánchez, M.3
  • 18
    • 0038070321 scopus 로고    scopus 로고
    • Preferential effects of the cannabinoid CB1 receptor antagonist, SR 141716, on food intake and body weight gain of obese (fa/fa) compared to lean Zucker rats
    • Vickers SP, Webster LJ, Wyatt A, et al. Preferential effects of the cannabinoid CB1 receptor antagonist, SR 141716, on food intake and body weight gain of obese (fa/fa) compared to lean Zucker rats. Psychopharmacology (Berl). 2003;167:103-111.
    • (2003) Psychopharmacology (Berl) , vol.167 , pp. 103-111
    • Vickers, S.P.1    Webster, L.J.2    Wyatt, A.3
  • 19
    • 0021813187 scopus 로고
    • Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man
    • Matthews DR, Hosker JP, Rudenski AS, et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28: 412-419.
    • (1985) Diabetologia , vol.28 , pp. 412-419
    • Matthews, D.R.1    Hosker, J.P.2    Rudenski, A.S.3
  • 20
    • 11144330214 scopus 로고    scopus 로고
    • Argan (Argania spinosa) oil lowers blood pressure and improves endothelial dysfunction in spontaneously hypertensive rats
    • Berrougui H, Alvarez de Sotomayor M, Pérez-Guerrero C, et al. Argan (Argania spinosa) oil lowers blood pressure and improves endothelial dysfunction in spontaneously hypertensive rats. Br J Nutr. 2004;92:921-929.
    • (2004) Br J Nutr , vol.92 , pp. 921-929
    • Berrougui, H.1    Alvarez De Sotomayor, M.2    Pérez-Guerrero, C.3
  • 21
    • 0029840830 scopus 로고    scopus 로고
    • Measurement of nitrate and nitrite in biological samples using nitrate reductase and Griess reaction
    • Granger DL, Taintor RR, Boockvar KS, et al. Measurement of nitrate and nitrite in biological samples using nitrate reductase and Griess reaction. Methods Enzymol. 1996;268:142-151.
    • (1996) Methods Enzymol , vol.268 , pp. 142-151
    • Granger, D.L.1    Taintor, R.R.2    Boockvar, K.S.3
  • 22
    • 42249099620 scopus 로고    scopus 로고
    • Dysregulation of peripheral endocannabinoid levels in hyperglycemia and obesity: Effect of high fat diets
    • Matias I, Petrosino S, Racioppi A, et al. Dysregulation of peripheral endocannabinoid levels in hyperglycemia and obesity: effect of high fat diets. Mol Cell Endocrinol. 2008;286(Suppl 1):S66-S78.
    • (2008) Mol Cell Endocrinol , vol.286 , Issue.SUPPL. 1
    • Matias, I.1    Petrosino, S.2    Racioppi, A.3
  • 23
    • 77957280284 scopus 로고    scopus 로고
    • The endocannabinoid system: Its roles in energy balance and potential as a target for obesity treatment
    • June 9 [Epub ahead of print]
    • André A, Gonthier MP. The endocannabinoid system: its roles in energy balance and potential as a target for obesity treatment. Int J Biochem Cell Biol. June 9, 2010 [Epub ahead of print].
    • (2010) Int J Biochem Cell Biol
    • André, A.1    Gonthier, M.P.2
  • 24
    • 33645509709 scopus 로고    scopus 로고
    • Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation
    • Du X, Edelstein D, Obici S, et al. Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation. J Clin Invest. 2006;116:1071-1080.
    • (2006) J Clin Invest , vol.116 , pp. 1071-1080
    • Du, X.1    Edelstein, D.2    Obici, S.3
  • 25
    • 33845875499 scopus 로고    scopus 로고
    • Vascular lipotoxicity: Endothelial dysfunction via fatty-acid-induced reactive oxygen species overproduction in obese Zucker diabetic fatty rats
    • Chinen I, Shimabukuro M, Yamakawa K, et al. Vascular lipotoxicity: endothelial dysfunction via fatty-acid-induced reactive oxygen species overproduction in obese Zucker diabetic fatty rats. Endocrinology. 2007; 148:160-165.
    • (2007) Endocrinology , vol.148 , pp. 160-165
    • Chinen, I.1    Shimabukuro, M.2    Yamakawa, K.3
  • 26
    • 76449113058 scopus 로고    scopus 로고
    • Altered arachidonic acid metabolism via COX-1 and COX-2 contributes to the endothelial dysfunction of penile arteries from obese Zucker rats
    • January 15 [Epub ahead of print]
    • Sánchez A, Contreras C, Villaba N, et al. Altered arachidonic acid metabolism via COX-1 and COX-2 contributes to the endothelial dysfunction of penile arteries from obese Zucker rats. Br J Pharmacol. January 15, 2010 [Epub ahead of print].
    • (2010) Br J Pharmacol
    • Sánchez, A.1    Contreras, C.2    Villaba, N.3
  • 29
    • 41749118516 scopus 로고    scopus 로고
    • Insulin resistance and impaired functional vasodilation in obese Zucker rats
    • Xiang L, Dearman J, Abram SR, et al. Insulin resistance and impaired functional vasodilation in obese Zucker rats. Am J Physiol Heart Circ Physiol. 2008;294:H1658-H1666.
    • (2008) Am J Physiol Heart Circ Physiol , vol.294
    • Xiang, L.1    Dearman, J.2    Abram, S.R.3
  • 30
    • 59849126844 scopus 로고    scopus 로고
    • Cyclooxygenase-2-derived prostaglandin F2alpha: An endo-thelium-derived contractile factor acting independently of other endothe-lium-derived contractile factors via vascular thromboxane receptors
    • Schrör K. Cyclooxygenase-2-derived prostaglandin F2alpha: an endo-thelium-derived contractile factor acting independently of other endothe-lium-derived contractile factors via vascular thromboxane receptors. Circ Res. 2009;104:141-143.
    • (2009) Circ Res , vol.104 , pp. 141-143
    • Schrör, K.1
  • 31
    • 0025572704 scopus 로고
    • A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism
    • Morrow JD, Hill KE, Burk RF, et al. A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. Proc Natl Acad Sci USA. 1990;87:9383-9387.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 9383-9387
    • Morrow, J.D.1    Hill, K.E.2    Burk, R.F.3
  • 32
    • 0036853663 scopus 로고    scopus 로고
    • Obesity increases prostanoid-mediated vasoconstriction and vascular thromboxane receptor gene expression
    • Traupe T, Lang M, Goettsch W, et al. Obesity increases prostanoid-mediated vasoconstriction and vascular thromboxane receptor gene expression. J Hypertens. 2002;20:2239-2245.
    • (2002) J Hypertens , vol.20 , pp. 2239-2245
    • Traupe, T.1    Lang, M.2    Goettsch, W.3
  • 34
    • 43549093962 scopus 로고    scopus 로고
    • High molecular weight adiponectin activates AMPK and suppresses cytokine-induced NF-kappaB activation in vascular endothelial cells
    • Hattori Y, Nakano Y, Hattori S, et al. High molecular weight adiponectin activates AMPK and suppresses cytokine-induced NF-kappaB activation in vascular endothelial cells. FEBS Lett. 2008;582:1719-1724.
    • (2008) FEBS Lett , vol.582 , pp. 1719-1724
    • Hattori, Y.1    Nakano, Y.2    Hattori, S.3
  • 35
    • 40149102381 scopus 로고    scopus 로고
    • Rimonabant (SR141716) exerts anti-proliferative and immunomodulatory effects in human peripheral blood mononuclear cells
    • Malfitano AM, Laezza C, Pisanti S, et al. Rimonabant (SR141716) exerts anti-proliferative and immunomodulatory effects in human peripheral blood mononuclear cells. Br J Pharmacol. 2008;153:1003-1010.
    • (2008) Br J Pharmacol , vol.153 , pp. 1003-1010
    • Malfitano, A.M.1    Laezza, C.2    Pisanti, S.3
  • 36
    • 38949151113 scopus 로고    scopus 로고
    • Cannabinoids stimulate prostaglandin production by human gestational tissues through a tissue-and CB1-receptor-specific mechanism
    • Mitchell MD, Sato TA, Wang A, et al. Cannabinoids stimulate prostaglandin production by human gestational tissues through a tissue-and CB1-receptor-specific mechanism. Am J Physiol Endocrinol Metab. 2008;294:E352-E356.
    • (2008) Am J Physiol Endocrinol Metab , vol.294
    • Mitchell, M.D.1    Sato, T.A.2    Wang, A.3
  • 37
    • 0035848818 scopus 로고    scopus 로고
    • Leptin-regulated endocanna-binoids are involved in maintaining food intake
    • Di Marzo V, Goparaju SK, Wang L, et al. Leptin-regulated endocanna-binoids are involved in maintaining food intake. Nature. 2001;410: 822-825.
    • (2001) Nature , vol.410 , pp. 822-825
    • Di Marzo, V.1    Goparaju, S.K.2    Wang, L.3
  • 38
    • 47749153343 scopus 로고    scopus 로고
    • Leptin receptor deficiency is associated with upregulation of cannabinoid 1 receptors in limbic brain regions
    • Thanos PK, Ramalhete RC, Michaelides M, et al. Leptin receptor deficiency is associated with upregulation of cannabinoid 1 receptors in limbic brain regions. Synapse. 2008;62:637-642.
    • (2008) Synapse , vol.62 , pp. 637-642
    • Thanos, P.K.1    Ramalhete, R.C.2    Michaelides, M.3
  • 39
    • 42549091102 scopus 로고    scopus 로고
    • Regulation of endothelial prostacyclin synthesis by protease-activated receptors: Mechanisms and significance
    • Wheeler-Jones CP. Regulation of endothelial prostacyclin synthesis by protease-activated receptors: mechanisms and significance. Pharmacol Rep. 2008;60:109-118.
    • (2008) Pharmacol Rep , vol.60 , pp. 109-118
    • Wheeler-Jones, C.P.1
  • 40
    • 33750616520 scopus 로고    scopus 로고
    • Signaling pathways involved in the cardioprotective effects of cannabinoids
    • Lépicier P, Bibeau-Poirier A, Lagneux C, et al. Signaling pathways involved in the cardioprotective effects of cannabinoids. J Pharmacol Sci. 2006;102:155-166.
    • (2006) J Pharmacol Sci , vol.102 , pp. 155-166
    • Lépicier, P.1    Bibeau-Poirier, A.2    Lagneux, C.3
  • 41
    • 41749085064 scopus 로고    scopus 로고
    • Alpha-adrenoceptor-mediated vasoconstriction is not involved in impaired functional vasodilation in the obese Zucker rat
    • Naik JS, Xiang L, Hodnett BL, et al. Alpha-adrenoceptor-mediated vasoconstriction is not involved in impaired functional vasodilation in the obese Zucker rat. Clin Exp Pharmacol Physiol. 2008;35:611-616.
    • (2008) Clin Exp Pharmacol Physiol , vol.35 , pp. 611-616
    • Naik, J.S.1    Xiang, L.2    Hodnett, B.L.3
  • 42
    • 0141628766 scopus 로고    scopus 로고
    • Investigation of basal endothelial function in the obese Zucker rat in vitro
    • Laight DW, Anggard EE, Carrier MJ. Investigation of basal endothelial function in the obese Zucker rat in vitro. Gen Pharmacol. 2000;35: 303-309.
    • (2000) Gen Pharmacol , vol.35 , pp. 303-309
    • Laight, D.W.1    Anggard, E.E.2    Carrier, M.J.3
  • 43
    • 33749321286 scopus 로고    scopus 로고
    • Progression of coronary and mesenteric vascular dysfunction in Zucker obese and Zucker diabetic fatty rats
    • Oltman CL, Richou LL, Davidson EP, et al. Progression of coronary and mesenteric vascular dysfunction in Zucker obese and Zucker diabetic fatty rats. Am J Physiol Heart Circ Physiol. 2006;291:H1780-H1787.
    • (2006) Am J Physiol Heart Circ Physiol , vol.291
    • Oltman, C.L.1    Richou, L.L.2    Davidson, E.P.3
  • 44
    • 0036202415 scopus 로고    scopus 로고
    • Modulation of noradrenaline-induced vasocon-striction in isolated perfused mesenteric arterial beds from obese Zucker rats in the presence and absence of insulin
    • He Y, MacLeod KM. Modulation of noradrenaline-induced vasocon-striction in isolated perfused mesenteric arterial beds from obese Zucker rats in the presence and absence of insulin. Can J Physiol Pharmacol. 2002;80:171-179.
    • (2002) Can J Physiol Pharmacol , vol.80 , pp. 171-179
    • He, Y.1    MacLeod, K.M.2
  • 45
    • 1642390940 scopus 로고    scopus 로고
    • Age-dependent changes in blood pressure and arterial reactivity in obese Zucker rats
    • Subramanian R, MacLeod KM. Age-dependent changes in blood pressure and arterial reactivity in obese Zucker rats. Eur J Pharmacol. 2003;477: 143-152.
    • (2003) Eur J Pharmacol , vol.477 , pp. 143-152
    • Subramanian, R.1    MacLeod, K.M.2
  • 46
    • 37149015513 scopus 로고    scopus 로고
    • Adiponectin improves endothelial function in hyperlipidemic rats by reducing oxidative/nitrative stress and differential regulation of eNOS/iNOS activity
    • Li R, Wang WQ, Zhang H, et al. Adiponectin improves endothelial function in hyperlipidemic rats by reducing oxidative/nitrative stress and differential regulation of eNOS/iNOS activity. Am J Physiol Endocrinol Metab. 2007;293:E1703-E1708.
    • (2007) Am J Physiol Endocrinol Metab , vol.293
    • Li, R.1    Wang, W.Q.2    Zhang, H.3
  • 47
    • 40849121130 scopus 로고    scopus 로고
    • A hypothesis: Adiponectin mediates anti-atherosclerosis via adventitia-AMPK-iNOS pathway
    • Cai XJ, Li CJ, Chen L, et al. A hypothesis: adiponectin mediates anti-atherosclerosis via adventitia-AMPK-iNOS pathway. Med Hypotheses. 2008;70:1044-1047.
    • (2008) Med Hypotheses , vol.70 , pp. 1044-1047
    • Cai, X.J.1    Li, C.J.2    Chen, L.3
  • 48
    • 58849159550 scopus 로고    scopus 로고
    • Overexpression of adiponectin receptors potentiates the antiinflammatory action of subeffective dose of globular adiponectin in vascular endothelial cells
    • Zhang P, Wang Y, Fan Y, et al. Overexpression of adiponectin receptors potentiates the antiinflammatory action of subeffective dose of globular adiponectin in vascular endothelial cells. Arterioscler Thromb Vasc Biol. 2009;29:67-74.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 67-74
    • Zhang, P.1    Wang, Y.2    Fan, Y.3
  • 49
    • 59049102067 scopus 로고    scopus 로고
    • Activated endocannabinoid system in coronary artery disease and antiinflammatory effects of cannabinoid 1 receptor blockade on macrophages
    • Sugamura K, Sugiyama S, Nozaki T, et al. Activated endocannabinoid system in coronary artery disease and antiinflammatory effects of cannabinoid 1 receptor blockade on macrophages. Circulation. 2009;119: 28-36.
    • (2009) Circulation , vol.119 , pp. 28-36
    • Sugamura, K.1    Sugiyama, S.2    Nozaki, T.3
  • 50
    • 77952604846 scopus 로고    scopus 로고
    • Cannabinoid-1 receptor activation induces reactive oxygen species-dependent and-independent mitogen-activated protein kinase activation and cell death in human coronary artery endothelial cells
    • Rajesh M, Mukhopadhyay P, Haskó G, et al. Cannabinoid-1 receptor activation induces reactive oxygen species-dependent and-independent mitogen-activated protein kinase activation and cell death in human coronary artery endothelial cells. Br J Pharmacol. 2010;160: 688-700.
    • (2010) Br J Pharmacol , vol.160 , pp. 688-700
    • Rajesh, M.1    Mukhopadhyay, P.2    Haskó, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.