Altered arachidonic acid metabolism via COX-1 and COX-2 contributes to the endothelial dysfunction of penile arteries from obese Zucker rats

British Journal of Pharmacology

Volumn 159, Issue 3, 2010, Pages 604-616

  Sanchez A ^a   Contreras, C ^a   Villalba, N ^a   Martinez P ^b   Martinez A C ^a   Briones A ^c   Salaices M ^c   Garcia Sacristan A ^a   Hernandez M ^a   Prieto, D ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^c UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Arachidonic acid; Constitutive COX 2; COX 1; Endothelial dysfunction; Insulin resistance; Obese Zucker rat; Penile arteries

Indexed keywords

ACETYLCHOLINE; ARACHIDONIC ACID; CYCLOOXYGENASE 1; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; INDOMETACIN; INSULIN; NORADRENALIN; PROSTAGLANDIN H2; PROSTAGLANDIN RECEPTOR; PROSTANOID; THROMBOXANE A2 RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARACHIDONIC ACID METABOLISM; ARTERY; ARTERY ENDOTHELIUM; ARTERY TONE; ARTICLE; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENZYME INHIBITION; IMMUNOHISTOCHEMISTRY; INSULIN RESISTANCE; MALE; MICROVASCULATURE; MYOGRAPHY; NONHUMAN; OBESITY; PENILE ARTERY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; VASOCONSTRICTION; VASODILATATION;

ACETYLCHOLINE; ANIMALS; ARACHIDONIC ACID; ARTERIES; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; HYPEREMIA; INSULIN RESISTANCE; MALE; NITRIC OXIDE SYNTHASE TYPE III; NOREPINEPHRINE; OBESITY; PENIS; PREDIABETIC STATE; RATS; RATS, ZUCKER; VASOCONSTRICTION; VASOCONSTRICTOR AGENTS; VASODILATION; VASODILATOR AGENTS;

EID: 76449113058     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00553.x     Document Type: Article

References (49)

1. Alexander SPH, Mathie A, Peters JA (2008). Guide to Receptors and Channels (GRAC), 3rd edition (2008 revision). Br J Pharmacol 153 (Suppl. 2 S1 S209.
2. Álvarez Y, Pérez-Giron JV, Hernanz R, Briones AM, García-Redondo A, Beltrán A et al. (2007). Losartan reduces the increased participation of cyclooxygenase-2-derived products in vascular responses of hypertensive rats. J Pharmacol Exp Ther 321 (1 381 388.
3. Angulo J, Cuevas P, Fernández A, Allona A, Moncada I, Martín-Morales A et al. (2006). Enhanced thromboxane receptor-mediated responses and impaired endothelium-dependent relaxation in human corpus cavernosum from diabetic impotent men: role of protein kinase C activity. J Pharmacol Exp Ther 319 (2 783 789.
4. Angulo J, Cuevas P, Fernández A, Gabancho S, Allona A, Martín-Morales A et al. (2003). Diabetes impairs endothelium-dependent relaxation of human penile vascular tissues mediated by NO and EDHF. Biochem Biophys Res Commun 312 (4 1202 1208.
5. Angulo J, Cuevas P, La Fuente JM, Pomerol JM, Ruiz-Castane E, Puigvert A et al. (2002). Regulation of human penile smooth muscle tone by prostanoid receptors. Br J Pharmacol 136 : 23 30.
6. Azadzoi KM, Kim N, Brown ML, Goldstein I, Cohen RA, Saenz de Tejada I (1992). Endothelium-derived nitric oxide and cyclooxygenase products modulate corpus cavernosum smooth muscle tone. J Urol 147 : 220 225.
7. Baber RS, Hunter CC, Trinity JB, Hyman AL, Kadowitz PJ (2003). Role of Cyclooxygenase-2 in the generation of vasoactive prostanoids in the rat pulmonary and systemic vascular beds. Circulation 108 : 896 901.
8. Baber SR, Deng W, Rodriguez J, Master RG, Bivalacqua TJ, Hyman AL et al. (2005). Vasoactive prostanoids are generated from arachidonic acid by COX-1 and COX-2 in the mouse. Am J Physiol Heart Circ Physiol 289 (4 H1476 H1487.
9. Bagi Z, Erdei N, Toth A, Li W, Hintze TH, Koller A et al. (2005). Type 2 diabetic mice have increased arteriolar tone and blood pressure: enhanced release of COX-2-derived constrictor prostaglandins. Arterioscler Thromb Vasc Biol 25 (8 1610 1616.
10. Billups KL (2005). Erectile dusfunction as an early sign of cardiovascular disease. Int J Impot Res 1 : S19 24.
11. Brock TG, McNish RW, Peters-Golden M (1999). Arachidonic acid is preferentially metabolized by cyclooxygenase-2 to prostacyclin and prostaglandin E2. J Biol Chem 274 (17 11660 11666.
12. Christ GJ, Maayani S, Valcic M, Melman A (1990). Pharmacological studies of human erectile tissue: characteristics of spontaneous contractions and alterations in alpha-adrenoceptor responsiveness with age and disease in isolated tissues. Br J Pharmacol 101 (2 375 381.
13. Daley JT, Brown ML, Watkins T, Traish AM, Huang YH, Moreland RB et al. (1996). Prostanoid production in rabbit corpus cavernosum: I. Regulation by oxygen tension. J Urol 155 : 1482 1487.
14. De Vriese AS, Verbeuren TJ, Van de Voorde J, Lameire NH, Vanhoutte PM (2000). Endothelial dysfunction in diabetes. Br J Pharmacol 130 (5 963 974.
15. Du X, Edelstein D, Obici S, Higham N, Zou MH, Brownlee M (2006). Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation. J Clin Invest 116 (4 1071 1080.
16. Ermert L, Ermert M, Althoff A, Merkle M, Grimminger F, Seeger W (1998). Vasoregulatory prostanoid generation proceeds via cyclooxygenase-2 in noninflamed rat lungs. J Pharmacol Exp Ther 286 (3 1309 1314.
17. Espósito K, Giugliano F, Martedì E, Feola G, Marfella R, D'Armiento M et al. (2005). High proportions of erectile dysfunction in men with the metabolic syndrome. Diabetes Care 28 (5 1201 1203.
18. Fonseca VA, Jawa A (2005). Endothelial and erectile dysfunction, diabetes mellitus, and the metabolic syndrome: common pathways and treatments? Am J Cardiol 96 (12B 13M 18M.
19. Goodwill AG, James ME, Frisbee JC (2008). Increased vascular thromboxane generation impairs dilation of skeletal muscle arterioles of obese Zucker rats with reduced oxygen tension. Am J Physiol Heart Circ Physiol 295 (4 H1522 H1528.
20. Guerre-Millo M (1997). Regulation of ob gene overexpression in obesity. Biomed Pharmacother 51 (8 318 323.
21. Guo Z, Su W, Allen S, Pang H, Daugherty A, Smart E et al. (2005). COX-2 up-regulation and vascular smooth muscle contractile hyperreactivity in spontaneous diabetic db/db mice. Cardiovasc Res 67 (4 723 735.
22. Hashitani H, Yanai Y, Shirasawa N, Soji T, Tomita A, Kohri K et al. (2005). Interaction between spontaneous and neurally mediated regulation of smooth muscle tone in the rabbit corpus cavernosum. J Physiol 569 (Pt 3 723 735.
23. Henrion D, Dechaux E, Dowell FJ, Maclour J, Samuel JL, Lévy BI et al. (1997). Alteration of flow-induced dilatation in mesenteric resistance arteries of L-NAME treated rats and its partial association with induction of cyclo-oxygenase-2. Br J Pharmacol 121 (1 83 90.
24. Herranz R, Briones AM, Alonso MJ, Vila E, Salaices M (2004). Hypertension alters role of iNOS, COX-2, and oxidative stress in bradykinin relaxation impairment after LPS in rat cerebral arteries. Am J Physiol Heart Circ Physiol 287 (1 H225 H234.
25. Hodnett BL, Dearman JA, Carter CB, Hester RL (2009). Attenuated PGI2 synthesis in Obese Zucker Rats. Am J Physiol Regul Integr Comp Physiol 296 (3 R715 R721.
26. Hsu SM, Raine L, Fanger H (1981). Use of avidin-biotin-peroxidase complex (ABC) in immunoperoxidase techniques: a comparison between ABC and unlabeled antibody (PAP) procedures. J Histochem Cytochem 29 : 577 580.
27. Kawka DW, Ouellet M, Hétu PO, Signer II, Riendeau D (2007). Double-label expression studies of prostacyclin synthase, thromboxane synthase and COX isoforms in normal aortic endothelium. Biochim et Biophys Acta 1771 : 45 54.
28. Keegan A, Cotter MA, Cameron NE (1999). Effects of diabetes and treatment with the antioxidant alpha-lipoic acid on endothelial and neurogenic responses of corpus cavernosum in rats. Diabetologia 42 : 343 350.
29. Kuboki K, Jiang ZY, Takahara N, Ha SW, Igarashi M, Yamauchi T et al. (2000). Regulation of endothelial constitutive nitric oxide synthase gene expression in endothelial cells and in vivo: a specific vascular action of insulin. Circulation 101 (6 676 681.
30. Laemmel E, Bonnardel-Phu E, Hou X, Seror J, Vicaut E (2003). Interaction between nitric oxide and prostanoids in arterioles of rat cremaster muscle in vivo. Am J Physiol Heart Circ Physiol. 285 (3 H1254 H1260.
31. Martínez AC, Prieto D, Hernández M, Rivera L, Recio P, García-Sacristán A et al. (2005). Endothelial mechanisms underlying responses to ACh in the horse deep dorsal penile vein. Eur J Pharmacol 515 : 150 159.
32. Matsumoto T, Kakami M, Noguchi E, Kobayashi T, Kamata K (2007). Imbalance between endothelium-derived relaxing and contracting factors in mesenteric arteries from aged OLETF rats, a model of Type 2 diabetes. Am J Physiol Heart Circ Physiol 293 (3 H1480 H1490.
33. Okahara K, Sun B, Kambayashi J (1998). Upregulation of prostacyclin synthesis-related gene expression by shear stress in vascular endothelial cells. Arterioscler Thromb Vasc Biol 18 (12 1922 1926.
34. Okon EB, Chung AW, Rauniyar P, Padilla E, Tejerina T, McManus BM et al. (2005). Compromised arterial function in human type 2 diabetic patiens. Diabetes 54 (8 2415 2423.
35. Prieto D (2008). Physiological regulation of penile arteries and veins. Int J Impot Res 20 : 17 29.
36. + channels and ouabain-sensitive mechanisms to the endothelium-dependent relaxations of horse penile small arteries. Br J Pharmacol 123 : 1609 1620.
37. Qui Z, Cai H, Morrow JD, Breyer MD (2006). Differentiation of cyclooxygenase 1- and 2-derived prostanoids in mouse kidney and aorta. Hypertension 48 (2 323 328.
38. Ruiz Rubio JL, Hernández M, Rivera de los Arcos L, Martínez AC, García-Sacristán A, Prieto D. (2004). Mechanisms of prostaglandin E1-induced relaxation in penile resistance arteries. J Urol 171 : 968 973. (Pubitemid 38090543)
39. Saenz de Tejada I, Goldstein I, Azadzoi K, Krane RJ, Cohen RA (1989). Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence. N Engl J Med 320 (16 1025 1030.
40. Shi Y, Vanhoutte PM (2008). Oxidative stress and COX cause hyper-responsiveness in vascular smooth muscle of the femoral artery from diabetic rats. Br J Pharmacol 154 (3 639 651.
41. Simonsen U, Contreras J, García-Sacristán A, Martínez AC (2001). Effect of sildenafil on non-adrenergic non-cholinergic neurotransmision in bovine penile small arteries. Eur J Pharmacol 412 (2 155 169.
42. Seibert K, Zhang Y, Leahy K, Hauser S, Masferrer J, Perkins W et al. (1994). Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc Natl Acad Sci USA 91 (25 12013 12017.
43. Topper JN, Cai J, Falb D, Gimbrone MA Jr. (1996). Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress. Proc Natl Acad Sci USA 93 (19 10417 10422.
44. Vanhoutte PM, Shimokawa H, Tang EH, Feletou M (2009). Endothelial dysfunction and vascular disease. Acta Physiol (Oxf) 196 (2 193 222.
45. Vickers MA, Wright EA (2004). Erectile dysfunction in patient with diabetes mellitus. Am J Manag Care 10 (Suppl. 1 S3 S11.
46. Villalba N, Martínez MP, Briones AM, Sánchez A, Salaíces M, García-Sacristán A et al. (2009). Differential structural and functional changes of penile and coronary arteries from obese Zucker rats. Am J Physiol Heart Circ Physiol 297 (2 H696 H707.
47. Warner TD, Mitchell JA (2004). Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic. FASEB J 18 (7 790 804.
48. Xiang L, Dearman J, Abram SR, Carter C, Hester RL (2008). Insulin resistance and impaired functional vasodilation in obese Zucker rats. Am J Physiol Heart Circ Physiol 294 (4 H1658 H1666.
49. Yang D, Félétou M, Boulanger CM, Wu HF, Levens N, Zhang JN et al. (2002). Oxygen-derived free radicals mediate endothelium-dependent contractions to acetylcholine in aortas from spontaneously hypertensive rats. Br J Pharmacol 136 (1 104 110.