α-Adrenoceptor-mediated vasoconstriction is not involved in impaired functional vasodilation in the obese zucker rat

Clinical and Experimental Pharmacology and Physiology

Volumn 35, Issue 5-6, 2008, Pages 611-616

  Naik, Jay S ^a   Xiang, Lusha ^b   Hodnett, Benjamin L ^b   Hester, Robert L ^b  

^a NEW MEXICO INSTITUTE OF MINING AND TECHNOLOGY   (United States)

^b UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

Author keywords

Blood flow; Functional hyperaemia; Metabolic syndrome; Microcirculation; Vasoconstriction

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; PHENTOLAMINE; PHENYLEPHRINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD FLOW; BLOOD PRESSURE MEASUREMENT; BLOOD VESSEL TONE; CONDUCTANCE; CONTROLLED STUDY; EXERCISE; HINDLIMB; HYPEREMIA; ILIAC ARTERY; LEAN BODY WEIGHT; MALE; METABOLIC SYNDROME X; MICROCIRCULATION; MUSCLE CONTRACTION; NONHUMAN; OBESITY; PERFUSION PRESSURE; RAT; RECEPTOR SENSITIVITY; TRAPEZIUS MUSCLE; VASOCONSTRICTION; VASODILATATION; ZUCKER RAT;

ANIMALS; BLOOD PRESSURE; HEART RATE; HYDRAZINES; MALE; MUSCLE, SKELETAL; OBESITY; PHENYLEPHRINE; RATS; RATS, ZUCKER; RECEPTORS, ADRENERGIC, ALPHA; VASOCONSTRICTION; VASODILATION;

EID: 41749085064     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2007.04849.x     Document Type: Article

References (36)

1. Ford ES. Prevalence of the metabolic syndrome in US populations. Endocrinol. Metab. Clin. North Am. 2004 33 : 333 50.
2. Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: Findings from the Third National Health and Nutrition Examination Survey. JAMA 2002 287 : 356 9.
3. Frisbee JC. Impaired hemorrhage tolerance in the obese Zucker rat model of metabolic syndrome. J. Appl. Physiol. 2006 100 : 465 73.
4. Naik JS, Xiang L, Hester RL. Enhanced role for RhoA-associated kinase in adrenergic-mediated vasoconstriction in gracilis arteries from obese Zucker rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2006 290 : R154 61.
5. Stepp DW, Frisbee JC. Augmented adrenergic vasoconstriction in hypertensive diabetic obese Zucker rats. Am. J. Physiol. Heart Circ. Physiol. 2002 282 : H816 20.
6. Okon EB, Szado T, Laher I, McManus B, van Breemen C. Augmented contractile response of vascular smooth muscle in a diabetic mouse model. J. Vasc. Res. 2003 40 : 520 30.
7. Schreihofer AM, Hair CD, Stepp DW. Reduced plasma volume and mesenteric vascular reactivity in obese Zucker rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2005 288 : R253 61.
8. Hall JE, Brands MW, Dixon W, Smith MJ. Obesity-induced hypertension. Renal function and systemic hemodynamics. Hypertension 1993 22 : 292 9.
9. Licata G, Scaglione R, Barbagallo M et al. Effect of obesity on left ventricular function studied by radionuclide angiocardiography. Int. J. Obes. 1991 15 : 295 302.
10. Schutte R, Huisman H, Schutte A, Malan N. Plasma endothelin-1 is not increased in overweight/obese hypertensive African women. Blood Press. 2005 14 : 279 83.
11. Scaglione R, Ganguzza A, Corrao S et al. Central obesity and hypertension: Pathophysiologic role of renal haemodynamics and function. Int. J. Obes. Relat. Metab. Disord. 1995 19 : 403 9.
12. Salvadori A, Fanari P, Fontana M et al. Oxygen uptake and cardiac performance in obese and normal subjects during exercise. Respiration 1999 66 : 25 33.
13. Norman A-C, Drinkard B, McDuffie JR, Ghorbani S, Yanoff LB, Yanovski JA. Influence of excess adiposity on exercise fitness and performance in overweight children and adolescents. Pediatrics 2005 115 : E690 6.
14. Xiang L, Naik J, Hester RL. Exercise-induced increase in skeletal muscle vasodilatory responses in obese Zucker rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2005 288 : R987 91.
15. Xiang L, Naik JS, Hodnett BL, Hester RL. Altered arachidonic acid metabolism impairs functional vasodilation in metabolic syndrome. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2006 290 : R134 8.
16. Alonso-Galicia M, Brands MW, Zappe DH, Hall JE. Hypertension in obese Zucker rats: Role of angiotensin II and adrenergic activity. Hypertension 1996 28 : 1047 54.
17. Kampf C, Bodin B, Kallskog O, Carlsson C, Jansson L. Marked increase in white adipose tissue blood perfusion in the type 2 diabetic GK rat. Diabetes 2005 54 : 2620 7.
18. Wertheimer E, Shapiro B. The physiology of adipose tissue. Physiol. Rev. 1948 28 : 451 64.
19. Bailey JK, Kindig CA, Behnke BJ, Musch TI, Schmid-Schoenbein GW, Poole DC. Spinotrapezius muscle microcirculatory function: Effects of surgical exteriorization. Am. J. Physiol. Heart Circ. Physiol. 2000 279 : H3131 7.
20. 2 in contracting rat spinotrapezius muscle. Am. J. Physiol. Heart Circ. Physiol. 1987 252 : H1192 202.
21. Barringer DL, Bunag RD. Uneven blunting of chronotropic baroreflexes in obese Zucker rats. Am. J. Physiol. Heart Circ. Physiol. 1989 256 : H417 21.
22. Bunaq R, Barringer DL. Obese Zucker rats, though still normotensive, already have imparied chronotropic baroreflexes. Clin. Exp. Hypertens. A 1988 10 : 257 62.
23. Schreihofer AM, Mobley SC, Mandel DA, Stepp DW. Impairment of sympathetic baroreceptor reflexes in obese Zucker rats. Am. J. Physiol. Heart Circ. Physiol. 2007 293 : H2543 9.
24. Huggett RJ, Burns J, Mackintosh AF, Mary SD. Sympathetic neural activation in nondiabetic metabolic syndrome and its further augmentation by hypertension. Hypertension 2004 44 : 847 52.
25. Alvarez GE, Beske SD, Ballard TP, Davy KP. Sympathetic neural activation in visceral obesity. Circulation 2002 106 : 2533 6.
26. Kuniyoshi FHS, Trombetta IC, Batalha LT et al. Abnormal neurovascular control during sympathoexcitation in obesity. Obes. Res. 2003 11 : 1411 19.
27. Morgan DA, Anderson EA, Mark AL. Renal sympathetic nerve activity is increased in obese Zucker rats. Hypertension 1995 25 : 834 8.
28. Carlson SH, Shelton J, White CR, Wyss JM. Elevated sympathetic activity contributes to hypertension and salt sensitivity in diabetic obese Zucker rats. Hypertension 2000 35 : 403 8.
29. Frisbee JC. Enhanced arteriolar alpha-adrenergic constriction impairs dilator responses and skeletal muscle perfusion in obese Zucker rats. J. Appl. Physiol. 2004 97 : 764 72.
30. Frisbee JC. Impaired skeletal muscle perfusion in obese Zucker rats. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2003 285 : R1124 34.
31. Buckwalter JB, Naik JS, Valic Z, Clifford PS. Exercise attenuates alpha-adrenergic-receptor responsiveness in skeletal muscle vasculature. J. Appl. Physiol. 2001 90 : 172 8.
32. Buckwalter JB, Clifford PS. Alpha-adrenergic vasoconstriction in active skeletal muscles during dynamic exercise. Am. J. Physiol. Heart Circ. Physiol. 1999 277 : H33 9.
33. Hajduczok G, Hade J, Mark A, Williams J, Felder R. Central command increases sympathetic nerve activity during spontaneous locomotion in cats. Circ. Res. 1991 69 : 66 75.
34. DiCarlo SE, Bishop VS. Onset of exercise shifts operating point of arterial baroreflex to higher pressures. Am. J. Physiol. Heart Circ. Physiol. 1992 262 : H303 7.
35. Newcomer SC, Leuenberger UA, Hogeman CS, Handly BD, Proctor DN. Different vasodilator responses of human arms and legs. J. Physiol. 2004 556 : 1001 11.
36. Hahn SA, Ferreira LF, Williams JB et al. Downhill treadmill running trains the rat spinotrapezius muscle. J. Appl. Physiol. 2007 102 : 412 16.